Erschienen in:
01.03.2014 | Editorial
SMART Designs in Observational Studies of Opioid Therapy Duration
verfasst von:
John W. Jackson, ScD, Joshua J. Gagne, PharmD, ScD
Erschienen in:
Journal of General Internal Medicine
|
Ausgabe 3/2014
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Excerpt
Chronic pain affects around 100 million US adults and is associated with $635 billion in annual direct and lost productivity costs.
1 With the growing acceptance of palliative treatment for pain, prescription opioid use has risen dramatically over the past decade.
2 Hydrocodone plus acetaminophen is the most commonly prescribed drug in the US.
3 Though effective in relieving pain, long-term opioid therapy has been linked to many safety concerns, including substance abuse, fractures, premature labor and neonatal abstinence syndrome, and deaths from accidental overdose.
2 …