Background
Methods
Study subjects
Diagnostic groups
Population data
Demographic data
Statistical methods
Results
Osteosarcoma
N | Pop (000’s) | All Crude Rate / million | ASR (95% CI) | N | Pop (000’s) | Male Crude Rate / million | ASR (95% CI) | N | Pop (000’s) | Female Crude Rate / million | ASR (95 % CI) | ASR Ratio M:F (95% CI) | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Age
| |||||||||||||
Ages 0 to 14 | 817 | 279909 | 2.92 | 2.78 (2.59,2.97) | 406 | 142623 | 2.85 | 2.70 (2.44,2.97) | 411 | 137286 | 2.99 | 2.86 (2.58,3.14) | 0.9 (0.8,1.1) |
Ages 15 to 29 | 1315 | 311514 | 4.22 | 3.97 (3.76,4.19) | 821 | 156621 | 5.24 | 4.95 (4.61,5.29) | 494 | 154894 | 3.19 | 2.98 (2.71,3.24) | 1.7 (1.5,1.9) |
Ages 30 to 49 | 434 | 400790 | 1.08 | 1.08 (0.97,1.18) | 266 | 199591 | 1.33 | 1.33 (1.17,1.49) | 168 | 201199 | 0.83 | 0.83 (0.70,0.95) | 1.6 (1.3,1.9) |
Period
| |||||||||||||
1980 - 1985 | 524 | 225881 | 2.32 | 2.15 (1.96,2.34) | 304 | 113741 | 2.67 | 2.44 (2.17,2.72) | 220 | 112140 | 1.96 | 1.85 (1.60,2.10) | 1.3 (1.1,1.6) |
1986 - 1995 | 1010 | 382985 | 2.64 | 2.74 (2.57,2.91) | 607 | 192375 | 3.16 | 3.21 (2.95,3.47) | 403 | 190609 | 2.11 | 2.26 (2.04,2.49) | 1.4 (1.2,1.6) |
1996 - 2005 | 1032 | 383347 | 2.69 | 2.84 (2.67,3.02) | 582 | 192718 | 3.02 | 3.15 (2.89,3.41) | 450 | 190629 | 2.36 | 2.53 (2.29,2.77) | 1.2 (1.1,1.4) |
Region
| |||||||||||||
North East | 123 | 45292 | 2.72 | 2.75 (2.25,3.24) | 73 | 22711 | 3.21 | 3.18 (2.44,3.92) | 50 | 22581 | 2.21 | 2.31 (1.66,2.96) | 1.4 (0.9,1.9) |
North West | 278 | 120449 | 2.31 | 2.31 (2.03,2.58) | 168 | 60464 | 2.78 | 2.73 (2.32,3.15) | 110 | 59985 | 1.83 | 1.88 (1.53,2.24) | 1.5 (1.1,1.8) |
Yorkshire & Humber | 236 | 87272 | 2.70 | 2.71 (2.36,3.06) | 147 | 43870 | 3.35 | 3.32 (2.78,3.86) | 89 | 43403 | 2.05 | 2.09 (1.65,2.53) | 1.6 (1.2,2.0) |
East Midlands | 193 | 71476 | 2.70 | 2.74 (2.34,3.13) | 100 | 36038 | 2.77 | 2.78 (2.23,3.33) | 93 | 35438 | 2.62 | 2.69 (2.13,3.25) | 1.0 (0.7,1.3) |
West Midlands | 238 | 93160 | 2.55 | 2.59 (2.25,2.92) | 128 | 46964 | 2.73 | 2.68 (2.21,3.15) | 110 | 46196 | 2.38 | 2.49 (2.02,2.96) | 1.1 (0.8,1.4) |
East of England | 233 | 91147 | 2.56 | 2.64 (2.30,2.99) | 129 | 45929 | 2.81 | 2.87 (2.37,3.37) | 104 | 45218 | 2.30 | 2.41 (1.94,2.88) | 1.2 (0.9,1.5) |
London | 341 | 129437 | 2.63 | 2.88 (2.56,3.20) | 200 | 64819 | 3.09 | 3.31 (2.83,3.78) | 141 | 64618 | 2.18 | 2.46 (2.04,2.88) | 1.3 (1.0,1.6) |
South East | 353 | 135307 | 2.61 | 2.67 (2.39,2.95) | 197 | 68226 | 2.89 | 2.91 (2.50,3.32) | 156 | 67081 | 2.33 | 2.42 (2.04,2.81) | 1.2 (0.9,1.5) |
South West | 198 | 79244 | 2.50 | 2.52 (2.16,2.87) | 115 | 39917 | 2.88 | 2.83 (2.30,3.35) | 83 | 39327 | 2.11 | 2.20 (1.72,2.69) | 1.3 (0.9,1.7) |
Wales | 119 | 49236 | 2.42 | 2.37 (1.94,2.80) | 77 | 24700 | 3.12 | 3.01 (2.33,3.69) | 42 | 24536 | 1.71 | 1.72 (1.19,2.25) | 1.7 (1.1,2.4) |
Scotland | 228 | 90201 | 2.53 | 2.55 (2.22,2.89) | 144 | 45202 | 3.19 | 3.19 (2.66,3.72) | 84 | 44999 | 1.87 | 1.90 (1.48,2.31) | 1.7 (1.2,2.1) |
Total
1
|
2566
|
992213
|
2.59
|
2.64 (2.53,2.74)
|
1493
|
498835
|
2.99
|
3.00 (2.85,3.16)
|
1073
|
493379
|
2.17
|
2.27 (2.13,2.41)
|
1.3 (1.2,1.4)
|
Model | Factors/interactions | df1
| deviance | AIC2
|
---|---|---|---|---|
0 | Null | 175672 | 18788.0 | 25587.9 |
1 | Gender | 175671 | 18728.0 | 25529.9 |
2 | Age | 175670 | 18074.1 | 24878.0 |
3 | Age & Gender | 175669 | 18017.2 | 24823.1 |
4 | Age, Gender*Age | 175668 | 17976.3 | 24784.2 |
5 | Age, Gender*Age & Region | 175658 | 17970.6 | 24798.5 |
6 | Age, Gender*Age & Population density | 175667 | 17961.4 | 24771.3 |
7 | Age, Gender*Age & Townsend | 175667 | 17947.5 | 24757.4 |
8 | Age, Gender*Age & Overcrowding | 175667 | 17968.4 | 24778.3 |
9 | Age, Gender*Age & No cars | 175667 | 17951.4 | 24761.3 |
10 | Age, Gender*Age & Unemployment | 175667 | 17955.9 | 24765.8 |
11 | Age, Gender*Age & Home ownership | 175667 | 17956.9 | 24766.8 |
12 | Age, Gender*Age, Townsend & Population density | 175666 | 17945.3 | 24757.2 |
13 | Age, Gender*Age, Overcrowding & Population density | 175666 | 17945.2 | 24757.1 |
14 | Age, Gender*Age, No cars & Population density | 175666 | 17947.5 | 24759.4 |
15 | Age, Gender*Age, Unemployment & Population density | 175666 | 17947.5 | 24759.4 |
16 | Age, Gender*Age, Home ownership & Population density | 175666 | 17947.1 | 24759.0 |
17 | Age, Gender*Age, Townsend & Townsend*female | 175666 | 17940.9 | 24752.8 |
Factor/interaction | Coefficient (95% CI1) | RR2 (95% CI) |
P value |
---|---|---|---|
Female | −0.490 (−0.588,-0.391) | 0.613 (0.555,0.676) | <0.001 |
Age 15-29 | 0.648 (0.528,0.768) | 1.912 (1.696,2.155) | <0.001 |
Age 30-49 | −0.739 (−0.882,-0.597) | 0.477 (0.414,0.551) | <0.001 |
Female & age 0-14 | 0.551 (0.380,0.722) | 1.736 (1.463,2.059) | <0.001 |
Townsend | −0.019 (−0.035,-0.004) | 0.981 (0.966,0.996) | 0.015 |
Female & Townsend | −0.032 (−0.056,-0.007) | 0.969 (0.946,0.993) | 0.010 |
Ewing sarcoma
N | Pop (000’s) | All Crude Rate / million | ASR (95% CI) | N | Pop (000’s) | Male Crude Rate/ million | ASR (95% CI) | N | Pop (000’s) | Female Crude Rate/ million | ASR (95% CI) | ASR Ratio M:F (95% CI) | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Age
| |||||||||||||
Ages 0 to 14 | 659 | 279909 | 2.35 | 2.28 (2.11,2.46) | 356 | 142623 | 2.50 | 2.43 (2.17,2.68) | 303 | 137286 | 2.21 | 2.13 (1.89,2.37) | 1.1 (1.0,1.3) |
Ages 15 to 29 | 800 | 311514 | 2.57 | 2.39 (2.23,2.56) | 516 | 156621 | 3.29 | 3.06 (2.79,3.32) | 284 | 154894 | 1.83 | 1.71 (1.51,1.92) | 1.8 (1.5,2.0) |
Ages 30 to 49 | 191 | 400790 | 0.48 | 0.47 (0.40,0.53) | 116 | 199591 | 0.58 | 0.57 (0.47,0.67) | 75 | 201199 | 0.37 | 0.36 (0.28,0.45) | 1.6 (1.1,2.0) |
Period
| |||||||||||||
1980 - 1985 | 331 | 225881 | 1.47 | 1.46 (1.30,1.62) | 186 | 113741 | 1.64 | 1.58 (1.35,1.82) | 145 | 112140 | 1.29 | 1.33 (1.11,1.55) | 1.2 (0.9,1.5) |
1986 - 1995 | 649 | 382985 | 1.69 | 1.81 (1.67,1.95) | 393 | 192375 | 2.04 | 2.16 (1.94,2.37) | 256 | 190609 | 1.34 | 1.46 (1.28,1.64) | 1.5 (1.2,1.7) |
1996 - 2005 | 670 | 383347 | 1.75 | 1.90 (1.76,2.05) | 409 | 192718 | 2.12 | 2.26 (2.04,2.48) | 261 | 190629 | 1.37 | 1.53 (1.34,1.72) | 1.5 (1.2,1.7) |
Region
| |||||||||||||
North East | 69 | 45292 | 1.52 | 1.64 (1.25,2.03) | 44 | 22711 | 1.94 | 2.08 (1.46,2.70) | 25 | 22581 | 1.11 | 1.19 (0.77,1.76) | 1.7 (0.9,2.6) |
North West | 191 | 120449 | 1.59 | 1.61 (1.38,1.84) | 112 | 60464 | 1.85 | 1.86 (1.51,2.21) | 79 | 59985 | 1.32 | 1.37 (1.06,1.67) | 1.4 (1.0,1.8) |
Yorkshire & Humber | 152 | 87272 | 1.74 | 1.83 (1.53,2.12) | 93 | 43870 | 2.12 | 2.18 (1.73,2.63) | 59 | 43403 | 1.36 | 1.47 (1.09,1.85) | 1.5 (1.0,2.0) |
East Midlands | 140 | 71476 | 1.96 | 2.02 (1.68,2.36) | 68 | 36038 | 1.89 | 1.90 (1.44,2.36) | 72 | 35438 | 2.03 | 2.14 (1.64,2.64) | 0.9 (0.6,1.2) |
West Midlands | 130 | 93160 | 1.40 | 1.45 (1.20,1.70) | 77 | 46964 | 1.64 | 1.70 (1.32,2.09) | 53 | 46196 | 1.15 | 1.19 (0.86,1.52) | 1.4 (0.9,1.9) |
East of England | 141 | 91147 | 1.55 | 1.68 (1.40,1.97) | 85 | 45929 | 1.85 | 1.98 (1.55,2.40) | 56 | 45218 | 1.24 | 1.39 (1.02,1.75) | 1.4 (0.9,1.9) |
London | 181 | 129437 | 1.40 | 1.58 (1.34,1.81) | 114 | 64819 | 1.76 | 1.97 (1.60,2.34) | 67 | 64618 | 1.04 | 1.18 (0.88,1.47) | 1.7 (1.1,2.2) |
South East | 212 | 135307 | 1.57 | 1.70 (1.46,1.93) | 120 | 68226 | 1.76 | 1.84 (1.50,2.17) | 92 | 67081 | 1.37 | 1.55 (1.23,1.87) | 1.2 (0.9,1.5) |
South West | 141 | 79244 | 1.78 | 1.86 (1.55,2.18) | 93 | 39917 | 2.33 | 2.39 (1.90,2.89) | 48 | 39327 | 1.22 | 1.31 (0.93,1.69) | 1.8 (1.2,2.5) |
Wales | 85 | 49236 | 1.73 | 1.80 (1.41,2.18) | 57 | 24700 | 2.31 | 2.35 (1.74,2.97) | 28 | 24536 | 1.14 | 1.23 (0.81,1.79) | 1.9 (1.0,2.8) |
Scotland | 197 | 90201 | 2.18 | 2.25 (1.93,2.57) | 119 | 45202 | 2.63 | 2.68 (2.19,3.17) | 78 | 44999 | 1.73 | 1.81 (1.40,2.22) | 1.5 (1.1,1.9) |
Total
1
|
1650
|
992213
|
1.66
|
1.76 (1.67,1.84)
|
988
|
498835
|
1.98
|
2.06 (1.92,2.19)
|
662
|
493379
|
1.34
|
1.45 (1.34,1.56)
|
1.4 (1.3,1.6)
|
Model | Factors/interactions | df1
| deviance | AIC2
|
---|---|---|---|---|
0 | Null | 175672 | 13680.3 | 18089.1 |
1 | Gender | 175671 | 13622.2 | 18033.0 |
2 | Age | 175670 | 13015.2 | 17428.0 |
3 | Age & Gender | 175669 | 12960.6 | 17375.3 |
4 | Age, Gender, Age*Gender | 175668 | 12942.9 | 17359.7 |
5 | Age, Gender, Age*Gender & Region | 175658 | 12911.1 | 17347.9 |
6 | Age, Gender, Age*Gender, EM3
| 175667 | 12938.4 | 17357.2 |
7 | Age, Gender, Age*Gender, Scotland, EM | 175666 | 12921.3 | 17342.1 |
8 | Age, Gender, Age*Gender, Scotland, EM & Population density | 175665 | 12883.6 | 17306.4 |
9 | Age, Gender, Age*Gender, Scotland, EM & Townsend | 175665 | 12895.5 | 17318.2 |
10 | Age, Gender, Age*Gender, Scotland, EM & Overcrowding | 175665 | 12912.1 | 17334.9 |
11 | Age, Gender, Age*Gender, Scotland, EM & No cars | 175665 | 12888.6 | 17311.4 |
12 | Age, Gender, Age*Gender, Scotland, EM & Unemployment | 175665 | 12904.7 | 17327.5 |
13 | Age, Gender, Age*Gender, Scotland, EM & Home ownership | 175665 | 12906.8 | 17329.6 |
14 | Age, Gender, Age*Gender, Scotland, EM, Population density & No cars | 175664 | 12875.2 | 17300.0 |
15 | Age, Gender, Age*Gender, Scotland, EM, Pop dens & Unemployment | 175664 | 12878.4 | 17303.2 |
16 | Age, Gender, Age*Gender, Scotland, EM, Population density & Townsend | 175664 | 12878.0 | 17302.8 |
17 | Age, Gender, Age*Gender, Scotland, EM, Pop dens & Overcrowding | 175664 | 12883.4 | 17308.2 |
18 | Age, Gender, Age*Gender, Scotland, EM, Pop dens & Home owner | 175664 | 12881.5 | 17306.3 |
Factor/interaction | Coefficient (95% CI1) | RR2 (95% CI) |
P value |
---|---|---|---|
Female | −0.548 (−0.679,-0.417) | 0.578 (0.507,0.659) | <0.001 |
Age 15-29 | 0.316 (0.180,0.452) | 1.372 (1.198,1.571) | <0.001 |
Age 30-49 | −1.385 (−1.569,-1.201) | 0.250 (0.208,0.301) | <0.001 |
Female & age 0-14 | 0.433 (0.230,0.636) | 1.542 (1.259,1.890) | <0.001 |
East Midlands | 0.188 (0.012,0.364) | 1.207 (1.012,1.440) | 0.037 |
Scotland | 0.356 (0.199,0.513) | 1.428 (1.221,1.671) | <0.001 |
Pop density (person / hectare) | −0.016 (−0.025,-0.007) | 0.984 (0.976,0.993) | <0.001 |
Non-car ownership (%) | −0.006 (−0.009,-0.002) | 0.994 (0.991,0.998) | 0.004 |