Introduction
Methods
Hospital patients and settings
Data acquisition
Definitions
Criteria set
Data analysis
Results
Characteristics | All patients (n = 398) | Patients with IE (n = 44) | Patients without IE (n = 354) |
---|---|---|---|
Age | 58.6 ± 17.1 | 44 ± 12.4 | 59.7 ± 17.3 |
Male | 238 (59.8 %) | 24 (54.5 %) | 214 (60.5 %) |
Nursing home resident | 58 (14.6 %) | 2 (4.5 %) | 56 (15.8 %) |
MRSA bacteremia characteristics | |||
Community | 105 (26.4 %) | 22 (50 %) | 83 (23.4 %) |
Health care-associated | 224 (56.3 %) | 18 (40.9 %) | 206 (58.2 %) |
Hospital-acquired | 69 (17.3 %) | 4 (9.1 %) | 65 (18.4 %) |
Duration of MRSA bacteremia (median) | 4.47 days | 6.86 days | 4.12 days |
Presumed source of infection | |||
Graft infection | 10 (2.5 %) | 1 (2.3 %) | 9 (2.5 %) |
Short term catheter | 55 (13.8 %) | 0 (0 %) | 55 (15.5 %) |
Implantable catheter | 33 (8.3 %) | 3 (6.8 %) | 30 (8.5 %) |
Skin/wound | 132 (33.2 %) | 9 (20.5 %) | 123 (34.7 %) |
Intra-abdominal | 10 (2.5 %) | 1 (2.3 %) | 9 (2.5 %) |
Respiratory | 48 (12.1 %) | 9 (20.5 %) | 39 (11 %) |
Para-spinal abscess | 2 (0.5 %) | 1 (2.3 %) | 1 (0.3 %) |
Urinary tract | 36 (9 %) | 0 (0 %) | 36 (10.3 %) |
Other | 72 (18.1 %) | 20 (45.5 %) | 52 (14.7 %) |
Comorbidities | |||
Diabetes | 161 (40.5 %) | 13 (29.5 %) | 148 (41.8 %) |
Hemodialysis | 90 (22.6 %) | 4 (9.1 %) | 86 (24.3 %) |
HIV | 20 (5 %) | 5 (11.4 %) | 15 (4.2 %) |
Nursing home resident | 58 (14.6 %) | 2 (4.5 %) | 56 (15.8 %) |
Diagnosis of infective endocarditis
Prediction criteria for diagnosis of IE
Prediction criterion | All patients (n = 398) | Without IE (n = 354) | With IE (n = 44) |
P-value | Odds ratio | Odds ratio 95 % confidence limits | |
---|---|---|---|---|---|---|---|
Prolonged bacteremia | 269 (67.5 %) | 232 (65.5 %) | 37 (84.1 %) | 0.167 | 2.131 | 0.729 | 6.229 |
Intravenous drug use | 85 (21.3 %) | 53 (15 %) | 32 (72.7 %) | <0.001* | 14.951 | 5.356 | 41.734 |
Implantable catheter | 60 (15 %) | 57 (16.1 %) | 3 (6.8 %) | 0.387 | 3.441 | 0.209 | 56.657 |
Intracardiac device | 19 (4.7 %) | 18 (5.1 %) | 1 (2.3 %) | 0.384 | 0.280 | 0.016 | 4.917 |
Prosthetic valve | 19 (4.7 %) | 7 (2 %) | 6 (13.6 %) | 0.002* | 13.086 | 2.529 | 67.704 |
Hemodialysis | 90 (22.6 %) | 86 (24.3 %) | 4 (9.1 %) | 0.122 | 0.068 | 0.002 | 2.040 |
Osteomyelitis | 52 (13 %) | 46 (13 %) | 6 (13.6 %) | 0.067 | 0.287 | 0.076 | 1.089 |
Previous IE | 19 (4.7 %%) | 10 (2.8 %) | 9 (20.5 %) | 0.117 | 2.849 | 0.769 | 10.554 |
Cardio-structural abnormality | 13 (3.2 %) | 9 (2.5 %) | 4 (9.1 %) | 0.035* | 6.095 | 1.132 | 32.833 |