Skip to main content
Erschienen in: Abdominal Radiology 2/2011

01.04.2011

Sources of false positives in computer-assisted CT colonography

verfasst von: Janne J. Näppi, Koichi Nagata

Erschienen in: Abdominal Radiology | Ausgabe 2/2011

Einloggen, um Zugang zu erhalten

Abstract

The application of computer-aided detection (CAD) is expected to improve reader sensitivity and to reduce inter-observer variance in computed tomographic (CT) colonography. However, current CAD systems display a large number of false-positive (FP) detections. The reviewing of a large number of FP CAD detections increases interpretation time, and it may also reduce the specificity and/or sensitivity of a computer-assisted reader. Therefore, it is important to be aware of the patterns and pitfalls of FP CAD detections. This pictorial essay reviews common sources of FP CAD detections that have been observed in the literature and in our experiments in computer-assisted CT colonography. Also the recommended computer-assisted reading technique is described.
Literatur
1.
Zurück zum Zitat Lefere P, Dachman AH, Gryspeerdt S (2007) Computed tomographic colonography: clinical value. Abdom Imaging 32:541–551PubMedCrossRef Lefere P, Dachman AH, Gryspeerdt S (2007) Computed tomographic colonography: clinical value. Abdom Imaging 32:541–551PubMedCrossRef
2.
Zurück zum Zitat Johnson CD, Chen MH, Toledano AY, et al. (2008) Accuracy of CT colonography for detection of large adenomas and cancers. N Engl J Med 359:1207–1217PubMedCrossRef Johnson CD, Chen MH, Toledano AY, et al. (2008) Accuracy of CT colonography for detection of large adenomas and cancers. N Engl J Med 359:1207–1217PubMedCrossRef
3.
Zurück zum Zitat Regge D, Laudi C, Galatola G, et al. (2009) Diagnostic accuracy of computed tomographic colonography for the detection of advanced neoplasia in individuals at increased risk of colorectal cancer. JAMA 301:2453–2461PubMedCrossRef Regge D, Laudi C, Galatola G, et al. (2009) Diagnostic accuracy of computed tomographic colonography for the detection of advanced neoplasia in individuals at increased risk of colorectal cancer. JAMA 301:2453–2461PubMedCrossRef
4.
Zurück zum Zitat Pickhardt PJ, Choi JR, Hwang I, et al. (2003) Computed tomographic virtual colonoscopy to screen for colorectal neoplasia in asymptomatic adults. N Engl J Med 349:2191–2200PubMedCrossRef Pickhardt PJ, Choi JR, Hwang I, et al. (2003) Computed tomographic virtual colonoscopy to screen for colorectal neoplasia in asymptomatic adults. N Engl J Med 349:2191–2200PubMedCrossRef
5.
Zurück zum Zitat Levin B, Lieberman DA, McFarland B, et al. (2008) Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer and the American College of Radiology. CA Cancer J Clin 58:130–160PubMedCrossRef Levin B, Lieberman DA, McFarland B, et al. (2008) Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer and the American College of Radiology. CA Cancer J Clin 58:130–160PubMedCrossRef
6.
Zurück zum Zitat Rockey DC (2009) Computed tomographic colonography: current perspectives and future directions. Gastroenterology 137:7–10PubMedCrossRef Rockey DC (2009) Computed tomographic colonography: current perspectives and future directions. Gastroenterology 137:7–10PubMedCrossRef
7.
Zurück zum Zitat Yoshida H, Näppi J (2007) CAD in CT colonography without and with oral contrast agents: progress and challenges. Comput Med Imaging Graph 31:267–284PubMedCrossRef Yoshida H, Näppi J (2007) CAD in CT colonography without and with oral contrast agents: progress and challenges. Comput Med Imaging Graph 31:267–284PubMedCrossRef
8.
Zurück zum Zitat Doi K (2005) Current status and future potential of computer-aided diagnosis in medical imaging. Br J Radiol 78:S3–S19PubMedCrossRef Doi K (2005) Current status and future potential of computer-aided diagnosis in medical imaging. Br J Radiol 78:S3–S19PubMedCrossRef
9.
Zurück zum Zitat Petrick N, Haider M, Summers RM, et al. (2008) CT colonography with computer-aided detection as a second reader: observer performance study. Radiology 246:148–156PubMedCrossRef Petrick N, Haider M, Summers RM, et al. (2008) CT colonography with computer-aided detection as a second reader: observer performance study. Radiology 246:148–156PubMedCrossRef
10.
Zurück zum Zitat Zheng B, Ganott MA, Britton CA, et al. (2001) Soft-copy mammographic readings with different computer-assisted detection cuing environments: preliminary findings. Radiology 221:633–637PubMedCrossRef Zheng B, Ganott MA, Britton CA, et al. (2001) Soft-copy mammographic readings with different computer-assisted detection cuing environments: preliminary findings. Radiology 221:633–637PubMedCrossRef
11.
Zurück zum Zitat Philpotts LE (2009) Can computer-aided detection be detrimental to mammographic interpretation? Radiology 253:17–22PubMedCrossRef Philpotts LE (2009) Can computer-aided detection be detrimental to mammographic interpretation? Radiology 253:17–22PubMedCrossRef
12.
Zurück zum Zitat Taylor SA, Greenhalgh R, Ilangovan R, et al. (2008) CT colonography and computer-aided detection: effect of false-positive results on reader specificity and reading efficiency in a low-prevalence screening population. Radiology 247:133–140PubMedCrossRef Taylor SA, Greenhalgh R, Ilangovan R, et al. (2008) CT colonography and computer-aided detection: effect of false-positive results on reader specificity and reading efficiency in a low-prevalence screening population. Radiology 247:133–140PubMedCrossRef
13.
Zurück zum Zitat Taylor SA, Brittenden J, Lenton J, et al. (2009) Influence of computer-aided detection false-positives on reader performance and diagnostic confidence for CT colonography. AJR Am J Roentgenol 192:1682–1688PubMedCrossRef Taylor SA, Brittenden J, Lenton J, et al. (2009) Influence of computer-aided detection false-positives on reader performance and diagnostic confidence for CT colonography. AJR Am J Roentgenol 192:1682–1688PubMedCrossRef
14.
Zurück zum Zitat Dachman AH, Lefere P, Gryspeerdt S, Morin M (2007) CT colonography: visualization methods, interpretation, and pitfalls. Radiol Clin N Am 45:347–359PubMedCrossRef Dachman AH, Lefere P, Gryspeerdt S, Morin M (2007) CT colonography: visualization methods, interpretation, and pitfalls. Radiol Clin N Am 45:347–359PubMedCrossRef
15.
Zurück zum Zitat Pickhardt PJ (2004) Differential diagnosis of polypoid lesions seen at CT colonography (virtual colonoscopy). Radiographics 24:1535–1556PubMedCrossRef Pickhardt PJ (2004) Differential diagnosis of polypoid lesions seen at CT colonography (virtual colonoscopy). Radiographics 24:1535–1556PubMedCrossRef
16.
Zurück zum Zitat Näppi J, Yoshida H (2008) Adaptive correction of the pseudo-enhancement of CT attenuation for fecal-tagging CT colonography. Med Image Anal 12:413–426PubMedCrossRef Näppi J, Yoshida H (2008) Adaptive correction of the pseudo-enhancement of CT attenuation for fecal-tagging CT colonography. Med Image Anal 12:413–426PubMedCrossRef
17.
Zurück zum Zitat Johnson CD, Dachman AH (2000) CT colonography: the next colon screening examination? Radiology 216:331–341PubMed Johnson CD, Dachman AH (2000) CT colonography: the next colon screening examination? Radiology 216:331–341PubMed
18.
Zurück zum Zitat McFarland EG (2002) Reader strategies for CT colonography. Abdom Imaging 27:275–283PubMed McFarland EG (2002) Reader strategies for CT colonography. Abdom Imaging 27:275–283PubMed
20.
Zurück zum Zitat O’Connor SD, Summers RM, Choi JR, Pickhardt PJ (2006) Oral contrast adherence to polyps on CT colonography. J Comput Assist Tomogr 30:51–57PubMedCrossRef O’Connor SD, Summers RM, Choi JR, Pickhardt PJ (2006) Oral contrast adherence to polyps on CT colonography. J Comput Assist Tomogr 30:51–57PubMedCrossRef
21.
Zurück zum Zitat Laks S, Macari M, Bini EJ (2004) Positional change in colon polyps at CT colonography. Radiology 231:761–766PubMedCrossRef Laks S, Macari M, Bini EJ (2004) Positional change in colon polyps at CT colonography. Radiology 231:761–766PubMedCrossRef
22.
Zurück zum Zitat Chen JC, Dachman AH (2006) Cecal mobility: a potential pitfall of CT colonography. AJR Am J Roentgenol 186:1086–1089PubMedCrossRef Chen JC, Dachman AH (2006) Cecal mobility: a potential pitfall of CT colonography. AJR Am J Roentgenol 186:1086–1089PubMedCrossRef
23.
Zurück zum Zitat Iafrate I, Rengo M, Ferrari R, et al. (2007) Spectrum of normal findings, anatomic variants and pathology of ileocecal valve: CT colonography appearances and endoscopic correlation. Abdom Imaging 32:589–595PubMedCrossRef Iafrate I, Rengo M, Ferrari R, et al. (2007) Spectrum of normal findings, anatomic variants and pathology of ileocecal valve: CT colonography appearances and endoscopic correlation. Abdom Imaging 32:589–595PubMedCrossRef
24.
Zurück zum Zitat Yitta S, Tatineny KC, Cipriani NA, Dachman AH (2006) Characterization of normal ileocecal valve density on CT colonography. J Comput Assist Tomogr 30:58–61PubMedCrossRef Yitta S, Tatineny KC, Cipriani NA, Dachman AH (2006) Characterization of normal ileocecal valve density on CT colonography. J Comput Assist Tomogr 30:58–61PubMedCrossRef
25.
Zurück zum Zitat Näppi J, Yoshida H (2007) Fully automated three-dimensional detection of polyps in fecal-tagging CT colonography. Acad Radiol 14:287–300PubMedCrossRef Näppi J, Yoshida H (2007) Fully automated three-dimensional detection of polyps in fecal-tagging CT colonography. Acad Radiol 14:287–300PubMedCrossRef
26.
Zurück zum Zitat Cai W, Zalis ME, Näppi J, Harris GJ, Yoshida H (2008) Structure-analysis method for electronic cleansing in cathartic and noncathartic CT colonography. Med Phys 35:3259–3277PubMedCrossRef Cai W, Zalis ME, Näppi J, Harris GJ, Yoshida H (2008) Structure-analysis method for electronic cleansing in cathartic and noncathartic CT colonography. Med Phys 35:3259–3277PubMedCrossRef
27.
Zurück zum Zitat Summers RM, Franaszek M, Miller MT, et al. (2005) Computer-aided detection of polyps on oral contrast-enhanced CT colonography. AJR Am J Roentgenol 184:105–108PubMed Summers RM, Franaszek M, Miller MT, et al. (2005) Computer-aided detection of polyps on oral contrast-enhanced CT colonography. AJR Am J Roentgenol 184:105–108PubMed
28.
Zurück zum Zitat Näppi J, Yoshida H (2009) Virtual tagging for laxative-free CT colonography: pilot evaluation. Med Phys 36:1830–1838PubMedCrossRef Näppi J, Yoshida H (2009) Virtual tagging for laxative-free CT colonography: pilot evaluation. Med Phys 36:1830–1838PubMedCrossRef
29.
Zurück zum Zitat Macari M, Megibow AJ (2001) Pitfalls of using three-dimensional CT colonography with two-dimensional imaging correlation. Am J Roentgenol 176:137–143 Macari M, Megibow AJ (2001) Pitfalls of using three-dimensional CT colonography with two-dimensional imaging correlation. Am J Roentgenol 176:137–143
30.
Zurück zum Zitat Lefere P, Gryspeerdt S, Baekelandt M, Dewyspelaere J, van Holsbeeck B (2003) Diverticular disease in CT colonography. Eur Radiol 13:L62–L74PubMedCrossRef Lefere P, Gryspeerdt S, Baekelandt M, Dewyspelaere J, van Holsbeeck B (2003) Diverticular disease in CT colonography. Eur Radiol 13:L62–L74PubMedCrossRef
31.
Zurück zum Zitat Lee MW, Kim SH, Park HS, et al. (2009) An anthropomorphic phantom study of computer-aided detection performance for polyp detection on CT colonography: a comparison of commercially and academically available systems. AJR Am J Roentgenol 193:445–454PubMedCrossRef Lee MW, Kim SH, Park HS, et al. (2009) An anthropomorphic phantom study of computer-aided detection performance for polyp detection on CT colonography: a comparison of commercially and academically available systems. AJR Am J Roentgenol 193:445–454PubMedCrossRef
32.
Zurück zum Zitat Hein PA, Krug LD, Romano VC, et al. (2010) Computer-aided detection in computed tomography colonography with full fecal tagging: comparison of standalone performance of 3 automated polyp detection systems. Can Assoc Radiol J 61:102–108PubMedCrossRef Hein PA, Krug LD, Romano VC, et al. (2010) Computer-aided detection in computed tomography colonography with full fecal tagging: comparison of standalone performance of 3 automated polyp detection systems. Can Assoc Radiol J 61:102–108PubMedCrossRef
33.
Zurück zum Zitat Lefere P, Gryspeerdt S, Baekelandt M, Van Holsbeeck B (2004) Laxative-free CT colonography. AJR Am J Roentgenol 183:945–948PubMed Lefere P, Gryspeerdt S, Baekelandt M, Van Holsbeeck B (2004) Laxative-free CT colonography. AJR Am J Roentgenol 183:945–948PubMed
34.
Zurück zum Zitat Johnson CD, Manduca A, Fletcher JG, et al. (2008) Noncathartic CT colonography with stool tagging: performance with and without electronic stool subtraction. AJR Am J Roentgenol 190:361–366PubMedCrossRef Johnson CD, Manduca A, Fletcher JG, et al. (2008) Noncathartic CT colonography with stool tagging: performance with and without electronic stool subtraction. AJR Am J Roentgenol 190:361–366PubMedCrossRef
35.
Zurück zum Zitat Taylor SA, Suzuki N, Beddoe G, Halligan S (2009) Flat neoplasia of the colon: CT colonography with CAD. Abdom Imaging 34:173–181PubMedCrossRef Taylor SA, Suzuki N, Beddoe G, Halligan S (2009) Flat neoplasia of the colon: CT colonography with CAD. Abdom Imaging 34:173–181PubMedCrossRef
36.
Zurück zum Zitat Summers RM, Frentz SM, Liu J, et al. (2009) Conspicuity of colorectal polyps at CT colonography: visual assessment, CAD performance, and the important role of polyp height. Acad Radiol 16:4–14PubMedCrossRef Summers RM, Frentz SM, Liu J, et al. (2009) Conspicuity of colorectal polyps at CT colonography: visual assessment, CAD performance, and the important role of polyp height. Acad Radiol 16:4–14PubMedCrossRef
37.
Zurück zum Zitat Lee SS, Park SH, Kim JK, et al. (2009) Panoramic endoluminal display with minimal image distortion using circumferential radial ray-casting for primary three-dimensional interpretation of CT colonography. Eur Radiol 19:1951–1958PubMedCrossRef Lee SS, Park SH, Kim JK, et al. (2009) Panoramic endoluminal display with minimal image distortion using circumferential radial ray-casting for primary three-dimensional interpretation of CT colonography. Eur Radiol 19:1951–1958PubMedCrossRef
38.
Zurück zum Zitat de Vries AH, Bipat S, Dekker E, et al. (2010) Polyp measurement based on CT colonography and colonoscopy: variability and systematic differences. Eur Radiol 20:1404–1413PubMedCrossRef de Vries AH, Bipat S, Dekker E, et al. (2010) Polyp measurement based on CT colonography and colonoscopy: variability and systematic differences. Eur Radiol 20:1404–1413PubMedCrossRef
39.
Zurück zum Zitat Park SH, Choi EK, Lee SS, et al. (2007) Polyp measurement reliability, accuracy, and discrepancy: optical colonoscopy versus CT colonography with pig colonic specimens. Radiology 244:157–164PubMedCrossRef Park SH, Choi EK, Lee SS, et al. (2007) Polyp measurement reliability, accuracy, and discrepancy: optical colonoscopy versus CT colonography with pig colonic specimens. Radiology 244:157–164PubMedCrossRef
40.
Zurück zum Zitat Taylor SA, Robinson C, Boone D, Honeyfield L, Halligan S (2009) Polyp characteristics correctly annotated by computer-aided detection software but ignored by reporting radiologists during CT colonography. Radiology 253:715–718PubMedCrossRef Taylor SA, Robinson C, Boone D, Honeyfield L, Halligan S (2009) Polyp characteristics correctly annotated by computer-aided detection software but ignored by reporting radiologists during CT colonography. Radiology 253:715–718PubMedCrossRef
41.
Zurück zum Zitat Fisichella VA, Jäderling F, Horvath S, et al. (2009) Computer-aided detection (CAD) as a second reader using perspective filet view at CT colonography: effect on performance of inexperienced readers. Clin Radiol 64:972–982PubMedCrossRef Fisichella VA, Jäderling F, Horvath S, et al. (2009) Computer-aided detection (CAD) as a second reader using perspective filet view at CT colonography: effect on performance of inexperienced readers. Clin Radiol 64:972–982PubMedCrossRef
42.
Zurück zum Zitat Mang T, Peloschek P, Plank C, et al. (2007) Effect of computer-aided detection as a second reader in multidetector-row CT colonography. Eur Radiol 17:2598–2607PubMedCrossRef Mang T, Peloschek P, Plank C, et al. (2007) Effect of computer-aided detection as a second reader in multidetector-row CT colonography. Eur Radiol 17:2598–2607PubMedCrossRef
43.
Zurück zum Zitat Bielen D, Kiss G (2007) Computer-aided detection for CT colonography: update 2007. Abdom Imaging 32:571–581PubMedCrossRef Bielen D, Kiss G (2007) Computer-aided detection for CT colonography: update 2007. Abdom Imaging 32:571–581PubMedCrossRef
44.
Zurück zum Zitat Yoshida H, Näppi J, MacEneaney P, Rubin DT, Dachman AH (2002) Computer-aided diagnosis scheme for detection of polyps at CT colonography. Radiographics 22:963–979PubMed Yoshida H, Näppi J, MacEneaney P, Rubin DT, Dachman AH (2002) Computer-aided diagnosis scheme for detection of polyps at CT colonography. Radiographics 22:963–979PubMed
Metadaten
Titel
Sources of false positives in computer-assisted CT colonography
verfasst von
Janne J. Näppi
Koichi Nagata
Publikationsdatum
01.04.2011
Verlag
Springer-Verlag
Erschienen in
Abdominal Radiology / Ausgabe 2/2011
Print ISSN: 2366-004X
Elektronische ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-010-9625-5

Weitere Artikel der Ausgabe 2/2011

Abdominal Radiology 2/2011 Zur Ausgabe

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

17.05.2024 Klinik aktuell Nachrichten

Sie sei „ethisch geboten“, meint Gesundheitsminister Karl Lauterbach: mehr Transparenz über die Qualität von Klinikbehandlungen. Um sie abzubilden, lässt er gegen den Widerstand vieler Länder einen virtuellen Klinik-Atlas freischalten.

Klinikreform soll zehntausende Menschenleben retten

15.05.2024 Klinik aktuell Nachrichten

Gesundheitsminister Lauterbach hat die vom Bundeskabinett beschlossene Klinikreform verteidigt. Kritik an den Plänen kommt vom Marburger Bund. Und in den Ländern wird über den Gang zum Vermittlungsausschuss spekuliert.

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

07.05.2024 Klinik aktuell Nachrichten

Extreme Arbeitsverdichtung und kaum Supervision: Dr. Andrea Martini, Sprecherin des Bündnisses Junge Ärztinnen und Ärzte (BJÄ) über den Frust des ärztlichen Nachwuchses und die Vorteile des Rucksack-Modells.

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.