Erschienen in:
01.05.2012 | Original Article
Skeletal muscle reoxygenation after high-intensity exercise in mitochondrial myopathy
verfasst von:
Daniela M. Bravo, Ana Cristina Gimenes, Rúbia B. Nascimento, Eloara V. M. Ferreira, Ana Cristina B. Siqueira, Ethiane D. S. Meda, J. Alberto Neder, Luiz Eduardo Nery
Erschienen in:
European Journal of Applied Physiology
|
Ausgabe 5/2012
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Abstract
This study addressed whether O2 delivery during recovery from high-intensity, supra-gas exchange threshold exercise would be matched to O2 utilization at the microvascular level in patients with mitochondrial myopathy (MM). Off-exercise kinetics of (1) pulmonary O2 uptake \( (\dot{V}{\text{O}}_{2} {\text{p}}), \) (2) an index of fractional O2 extraction by near-infrared spectroscopy (Δ[deoxy-Hb + Mb]) in the vastus lateralis and (3) cardiac output (Q
T
′
) by impedance cardiography were assessed in 12 patients with biopsy-proven MM (chronic progressive external ophthalmoplegia) and 12 age- and gender-matched controls. Kinetics of \( \dot{V}{\text{O}}_{2} {\text{p}} \) were significantly slower in patients than controls (τ = 53.8 ± 16.5 vs. 38.8 ± 7.6 s, respectively; p < 0.05). Q
T
′
, however, declined at similar rates (τ = 64.7 ± 18.8 vs. 73.0 ± 21.6 s; p > 0.05) being typically slower than \( \dot{V}{\text{O}}_{2} {\text{p}} \) in both groups. Importantly, Δ[deoxy-Hb + Mb] dynamics (MRT) were equal to, or faster than, \( \tau \dot{V}{\text{O}}_{2} {\text{p}} \) in patients and controls, respectively. In fact, there were no between-group differences in \( \tau \dot{V}{\text{O}}_{2} {\text{p}} \)/MRTΔ[deoxy-Hb + Mb] (1.1 ± 0.4 vs. 1.0 ± 0.2, p > 0.05) thereby indicating similar rates of microvascular O2 delivery. These data indicate that the slower rate of recovery of muscle metabolism after high-intensity exercise is not related to impaired microvascular O2 delivery in patients with MM. This phenomenon, therefore, seems to reflect the intra-myocyte abnormalities that characterize this patient population.