Ausgabe 6/2020
Inhalt (17 Artikel)
NUC-1031 in biliary tract cancer: from bench to bedside and back?
Lenka N. C. Boyd, Godefridus J. Peters, Geert Kazemier, Elisa Giovannetti
Assessing the translational value of pre-clinical studies for clinical response rate in oncology: an exploratory investigation of 42 FDA-approved small-molecule targeted anticancer drugs
Wenying Angela Liu, Li Yu, Peter N. Morcos, Francois Mercier, Barbara J. Brennan
Detection of trifluridine in tumors of patients with metastatic colorectal cancer treated with trifluridine/tipiracil
Yoshiaki Fujimoto, Ryota Nakanishi, Mamoru Nukatsuka, Kazuaki Matsuoka, Koji Ando, Takeshi Wakasa, Hiroyuki Kitao, Eiji Oki, Yoshihiko Maehara, Masaki Mori
In vivo assessment of the drug interaction between sorafenib and paracetamol in rats
Agnieszka Karbownik, Katarzyna Sobańska, Tomasz Grabowski, Joanna Stanisławiak-Rudowicz, Anna Wolc, Edmund Grześkowiak, Edyta Szałek
The gut microbiota attenuates muscle wasting by regulating energy metabolism in chemotherapy-induced malnutrition rats
Haitao Chen, Chao Xu, Fan Zhang, Yu Liu, Yong Guo, Qinghua Yao
Evaluation of NUC-1031: a first-in-class ProTide in biliary tract cancer
Mansi Arora, James M. Bogenberger, Amro Abdelrahman, Jennifer L. Leiting, Xianfeng Chen, Jan B. Egan, Aradhana Kasimsetty, Elzbieta Lenkiewicz, Smriti Malasi, Pedro Luiz Serrano Uson, Bolni Marius Nagalo, Yumei Zhou, Marcela A. Salomao, Heidi E. Kosiorek, Esteban Braggio, Michael T. Barrett, Mark J. Truty, Mitesh J. Borad
MEK inhibition overcomes everolimus resistance in gastric cancer
Hongfang Liu, Yang Yao, Juan Zhang, Jing Li
A phase I dose-escalation study of the polyamine analog PG-11047 in patients with advanced solid tumors
Tracy Murray Stewart, Apurva A. Desai, Michael L. Fitzgerald, Laurence J. Marton, Robert A. Casero Jr.
Anticancer effects of brusatol in nasopharyngeal carcinoma through suppression of the Akt/mTOR signaling pathway
Songbin Guo, Jinling Zhang, Cairong Wei, Zhiyong Lu, Rulong Cai, Danqi Pan, Hanbin Zhang, Baoxia Liang, Zhenfeng Zhang
Pharmacokinetics and tolerability of fedratinib, an oral, selective Janus kinase 2 inhibitor, in subjects with renal or hepatic impairment
Ken Ogasawara, William B. Smith, Christine Xu, Jian Yin, Maria Palmisano, Gopal Krishna
Variants of carboxylesterase 1 have no impact on capecitabine pharmacokinetics and toxicity in capecitabine plus oxaliplatin treated-colorectal cancer patients
Natsumi Matsumoto, Yutaro Kubota, Hiroo Ishida, Masae Sekido, Ryotaro Ohkuma, Tomoyuki Ishiguro, Yuya Hirasawa, Hirotsugu Ariizumi, Takuya Tsunoda, Toshikazu Ikusue, Kouji Kobayashi, Atsushi Hisamatsu, Hirokazu Toshima, Ken Shimada, Ken-ichi Fujita
Protein expression profiling identifies differential modulation of homologous recombination by platinum-based antitumor agents
Guangan He, Xiaolei Xie, Zahid H. Siddik
Exposure–response analysis of endoxifen serum concentrations in early-breast cancer
Anabel Beatriz Sanchez-Spitman, Dirk-Jan A. R. Moes, Jesse J. Swen, Vincent O. Dezentjé, Diether Lambrechts, Patrick Neven, Hans Gelderblom, Henk-Jan Guchelaar
Antitumor effects of ivermectin at clinically feasible concentrations support its clinical development as a repositioned cancer drug
Mandy Juarez, Alejandro Schcolnik-Cabrera, Guadalupe Dominguez-Gomez, Alma Chavez-Blanco, Jose Diaz-Chavez, Alfonso Duenas-Gonzalez
In vitro drug sensitivity (IDS) of patient-derived primary osteosarcoma cells as an early predictor of the clinical outcomes of osteosarcoma patients
Jeerawan Klangjorhor, Areerak Phanphaisarn, Pimpisa Teeyakasem, Parunya Chaiyawat, Phichayut Phinyo, Jongkolnee Settakorn, Nipon Theera-Umpon, Dumnoensun Pruksakorn
CD73 as a target to improve temozolomide chemotherapy effect in glioblastoma preclinical model
J. H. Azambuja, R. S. Schuh, L. R. Michels, N. E. Gelsleichter, L. R. Beckenkamp, G. S. Lenz, F. H. de Oliveira, M. R. Wink, M. A. Stefani, A. M. O. Battastini, H. F. Teixeira, E. Braganhol
Expression of Concern: shRNA-mediated silencing of ZFX attenuated the proliferation of breast cancer cells
Hongjian Yang, Yue Lu, Yabing Zheng, Xingfei Yu, Xianghou Xia, Xiangming He, Weiliang Feng, Lei Xing, Zhiqiang Ling