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World Journal of Surgery

Erschienen in:

01.03.2017 | Scientific Review

Solid Pseudopapillary Neoplasms of the Pancreas: A Surgical and Genetic Enigma

verfasst von: Leon Naar, Despoina-Amalia Spanomichou, Aikaterini Mastoraki, Vassilios Smyrniotis, Nikolaos Arkadopoulos

Erschienen in: World Journal of Surgery | Ausgabe 7/2017

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Abstract

Solid pseudopapillary neoplasms of the pancreas are rare tumors accounting for 1–2% of pancreatic exocrine neoplasms. This entity was first described by Dr. Frantz in 1959 and was defined by the World Health Organization in 1996 as “solid pseudopapillary tumor.” It is most often a benign neoplasm, but 10–15% of the cases are malignant. Over the past decades, the incidence of this tumor is increasing. However, many surgeons are still unfamiliar with this neoplasm and its unique characteristics, which can lead to pitfalls in the diagnosis and treatment. The correct diagnosis of SPNP is of utmost importance since it has a low malignant potential and with the appropriate treatment, patients have a long life expectancy. There are many genetic alterations, involving various signaling pathways that have been associated with SPNP and are very important in diagnosing the tumor. The cornerstone of SPNP treatment includes surgical excision of the tumor, preserving as much pancreatic tissue as possible. We review the information in the literature regarding more organ-preserving techniques and possible clinical features that might indicate a malignant potential, thus demanding a more radical intraoperative excision.

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Titel: Solid Pseudopapillary Neoplasms of the Pancreas: A Surgical and Genetic Enigma
verfasst von: Leon Naar
Despoina-Amalia Spanomichou
Aikaterini Mastoraki
Vassilios Smyrniotis
Nikolaos Arkadopoulos
Publikationsdatum: 01.03.2017
Verlag: Springer International Publishing
Erschienen in: World Journal of Surgery / Ausgabe 7/2017
Print ISSN: 0364-2313
Elektronische ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-017-3921-y

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Appendizitis BDC Leitlinien Webinare

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Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric

Springer Medizin

Abstract

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