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Clinical Rheumatology

Erschienen in:

15.07.2021 | Original Article

Simple metabolic markers associated with tophaceous gout

verfasst von: Wei Liu, Hui Song, Siliang Man, Hongchao Li, Siming Gao

Erschienen in: Clinical Rheumatology | Ausgabe 12/2021

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Abstract

Introduction

The relationship between tophaceous gout and metabolic markers is not well understood. The aim of this study was to compare the correlations between different metabolic markers and tophi and evaluate their potential predictive values for tophus.

Method

We analysed the data of gout patients in Beijing Jishuitan Hospital from 2013 to 2020. Ten laboratory indicators (UA, eGFR, underexcretion, GLU, TRIG, HDL-C, ALT, TBIL, γ-GT and UPH) were included to evaluate the relationship between tophaceous gout and metabolic markers.

Results

Tophi was present in 14.7% (119/808) of gout patients. UA, eGFR, ALT and γ-GT were independently related to the development of tophi; UA and γ-GT were positively correlated. The γ-GT/ALT ratio and UA/eGFR ratio showed a positive correlation with tophi, with (rho, P) of (0.305, < 0.001) and (0.195, < 0.001), respectively. The γ-GT/ALT ratio showed the best classificatory performance (AUC = 0.749, P < 0.001) for tophi among the four positive correlation indicators. With increasing integer γ-GT/ALT ratio, the incidence of tophi (4.9%, 9.7%, 22.3% and 38.4%, P < 0.001), chronic kidney disease (2.5%, 5.2%, 12.3% and 19.2%, P < 0.001) and hyperuricemia over 10 years (6.6%, 10.7%, 18.5% and 26.4%, P < 0.001) showed a progressive increase. The γ-GT/ALT ratio was positively correlated with the number of tophi and duration of hyperuricemia, negatively correlated with eGFR.

Conclusions

UA, eGFR, γ-GT and ALT were independently associated with tophi. The γ-GT/ALT ratio may be used as a predictor or monitor of tophi.

Key Points

• We found that UA, eGFR, γ-GT and ALT were independently related to tophi among clinical commonly indicators.

• The γ-GT/ALT ratio performed best in the identification of tophaceous gout from gout.

• The incidence of tophi and chronic kidney disease and duration of hyperuricemia increased with γ-GT/ALT ratio.

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Titel: Simple metabolic markers associated with tophaceous gout
verfasst von: Wei Liu
Hui Song
Siliang Man
Hongchao Li
Siming Gao
Publikationsdatum: 15.07.2021
Verlag: Springer International Publishing
Erschienen in: Clinical Rheumatology / Ausgabe 12/2021
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-021-05861-x

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Simple metabolic markers associated with tophaceous gout

Abstract

Introduction

Method

Results

Conclusions

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Abstract

Introduction

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