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European Journal of Applied Physiology

Erschienen in:

19.07.2023 | Original Article

Skipping breakfast does not accelerate the hyperglycemia-induced endothelial dysfunction but reduces blood flow of the brachial artery in young men

verfasst von: Tatsuki Kamoda, Rintaro Sakamoto, Masaki Katayose, Saki Yamamoto, Toru Neki, Kohei Sato, Erika Iwamoto

Erschienen in: European Journal of Applied Physiology | Ausgabe 1/2024

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Abstract

Purpose

Postprandial hyperglycemia is assumed to have a negative impact on flow-mediated dilation (FMD), an index of endothelial function, and blood flow of the peripheral conduit arteries. This study aimed to determine whether the enhancement of postprandial hyperglycemia by skipping breakfast accelerates endothelial dysfunction and reduces the blood flow in the brachial artery in young men.

Methods

Using a randomized cross-over design, ten healthy men completed two trials: with and without breakfast (Eating and Fasting trials, respectively). Venous blood sampling and brachial FMD tests were conducted before, 30, 60, 90, and 120 min after a 75-g oral glucose tolerance test (OGTT).

Results

Skipping breakfast boosted post-OGTT glucose levels than having breakfast (P = 0.01). The magnitude of the decrease in FMD via OGTT did not vary between trials (main effect of trial P = 0.55). Although brachial blood flow tended to decrease after OGTT in both trials (interaction and main effect of time P = 0.61 and P = 0.054, respectively), the decrease in blood flow following OGTT was greater in the Fasting trial than in the Eating trial (main effect of trial, mean difference = − 15.8 mL/min [95%CI = − 25.6 to − 6.0 mL/min], P < 0.01).

Conclusion

Skipping breakfast did not enhance the magnitude of the decrease in FMD following glucose loading, but did accelerate hyperglycemia-induced reduction in brachial blood flow. Current findings suggest that even missing one breakfast has negative impacts on the blood flow regulation of the peripheral conduit arteries in young men who habitually eat breakfast.

Alberti KG, Zimmet PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15(7):539–553CrossRefPubMed

Atkinson G, Batterham AM, Thijssen DH, Green DJ (2013) A new approach to improve the specificity of flow-mediated dilation for indicating endothelial function in cardiovascular research. J Hypertens 31(2):287–291. https://doi.org/10.1097/HJH.0b013e32835b8164CrossRefPubMed

Ballard KD, Berry CW, Varty CJ, Arslain KB, Timmerman KL (2019) Aerobic or resistance exercise performed the previous day does not attenuate postprandial hyperglycemia-induced endothelial dysfunction in overweight/obese adults. Eur J Appl Physiol 119(8):1855–1863. https://doi.org/10.1007/s00421-019-04174-xCrossRefPubMed

Baron AD, Laakso M, Brechtel G, Hoit B, Watt C, Edelman SV (1990) Reduced postprandial skeletal muscle blood flow contributes to glucose intolerance in human obesity. J Clin Endocrinol Metab 70(6):1525–1533. https://doi.org/10.1210/jcem-70-6-1525CrossRefPubMed

Bi H, Gan Y, Yang C, Chen Y, Tong X, Lu Z (2015) Breakfast skipping and the risk of type 2 diabetes: a meta-analysis of observational studies. Public Health Nutr 18(16):3013–3019. https://doi.org/10.1017/S1368980015000257CrossRefPubMedPubMedCentral

Bjørnarå HB, Vik FN, Brug J, Manios Y, De Bourdeaudhuij I, Jan N, Maes L, Moreno LA, Dössegger A, Bere E (2014) The association of breakfast skipping and television viewing at breakfast with weight status among parents of 10–12-year-olds in eight European countries; the energy (EuropeaN Energy balance Research to prevent excessive weight Gain among Youth) cross-sectional study. Public Health Nutr 17(4):906–914. https://doi.org/10.1017/s136898001300061xCrossRefPubMed

Black MA, Cable NT, Thijssen DH, Green DJ (2008) Importance of measuring the time course of flow-mediated dilatation in humans. Hypertension 51(2):203–210. https://doi.org/10.1161/HYPERTENSIONAHA.107.101014CrossRefPubMed

Bock JM, Iwamoto E, Horak JG, Feider AJ, Hanada S, Casey DP (2020) Aerobic exercise offsets endothelial dysfunction induced by repetitive consumption of sugar-sweetened beverages in young healthy men. Am J Physiol Regul Integr Comp Physiol 319(1):R11-18. https://doi.org/10.1152/ajpregu.00055.2020CrossRefPubMed

Boden G (2011) Obesity, insulin resistance and free fatty acids. Curr Opin Endocrinol Diabetes Obes 18(2):139–143. https://doi.org/10.1097/MED.0b013e3283444b09CrossRefPubMedPubMedCentral

Cagnacci A, Soldani R, Carriero P, Paoletti A, Fioretti P, Melis G (1992) Effects of low doses of transdermal 17 beta-estradiol on carbohydrate metabolism in postmenopausal women. J Clin Endocrinol Metab 74:1396–1400PubMed

Ceriello A, Esposito K, Piconi L, Ihnat M, Thorpe J, Testa R, Bonfigli AR, Giugliano D (2008a) Glucose “peak” and glucose “spike”: impact on endothelial function and oxidative stress. Diabetes Res Clin Pract 82(2):262–267. https://doi.org/10.1016/j.diabres.2008.07.015CrossRefPubMed

Ceriello A, Esposito K, Piconi L, Ihnat MA, Thorpe JE, Testa R, Boemi M, Giugliano D (2008b) Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients. Diabetes 57(5):1349–1354. https://doi.org/10.2337/db08-0063CrossRefPubMed

Ceriello A, Novials A, Canivell S, La Sala L, Pujadas G, Esposito K, Testa R, Bucciarelli L, Rondinelli M, Genovese S (2014) Simultaneous GLP-1 and insulin administration acutely enhances their vasodilatory, antiinflammatory, and antioxidant action in type 2 diabetes. Diabetes Care 37(7):1938–1943. https://doi.org/10.2337/dc13-2618CrossRefPubMed

Cho YI, Cho DJ, Rosenson RS (2014) Endothelial shear stress and blood viscosity in peripheral arterial disease. Curr Atheroscler Rep 16(4):404. https://doi.org/10.1007/s11883-014-0404-6CrossRefPubMed

Chung ST, Ha J, Onuzuruike AU, Kasturi K, Galvan-De La Cruz M, Bingham BA, Baker RL, Utumatwishima JN, Mabundo LS, Ricks M, Sherman AS, Sumner AE (2017) Time to glucose peak during an oral glucose tolerance test identifies prediabetes risk. Clin Endocrinol (Oxf) 87(5):484–491. https://doi.org/10.1111/cen.13416CrossRefPubMed

Clerk LH, Vincent MA, Barrett EJ, Lankford MF, Lindner JR (2007) Skeletal muscle capillary responses to insulin are abnormal in late-stage diabetes and are restored by angiotensin-converting enzyme inhibition. Am J Physiol Endocrinol Metab 293(6):E1804-1809. https://doi.org/10.1152/ajpendo.00498.2007CrossRefPubMed

Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, Deanfield J, Drexler H, Gerhard-Herman M, Herrington D, Vallance P, Vita J, Vogel R (2002) Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the international brachial artery reactivity task force. J Am Coll Cardiol 39(2):257–265. https://doi.org/10.1016/s0735-1097(01)01746-6CrossRefPubMed

Di Flaviani A, Picconi F, Di Stefano P, Giordani I, Malandrucco I, Maggio P, Palazzo P, Sgreccia F, Peraldo C, Farina F, Frajese G, Frontoni S (2011) Impact of glycemic and blood pressure variability on surrogate measures of cardiovascular outcomes in type 2 diabetic patients. Diabetes Care 34(7):1605–1609. https://doi.org/10.2337/dc11-0034CrossRefPubMedPubMedCentral

Evenepoel C, Clevers E, Deroover L, Van Loo W, Matthys C, Verbeke K (2020) Accuracy of nutrient calculations using the consumer-focused online app myfitnesspal: validation study. J Med Internet Res 22(10):e18237. https://doi.org/10.2196/18237CrossRefPubMedPubMedCentral

Fan M, Lyu J, He P (2014) Guidelines for data processing and analysis of the international physical activity questionnaire (IPAQ) -short and long forms-. Zhonghua Liu Xing Bing Xue Za Zhi 35:961–964PubMed

Grassi G, Biffi A, Dell’Oro R, Quarti Trevano F, Seravalle G, Corrao G, Perseghin G, Mancia G (2020) Sympathetic neural abnormalities in type 1 and type 2 diabetes: a systematic review and meta-analysis. J Hypertens 38(8):1436–1442. https://doi.org/10.1097/HJH.0000000000002431CrossRefPubMed

Horikawa C, Kodama S, Yachi Y, Heianza Y, Hirasawa R, Ibe Y, Saito K, Shimano H, Yamada N, Sone H (2011) Skipping breakfast and prevalence of overweight and obesity in Asian and Pacific regions: a meta-analysis. Prev Med 53(4–5):260–267. https://doi.org/10.1016/j.ypmed.2011.08.030CrossRefPubMed

International Diabetes Federation. IDF Diabetes Atlas, 10th edn. Brussels, Belgium: 2021. Available at: https://www.diabetesatlas.org. Accessed 15 Feb 2023

Iwamoto E, Bock JM, Casey DP (2018) High-intensity exercise enhances conduit artery vascular function in older adults. Med Sci Sports Exerc 50(1):124–130. https://doi.org/10.1249/mss.0000000000001405CrossRefPubMedPubMedCentral

Jakubowicz D, Wainstein J, Ahren B, Landau Z, Bar-Dayan Y, Froy O (2015) Fasting until noon triggers increased postprandial hyperglycemia and impaired insulin response after lunch and dinner in individuals with type 2 diabetes: a randomized clinical trial. Diabetes Care 38(10):1820–1826. https://doi.org/10.2337/dc15-0761CrossRefPubMed

Jakubowicz D, Wainstein J, Landau Z, Raz I, Ahren B, Chapnik N, Ganz T, Menaged M, Barnea M, Bar-Dayan Y, Froy O (2017) Influences of breakfast on clock gene expression and postprandial Glycemia in healthy individuals and individuals with diabetes: a randomized clinical trial. Diabetes Care 40(11):1573–1579. https://doi.org/10.2337/dc16-2753CrossRefPubMed

Jovanovic A, Leverton E, Solanky B, Ravikumar B, Snaar JE, Morris PG, Taylor R (2009) The second-meal phenomenon is associated with enhanced muscle glycogen storage in humans. Clin Sci (Lond) 117(3):119–127. https://doi.org/10.1042/CS20080542CrossRefPubMed

Kim JA, Montagnani M, Koh KK, Quon MJ (2006) Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation 113(15):1888–1904. https://doi.org/10.1161/circulationaha.105.563213CrossRefPubMed

Kobayashi F, Ogata H, Omi N, Nagasaka S, Yamaguchi S, Hibi M, Tokuyama K (2014) Effect of breakfast skipping on diurnal variation of energy metabolism and blood glucose. Obes Res Clin Pract 8(3):e201-298. https://doi.org/10.1016/j.orcp.2013.01.001CrossRefPubMed

Ministry of Health, Labour and Welfare (Japan) (2017) National Institute of Health and Nutrition (Japan). Japan National Health and Nutrition Survey 2017. https://www.mhlw.go.jp/content/000681194.pdf. Accessed 15 Feb 2023

Lee SH, Tura A, Mari A, Ko SH, Kwon HS, Song KH, Yoon KH, Lee KW, Ahn YB (2011) Potentiation of the early-phase insulin response by a prior meal contributes to the second-meal phenomenon in type 2 diabetes. Am J Physiol Endocrinol Metab 301(5):E984-990. https://doi.org/10.1152/ajpendo.00244.2011CrossRefPubMed

Levitan EB, Song Y, Ford ES, Liu S (2004) Is nondiabetic hyperglycemia a risk factor for cardiovascular disease? a meta-analysis of prospective studies. Arch Intern Med 164(19):2147–2155. https://doi.org/10.1001/archinte.164.19.2147CrossRefPubMed

Lyerly JE, Huber LR, Warren-Findlow J, Racine EF, Dmochowski J (2014) Is breakfast skipping associated with physical activity among U.S. adolescents? a cross-sectional study of adolescents aged 12–19 years, national health and nutrition examination survey (NHANES). Public Health Nutr 17(4):896–905. https://doi.org/10.1017/s1368980013000700CrossRefPubMed

Ma Y, Bertone ER, Stanek EJ 3rd, Reed GW, Hebert JR, Cohen NL, Merriam PA, Ockene IS (2003) Association between eating patterns and obesity in a free-living US adult population. Am J Epidemiol 158(1):85–92. https://doi.org/10.1093/aje/kwg117CrossRefPubMed

Mah E, Noh SK, Ballard KD, Matos ME, Volek JS, Bruno RS (2011) Postprandial hyperglycemia impairs vascular endothelial function in healthy men by inducing lipid peroxidation and increasing asymmetric dimethylarginine:arginine. J Nutr 141(11):1961–1968. https://doi.org/10.3945/jn.111.144592CrossRefPubMed

Mah E, Noh SK, Ballard KD, Park HJ, Volek JS, Bruno RS (2013) Supplementation of a gamma-tocopherol-rich mixture of tocopherols in healthy men protects against vascular endothelial dysfunction induced by postprandial hyperglycemia. J Nutr Biochem 24(1):196–203. https://doi.org/10.1016/j.jnutbio.2012.04.015CrossRefPubMed

Maruhashi T, Higashi Y (2021) Pathophysiological association between diabetes mellitus and endothelial dysfunction. Antioxidants (Basel) 10(8):1306. https://doi.org/10.3390/antiox10081306CrossRefPubMed

Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28(7):412–419. https://doi.org/10.1007/bf00280883CrossRefPubMed

Mekary RA, Giovannucci E, Willett WC, van Dam RM, Hu FB (2012) Eating patterns and type 2 diabetes risk in men: breakfast omission, eating frequency, and snacking. Am J Clin Nutr 95(5):1182–1189. https://doi.org/10.3945/ajcn.111.028209CrossRefPubMedPubMedCentral

Meza CA, La Favor JD, Kim DH, Hickner RC (2019) Endothelial dysfunction: is there a hyperglycemia-induced imbalance of NOX and NOS? Int J Mol Sci 20(15):3775. https://doi.org/10.3390/ijms20153775CrossRefPubMedPubMedCentral

Mikhail N, Tuck ML (2000) Insulin and the vasculature. Curr Hypertens Rep 2(2):148–153. https://doi.org/10.1007/s11906-000-0074-3CrossRefPubMed

Muniyappa R, Quon MJ (2007) Insulin action and insulin resistance in vascular endothelium. Curr Opin Clin Nutr Metab Care 10(4):523–530. https://doi.org/10.1097/MCO.0b013e32819f8ecdCrossRefPubMed

Mushtaq M, Abdul Mateen M, Kim UH (2019) Hyperglycemia associated blood viscosity can be a nexus stimuli. Clin Hemorheol Microcirc 71(1):103–112. https://doi.org/10.3233/ch-180426CrossRefPubMed

Nordestgaard BG, Langsted A, Mora S, Kolovou G, Baum H, Bruckert E, Watts GF, Sypniewska G, Wiklund O, Borén J, Chapman MJ, Cobbaert C, Descamps OS, von Eckardstein A, Kamstrup PR, Pulkki K, Kronenberg F, Remaley AT, Rifai N, Ros E, Langlois M, Society ftEA, Chemistry tEFoC, initiative LMjc (2016) Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cut-points—a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine. Eur Heart J 37 (25):1944-1958. doi:https://doi.org/10.1093/eurheartj/ehw152

Ogata H, Hatamoto Y, Goto Y, Tajiri E, Yoshimura E, Kiyono K, Uehara Y, Kawanaka K, Omi N, Tanaka H (2019) Association between breakfast skipping and postprandial hyperglycaemia after lunch in healthy young individuals. Br J Nutr 122(4):431–440. https://doi.org/10.1017/S0007114519001235CrossRefPubMed

Olver TD, Hazell TJ, Hamilton CD, Shoemaker JK, Lemon PW (2012) Impaired superficial femoral artery vasodilation and leg blood flow in young obese women following an oral glucose tolerance test. Appl Physiol Nutr Metab 37(1):176–183. https://doi.org/10.1139/h11-148CrossRefPubMed

Padilla J, Manrique-Acevedo C, Martinez-Lemus LA (2022) New insights into mechanisms of endothelial insulin resistance in type 2 diabetes. Am J Physiol Heart Circ Physiol 323(6):H1231-1238. https://doi.org/10.1152/ajpheart.00537.2022CrossRefPubMedPubMedCentral

Pendergast FJ, Livingstone KM, Worsley A, McNaughton SA (2016) Correlates of meal skipping in young adults: a systematic review. Int J Behav Nutr Phys Act 13(1):125. https://doi.org/10.1186/s12966-016-0451-1CrossRefPubMedPubMedCentral

Persson CE, Rothenberg E, Hansson PO, Welin C, Strandhagen E (2019) Cardiovascular risk factors in relation to dietary patterns in 50-year-old men and women: a feasibility study of a short FFQ. Public Health Nutr 22(4):645–653. https://doi.org/10.1017/s1368980018002264CrossRefPubMed

Reynolds LJ, Credeur DP, Manrique C, Padilla J, Fadel PJ, Thyfault JP (2017) Obesity, type 2 diabetes, and impaired insulin-stimulated blood flow: role of skeletal muscle NO synthase and endothelin-1. J Appl Physiol 122(1):38–47. https://doi.org/10.1152/japplphysiol.00286.2016CrossRefPubMed

Roberts-Thomson KM, Betik AC, Premilovac D, Rattigan S, Richards SM, Ross RM, Russell RD, Kaur G, Parker L, Keske MA (2020) Postprandial microvascular blood flow in skeletal muscle: similarities and disparities to the hyperinsulinaemic-euglycaemic clamp. Clin Exp Pharmacol Physiol 47(4):725–737. https://doi.org/10.1111/1440-1681.13237CrossRefPubMed

Roberts-Thomson KM, Parker L, Betik AC, Wadley GD, Gatta PAD, Marwick TH, Keske MA (2022) Oral and intravenous glucose administration elicit opposing microvascular blood flow responses in skeletal muscle of healthy people: role of incretins. J Physiol 600(7):1667–1681. https://doi.org/10.1113/jp282428CrossRefPubMed

Rong S, Snetselaar LG, Xu G, Sun Y, Liu B, Wallace RB, Bao W (2019) Association of skipping breakfast with cardiovascular and all-cause mortality. J Am Coll Cardiol 73(16):2025–2032. https://doi.org/10.1016/j.jacc.2019.01.065CrossRefPubMed

Rothenberg E, Strandhagen E, Samuelsson J, Ahlner F, Rydberg Sterner T, Skoog I, Lundberg CE (2021) Relative validity of a short 15-item food frequency questionnaire measuring dietary quality, by the diet history method. Nutrients. https://doi.org/10.3390/nu13113754CrossRefPubMedPubMedCentral

Smith KJ, Gall SL, McNaughton SA, Blizzard L, Dwyer T, Venn AJ (2010) Skipping breakfast: longitudinal associations with cardiometabolic risk factors in the Childhood Determinants of Adult Health Study. Am J Clin Nutr 92(6):1316–1325. https://doi.org/10.3945/ajcn.2010.30101CrossRefPubMed

Someya Y, Tamura Y, Suzuki R, Kaga H, Kadowaki S, Sugimoto D, Kakehi S, Funayama T, Furukawa Y, Takeno K, Sato J, Kanazawa A, Kawamori R, Watada H (2018) Characteristics of glucose metabolism in underweight Japanese women. J Endocr Soc 2(3):279–289. https://doi.org/10.1210/js.2017-00418CrossRefPubMedPubMedCentral

Steinberg HO, Brechtel G, Johnson A, Fineberg N, Baron AD (1994) Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent a novel action of insulin to increase nitric oxide release. J Clin Invest 94(3):1172–1179. https://doi.org/10.1172/jci117433CrossRefPubMedPubMedCentral

Teixeira V, Voci SM, Mendes-Netto RS, da Silva DG (2018) The relative validity of a food record using the smartphone application MyFitnessPal. Nutr Diet 75(2):219–225. https://doi.org/10.1111/1747-0080.12401CrossRefPubMed

Thijssen DH, Black MA, Pyke KE, Padilla J, Atkinson G, Harris RA, Parker B, Widlansky ME, Tschakovsky ME, Green DJ (2011) Assessment of flow-mediated dilation in humans: a methodological and physiological guideline. Am J Physiol Heart Circ Physiol 300(1):H2-12. https://doi.org/10.1152/ajpheart.00471.2010CrossRefPubMed

Thijssen DH, Bruno RM, van Mil A, Holder SM, Faita F, Greyling A, Zock PL, Taddei S, Deanfield JE, Luscher T, Green DJ, Ghiadoni L (2019) Expert consensus and evidence-based recommendations for the assessment of flow-mediated dilation in humans. Eur Heart J 40(30):2534–2547. https://doi.org/10.1093/eurheartj/ehz350CrossRefPubMed

Title LM, Cummings PM, Giddens K, Nassar BA (2000) Oral glucose loading acutely attenuates endothelium-dependent vasodilation in healthy adults without diabetes: an effect prevented by vitamins C and E. J Am Coll Cardiol 36(7):2185–2191. https://doi.org/10.1016/s0735-1097(00)00980-3CrossRefPubMed

Tominaga M, Eguchi H, Manaka H, Igarashi K, Kato T, Sekikawa A (1999) Impaired glucose tolerance is a risk factor for cardiovascular disease, but not impaired fasting glucose. The Funagata Diabetes Study Diabetes Care 22(6):920–924. https://doi.org/10.2337/diacare.22.6.920CrossRefPubMed

Vincent MA, Clerk LH, Lindner JR, Klibanov AL, Clark MG, Rattigan S, Barrett EJ (2004) Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo. Diabetes 53(6):1418–1423. https://doi.org/10.2337/diabetes.53.6.1418CrossRefPubMed

Walsh LK, Ghiarone T, Olver TD, Medina-Hernandez A, Edwards JC, Thorne PK, Emter CA, Lindner JR, Manrique-Acevedo C, Martinez-Lemus LA, Padilla J (2019) Increased endothelial shear stress improves insulin-stimulated vasodilatation in skeletal muscle. J Physiol 597(1):57–69. https://doi.org/10.1113/jp277050CrossRefPubMed

Wilding JP (2007) The importance of free fatty acids in the development of Type 2 diabetes. Diabet Med 24(9):934–945. https://doi.org/10.1111/j.1464-5491.2007.02186.xCrossRefPubMed

Wolever TM, Jenkins DJ (1986) The use of the glycemic index in predicting the blood glucose response to mixed meals. Am J Clin Nutr 43(1):167–172CrossRefPubMed

Titel: Skipping breakfast does not accelerate the hyperglycemia-induced endothelial dysfunction but reduces blood flow of the brachial artery in young men
verfasst von: Tatsuki Kamoda
Rintaro Sakamoto
Masaki Katayose
Saki Yamamoto
Toru Neki
Kohei Sato
Erika Iwamoto
Publikationsdatum: 19.07.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Applied Physiology / Ausgabe 1/2024
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-023-05273-6

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Skipping breakfast does not accelerate the hyperglycemia-induced endothelial dysfunction but reduces blood flow of the brachial artery in young men

Abstract

Purpose

Methods

Results

Conclusion

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Rauschtrinken in der frühen Adoleszenz

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Abstract

Purpose

Methods

Results

Conclusion

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