Sphincter of Oddi dysfunction: Does Psychosocial Distress Play a Role?

Sphincter of Oddi dysfunction (SOD) is a functional gastrointestinal disorder characterized by pancreatobiliary-type of pain in the absence of organic abnormalities. The aim of this study was to investigate specific psychosocial predictors of functional outcome in a group of patients consecutively referred to a gastroenterological department for biliary-type of pain. Based on medical examination patients were divided into functional (SOD) and organic groups. Self-administered questionnaires regarding demographic characteristics, psychological distress (Symptom Check-List-90–R, [SCL-90-R]), severity of acute and chronic stress, level of subjective well-being and satisfaction with health were completed. The analyses were based on the logistic regression approach. In this sample, SOD patients were older than organic patients and more likely female. Logistic regression analysis showed that higher acute stress (i.e., main effect) was associated with a decreased likelihood of functional (SOD) outcome, whereas the combination of acute stress with chronic stress and the combination of acute stress with higher severity of psychopathology (i.e., interaction effect) was associated with an increased likelihood of functional (SOD) outcome. These findings suggest stressful life events in combination with certain psychological symptoms can play a role in the symptom presentation of patients with sphincter of Oddi dysfunction.