Key messages
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Few re-uses have been published since the creation of the three data-sharing platforms.
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Most of them were secondary analyses or meta-analyses.
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No systematic impact of re-use was found in terms of the Altmetric Attention Score, media attention, social media attention and citation metrics however small averaged differences in favor of re-use are still plausible.
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Citations by policy sources of reuses were rare, and likewise for the controls.
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Re-uses with highest Altmetric Attention Score were mainly IPD meta-analyses
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Re-analyses were rare, however two out of the three were among the re-uses with the highest Altmetric Attention Score.
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Importantly, a high Altmetric Attention Score does not imply high scientific quality.
Introduction
Method
Eligibility criteria
Cases (Re-uses)
Controls
Primary publications
Data sources
Outcomes
Primary outcome
Secondary outcomes
Data analysis
Results
Changes to the initial protocol
Study identification
Description of studies included
Media attention and impact of re-use
Control (N = 89) | Re-use (N = 89) | Total (N = 178) |
p-value | |
---|---|---|---|---|
Altmetric Attention Score | 2.8 (0.3—12.3) | 5.9 (1.3—22.2) | 3.9 (0.5—15.9) | 0.14 |
Number of citationsa
| 4 (1 – 11.5) | 3 (1—8) | 3 (1—9) | 0.30 |
Number of policy sources that have mentioned the publication | 0 (0—0) | 0 (0—0) | 0 (0—0) | 0.52 |
Number of the news sources that have mentioned the publication | 0 (0—0) | 0 (0—1) | 0 (0 – 0.8) | 0.64 |
Number of blogs that have mentioned the publication | 0 (0—0) | 0 (0—0) | 0 (0—0) | 0.17 |
Number of the Twitter accounts that have tweeted this publication | 4 (1 – 10) | 5 (1 – 17) | 4 (1 – 13.75) | 0.14 |
Number of pages shared on Facebook | 0 (0—1) | 0 (0—1) | 0 (0—1) | 0.74 |
Number of Reddit threads posted about this publication | 0 (0—0) | 0 (0—0) | 0 (0—0) | 0.17 |
Number of the Youtube/Vimeo channels | 0 (0—0) | 0 (0—0) | 0 (0—0) | 1 |
Number of the accounts that have shared on Google + | 0 (0—0) | 0 (0—0) | 0 (0—0) | 0.40 |
Total Reader Counts | 15 (2—36) | 15 (4—31) | 15 (3.3 – 35.3) | 0.91 |
Readers in citeulike | 0 (0—0) | 0 (0—0) | 0 (0—0) | 0.32 |
Readers in Mendeley | 15 (2—36) | 15 (4—31) | 15 (3.3 – 35.3) | 0.90 |
Readers in Connotea | 0 (0—0) | 0 (0—0) | 0 (0—0) | / |
Published outputs | Title | Type of study | Policy sources | How cited |
---|---|---|---|---|
Joanna Le Noury et al. 2015 | Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence | Re-analysis | The state of open data. 25 Oct 2016 | In a chapter stating the ethical necessity of open data in medical research, the re-use is cited as a subsequent analysis that debunked the previous results of the study 329 which stated that “Paroxetine is generally well tolerated and effective for major depression in adolescents” |
Merryn Voysey et al. 2017 | The Influence of Maternally Derived Antibody and Infant Age at Vaccination on Infant Vaccine Responses | Meta-analysis | World Health Organization. (2018). The immunological basis for immunization series: module 3: tetanus: update 2018. World Health Organization. https://apps.who.int/iris/handle/10665/275340. License: CC BY-NC-SA 3.0 IGO | The re-use was cited in the immunological basis for immunization series: module 3: tetanus: update 2018 from World Health Organization but the exact context in the text was not found |
Joseline Guetsop Zafack et al. 2019 | Adverse events following immunisation with four-component meningococcal serogroup B vaccine (4CMenB): interaction with co-administration of routine infant vaccines and risk of recurrence in European randomised controlled trials | Secondary analysis | The National Immunisation Programme in the Netherlands: Surveillance and developments in 2018–2019 | The re-use was cited in the national immunisation programme in the Netherlands for the 2018–2019 period but the exact context was not found in the text |
Mark Corbett et al. 2017 | Certolizumab pegol and secukinumab for treating active psoriatic arthritis following inadequate response to disease-modifying antirheumatic drugs: a systematic review and economic evaluation | Meta-analysis | National Institute for Health Care Excellence (NICE) guidance: Ixekizumab for treating active psoriatic arthritis after inadequate response to DMARDs (https://www.nice.org.uk/guidance/ta537/evidence/committee-papers-pdf-4913117821) | The meta-analysis was cited in NICE as a reference regarding the use of a York model and details on its implementation (5 times): a reference regarding resource use estimates for controlled and uncontrolled psoriasis, a reference for psoriasis severity classification according to the York model, a reference for psoriasis evolution without treatment and a reference stating the lack of clinically meaningful difference in bDMARD responses rates for joint disease or psoriasis between 12 to 24 weeks |
G. A. Mospan et al. 2016 | 5-Day versus 10-Day Course of Fluoroquinolones in Outpatient Males with a Urinary Tract Infection (UTI) | Secondary analysis | NICE guidance: Urinary tract infection (lower): antimicrobial prescribing (evidence review) | The re-use is cited as an excluded study in the NICE evidence review (non-relevant population) so it did not contribute to the policy source content |
Lauren M. Schwartz et al. 2016 | Rotavirus vaccine effectiveness in low-income settings: An evaluation of the test-negative design | Secondary analysis | World Health Organization. (2020). The immunological basis for immunization series: module 21: rotavirus vaccines. World Health Organization. https://apps.who.int/iris/handle/10665/331323. License: CC BY-NC-SA 3.0 IGO | The re-use was cited in the immunological basis for immunization series: module 21: rotavirus vaccines from World Health Organization but the exact context was not found in the text |
Published outputs | Title | Theme | Platform | Type of study | Altmetric score | Tweets | Policy sources | Newspapers |
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Joanna Le Noury et al. 2015 | Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence | Psychology/psychiatry (child and adults) | CSDR | Re-analysis | 1407.5 | X | X | X |
F Hieronymus et al. 2017 | Efficacy of selective serotonin reuptake inhibitors in the absence of side effects: a mega-analysis of citalopram and paroxetine in adult depression | Psychology/psychiatry (child and adults) | CSDR | Meta-analysis | 262.6 | X | X | |
Johannes Schneider-Thoma et al. 2018 | Second-generation antipsychotic drugs and short-term mortality: a systematic review and meta-analysis of placebo-controlled randomised controlled trials | Psychology/psychiatry (child and adults) | YODA | Meta-analysis | 132.7 | X | X | |
Johannes Schneider-Thoma et al. 2019 | Second-generation antipsychotic drugs and short-term somatic serious adverse events: a systematic review and meta-analysis | Psychology/psychiatry (child and adults) | YODA | Meta-analysis | 107.9 | X | X | |
Monique B. Nilsson et al. 2017 | Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with ß-blockers | Medicine (adults) | CSDR | Secondary analysis | 101.6 | X | X | |
John M. Dennis et al. 2018 | Sex and BMI Alter the Benefits and Risks of Sulfonylureas and Thiazolidinediones in Type 2 Diabetes: A Framework for Evaluating Stratification Using Routine Clinical and Individual Trial Data | Medicine (adults) | CSDR | Secondary analysis | 91.8 | X | X | |
Sarah J Nevitt et al. 2017 | Exploring changes over time and characteristics associated with data retrieval across individual participant data meta-analyses: systematic review | Medicine (adults) | CSDR | Methodological | 64.9 | X | ||
Siddharth Singh et al. 2018 | No Benefit of Concomitant 5-Aminosalicylates in Patients With Ulcerative Colitis Escalated to Biologic Therapy: Pooled Analysis of Individual Participant Data From Clinical Trials | Medicine (adults) | YODA | Meta-analysis | 60.7 | X | X | |
Akbar K. Waljee et al. 2019 | Development and Validation of Machine Learning Models in Prediction of Remission in Patients With Moderate to Severe Crohn Disease | Medicine (adults) | YODA | Secondary analysis | 59.4 | X | X | |
Z.Z.N. Yiu et al. 2019 | A standardization approach to compare treatment safety and effectiveness outcomes between clinical trials and real-world populations in psoriasis | Medicine (adults) | YODA | Methodological | 55.6 | X | X | |
Hawkins C. Gay et al. 2017 | Feasibility, Process, and Outcomes of Cardiovascular Clinical Trial Data Sharing | Medicine (adults) | YODA | Re-analysis | 46 | X | X | |
Merryn Voysey et al. 2017 | The Influence of Maternally Derived Antibody and Infant Age at Vaccination on Infant Vaccine Responses | Paediatric | CSDR | Meta-analysis | 37.3 | X | X | X |
Ymkje Anna de Vries et al. 2018 | Predicting antidepressant response by monitoring early improvement of individual symptoms of depression: individual patient data meta-analysis | Psychology/psychiatry (child and adults) | CSDR | Meta-analysis | 30.4 | X | ||
Shereen Oon et al. 2019 | Lupus Low Disease Activity State (LLDAS) discriminates responders in the BLISS-52 and BLISS-76 phase III trials of belimumab in systemic lupus erythematosus | Medicine (adults) | CSDR | Secondary analysis | 29.9 | X | X | |
Ymkje Anna Vries et al. 2018 | Initial severity and antidepressant efficacy for anxiety disorders, obsessive–compulsive disorder, and posttraumatic stress disorder: An individual patient data meta-analysis | Psychology/psychiatry (child and adults) | CSDR | Meta-analysis | 29.8 | X | ||
Joseline Guetsop Zafack et al. 2019 | Adverse events following immunisation with four-component meningococcal serogroup B vaccine (4CMenB): interaction with co-administration of routine infant vaccines and risk of recurrence in European randomised controlled trials | Medicine (adults) | CSDR | Secondary analysis | 29.6 | X | X | |
Andriy Noshchenko et al. 2015 | What Is the Clinical Relevance of Radiographic Nonunion After Single-Level Lumbar Interbody Arthrodesis in Degenerative Disc Disease? | Medicine (adults) | YODA | Meta-analysis | 27.9 | X | X | |
Runsheng Wang et al. 2018 | Comparative Efficacy of Tumor Necrosis Factor-a Inhibitors in Ankylosing Spondylitis: A Systematic Review and Bayesian Network Metaanalysis | Medicine (adults) | YODA | Meta-analysis | 26.6 | X | X | |
Jacob Spertus et al. 2018 | Risk of weight gain for specific antipsychotic drugs: a meta-analysis | Psychology/psychiatry (child and adults) | YODA | Meta-analysis | 25.6 | X | X | |
Amber L. Laurie et al. 2016 | Meta-analysis of the Impact of Patient Characteristics on Estimates of Effectiveness and Harms of Recombinant Human Bone Morphogenetic Protein-2 in Lumbar Spinal Fusion | Medicine (adults) | YODA | Meta-analysis | 23.5 | X | X |