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Inflammation Research
Erschienen in: Inflammation Research 11/2010

01.11.2010 | Original Research Paper

Single nucleotide polymorphisms in inflammatory genes and the risk of early onset of lone atrial fibrillation

verfasst von: Kristoffer M. A. Henningsen, Morten S. Olesen, Maria Pedersen, Lone Nielsen, Stig Haunsø, Helle Bruunsgaard, Jesper Hastrup Svendsen

Erschienen in: Inflammation Research | Ausgabe 11/2010

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Abstract

Background

Systemic low-grade inflammation is a prognostic risk factor of atrial fibrillation (AF).

Objective

We hypothesized that genetic polymorphisms, which determine the rate of inflammatory cytokines, are associated with the risk of AF, independently of comorbidity.

Methods and results

We included 192 patients with so-called lone AF and age 40 years or below, and 188 healthy controls. All patients were genotyped for single nucleotide polymorphisms (SNPs) in inflammatory genes using fluorescence-based real-time polymerase chain reaction (PCR). A case-control analysis of the C/C, C/T and T/T genotypes on IL1A-889 revealed a significant difference in both the frequency of genotypes (p = 0.03) and in the allelic frequency (p = 0.015). These differences were not significant after Bonferroni corrections. For IL1B-511, IL10-592, IL10-1082, IL18-137, IL18-607 and TNF-308 there were no significant differences, neither in genotype frequency, nor in allelic frequency between the lone AF patients and the controls.

Conclusion

Our study failed to show an association between polymorphisms in inflammatory genes and early onset of lone AF. It remains to be established whether polymorphisms in inflammatory genes play a causative role in the pathophysiology of AF.
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Metadaten
Titel
Single nucleotide polymorphisms in inflammatory genes and the risk of early onset of lone atrial fibrillation
verfasst von
Kristoffer M. A. Henningsen
Morten S. Olesen
Maria Pedersen
Lone Nielsen
Stig Haunsø
Helle Bruunsgaard
Jesper Hastrup Svendsen
Publikationsdatum
01.11.2010
Verlag
SP Birkhäuser Verlag Basel
Erschienen in
Inflammation Research / Ausgabe 11/2010
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-010-0210-8

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