BMC Medical Research Methodology 1/2021

Open Access Research article

COVID-19-related medical research: a meta-research and critical appraisal

Open Access Research article

Alternative adjustment for seasonality and long-term time-trend in time-series analysis for long-term environmental exposures and disease counts

Open Access Review

Virtual controls as an alternative to randomized controlled trials for assessing efficacy of interventions

Open Access Research article

Ordinal outcome analysis improves the detection of between-hospital differences in outcome

Open Access Research article

Multiple imputation validation study: addressing unmeasured survey data in a longitudinal design

Open Access Research article

Quantifying the under-reporting of uncorrelated longitudal data: the genital warts example

Open Access Research article

Improved selection of participants in genetic longevity studies: family scores revisited

Open Access Research article

Development and validation of prediction model to estimate 10-year risk of all-cause mortality using modern statistical learning methods: a large population-based cohort study and external validation

Open Access Research article

Re-evaluation of the comparative effectiveness of bootstrap-based optimism correction methods in the development of multivariable clinical prediction models

Open Access Research article

Methodology in core outcome set (COS) development: the impact of patient interviews and using a 5-point versus a 9-point Delphi rating scale on core outcome selection in a COS development study

Open Access COVID-19 Research article

Incorporating and addressing testing bias within estimates of epidemic dynamics for SARS-CoV-2

Open Access Research article

Pattern-mixture model in network meta-analysis of binary missing outcome data: one-stage or two-stage approach?

Open Access Research article

Missing not at random in end of life care studies: multiple imputation and sensitivity analysis on data from the ACTION study

Open Access Research article

Impact of time-varying cumulative bevacizumab exposures on survival: re-analysis of data from randomized clinical trial in patients with metastatic colo-rectal cancer

Open Access COVID-19 Research article

Short-term real-time prediction of total number of reported COVID-19 cases and deaths in South Africa: a data driven approach

Open Access Research article

Relaxing the assumption of constant transition rates in a multi-state model in hospital epidemiology

Open Access Research article

Flexible modelling of risk factors on the incidence of pneumonia in young children in South Africa using piece-wise exponential additive mixed modelling

Open Access Research article

Fitting a shared frailty illness-death model to left-truncated semi-competing risks data to examine the impact of education level on incident dementia

Open Access Research article

Understanding participation in European cohort studies of preterm children: the views of parents, healthcare professionals and researchers

Open Access Research article

Informing the research agenda for optimizing audit and feedback interventions: results of a prioritization exercise

Open Access Research article

When does the use of individual patient data in network meta-analysis make a difference? A simulation study

Open Access Research article

Using electronic health records to inform trial feasibility in a rare autoimmune blistering skin disease in England

Open Access Research article

National surveillance of stroke quality of care and outcomes by applying post-stratification survey weights on the Get With The Guidelines-Stroke patient registry

Open Access Research article

Methodological approaches to imputing early-pregnancy weight based on weight measures collected during pregnancy

Open Access Research article

Telephone peer recruitment and interviewing during a respondent-driven sampling (RDS) survey: feasibility and field experience from the first phone-based RDS survey among men who have sex with men in Côte d’Ivoire

Open Access Research article

Psychometric validation techniques applied to the IND-VFQ-33 visual function questionnaire: the Hyderabad ocular morbidity in the elderly study (HOMES)

Open Access Research article

The STS case study: an analysis method for longitudinal qualitative research for implementation science

Open Access COVID-19 Commentary

The unintended consequences of COVID-19 mitigation measures matter: practical guidance for investigating them

Open Access Research article

Revisiting methods for modeling longitudinal and survival data: Framingham Heart Study

Open Access COVID-19 Research article

Inferencing superspreading potential using zero-truncated negative binomial model: exemplification with COVID-19

Open Access Research article

Examining the effectiveness of telemonitoring with routinely acquired blood pressure data in primary care: challenges in the statistical analysis

Open Access Technical advance

Conceptualising natural and quasi experiments in public health

Open Access Research article

There is still room for improvement in the completeness of abstract reporting according to the PRISMA-A checklist: a cross-sectional study on systematic reviews in periodontology

Open Access Research article

Ensemble bootstrap methodology for forecasting dynamic growth processes using differential equations: application to epidemic outbreaks

Open Access Research article

Causal inference concepts applied to three observational studies in the context of vaccine development: from theory to practice

Open Access Technical advance

Regression models for interval censored data using parametric pseudo-observations

Open Access Research article

A framework for exploring non-response patterns over time in health surveys

Open Access Research article

Conducting household surveys on reproductive health in urban settings: lessons from Karachi, Pakistan

Open Access Research article

A scoping review of studies using observational data to optimise dynamic treatment regimens

Open Access Research article

Body mass index changes: an assessment of the effects of age and gender using the e-norms method

Open Access Research article

Using a distribution-based approach and systematic review methods to derive minimum clinically important differences

Open Access COVID-19 Research article

Analysis of clinical and methodological characteristics of early COVID-19 treatment clinical trials: so much work, so many lost opportunities

Open Access Technical advance

A data visualisation method for assessing exposure misclassification in case-crossover studies: the example of tricyclic antidepressants and the risk of hip fracture in older people

Open Access Research article

Design and implementation of a massive open online course on enhancing the recruitment of minorities in clinical trials – Faster Together

Open Access Research article

Minimal important difference and patient acceptable symptom state for pain, Constant-Murley score and Simple Shoulder Test in patients with subacromial pain syndrome

Open Access Research article

Investigating psychometric properties of the arm activity measure – Thai version (ArmA-TH) sub‐scales using the Rasch model

Open Access Technical advance

Waist circumference prediction for epidemiological research using gradient boosted trees

Open Access Research article

Reduction in number to treat versus number needed to treat

Open Access Research article

Population segmentation of type 2 diabetes mellitus patients and its clinical applications - a scoping review

Open Access Research article

Outbreaks of publications about emerging infectious diseases: the case of SARS-CoV-2 and Zika virus

Open Access Research article

Measuring test-retest reliability (TRR) of AMSTAR provides moderate to perfect agreement – a contribution to the discussion of the importance of TRR in relation to the psychometric properties of assessment tools

Open Access Research article

Estimating restricted mean survival time and expected life-years lost in the presence of competing risks within flexible parametric survival models

Open Access COVID-19 Research article

Accounting for confounding by time, early intervention adoption, and time-varying effect modification in the design and analysis of stepped-wedge designs: application to a proposed study design to reduce opioid-related mortality

Open Access Research article

Challenges, facilitators and barriers to screening study participants in early disease stages-experience from the MACUSTAR study

Open Access Technical advance

Group testing can improve the cost-efficiency of prospective-retrospective biomarker studies

Open Access Research article

Time dependent hazard ratio estimation using instrumental variables without conditioning on an omitted covariate

Open Access Research article

International representation of authors, editors and research in neurology journals

Open Access Technical advance

Interrupted time series analysis using autoregressive integrated moving average (ARIMA) models: a guide for evaluating large-scale health interventions

Open Access Research article

Estimates of the mean difference in orthopaedic randomized trials: obligatory yet obscure

Open Access Research article

Comparing the use of aggregate data and various methods of integrating individual patient data to network meta-analysis and its application to first-line ART

Open Access Research article

Recruiting general practitioners and patients with dementia into a cluster randomised controlled trial: strategies, barriers and facilitators

Open Access Research article

Fast and optimal algorithm for case-control matching using registry data: application on the antibiotics use of colorectal cancer patients

Open Access Research article

Facilitating harmonized data quality assessments. A data quality framework for observational health research data collections with software implementations in R

Open Access Technical advance

Deep generative models in DataSHIELD

Open Access Research article

Type I error control for cluster randomized trials under varying small sample structures

Open Access Research article

Impact of comorbidity assessment methods to predict non-cancer mortality risk in cancer patients: a retrospective observational study using the National Health Insurance Service claims-based data in Korea

Open Access Research article

Comparative diagnostic accuracy studies with an imperfect reference standard – a comparison of correction methods

Open Access COVID-19 Research article

A risk assessment tool for resumption of research activities during the COVID-19 pandemic for field trials in low resource settings

Open Access Research article

Phase I dose-escalation oncology trials with sequential multiple schedules

Open Access Research article

The impact of grey zones on the accuracy of agreement measures for ordinal tables

Open Access Research article

Investigating factors affecting the interval between a burn and the start of treatment using data mining methods and logistic regression

Open Access Research article

A review of the use of controlled multiple imputation in randomised controlled trials with missing outcome data

Open Access Research article

A demonstration of using formal consensus methods within guideline development; a case study

Open Access Research article

Utilizing machine learning dimensionality reduction for risk stratification of chest pain patients in the emergency department

Open Access Research article

Intention-to-treat analysis may be more conservative than per protocol analysis in antibiotic non-inferiority trials: a systematic review

Open Access Research article

Guidelines are needed for studies of pre-treatment HIV drug resistance: a methodological study

Open Access Research article

Characteristics and patient-reported outcomes associated with dropout in severely affected oncological patients: an exploratory study

Open Access Research article

Generative adversarial networks for imputing missing data for big data clinical research

Open Access Research article

Growth mixture models: a case example of the longitudinal analysis of patient‐reported outcomes data captured by a clinical registry

Open Access Research article

Shifting research culture to address the mismatch between where trials recruit and where populations with the most disease live: a qualitative study

Open Access Research article

The use of experimental vignette studies to identify drivers of variations in the delivery of health care: a scoping review

Open Access COVID-19 Research article

Instruments to measure fear of COVID-19: a diagnostic systematic review

Open Access Research article

LASSO type penalized spline regression for binary data

Open Access Research article

Direct modelling of age standardized marginal relative survival through incorporation of time-dependent weights

Open Access Research article

Development of a temporally harmonized asset index: evidence from across 50 years of follow up of a birth cohort in Guatemala

Open Access Research article

Neutral theory: applicability and neutrality of using generic health-related quality of life tools in diseases or conditions where specific tools are available

Open Access Research article

Using logic regression to characterize extreme heat exposures and their health associations: a time-series study of emergency department visits in Atlanta

Open Access Research article

Crowdsourcing citation-screening in a mixed-studies systematic review: a feasibility study

Open Access Research article

A systematic review of the quality of conduct and reporting of survival analyses of tuberculosis outcomes in Africa

Open Access Technical advance

Data quality assessment and subsampling strategies to correct distributional bias in prevalence studies

Open Access COVID-19 Commentary

Clinical research activities during COVID-19: the point of view of a promoter of academic clinical trials

Open Access Research article

Stakeholder-engaged process for refining the design of a clinical trial in home hospice

Open Access Research article

Sampling strategies to evaluate the prognostic value of a new biomarker on a time-to-event end-point

Open Access Research article

Database selection and data gathering methods in systematic reviews of qualitative research regarding diabetes mellitus - an explorative study

Open Access Research article

Intra-database validation of case-identifying algorithms using reconstituted electronic health records from healthcare claims data

Open Access Research article

Application of machine learning in predicting hospital readmissions: a scoping review of the literature

Open Access Research article

Dealing with missing delirium assessments in prospective clinical studies of the critically ill: a simulation study and reanalysis of two delirium studies

Open Access Research article

Evaluation by simulation of clinical trial designs for evaluation of treatment during a viral haemorrhagic fever outbreak

Open Access Research

Using the geometric average hazard ratio in sample size calculation for time-to-event data with composite endpoints

Open Access Article

A strategy for optimal fitting of multiplicative and additive hazards regression models

Open Access Research article

Quality assessment tools used in systematic reviews of in vitro studies: A systematic review

Open Access Research article

Using random forests to model 90-day hometime in people with stroke

Open Access COVID-19 Technical advance

How to specify healthcare process improvements collaboratively using rapid, remote consensus-building: a framework and a case study of its application

Open Access Research

Dynamic prediction based on variability of a longitudinal biomarker

Open Access Research article

A population‐based study to develop juvenile arthritis case definitions for administrative health data using model‐based dynamic classification

Open Access Research

Methodology of the DCCSS later fatigue study: a model to investigate chronic fatigue in long-term survivors of childhood cancer

Open Access Research article

Classifying information-sharing methods

Open Access Research

Classification of PR-positive and PR-negative subtypes in ER-positive and HER2-negative breast cancers based on pathway scores

Open Access Research article

Applied comparison of large‐scale propensity score matching and cardinality matching for causal inference in observational research

Open Access Research

Randomized test-treatment studies with an outlook on adaptive designs

Open Access Software

IPDfromKM: reconstruct individual patient data from published Kaplan-Meier survival curves

Open Access Research

An ego-centred approach for the evaluation of spatial effects on health in urban areas based on parametric semi-variogram models: concept and validation

Open Access Technical advance

A method for assessing robustness of the results of a star-shaped network meta-analysis under the unidentifiable consistency assumption

Open Access Research

Incorporating single-arm studies in meta-analysis of randomised controlled trials: a simulation study

Open Access Research article

Validity of using mobile phone surveys to evaluate community health worker program in Mali

Open Access Research

Discovering the underlying typology of emergency departments

Open Access COVID-19 Commentary

Open science saves lives: lessons from the COVID-19 pandemic

Open Access Research article

Strategies for assessing the impact of loss to follow-up on estimates of neurodevelopmental impairment in a very preterm cohort at 2 years of age

Open Access Research

Social media attention and citations of published outputs from re-use of clinical trial data: a matched comparison with articles published in the same journals

Open Access Research article

Delays in reporting and publishing trial results during pandemics: cross sectional analysis of 2009 H1N1, 2014 Ebola, and 2016 Zika clinical trials

Open Access Research

Development of a clinical tool for rating the body function categories of the ICF generic-30/rehabilitation set in Japanese rehabilitation practice and examination of its interrater reliability

Open Access Research

Systematic review and meta analysis of differential attrition between active and control arms in randomized controlled trials of lifestyle interventions in chronic disease

Open Access Research

Most published meta-regression analyses based on aggregate data suffer from methodological pitfalls: a meta-epidemiological study

Open Access Research article

Modelling hospital outcome: problems with endogeneity

Open Access Research

A scoping review of Q-methodology in healthcare research

Open Access COVID-19 Research

Estimating age-specific COVID-19 fatality risk and time to death by comparing population diagnosis and death patterns: Australian data

Open Access Research

Development and validation of a risk index to predict kidney graft survival: the kidney transplant risk index

Open Access Research article

The minimal perceived change: a formal model of the responder definition according to the patient’s meaning of change for patient-reported outcome data analysis and interpretation

Open Access Research

Psychometric properties of instruments to measure parenting practices and children’s movement behaviors in low-income families from Brazil

Open Access Technical advance

How to analyze work productivity loss due to health problems in randomized controlled trials? A simulation study

Open Access Research

The INSPIRE Population Survey: development, dissemination and respondent characteristics

Open Access Research article

Multiple imputation to quantify misclassification in observational studies of the cognitively impaired: an application for pain assessment in nursing home residents

Open Access Research

Strengthening methods for tracking adaptations and modifications to implementation strategies

Open Access Research

Comparison of six statistical methods for interrupted time series studies: empirical evaluation of 190 published series

Open Access Research article

Risk prediction in multicentre studies when there is confounding by cluster or informative cluster size

Open Access Research

Noncollapsibility and its role in quantifying confounding bias in logistic regression

Open Access Research

Bayesian updating: increasing sample size during the course of a study

Open Access Research article

Comparing regression modeling strategies for predicting hometime

Open Access Research article

Consequences of ignoring clustering in linear regression

Open Access Research article

Managing overlap of primary study results across systematic reviews: practical considerations for authors of overviews of reviews

Open Access Research

Translation, transcultural adaptation and validation to Brazilian Portuguese of tools for adverse drug reaction assessment in children

Open Access Research

Evaluating the relationship between citation set size, team size and screening methods used in systematic reviews: a cross-sectional study

Open Access Software

RITS: a toolbox for assessing complex interventions via interrupted time series models

Open Access Research article

A new likelihood model for analyses of pharmacoepidemiologic case–control studies which avoids decision rules for determining latent exposure status

Open Access Research article

Survey design and analysis considerations when utilizing misclassified sampling strata

Open Access COVID-19 Research article

Absolute mortality risk assessment of COVID-19 patients: the Khorshid COVID Cohort (KCC) study

Open Access COVID-19 Research

Need of care in interpreting Google Trends-based COVID-19 infodemiological study results: potential risk of false-positivity

Open Access Research

Multivariate meta-analysis of critical care meta-analyses: a meta-epidemiological study

Open Access Research article

Assessing the risk of performance and detection bias in Cochrane reviews as a joint domain is less accurate compared to two separate domains

Open Access Research

Statistical analysis of two arm randomized pre-post designs with one post-treatment measurement

Open Access Technical advance

High performance implementation of the hierarchical likelihood for generalized linear mixed models: an application to estimate the potassium reference range in massive electronic health records datasets

Open Access Research

Characteristics and practices of school-based cluster randomised controlled trials for improving health outcomes in pupils in the United Kingdom: a methodological systematic review

Open Access Research

A multiyear systematic survey of the quality of reporting for randomised trials in dentistry, neurology and geriatrics published in journals of Spain and Latin America

Open Access Research

Overcoming the problems caused by collinearity in mixed-effects logistic model: determining the contribution of various types of violence on depression in pregnant women

Open Access Research article

A new hybrid record linkage process to make epidemiological databases interoperable: application to the GEMO and GENEPSO studies involving BRCA1 and BRCA2 mutation carriers

Open Access Correction

Correction to: How to specify healthcare process improvements collaboratively using rapid, remote consensus-building: a frame work and a case study of its application

Open Access Research article

A new method for testing reproducibility in systematic reviews was developed, but needs more testing

Open Access Research

Machine learning in medicine: a practical introduction to natural language processing

Open Access Research

Use of machine learning techniques to identify HIV predictors for screening in sub-Saharan Africa

Open Access Research

Central data monitoring in the multicentre randomised SafeBoosC-III trial – a pragmatic approach

Open Access Research

Predisposing factors of long-term responsiveness in a cardio-metabolic cohort: Tehran Lipid and Glucose Study

Open Access Research

Comparison of prevalence and exposure-disease associations using self-report and hospitalization data among enrollees of the world trade center health registry

Open Access COVID-19 Research

Hospital workers mental health during the COVID-19 pandemic: methods of data collection and characteristics of study sample in a university hospital in Milan (Italy)

Open Access COVID-19 Research

Quantifying and communicating the burden of COVID-19

Open Access Research article

Negative SARS-CoV-2 PCR or rapid antigen test result and the subsequent risk of being infectious: a mathematical simulation study

Open Access Research

Symptom clusters among cancer survivors: what can machine learning techniques tell us?

Open Access Research article

Evaluation of a geriatrics primary care model using prospective matching to guide enrollment

Open Access Research

A roadmap to using randomization in clinical trials

Open Access Research

Creating efficiencies in the extraction of data from randomized trials: a prospective evaluation of a machine learning and text mining tool

Open Access Research

Modeling of atrophy size trajectories: variable transformation, prediction and age-of-onset estimation

Open Access Research article

Bayesian Hodges-Lehmann tests for statistical equivalence in the two-sample setting: Power analysis, type I error rates and equivalence boundary selection in biomedical research

Open Access Research

Using web conferencing to engage Aboriginal and Torres Strait Islander young people in research: a feasibility study

Open Access Article

Two-stage sampling in the estimation of growth parameters and percentile norms: sample weights versus auxiliary variable estimation

Open Access Correction

Correction to: Applied comparison of large-scale propensity score matching and cardinality matching for causal inference in observational research

Open Access COVID-19 Research article

Use of research electronic data capture (REDCap) in a COVID-19 randomized controlled trial: a practical example

Open Access Research

The effect of home visits as an additional recruitment step on the composition of the final sample: a cross-sectional analysis in two study centers of the German National Cohort (NAKO)

Open Access Research

Impact of a non-constant baseline hazard on detection of time-dependent treatment effects: a simulation study

Open Access Research

Recruitment principles and strategies for supportive care research in pediatric oncology

Open Access Research

Predicting postoperative surgical site infection with administrative data: a random forests algorithm

Open Access Research

Evaluating the impact of covariate lookback times on performance of patient-level prediction models

Open Access Research

Evaluation of statistical methods used in the analysis of interrupted time series studies: a simulation study

Open Access Research article

Investigator initiated trials versus industry sponsored trials - translation of randomized controlled trials into clinical practice (IMPACT)

Open Access Research

Applying a novel approach to scoping review incorporating artificial intelligence: mapping the natural history of gonorrhoea

Open Access Research

A meta-review demonstrates improved reporting quality of qualitative reviews following the publication of COREQ- and ENTREQ-checklists, regardless of modest uptake

Open Access Research

Strategies to maximise study retention and limit attrition bias in a prospective cohort study of men reporting a history of injecting drug use released from prison: the prison and transition health study

Open Access Research article

A Bayesian latent class mixture model with censoring for correlation analysis in antimicrobial resistance across populations

Open Access Research

Clinical researchers’ lived experiences with data quality monitoring in clinical trials: a qualitative study

Open Access Research

Patient-centered infertility questionnaire for female clients (PCIQ-F): part I: questionnaire development

Open Access Commentary

Conducting proportional meta-analysis in different types of systematic reviews: a guide for synthesisers of evidence

Open Access Research

Minimizing bias in massive multi-arm observational studies with BCAUS: balancing covariates automatically using supervision

Open Access Research

Mitigating selection bias in organ allocation models

Open Access Research

An improved method for the effect estimation of the intermediate event on the outcome based on the susceptible pre-identification

Open Access Research

A comparative study of forest methods for time-to-event data: variable selection and predictive performance

Open Access Research

Measuring advance care planning behavior in Dutch adults: translation, cultural adaptation and validation of the Advance Care Planning Engagement Survey

Open Access Research

Can the adverse childhood experiences (ACEs) checklist be utilized to predict emergency department visits among children and adolescents?

Open Access Research

Statistical model building: Background “knowledge” based on inappropriate preselection causes misspecification

Open Access Research

Analytical challenges in estimating the effect of exposures that are bounded by follow-up time: experiences from the Blood Stream Infection—Focus on Outcomes study

Open Access Research

Joint latent class model: Simulation study of model properties and application to amyotrophic lateral sclerosis disease

Open Access Research

To tune or not to tune, a case study of ridge logistic regression in small or sparse datasets

Open Access Research

Sequential Multiple Assignment Randomized Trial (SMART) to identify optimal sequences of telemedicine interventions for improving initiation of insulin therapy: A simulation study

Open Access Research

Chi-square test under indeterminacy: an application using pulse count data

Open Access Research article

Patient-centered practices for engaging transgender and gender diverse patients in clinical research studies

Open Access Research

Embedding mentoring to support trial processes and implementation fidelity in a randomised controlled trial of vocational rehabilitation for stroke survivors

Open Access Research

Assessing the hospital volume-outcome relationship in surgery: a scoping review

Open Access Research

Quantifying parent engagement in the randomized Fuel for Fun impact study identified design considerations and BMI relationships

Open Access Research

Effects of different invitation strategies on participation in a cohort study of Iranian public sector employees: a cluster randomized trial

Open Access Research

Methods for the inclusion of real-world evidence in network meta-analysis

Open Access Research

Joint modelling of multivariate longitudinal clinical laboratory safety outcomes, concomitant medication and clinical adverse events: application to artemisinin-based treatment during pregnancy clinical trial

Open Access Research

What do stroke survivors’ value about participating in research and what are the most important research problems related to stroke or transient ischemic attack (TIA)? A survey

Open Access Research

Determining diagnosis date of diabetes using structured electronic health record (EHR) data: the SEARCH for diabetes in youth study

Open Access Software

Employing multiple synchronous outcome samples per subject to improve study efficiency

Open Access Research

Are morbidity and mortality estimates from randomized controlled trials externally valid? A comparison of outcomes among infants enrolled into an RCT or a cohort study in Botswana

Open Access Research

Predictive P-score for treatment ranking in Bayesian network meta-analysis

Open Access Research

A novel weighting method to remove bias from within-subject exposure dependency in case-crossover studies

Open Access COVID-19 Research

Analysis of COVID-19 data using neutrosophic Kruskal Wallis H test

Open Access Research

Random survival forests for dynamic predictions of a time-to-event outcome using a longitudinal biomarker

Open Access Research

GoodReports: developing a website to help health researchers find and use reporting guidelines

Open Access Research

Statistical reanalysis of vascular event outcomes in primary and secondary vascular prevention trials

Open Access Research article

coreSCD: multi-stakeholder consensus on core outcomes for sickle cell disease clinical trials

Open Access Research article

Response rate of patient reported outcomes: the delivery method matters

Open Access Research

Bayesian additional evidence for decision making under small sample uncertainty

Open Access Research

Methodological challenges and solution strategies during implementation of a midwife-led multicenter randomized controlled trial (RCT) in maternity hospitals

Open Access Research

Methodological quality for systematic reviews of adverse events with surgical interventions: a cross-sectional survey

Open Access Research

Prevalence of evidence of inconsistency and its association with network structural characteristics in 201 published networks of interventions

Open Access Research article

Evaluating complex interventions in context: systematic, meta-narrative review of case study approaches

Open Access Research

Mediation analysis methods used in observational research: a scoping review and recommendations

Open Access Research

Pre-statistical harmonization of behavioral instruments across eight surveys and trials

Open Access Research

Understanding the groups of care transition strategies used by U.S. hospitals: an application of factor analytic and latent class methods

Open Access COVID-19 Research

Inspection plan for COVID-19 patients for Weibull distribution using repetitive sampling under indeterminacy

Open Access Research

Satisfaction and experience with colorectal cancer screening: a systematic review of validated patient reported outcome measures

Open Access COVID-19 Research

Methods to support evidence-informed decision-making in the midst of COVID-19: creation and evolution of a rapid review service from the National Collaborating Centre for Methods and Tools

Open Access Research

Spatial data analysis of malnutrition among children under-five years in Ethiopia

Open Access Research

Incentive delivery timing and follow-up survey completion in a prospective cohort study of injured children: a randomized experiment comparing prepaid and postpaid incentives

Open Access Review

A narrative review on the validity of electronic health record-based research in epidemiology

Open Access Research

Independence estimators for re-randomisation trials in multi-episode settings: a simulation study

Open Access Research

Predictors for participation in DNA self-sampling of childhood cancer survivors in Switzerland

Open Access Research

Low methodological quality of systematic reviews on acupuncture: a cross-sectional study

Open Access Research

Standardizing registry data to the OMOP Common Data Model: experience from three pulmonary hypertension databases

Open Access Research

Analysis of multivariate longitudinal substance use outcomes using multivariate mixed cumulative logit model

Open Access Research

Reporting of methods to prepare, pilot and perform data extraction in systematic reviews: analysis of a sample of 152 Cochrane and non-Cochrane reviews

Open Access Research

Major adverse cardiovascular event definitions used in observational analysis of administrative databases: a systematic review

Open Access Research article

Improving retention of community-recruited participants in HIV prevention research through Saturday household visits; findings from the HPTN 071 (PopART) study in South Africa

Open Access Research

Frequency and characteristics of promissory conference abstracts, i.e. abstracts without results, accepted at Cochrane Colloquia 1994-2020

Open Access Research

Visualizing adverse events in clinical trials using correspondence analysis with R-package visae

Open Access Research

A simulation study for evaluating the performance of clustering measures in multilevel logistic regression

Open Access Research article

General characteristics and reasons for the discontinuation of drug clinical trials in mainland China

Open Access Research

Effects of personalized invitation letters on research participation among general practitioners: a randomized trial

Open Access Research

Appraising clinical applicability of studies: mapping and synthesis of current frameworks, and proposal of the FrACAS framework and VICORT checklist

Open Access Research

Predicting clinical events using Bayesian multivariate linear mixed models with application to scleroderma

Open Access Technical advance

Advancing data science in drug development through an innovative computational framework for data sharing and statistical analysis

Open Access Research

Methodological aspects for accelerometer-based assessment of physical activity in heart failure and health

Open Access Research

Methodological implications of adapting and applying a web-based questionnaire on health problems to adolescent football players

Open Access Research

Estimating the natural indirect effect and the mediation proportion via the product method

Open Access Research

On clinical trial fragility due to patients lost to follow up

Open Access COVID-19 Research article

Impact of the COVID-19 pandemic on publication dynamics and non-COVID-19 research production

Open Access Research

Oversampling and replacement strategies in propensity score matching: a critical review focused on small sample size in clinical settings

Open Access Research article

Evaluating the performance of propensity score matching based approaches in individual patient data meta-analysis

Open Access Research

Instrumental variable estimation for a time-varying treatment and a time-to-event outcome via structural nested cumulative failure time models

Open Access Research

Does pre-notification increase questionnaire response rates: a randomised controlled trial nested within a systematic review

Open Access Research

Predicting the natural history of metabolic syndrome with a Markov-system dynamic model: a novel approach

Open Access Research

Similarities, reliability and gaps in assessing the quality of conduct of systematic reviews using AMSTAR-2 and ROBIS: systematic survey of nutrition reviews

Open Access Software

Development of a dynamic interactive web tool to enhance understanding of multi-state model analyses: MSMplus

Open Access Research

Comparing current and emerging practice models for the extrapolation of survival data: a simulation study and case-study

Open Access Research

Exploring the impact of ineligibility on individuals expressing interest in a trial aimed at improving daily functioning regarding perceptions of self, research and likelihood of future participation

Open Access Research

Does advance contact with research participants increase response to questionnaires: an updated systematic review and meta-analysis

Open Access Technical advance

Time-varying associations between an exposure history and a subsequent health outcome: a landmark approach to identify critical windows

Open Access COVID-19 Research

Predicting COVID-19 mortality risk in Toronto, Canada: a comparison of tree-based and regression-based machine learning methods

Open Access Research

Modular literature review: a novel systematic search and review method to support priority setting in health policy and practice

Open Access Research

A latent-class heteroskedastic hurdle trajectory model: patterns of adherence in obstructive sleep apnea patients on CPAP therapy

Open Access Research

Concordance rate of a four-quadrant plot for repeated measurements

Open Access Research

New adaptive lasso approaches for variable selection in automated pharmacovigilance signal detection

Open Access COVID-19 Research

Impact of vaccine prioritization strategies on mitigating COVID-19: an agent-based simulation study using an urban region in the United States

Open Access Research

Feasibility of a hybrid clinical trial for respiratory virus detection in toddlers during the influenza season

Open Access Research

Ethnographic research as an evolving method for supporting healthcare improvement skills: a scoping review

Open Access Research

Communicating incidental and reportable findings from research MRIs: considering factors beyond the findings in an underrepresented pediatric population

Open Access Correction

Correction to: Applying a novel approach to scoping review incorporating artificial intelligence: mapping the natural history of gonorrhoea

Open Access Research

Analysis of zero inflated dichotomous variables from a Bayesian perspective: application to occupational health

Open Access Article

An adaptive gBOIN design with shrinkage boundaries for phase I dose-finding trials

Open Access Research

Moving beyond the classic difference-in-differences model: a simulation study comparing statistical methods for estimating effectiveness of state-level policies

Open Access Research article

Improving postal survey response using behavioural science: a nested randomised control trial

Open Access Research

The automation of relevant trial registration screening for systematic review updates: an evaluation study on a large dataset of ClinicalTrials.gov registrations

Open Access Research

Impact of limited sample size and follow-up on single event survival extrapolation for health technology assessment: a simulation study

Open Access Research

Modelling of longitudinal data to predict cardiovascular disease risk: a methodological review

Open Access Research

The roles of predictors in cardiovascular risk models - a question of modeling culture?

Open Access Research

Guidance for using artificial intelligence for title and abstract screening while conducting knowledge syntheses

Open Access Research article

Early experience with an opt-in research register - Scottish Health Research Register (SHARE): a multi-method evaluation of participant recruitment performance

Open Access Research

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Springer Medizin

BMC Medical Research Methodology

Inhalt (287 Artikel)