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Current Osteoporosis Reports

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18.01.2018 | Osteocytes (T Bellido and J Klein Nulend, Section Editors)

Solute Transport in the Bone Lacunar-Canalicular System (LCS)

verfasst von: Liyun Wang

Erschienen in: Current Osteoporosis Reports | Ausgabe 1/2018

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Abstract

Purpose of Review

Solute transport in the lacunar-canalicular system (LCS) plays important roles in osteocyte metabolism and cell-cell signaling. This review will summarize recent studies that establish pericellular matrix (PCM), discovered inside the LCS, as a crucial regulator of solute transport in bone.

Recent Findings

Utilizing confocal imaging and mathematical modeling, recent studies successfully quantified molecular diffusion and convection in the LCS as well as the size-dependent sieving effects of the PCM, leading to the quantification of the effective PCM fiber spacing (10 to 17 nm) in murine adult bones. Perlecan/HSPG2, a large linear proteoglycan, was identified to be an essential PCM component.

Summary

The PCM-filled LCS is bone’s chromatographic column, where fluid/solute transport to and from the osteocytes is regulated. The chemical composition, deposition rate, and turnover rate of the osteocyte PCM should be further defined to better understand osteocyte physiology and bone metabolism.

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Titel: Solute Transport in the Bone Lacunar-Canalicular System (LCS)
verfasst von: Liyun Wang
Publikationsdatum: 18.01.2018
Verlag: Springer US
Erschienen in: Current Osteoporosis Reports / Ausgabe 1/2018
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-018-0414-3

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Abstract

Purpose of Review

Recent Findings

Summary

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