Background
Social cognition, psychopathology and social outcomes in individuals with 22q11DS
Method
Search strategy
Eligibility criteria
Study selection
Results
Study characteristics
Author (year) | Country | N | Age M (SD), (range) | Gender N (%F) | IQ (SD), (range) | Detection method | Social Cognition Assessment | Psychopathology Assessment | Social Outcomes Assessment |
---|---|---|---|---|---|---|---|---|---|
Campbell et al. (2011) [50] | UK | 50 | 10.99 (2.9), (6–16.75) | 28 (56%) | 65.8 (9.32), (40–94) | FISH | EP: MRC Face Processing Skills Battery ToM: False-belief stories | SDQ (emotional problems) | SDQ (peer relationship problems) |
Ho et al. (2012) [52] | USA | 63 | 13.7 (5.5), (6–25) /17.1 (1.9), (14–22) | 11 (38%) /20 (59%) | 80.5 (13.7), (−)/ 74.5 (13.2),(−) | Diagnostically confirmeda | ToM: The Animations Task | ADOS, ADI-R, SCID | SRS |
Shashi et al. (2012) [53] | USA | 66 | 10.5 (2.6), (−) | 32 (48%) | (−) | Diagnostically confirmeda | EP: DANVA, Child Facial Expressions and the Child Paralanguage Subtests | CBCL, C-DISC, GAF | SSRS |
Campbell et al. (2015) [54] | Australia | 24 | 16.75 (−), (12–21) | 14 (58%) | 75.88 (14.93), (56–115) | Diagnostically confirmeda | EP: EAT ToM: PST (false-belief vs. social-script, mechanical, capture) | SCID, K-SADS-PL, SDQ (emotional problems) | SDQ (peer relationship problems) |
Vangkilde et al. (2016) [49] | Denmark | 29 | 15.7 (2.8), (−) | 19 (65%) | 79.52 (−), (35–113) | SNP array analysis | EP: ERT ToM: TASIT | SIPS | ABAS-II, SRS |
Badoud et al. (2017) [55] | Switzerland | 29 | 17.79 (2.89), (11–21) | 13 (45%) | 75.33 (11.66), (−) | QF-PCR | EP: Pictures of Facial Affect ToM: The Director Task | SPQ | VABS |
Schneider et al. (2017) [56] | Switzerland | 35 | 18.06 (3.40), (11–24) | 21 (60%) | (−) | QF-PCR | EP: BFRT | SPQ,YSR/ASR (anxiety and depression) | DAS (dysfunctional beliefs: negative performance beliefs, need for approval) |
Dubourg et al. (2018) [57] | Switzerland | 22 | 20.3 (5.2), (12–32) | 17 (77%) | 74 (12), (−) | QF-PCR | EP: BFRT Social Perception: IAPS and scrambled images | K-SADS-PL, SCID-I, SIPS, DICA | SRS |
Zaharia et al. (2018) [58] | Switzerland | 75 | Longit. (T1)12.81 (3.57), (−) | 40 (53%) | 71.96 (11.25), (−) | QF-PCR | EP: Face Discrimination Task (Jane task/featural and configural) | CBCL, ABCL, PANSS | PANSS (poor social abilities - negative symptoms subscale) |
Weinberger et al. (2018) [59] | Israel | 44 | 20.7 (6.0), (12–33) | 21 (48%) | 77.2 (11.0), (−) | FISH | EP: Penn Computerized Neurocognitive Battery (Penn Emotion Identification Test Penn Emotion Differentiation Test Penn Age Differentiation Test) | SIPS/SOPS, K-SADS or SCID | VABS |
Links between social cognitive domains and psychopathology and/or social outcomes
Author (year) | N | Age M (SD), (range) | IQ (SD), (range) | Social Cognition | Social Cognition – Psychopathology | Social Cognition - Social Outcomes | ||||
---|---|---|---|---|---|---|---|---|---|---|
Task | Instrument | Measure | Association | Instrument | Measure | Association | ||||
EP | ||||||||||
Schneider et al. (2017) [56] | 35 | 18.06 (3.40), (11–24) | (−) | BFRT BFRT | SPQ SPQ | paranoid schiz.symptoms negative schiz.symptoms | r = − 0.362, p = 0.022 r = −0.321, p = 0.060 | DAS | severity of negative performance beliefs | r = −0.388, p = 0.021 |
Zaharia et al. (2018) [58] | 75 | T1 12.81 (3.57),(−) | 71.96 (11.25),(−) | Face Discrimination Task:correct answers on CD trials | PANSS | negative symptoms | r = −0.293, p = 0.02 | PANSS negative | used as measure of social abilities | r = − 0.293, p = 0.02 |
Face Discrimination Task | A-CBCL | internalizing, anxious/depressive symptoms | 0 | |||||||
Vangkilde et al. (2016) [49] | 29 | 15.7 (2.8), (−) | 79.52 (−), (35–113) | ERT ERT | SIPS | negative prod.symptoms | d.r. | ABAS Social (p/s.r.) SRS Total (p.r.) | social functioning social skills | 0 0 |
Badoud et al. (2017) [55] | 28 | 17.79 (2.89), (11–21) | 75.33 (11.66),(−) | Pictures of Facial Affect | SPQ | schizitypal traits | 0 | VABS (p.r.) | communication, daily living skills, socialization | 0 |
Weinberger et al. (2018) [59] | 44 | 20.7 (6.0), (12–33) | 77.2 (11.0),(−) | Social Cognition Total: (Emotion Ident., Differention Age Differentiation) | SIPS SOPS | negative symptoms negative prod. symptoms (total negative score) | 0 0 | VABS (p.r.) | communication, daily living skills, socialization | n.r. |
Campbell et al. (2011) [50] | 50 | 10.99 (2.9), (6–17) | 65.8 (9.3), (40–94) | Face Process Skills Battery | SDQ | emotional problems | n.r. | SDQ (p.r.) | peer relationship problems | r = 0.33, p < 0.03 |
Campbell et al. (2015) [54] | 24 | 16.75 (3.14), (12–21) | 75.9 (14.9), (56–115) | EAT | SDQ | emotional problems | n.r. | SDQ (p.r.) | peer relationship problems | beta = 0.69, p < 0.05 |
Dubourg et al. (2018) [57] | 22 | 20.3 (5.2), (12–32) | 74 (12),(−) | BFRT BFRT BFRT BFRT | DICA, SCID-I K-SADS-PL SIPS SIPS | psychiatric disorders psychiatric disorders positive prod. symptoms negative prod. symptoms | n.r. n.r. n.r. n.r. | SRS (p.r.) | social skills | 0 |
Shashi et al. (2012) [53] | 66 | 10.5 (2.6), (−) | (−) | DANVA | CBCL, C-DISC | psychiatric disorders | n.r. | SSRS Total (p.r.) | social skills | 0 |
ToM | ||||||||||
Vangkilde et al. (2016) [49] | 29 | 15.7 (2.8), (−) | 79.52 (−), (35–113) | TASIT Total TASIT Total | SIPS | negative prod. symptoms positive prod. symptoms | d.r. 0 | ABAS Social (p./s.r) SRS Total (p.r.) | social functioning social skills | 0 0 |
Badoud et al. (2017) [55] | 28 | 17.79 (2.89), (11–21) | 75.33 (11.66), (−) | The Director Task The Director Task | SPQ SPQ | negative schiz. traits disorganised schiz. traits | RT, r = 0.425, p = 0.062 RT, r = 0.393, p = 0.087 | VABS (p.r.) | communication, daily living skills, socialization | 0 |
(without participants on antipsychotic medication) | The Director Task The Director Task The Director Task | SPQ SPQ SPQ | positive schiz. traits negative schiz. traits disorganised schiz. traits | r = 0.464, p = 0.046 r = 0.598, p = 0.007 r = 0.576, p = 0.010 | ||||||
Ho et al. (2012) [52](SUNY) (UCLA) | 63 | The Animations Task: | ||||||||
34 29 | 17.1 (1.9), (14–22) 13.7 (5.5), (6–25) | 74.5 (13.2), (−) 80.5 (13.7), (−) | Intentionality Appropriatedness | SIPS SIPS | negative prod. symptoms positive prod. symptoms | 0 0 | SRS (p.r.) SRS (p.r.) | social skills social skills | r = −0.283, p < 0.05 r = −0.314, p < 0.05 | |
Campbell et al. (2011) [50] | 50 | 10.99 (2.9), (6–17) | 65.8 (9.3), (40–94) | false-belief stories | SDQ | emotional problems | n.r. | SDQ (p.r.) | peer relationship problems | r = 0.3, p < 0.03 |
Campbell et al. (2015) [54] | 24 | 16.75 (3.14), (12–21) | 75.9 (14.9), (56–115) | PST (false-belief stories) | SDQ | emotional problems | n.r. | SDQ (p.r.) | peer relationship problems | 0 |
Emotion processing - social-perceptual (affective) part
Theory of mind (ToM) - social-cognitive (reflective) part
Links between social cognitive domains and other variables
Social Cognition | ||||||
---|---|---|---|---|---|---|
Author | N | Age M (SD), (range) | IQ (SD), (range) | Task | Variable | Association |
EP | ||||||
Vangkilde et al. (2016) [49] | 29 | 15.7 (2.8), (−) | 79.52 (−), (35–113) | ERT | IQ | r = 0.43, p = 0.02 |
Zaharia et al. (2018) [58] | 75 | T1 12.81 (3.57), (−) | 71.96 (11.25), (−) | Face Discrimination Task | IQ | 0 |
Shashi et al. (2012) [53] | 66 | 10.5 (2.6), (−) | (−) | DANVA | IQ | 0 |
Badoud et al. (2017) [55] | 29 | 17.79 (2.89), (11–21) | 75.33 (11.66), (−) | Pictures of Facial Affect | IQ | 0 |
Vangkilde et al. (2016) [49] | 29 | 15.7 (2.8), (−) | 79.52 (−), (35–113) | ERT | age | F = 10.58, p = 0.002 |
Campbell et al. (2011) [50] | 50 | 10.99 (2.9), (6–17) | 65.8 (9.3), (40–94) | Face Process Skills Battery | ||
Identity | age | beta = 0.235, p < 0.005 | ||||
Gaze | age | beta = 0.226, p < 0.02 | ||||
Facial speech | age | beta = 0.242, p < 0.03 | ||||
Zaharia et al. (2018) [58] | 75 | T1 12.81 (3.57), (−) | 71.96 (11.25), (−) | Face Discrimination Task | age | d.r. |
Badoud et al. (2017) [55] | 29 | 17.79 (2.89), (11–21) | 75.33 (11.66), (−) | Picturres of Facial Affect | age | 0 |
Campbell et al. (2011) [50] | 50 | 10.99 (2.9), (6–17) | 65.8 (9.3), (40–94) | Face Process Skills Battery | WM | r = 0.44, p < 0.001 |
Campbell et al. (2011) [50] | 50 | 10.99 (2.9), (6–17) | 65.8 (9.3), (40–94) | Face Process Skills Battery | grammar reception | r = 0.646, p < 0.0005 |
Shashi et al. (2012) [53] | 66 | 10.5 (2.6), (−) | (−) | DANVA | EF | 0 |
Shashi et al. (2012) [53] | 66 | 10.5 (2.6), (−) | (−) | DANVA | verbal learning and memory | 0 |
Shashi et al. (2012) [53] | 66 | 10.5 (2.6), (−) | (−) | DANVA | sustained attention | 0 |
ToM | ||||||
Ho et al. (2012) [52] | 34 | 17.1 (1.9), (14–22) | 74.5 (13.2), (−) | The Animations Task: | ||
Intentionality (SUNY) | IQ | r = 0.511, p < 0.01 | ||||
Appropriatedness (SUNY) | IQ | r = 0.463, p < 0.01 | ||||
Appropriatedness (random) | IQ | r = 0.453, p < 0.01 | ||||
Ho et al. (2012) [52] | 29 | 13.7 (5.5), (6–25) | 80.5 (13.7), (−) | The Animations Task: | ||
Intentionality (UCLA) | IQ | 0 | ||||
Appropriatedness (UCLA) | IQ | 0 | ||||
Vangkilde et al. (2016) [49] | 29 | 15.7 (2.8), (−) | 79.52 (−), (35–113) | TASIT | IQ | 0 |
Badoud et al. (2017) [55] | 29 | 17.79 (2.89), (11–21) | 75.33 (11.66), (−) | The Director Task | IQ | 0 |
Campbell et al. (2011) [50] | 50 | 10.99 (2.9), (6–17) | 65.8 (9.3), (40–94) | False-belief stories | age | r = 0.61, p < 0.0005 |
Vangkilde et al. (2016) [49] | 29 | 15.7 (2.8), (−) | 79.52 (−), (35–113) | TASIT | age | r = 0.35, p = 0.07 |
Ho et al. (2012) [52] | 63 | The Animations Task: | ||||
(SUNY) | 34 | 17.1 (1.9), (14–22) | 74.5 (13.2), (−) | Intentionality (SUNY, UCLA) | age | 0 |
(UCLA) | 29 | 13.7 (5.5), (6–25) | 80.5 (13.7), (−) | Appropriatedness (SUNY, UCLA) | age | 0 |
Badoud et al. (2017) [55] | 29 | 17.79 (2.89), (11–21) | 75.33 (11.66), (−) | The Director Task | age | 0 |
Campbell et al. (2015) [54] | 24 | 16.75 (3.14), (12–21) | 75.9 (14.9), (56–115) | PST (false-belief stories) | EF | beta = 0.44, p < 0.01 |
Campbell et al. (2011) [50] | 50 | 10.99 (2.9), (6–17) | 65.8 (9.3), (40–94) | False belief-stories | grammar reception | r = 0.347, p < 0.015 |