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Journal of Translational Medicine

Ausgabe 1/2021

Inhalt (529 Artikel)

Open Access Research

Hemolysis at low blood flow rates: in-vitro and in-silico evaluation of a centrifugal blood pump

Malte Schöps, Sascha H. Groß-Hardt, Thomas Schmitz-Rode, Ulrich Steinseifer, Daniel Brodie, Johanna C. Clauser, Christian Karagiannidis

Open Access Research

Effects of time-restricted feeding in weight loss, metabolic syndrome and cardiovascular risk in obese women

Jéssica D. Schroder, Hugo Falqueto, Aline Mânica, Daniela Zanini, Tácio de Oliveira, Clodoaldo A. de Sá, Andréia Machado Cardoso, Leandro Henrique Manfredi

Open Access Research

A novel immune classification reveals distinct immune escape mechanism and genomic alterations: implications for immunotherapy in hepatocellular carcinoma

Zaoqu Liu, Yuyuan Zhang, Chengcheng Shi, Xueliang Zhou, Kaihao Xu, Dechao Jiao, Zhenqiang Sun, Xinwei Han

Open Access Research

Multi-omic signatures of atherogenic dyslipidaemia: pre-clinical target identification and validation in humans

Mariola Olkowicz, Izabela Czyzynska-Cichon, Natalia Szupryczynska, Renata B. Kostogrys, Zdzislaw Kochan, Janusz Debski, Michal Dadlez, Stefan Chlopicki, Ryszard T. Smolenski

Open Access Research

Genomic profile of metastatic breast cancer patient-derived xenografts established using percutaneous biopsy

Seongyeong Kim, Dongjin Shin, Ahrum Min, Minjung Kim, Deukchae Na, Han-Byeol Lee, Han Suk Ryu, Yaewon Yang, Go-Un Woo, Kyung-Hun Lee, Dae-Won Lee, Tae-Yong Kim, Charles Lee, Seock-Ah Im, Jong-Il Kim

Open Access Review

Hypoxia and the phenomenon of immune exclusion

Violena Pietrobon, Francesco M. Marincola

Open Access Research

Deep learning model for classifying endometrial lesions

YunZheng Zhang, ZiHao Wang, Jin Zhang, CuiCui Wang, YuShan Wang, Hao Chen, LuHe Shan, JiaNing Huo, JiaHui Gu, Xiaoxin Ma

Open Access Review

Immune responses to azacytidine in animal models of inflammatory disorders: a systematic review

Sija Landman, Chiel van der Horst, Piet E. J. van Erp, Irma Joosten, Rob de Vries, Hans J. P. M. Koenen

Open Access Meeting report

Perspectives in immunotherapy: meeting report from the “Immunotherapy Bridge” (December 4th–5th, 2019, Naples, Italy)

Paolo A. Ascierto, Lisa H. Butterfield, Katie Campbell, Bruno Daniele, Michael Dougan, Leisha A. Emens, Silvia Formenti, Filip Janku, Samir N. Khleif, Tomas Kirchhoff, Alessandro Morabito, Yana Najjar, Paul Nathan, Kunle Odunsi, Akash Patnaik, Chrystal M. Paulos, Bradley I. Reinfeld, Heath D. Skinner, John Timmerman, Igor Puzanov

Open Access Research

Titanium-interlayer mediated hydroxyapatite coating on polyetheretherketone: a prospective study in patients with single-level cervical degenerative disc disease

Ce Zhu, Miaomiao He, Lili Mao, Tao Li, Li Zhang, Limin Liu, Ganjun Feng, Yueming Song

Open Access Methodology

Qualitative and quantitative comparison of cell-free DNA and cell-free fetal DNA isolation by four (semi-)automated extraction methods: impact in two clinical applications: chimerism quantification and noninvasive prenatal diagnosis

Pascal Pedini, Hajer Graiet, Laurine Laget, Lugdivine Filosa, Jade Chatron, Nicem Cherouat, Jacques Chiaroni, Lucas Hubert, Coralie Frassati, Christophe Picard

Open Access Research

Amniotic fluid-derived multipotent stromal cells drive diabetic wound healing through modulation of macrophages

Bibi S. Subhan, Jennifer Kwong, Joseph F. Kuhn, Arie Monas, Sonali Sharma, Piul S. Rabbani

Open Access Research

A monocentric phase I study of vemurafenib plus cobimetinib plus PEG-interferon (VEMUPLINT) in advanced melanoma patients harboring the V600BRAF mutation

Ester Simeone, Giosuè Scognamiglio, Mariaelena Capone, Diana Giannarelli, Antonio M. Grimaldi, Domenico Mallardo, Gabriele Madonna, Marcello Curvietto, Assunta Esposito, Fabio Sandomenico, Francesco Sabbatino, Nicholas L. Bayless, Sarah Warren, SuFey Ong, Gerardo Botti, Keith T. Flaherty, Soldano Ferrone, Paolo A. Ascierto

Open Access Research

Effect of a novel functional tomato sauce (OsteoCol) from vine-ripened tomatoes on serum lipids in individuals with common hypercholesterolemia: tomato sauce and hypercholesterolemia

Yvelise Ferro, Elisa Mazza, Elvira Angotti, Roberta Pujia, Angela Mirarchi, Maria Antonietta Salvati, Rosa Terracciano, Rocco Savino, Stefano Romeo, Antonio Scuteri, Rosario Mare, Francesco Saverio Costanzo, Arturo Pujia, Tiziana Montalcini

Open Access Research

An analytical method for the identification of cell type-specific disease gene modules

Jinting Guan, Yiping Lin, Yang Wang, Junchao Gao, Guoli Ji

Open Access Methodology

Validation of a method evaluating T cell metabolic potential in compliance with ICH Q2 (R1)

Patricia Mercier-Letondal, Chrystel Marton, Yann Godet, Jeanne Galaine

Open Access Review

Anti-migraine agents from an immunological point of view

Mushref Bakri Assas

Open Access Research

Improvement of urinary tract symptoms and quality of life in benign prostate hyperplasia patients associated with consumption of a newly developed whole tomato-based food supplement: a phase II prospective, randomized double-blinded, placebo-controlled study

Luigi Cormio, Beppe Calò, Ugo Falagario, Manuela Iezzi, Alessia Lamolinara, Paola Vitaglione, Giovanni Silecchia, Giuseppe Carrieri, Vincenzo Fogliano, Stefano Iacobelli, Pier Giorgio Natali, Mauro Piantelli

Open Access Research

The risk and added values of the atherosclerotic cardiovascular risk enhancers on prediction of cardiovascular events: Tehran lipid and glucose study

Farzad Hadaegh, Samaneh Asgari, Fatemeh Moosaie, Meysam Orangi, Farzaneh Sarvghadi, Davood Khalili, Fereidoun Azizi

Open Access Research

Model based on five tumour immune microenvironment-related genes for predicting hepatocellular carcinoma immunotherapy outcomes

Xinyu Gu, Jun Guan, Jia Xu, Qiuxian Zheng, Chao Chen, Qin Yang, Chunhong Huang, Gang Wang, Haibo Zhou, Zhi Chen, Haihong Zhu

Open Access Research

Immune landscape and prognostic immune-related genes in KRAS-mutant colorectal cancer patients

Jungang Liu, Xiaoliang Huang, Haizhou Liu, Chunyin Wei, Haiming Ru, Haiquan Qin, Hao Lai, Yongsheng Meng, Guo Wu, Weishun Xie, Xianwei Mo, Caroline H. Johnson, Yawei Zhang, Weizhong Tang

Open Access COVID-19 Research

CT radiomics facilitates more accurate diagnosis of COVID-19 pneumonia: compared with CO-RADS

Huanhuan Liu, Hua Ren, Zengbin Wu, He Xu, Shuhai Zhang, Jinning Li, Liang Hou, Runmin Chi, Hui Zheng, Yanhong Chen, Shaofeng Duan, Huimin Li, Zongyu Xie, Dengbin Wang

Open Access COVID-19 Research

Analysis of viral load in different specimen types and serum antibody levels of COVID-19 patients

Ling Li, Chianru Tan, Jia Zeng, Chen Luo, Shi Hu, Yanke Peng, Wenjuan Li, Zhixiong Xie, Yueming Ling, Xuejun Zhang, E. Deng, Haixia Xu, Jue Wang, Yudi Xie, Yaling Zhou, Wei Zhang, Yong Guo, Zhong Liu

Open Access COVID-19 Research

Transcriptome of nasopharyngeal samples from COVID-19 patients and a comparative analysis with other SARS-CoV-2 infection models reveal disparate host responses against SARS-CoV-2

Abul Bashar Mir Md. Khademul Islam, Md. Abdullah-Al-Kamran Khan, Rasel Ahmed, Md. Sabbir Hossain, Shah Md. Tamim Kabir, Md. Shahidul Islam, A. M. A. M. Zonaed Siddiki

Open Access Research

Transcriptomic analysis identifies organ-specific metastasis genes and pathways across different primary sites

Lin Zhang, Ming Fan, Francesco Napolitano, Xin Gao, Ying Xu, Lihua Li

Open Access Methodology

Optimization of the Mainzelliste software for fast privacy-preserving record linkage

Florens Rohde, Martin Franke, Ziad Sehili, Martin Lablans, Erhard Rahm

Open Access Research

Identification of key biomarkers and immune infiltration in systemic lupus erythematosus by integrated bioinformatics analysis

Xingwang Zhao, Longlong Zhang, Juan Wang, Min Zhang, Zhiqiang Song, Bing Ni, Yi You

Open Access Research

Accuracy of the end-expiratory lung volume measured by the modified nitrogen washout/washin technique: a bench study

Joana Berger-Estilita, Matthias Haenggi, Daniel Ott, David Berger

Open Access Research

Reduction of miR-744 delivered by NSCLC cell-derived extracellular vesicles upregulates SUV39H1 to promote NSCLC progression via activation of the Smad9/BMP9 axis

Liming Gao, Qi Tian, Tong Wu, Shanshan Shi, Xiaobo Yin, Lijie Liu, Lei Zheng, Ping Wang, Yaling Tian, Shufeng Xu

Open Access Research

Distinct osmoregulatory responses to sodium loading in patients with altered glycosaminoglycan structure: a randomized cross-over trial

Eliane F. E. Wenstedt, Jetta J. Oppelaar, Stijn Besseling, Nienke M. G. Rorije, Rik H. G. Olde Engberink, Arie Oosterhof, Toin H. van Kuppevelt, Bert-Jan H. van den Born, Jan Aten, Liffert Vogt

Open Access Research

Blood-based extracellular matrix biomarkers as predictors of survival in patients with metastatic pancreatic ductal adenocarcinoma receiving pegvorhyaluronidase alfa

Song Wang, Cecilie L. Bager, Morten A. Karsdal, Dimitrios Chondros, Darin Taverna, Nicholas Willumsen

Open Access Review

Patient-derived organoid (PDO) platforms to facilitate clinical decision making

Lisa Liu, Lei Yu, Zhichao Li, Wujiao Li, WeiRen Huang

Open Access Research

Assessing the clinical utility of genetic risk scores for targeted cancer screening

Carly A. Conran, Zhuqing Shi, William Kyle Resurreccion, Rong Na, Brian T. Helfand, Elena Genova, Siqun Lilly Zheng, Charles B. Brendler, Jianfeng Xu

Open Access Research

HELQ and EGR3 expression correlate with IGHV mutation status and prognosis in chronic lymphocytic leukemia

Chao Guo, Ya-yue Gao, Qian-qian Ju, Chun-xia Zhang, Ming Gong, Zhen-ling Li

Open Access Research

Role of epidermal growth factor receptor inhibitor-induced interferon pathway signaling in the head and neck squamous cell carcinoma therapeutic response

Sean P. Korpela, Trista K. Hinz, Ayman Oweida, Jihye Kim, Jacob Calhoun, Robert Ferris, Raphael A. Nemenoff, Sana D. Karam, Eric T. Clambey, Lynn E. Heasley

Open Access Research

The association of priori and posteriori dietary patterns with the risk of incident hypertension: Tehran Lipid and Glucose Study

Azra Ramezankhani, Firoozeh Hosseini-Esfahani, Parvin Mirmiran, Fereidoun Azizi, Farzad Hadaegh

Open Access Research

Chromatin conformation changes in peripheral blood can detect prostate cancer and stratify disease risk groups

Heba Alshaker, Robert Mills, Ewan Hunter, Matthew Salter, Aroul Ramadass, Benjamin Matthew Skinner, Willem Westra, Jayne Green, Alexandre Akoulitchev, Mathias Winkler, Dmitri Pchejetski

Open Access Research

Treatment with therapeutic anticoagulation is not associated with immunotherapy response in advanced cancer patients

Paul Johannet, Amelia Sawyers, Nicholas Gulati, Douglas Donnelly, Samuel Kozloff, Yingzhi Qian, Alfredo Floristan, Eva Hernando, Judy Zhong, Iman Osman

Open Access Research

Are there subgroups of chronic fatigue syndrome? An exploratory cluster analysis of biological markers

Tarjei Tørre Asprusten, Line Sletner, Vegard Bruun Bratholm Wyller

Open Access Research

The potential role of chemotaxis and the complement system in the formation and progression of thoracic aortic aneurysms inferred from the weighted gene coexpression network analysis

Chuxiang Lei, Dan Yang, Wenlin Chen, Haoxuan Kan, Fang Xu, Hui Zhang, Wei Wang, Lei Ji, Yuehong Zheng

Open Access Research

Circulating tumor DNA as a prognostic marker in high-risk endometrial cancer

Weiwei Feng, Nan Jia, Haining Jiao, Jun Chen, Yan Chen, Yueru Zhang, Menghan Zhu, Chongying Zhu, Lifei Shen, Wenqing Long

Open Access Research

Circulating levels of IL-33 are elevated by obesity and positively correlated with metabolic disorders in Chinese adults

Haoneng Tang, Ning Liu, Xiaojing Feng, Yanyi Yang, Yiyuan Fang, Siqi Zhuang, Yufeng Dai, Meilian Liu, Lingli Tang

Open Access Research

Non-invasive monitoring of pH and oxygen using miniaturized electrochemical sensors in an animal model of acute hypoxia

Laura Pla, Sergio Berdún, Mònica Mir, Lourders Rivas, Sandrine Miserere, Samuel Dulay, Josep Samitier, Elisenda Eixarch, Miriam Illa, Eduard Gratacós

Open Access Research

β-Glucan from Lentinula edodes prevents cognitive impairments in high-fat diet-induced obese mice: involvement of colon-brain axis

Wei Pan, Pengfei Jiang, Jinxiu Zhao, Hongli Shi, Peng Zhang, Xiaoying Yang, Joanna Biazik, Minmin Hu, Hui Hua, Xing Ge, Xu-Feng Huang, Yinghua Yu

Open Access COVID-19 Research

Development and validation of a prognostic COVID-19 severity assessment (COSA) score and machine learning models for patient triage at a tertiary hospital

Verena Schöning, Evangelia Liakoni, Christine Baumgartner, Aristomenis K. Exadaktylos, Wolf E. Hautz, Andrew Atkinson, Felix Hammann

Open Access Research

Gender-specific associations between polymorphisms of the circadian gene RORA and cutaneous melanoma susceptibility

Clara Benna, Senthilkumar Rajendran, Giovanna Spiro, Chiara Menin, Luigi Dall’Olmo, Carlo Riccardo Rossi, Simone Mocellin

Open Access Research

Eight-lncRNA signature of cervical cancer were identified by integrating DNA methylation, copy number variation and transcriptome data

Qihang Zhong, Minzhen Lu, Wanqiong Yuan, Yueyi Cui, Hanqiang Ouyang, Yong Fan, Zhaohui Wang, Congying Wu, Jie Qiao, Jing Hang

Open Access Retraction Note

Retraction Note to: microRNA-128 mediates CB1 expression and regulates NF-KB/p-JNK axis to influence the occurrence of diabetic bladder disease

Xin Gou, Jing Wu, Mingqing Huang, Yuting Weng, Tongxin Yang, Tao Chen, Guiqing Li, Kewei Fang

Open Access Research

Exogenous bacterial DnaK increases protein kinases activity in human cancer cell lines

Francesca Benedetti, Sabrina Curreli, Robert C. Gallo, Davide Zella

Open Access Research

Biomarker profiling for risk of future heart failure (HFpEF) development

Chris J. Watson, Joe Gallagher, Mark Wilkinson, Adam Russell-Hallinan, Isaac Tea, Stephanie James, James O’Reilly, Eoin O’Connell, Shuaiwei Zhou, Mark Ledwidge, Ken McDonald

Open Access Research

Rosuvastatin exerts anti-atherosclerotic effects by improving macrophage-related foam cell formation and polarization conversion via mediating autophagic activities

Xinxin Zhang, Yating Qin, Xiaoning Wan, Hao Liu, Chao Lv, Weibin Ruan, Lin He, Li Lu, Xiaomei Guo

Open Access COVID-19 Letter to the Editor

Biomarkers of COVID-19 severity may not serve patients with polycystic ovary syndrome

Abu Saleh Md Moin, Manjula Nandakumar, Thozhukat Sathyapalan, Stephen L. Atkin, Alexandra E. Butler

Open Access Correction

Correction to: Identification of key biomarkers and immune infiltration in systemic lupus erythematosus by integrated bioinformatics analysis

Xingwang Zhao, Longlong Zhang, Juan Wang, Min Zhang, Zhiqiang Song, Bing Ni, Yi You

Open Access Research

MDAKRLS: Predicting human microbe-disease association based on Kronecker regularized least squares and similarities

Da Xu, Hanxiao Xu, Yusen Zhang, Mingyi Wang, Wei Chen, Rui Gao

Open Access Research

The role of ARHGAP9: clinical implication and potential function in acute myeloid leukemia

Caixia Han, Shujiao He, Ruiqi Wang, Xuefeng Gao, Hong Wang, Jingqiao Qiao, Xiangyu Meng, Yonghui Li, Li Yu

Open Access Retraction Note

Retraction Note to: Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade

Hsing-Chun Kuo, Chien-Chang Lu, Chien-Heng Shen, Shui-Yi Tung, Meng Chiao Hsieh, Ko-Chao Lee, Li-Ya Lee, Chin-Chu Chen, Chih-Chuan Teng, Wen-Shih Huang, Te-Chuan Chen, Kam-Fai Lee

Open Access Research

A theoretical model of health management using data-driven decision-making: the future of precision medicine and health

Eva Kriegova, Milos Kudelka, Martin Radvansky, Jiri Gallo

Open Access Research

Role of SIK1 in the transition of acute kidney injury into chronic kidney disease

Jinxiu Hu, Jiao Qiao, Qun Yu, Bing Liu, Junhui Zhen, Yue Liu, Qiqi Ma, Yanmei Li, Qianhui Wang, Cheng Wang, Zhimei Lv

Open Access Research

Avelumab treatment in Italian patients with metastatic Merkel cell carcinoma: experience from an expanded access program

Giovanni Grignani, Vanna Chiarion Sileni, Carmine Pinto, Roberta Depenni, Nicola Fazio, Luca Galli, Dario Giuffrida, Carlo Carnaghi, Domenico Ciliberto, Domenico C. Corsi, Paola Queirolo, Elena Benincasa, Filippo Venturini, Gennaro Fazzi, Nuno Costa, Paolo Antonio Ascierto

Open Access Research

Cross-talk between ANGPTL4 gene SNP Rs1044250 and weight management is a risk factor of metabolic syndrome

Zhoujie Tong, Jie Peng, Hongtao Lan, Wenwen Sai, Yulin Li, Jiaying Xie, Yanmin Tan, Wei Zhang, Ming Zhong, Zhihao Wang

Open Access Research

Genome-wide analysis identifies critical DNA methylations within NTRKs genes in colorectal cancer

Zijian Chen, Zenghong Huang, Yanxin Luo, Qi Zou, Liangliang Bai, Guannan Tang, Xiaolin Wang, Guangwen Cao, Meijin Huang, Jun Xiang, Huichuan Yu

Open Access COVID-19 Research

One-tube SARS-CoV-2 detection platform based on RT-RPA and CRISPR/Cas12a

Yangyang Sun, Lei Yu, Chengxi Liu, Shanting Ye, Wei Chen, Dechang Li, Weiren Huang

Open Access Research

A nomogram to predict the high-risk RS in HR+/HER2-breast cancer patients older than 50 years of age

Jing Yu, Jiayi Wu, Ou Huang, Jianrong He, Li Zhu, Weiguo Chen, Yafen Li, Xiaosong Chen, Kunwei Shen

Open Access Review

Translational research in Uganda: linking basic science to bedside medicine in a resource limited setting

Richard Kwizera, Emmanuel Mande, Denis Omali, Samuel Okurut, Sheila Nabweyambo, Rose Nabatanzi, Damalie Nakanjako, David B. Meya

Open Access Research

Tumor immunogenomic signatures improve a prognostic model of melanoma survival

Leah Morales, Danny Simpson, Robert Ferguson, John Cadley, Eduardo Esteva, Kelsey Monson, Vylyny Chat, Carlos Martinez, Jeffrey Weber, Iman Osman, Tomas Kirchhoff

Open Access COVID-19 Research

Combined lymphocyte/monocyte count, D-dimer and iron status predict COVID-19 course and outcome in a long-term care facility

Flavia Biamonte, Cirino Botta, Maria Mazzitelli, Salvatore Rotundo, Enrico Maria Trecarichi, Daniela Foti, Carlo Torti, Giuseppe Viglietto, Daniele Torella, Francesco Costanzo

Open Access Research

Insulin treatment improves liver histopathology and decreases expression of inflammatory and fibrogenic genes in a hyperglycemic, dyslipidemic hamster model of NAFLD

Victoria Svop Jensen, Christian Fledelius, Christina Zachodnik, Jesper Damgaard, Helle Nygaard, Kristina Steinicke Tornqvist, Rikke Kaae Kirk, Birgitte Martine Viuff, Erik Max Wulff, Jens Lykkesfeldt, Henning Hvid

Open Access Review

A systematic review of nutraceutical interventions for mitochondrial dysfunctions in myalgic encephalomyelitis/chronic fatigue syndrome

Rebekah Maksoud, Cassandra Balinas, Sean Holden, Hélène Cabanas, Donald Staines, Sonya Marshall-Gradisnik

Open Access Research

Chimeric antigen receptor T cells engineered to secrete CD40 agonist antibodies enhance antitumor efficacy

Yajun Zhang, Pei Wang, Tengjiao Wang, Yuan Fang, Yongmei Ding, Qijun Qian

Open Access Review

Translational stem cell therapy: vascularized skin grafts in skin repair and regeneration

Qian Hua Phua, Hua Alexander Han, Boon-Seng Soh

Open Access Research

Sex specific trajectories of central adiposity, lipid indices, and glucose level with incident hypertension: 12 years Follow-up in Tehran lipid and glucose study

Noushin Sadat Ahanchi, Seyed Saeed Tamehri Zadeh, Davood Khalili, Fereidoun Azizi, Farzad Hadaegh

Open Access Research

Identification of susceptibility loci for cardiovascular disease in adults with hypertension, diabetes, and dyslipidemia

Youhyun Song, Ja-Eun Choi, Yu-Jin Kwon, Hyuk-Jae Chang, Jung Oh Kim, Da-Hyun Park, Jae-Min Park, Seong-Jin Kim, Ji Won Lee, Kyung-Won Hong

Open Access Research

Niclosamide suppresses the expansion of follicular helper T cells and alleviates disease severity in two murine models of lupus via STAT3

Se Gwang Jang, Jaeseon Lee, Seung-Min Hong, Young-Seok Song, Min Jun Kim, Seung-Ki Kwok, Mi-La Cho, Sung-Hwan Park

Open Access Editorial

Cancer metabolism

Violena Pietrobon

Open Access Research

tRFTars: predicting the targets of tRNA-derived fragments

Qiong Xiao, Peng Gao, Xuanzhang Huang, Xiaowan Chen, Quan Chen, Xinger Lv, Yu Fu, Yongxi Song, Zhenning Wang

Open Access Research

Identification and characterization of heteroclitic peptides in TCR-binding positions with improved HLA-binding efficacy

Beatrice Cavalluzzo, Concetta Ragone, Angela Mauriello, Annacarmen Petrizzo, Carmen Manolio, Andrea Caporale, Luigi Vitagliano, Menotti Ruvo, Luigi Buonaguro, Maria Tagliamonte

Open Access Research

FOXO1 mitigates the SMAD3/FOXL2C134W transcriptomic effect in a model of human adult granulosa cell tumor

Christian Secchi, Paola Benaglio, Francesca Mulas, Martina Belli, Dwayne Stupack, Shunichi Shimasaki

Open Access Research

Pulmonary midkine inhibition ameliorates sepsis induced lung injury

Jing-Yuan Xu, Wei Chang, Qin Sun, Fei Peng, Yi Yang

Open Access Research

High lymphocyte population-related predictive factors for a long-term response in non-small cell lung cancer patients treated with pemetrexed: a retrospective observational study

Issei Sumiyoshi, Takahiro Okabe, Shinsaku Togo, Haruhi Takagi, Hiroaki Motomura, Yusuke Ochi, Naoko Shimada, Mizuki Haraguchi, Rina Shibayama, Yuichi Fujimoto, Junko Watanabe, Moe Iwai, Kotaro Kadoya, Shin-ichiro Iwakami, Kazuhisa Takahashi

Open Access Letter to the Editor

Could asymptomatic carriers spread the SARS-CoV-2 infection? Experience from the Italian second wave

Luigi Atripaldi, Silvia Sale, Mariaelena Capone, Vincenzo Montesarchio, Roberto Parrella, Gerardo Botti, Paolo Antonio Ascierto, Gabriele Madonna

Open Access Research

Long non-coding RNA ROR recruits histone transmethylase MLL1 to up-regulate TIMP3 expression and promote breast cancer progression

Aixia Hu, Fan Hong, Daohong Li, Yuwei Jin, Lingfei Kon, Ziguang Xu, Hui He, Qi Xie

Open Access Research

Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway

Jiucui Li, Kongmiao Lu, Fenglan Sun, Shanjuan Tan, Xiao Zhang, Wei Sheng, Wanming Hao, Min Liu, Weihong Lv, Wei Han

Open Access Research

Lipoprotein glomerulopathy induced by ApoE Kyoto mutation in ApoE-deficient mice

Hongyan Wu, Jing Yang, Yun-Qiang Liu, Song Lei, Mei Yang, Zhi Yang, Yuan Yang, Zhangxue Hu

Open Access Research

Hypermethylation of heparanase 2 promotes colorectal cancer proliferation and is associated with poor prognosis

Hui Zhang, Chenxin Xu, Chen Shi, Junying Zhang, Ting Qian, Zhuo Wang, Rong Ma, Jianzhong Wu, Feng Jiang, Jifeng Feng

Open Access Research

M2 macrophage-derived exosomal microRNAs inhibit cell migration and invasion in gliomas through PI3K/AKT/mTOR signaling pathway

Jie Yao, Zefen Wang, Yong Cheng, Chao Ma, Yahua Zhong, Yilei Xiao, Xu Gao, Zhiqiang Li

Open Access COVID-19 Correction

Correction to: The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome

Mathieu Blot, Jean-Baptiste Bour, Jean Pierre Quenot, Abderrahmane Bourredjem, Maxime Nguyen, Julien Guy, Serge Monier, Marjolaine Georges, Audrey Large, Auguste Dargent, Alexandre Guilhem, Suzanne Mouries-Martin, Jeremy Barben, Belaid Bouhemad, Pierre‑Emmanuel Charles, Pascal Chavanet, Christine Binquet, Lionel Piroth, Pascal Andreu, François Aptel, Marie Labruyère, Sébastien Prin, Guillaume Beltramo, Philippe Bonniaud, Philip Bielefeld, Hervé Devilliers, Bernard Bonnotte, Marielle Buisson, Alain Putot

Open Access Research

LncRNA-Gm9795 promotes inflammation in non-alcoholic steatohepatitis via NF-B/JNK pathway by endoplasmic reticulum stress

Liangying Ye, Dan Zhao, Yangzhi Xu, Jiaen Lin, Jiahui Xu, Kunyuan Wang, Zhanhui Ye, Yufeng Luo, Shiming Liu, Hui Yang

Open Access COVID-19 Letter to the Editor

How can we weather a virus storm? Health prediction inspired by meteorology could be the answer

Roberto Buizza, Enrico Capobianco, Pier Francesco Moretti, Paolo Vineis

Open Access Review

Evaluation of exosome derivatives as bio-informational reprogramming therapy for cancer

Michael J. Gonzalez, Mercedes F. Kweh, Pier Mario Biava, Jose Olalde, Alondra P. Toro, Pascal J. Goldschmidt-Clermont, Ian A. White

Open Access Research

Extracellular vesicles isolated by size-exclusion chromatography present suitability for RNomics analysis in plasma

Yang Yang, Yaojie Wang, Sisi Wei, Chaoxi Zhou, Jiarui Yu, Guiying Wang, Wenxi Wang, Lianmei Zhao

Open Access COVID-19 Correction

Correction to: COVID-19 biomarkers for severity mapped to polycystic ovary syndrome

Abu Saleh Md Moin, Thozhukat Sathyapalan, Stephen L. Atkin, Alexandra E. Butler

Open Access Correction

Correction to: The DNA methylation of FOXO3 and TP53 as a blood biomarker of late-onset asthma

Lin Yuan, Leyuan Wang, Xizi Du, Ling Qin, Ming Yang, Kai Zhou, Mengping Wu, Yu Yang, Zhiyuan Zheng, Yang Xiang, Xiangping Qu, Huijun Liu, Xiaoqun Qin, Chi Liu

Open Access Research

Novel and recurrent BRCA1/BRCA2 germline mutations in patients with breast/ovarian cancer: a series from the south of Tunisia

Dorra Ben Ayed-Guerfali, Wala Ben Kridis-Rejab, Nihel Ammous-Boukhris, Wajdi Ayadi, Slim Charfi, Afef Khanfir, Tahia Sellami-Boudawara, Mounir Frikha, Jamel Daoud, Raja Mokdad-Gargouri

Open Access COVID-19 Methodology

A versatile web app for identifying the drivers of COVID-19 epidemics

Wayne M. Getz, Richard Salter, Ludovica Luisa Vissat, Nir Horvitz

Open Access Letter to the Editor

Differing endometrial expression of calcium modulating transient receptor potential channels

Maryam Ghavideldarestani, Alexandra E. Butler, Stephen L. Atkin

Open Access Review

MBTPS2, a membrane bound protease, underlying several distinct skin and bone disorders

Natarin Caengprasath, Thanakorn Theerapanon, Thantrira Porntaveetus, Vorasuk Shotelersuk

Open Access Research

Creatine homeostasis and protein energy wasting in hemodialysis patients

Adrian Post, Joëlle C. Schutten, Daan Kremer, Yvonne van der Veen, Dion Groothof, Camilo G. Sotomayor, Christa A. Koops, Pim de Blaauw, Ido P. Kema, Ralf Westerhuis, Theo Wallimann, M. Rebecca Heiner-Fokkema, Stephan J. L. Bakker, Casper F. M. Franssen

Open Access Research

Generation and validation of a formula to calculate hemoglobin loss on a cohort of healthy adults subjected to controlled blood loss

Max Hahn-Klimroth, Philipp Loick, Soo-Zin Kim-Wanner, Erhard Seifried, Halvard Bonig

Open Access Research

Inhibition of EZH2 by chidamide exerts antileukemia activity and increases chemosensitivity through Smo/Gli-1 pathway in acute myeloid leukemia

Xuejie Jiang, Ling Jiang, Jiaying Cheng, Fang Chen, Jinle Ni, Changxin Yin, Qiang Wang, Zhixiang Wang, Dan Fang, Zhengshan Yi, Guopan Yu, Qingxiu Zhong, Bing Z. Carter, Fanyi Meng

Open Access Review

GRP78 in lung cancer

Shengkai Xia, Wenzhe Duan, Wenwen Liu, Xinri Zhang, Qi Wang

Open Access Research

The role of opioids in cancer response to immunotherapy

Andrea Botticelli, Alessio Cirillo, Giulia Pomati, Bruna Cerbelli, Simone Scagnoli, Michela Roberto, Alain Gelibter, Giulia Mammone, Maria Letizia Calandrella, Edoardo Cerbelli, Francesca Romana Di Pietro, Federica De Galitiis, Gaetano Lanzetta, Enrico Cortesi, Silvia Mezi, Paolo Marchetti

Open Access Research

CMTM6 promotes migration, invasion, and EMT by interacting with and stabilizing vimentin in hepatocellular carcinoma cells

Xiaoting Huang, Leyang Xiang, Baiyao Wang, Jijie Hu, Chunshan Liu, Anbang Ren, Kunpeng Du, Gengtai Ye, Yingying Liang, Yunqiang Tang, Dinghua Yang, Yawei Yuan

Open Access Research

Association of exacerbation phenotype with the sputum microbiome in chronic obstructive pulmonary disease patients during the clinically stable state

Chia-Yu Yang, Shiao-Wen Li, Chia-Yin Chin, Chia-Wei Hsu, Chi-Ching Lee, Yuan-Ming Yeh, Kuo-An Wu

Open Access Research

Prediction of hepatocellular carcinoma risk in patients with chronic liver disease from dynamic modular networks

Yinying Chen, Wei Yang, Qilong Chen, Qiong Liu, Jun Liu, Yingying Zhang, Bing Li, Dongfeng Li, Jingyi Nan, Xiaodong Li, Huikun Wu, Xinghua Xiang, Yehui Peng, Jie Wang, Shibing Su, Zhong Wang

Open Access Research

A circular RNA derived from PLXNB2 as a valuable predictor of the prognosis of patients with acute myeloid leukaemia

Leilei Lin, Yu Wang, Sicheng Bian, Lili Sun, Zhibo Guo, Desheng Kong, Linlin Zhao, Dan Guo, Qi Li, Min Wu, Yuhuang Wang, Yuying Wang, Yinghua Li

Open Access Research

Multi-omics characterization and validation of invasiveness-related molecular features across multiple cancer types

Guoshu Bi, Jiaqi Liang, Yuansheng Zheng, Runmei Li, Mengnan Zhao, Yiwei Huang, Cheng Zhan, Songtao Xu, Hong Fan

Open Access Research

Cerebrospinal fluid cells immune landscape in multiple sclerosis

Zijian Li, Yongchao Liu, Aili Jia, Yueran Cui, Juan Feng

Open Access Research

Expression and prognostic roles of PRDXs gene family in hepatocellular carcinoma

Mingxing Xu, Jianliang Xu, Dun Zhu, Rishun Su, Baoding Zhuang, Ruiyun Xu, Lingli Li, Shuxian Chen, Yunbiao Ling

Open Access COVID-19 Research

The effect of omega-3 fatty acid supplementation on clinical and biochemical parameters of critically ill patients with COVID-19: a randomized clinical trial

Saeid Doaei, Somayeh Gholami, Samira Rastgoo, Maryam Gholamalizadeh, Fatemeh Bourbour, Seyedeh Elaheh Bagheri, Forough Samipoor, Mohammad Esmail Akbari, Mahdi Shadnoush, Fereshteh Ghorat, Seyed Alireza Mosavi Jarrahi, Narjes Ashouri Mirsadeghi, Azadeh Hajipour, Parvin Joola, Alireza Moslem, Mark O. Goodarzi

Open Access COVID-19 Research

Influence of COVID-19 on lifestyle behaviors in the Middle East and North Africa Region: a survey of 5896 individuals

Mohamed Abouzid, Dina M. El-Sherif, Nael Kamel Eltewacy, Nesrine Ben Hadj Dahman, Salah A. Okasha, Sherief Ghozy, Sheikh Mohammed Shariful Islam, Akram Ramadan Farag Elburki, Almajdoub Ali Mohammed Ali, Moufiq Abdulrasul Hasan, Emadaldin Awad Amgrab ALI, Mahmoud N. Gumma Mohamed, Mareb H. Ahmed, Ayat K. Taher, Luma Saad Abdalbaqi, Nuha Hadi Jasim, Ibrahim Adel Aziz, Amna Babiker Dafaallah, Sirine Ben Dalla, Omar Mastouri, Chams Zarrad, Asmaa E. Abdelslam, Ahmed Taha A. Sayed, Kyrillos Wassim, Mahmoud Shaban, Tarek Mohamed Fayez, Mohammed Nasser, Zahraa Radhi, Zahraa Alkuwaiti, Amina Alsaffar, Asmaa M. Elaidy, Majeda Hammoud, Sabri M. Hammoud, Ali Saheb Alturki, Tasneem Jarkhi, Rama Hamza, Nourelhuda Mahmoud Issa, Reham Ahmad Kaakeh, Omar Alfatohi Aljondi, Ahmed Ali Ahmed, Mona H. Ibrahim, Islam Samy, Fatima Abdulrahman, Walaa Sabry Fouad, Normala Shahin, Saif Salman, Sumaia Ghunaim, Sarah Elayyan, Farah Ahmed Alkhaled, Deena Elsori, Samy Nael Altayeb, Elias Edward Lahham, Afnan W. M. Jobran, Asil Nael Salman, Aroub Imad Abdelhaq, Ola Hassan Akkawi, Ali Hassan Salah Al-Hadi, Sadeq Nagi Rashed Gozelan, Hatem Sultan Ahmed Qasim, Abdullah Ahmed Areqi, Azal Abduulah Abdurab Thabet, Boutheyna Drid, Sara Menzer, Melissa Hamdani, Zighed Alya, Najlae Adadi, Zakaria El Hamri, Hinde El Mouhi

Open Access Research

Prediction of steroid resistance and steroid dependence in nephrotic syndrome children

Katarzyna Zaorska, Piotr Zawierucha, Monika Świerczewska, Danuta Ostalska-Nowicka, Jacek Zachwieja, Michał Nowicki

Open Access Letter to the Editor

Glucose excursions in type 2 diabetes modulate amyloid-related proteins associated with dementia

Abu Saleh Md Moin, Ahmed Al-Qaissi, Thozhukat Sathyapalan, Stephen L. Atkin, Alexandra E. Butler

Open Access Research

Immunotherapy may protect cancer patients from SARS-CoV-2 infection: a single-center retrospective analysis

Maria Antonietta Isgrò, Maria Grazia Vitale, Egidio Celentano, Flavia Nocerino, Giuseppe Porciello, Marcello Curvietto, Domenico Mallardo, Concetta Montagnese, Luigi Russo, Nicoletta Zanaletti, Antonio Avallone, Matilde Pensabene, Michelino De Laurentiis, Sara Centonze, Sandro Pignata, Lucia Cannella, Alessandro Morabito, Francesco Caponigro, Gerardo Botti, Giuseppe Valentino Masucci, Diana Giannarelli, Ernesta Cavalcanti, Paolo Antonio Ascierto

Open Access Review

High efficacy of onabotulinumtoxinA treatment in patients with comorbid migraine and depression: a meta-analysis

Oreste Affatato, Thiago C. Moulin, Claudia Pisanu, Victoria S. Babasieva, Marco Russo, Elif I. Aydinlar, Paola Torelli, Vladimir N. Chubarev, Vadim V. Tarasov, Helgi B. Schiöth, Jessica Mwinyi

Open Access Letter to the Editor

Intranasal leptin improves survival after opioid overdose in a mouse model

Carla Freire, Huy Pho, Shannon Bevans-Fonti, Luiz U. Sennes, Vsevolod Y. Polotsky

Open Access Research

Integrated analysis of lncRNA, miRNA and mRNA profiles reveals potential lncRNA functions during early HIV infection

Lianwei Ma, Hui Zhang, Yue Zhang, Hailong Li, Minghui An, Bin Zhao, Haibo Ding, Junjie Xu, Hong Shang, Xiaoxu Han

Open Access Correction

Correction to: Effects of acute hypoxia on human adipose tissue lipoprotein lipase activity and lipolysis

Bimit Mahat, Étienne Chassé, Jean-François Mauger, Pascal Imbeault

Open Access Review

Diagnosis and treatment of type 1 diabetes at the dawn of the personalized medicine era

Ammira Al-Shabeeb Akil, Esraa Yassin, Aljazi Al-Maraghi, Elbay Aliyev, Khulod Al-Malki, Khalid A. Fakhro

Open Access COVID-19 Research

Gene signature and immune cell profiling by high-dimensional, single-cell analysis in COVID-19 patients, presenting Low T3 syndrome and coexistent hematological malignancies

Salvatore Sciacchitano, Claudia De Vitis, Michela D’Ascanio, Simonetta Giovagnoli, Chiara De Dominicis, Andrea Laghi, Paolo Anibaldi, Andrea Petrucca, Gerardo Salerno, Iolanda Santino, Rachele Amodeo, Maurizio Simmaco, Christian Napoli, Agostino Tafuri, Arianna Di Napoli, Andrea Sacconi, Valentina Salvati, Gennaro Ciliberto, Maurizio Fanciulli, Giulia Piaggio, Luisa de Latouliere, Alberto Ricci, Rita Mancini

Open Access Research

Diagnostic performance of Oncuria™, a urinalysis test for bladder cancer

Yosuke Hirasawa, Ian Pagano, Runpu Chen, Yijun Sun, Yunfeng Dai, Amit Gupta, Sergei Tikhonenkov, Steve Goodison, Charles J. Rosser, Hideki Furuya

Open Access Meeting report

The “Great Debate” at Melanoma Bridge 2020: December, 5th, 2020

Paolo A. Ascierto, Michael B. Atkins, Alexander M. Eggermont, Jeffrey E. Gershenwald, Jean-Jacques Grob, Omid Hamid, Vernon K. Sondak, Jeffrey A. Sosman, Hussein A. Tawbi, Jeffrey S. Weber, Corrado Caracò, Iman Osman, Igor Puzanov

Open Access Research

Antitumor effect of IL-12 gene-modified bone marrow mesenchymal stem cells combined with Fuzheng Yiliu decoction in an in vivo glioma nude mouse model

Jianjun Wu, Shoupin Xie, Hailong Li, Yanxia Zhang, Jia Yue, Chunlu Yan, Kai Liu, Yongqi Liu, Rui Xu, Guisen Zheng

Open Access Meeting report

The “Great Debate” at Immunotherapy Bridge 2020, December 3rd, 2020

Paolo A. Ascierto, Joshua Brody, Lisa H. Butterfield, Olivera J. Finn, John Goldberg, Francesco Perrone, Ryan J. Sullivan, Bernard A. Fox, Patrick Hwu, Igor Puzanov

Open Access COVID-19 Research

Allogeneic transplant procurement in the times of COVID-19: Quality report from the central European cryopreservation site

Eliza Wiercinska, Vera Schlipfenbacher, Gesine Bug, Peter Bader, Mareike Verbeek, Erhard Seifried, Halvard Bonig

Open Access Correction

Correction to: Testosterone induces renal tubular epithelial cell death through the HIF-1α/BNIP3 pathway

Yonghan Peng, Ziyu Fang, Min Liu, Zeyu Wang, Ling Li, Shaoxiong Ming, Chaoyue Lu, Hao Dong, Wenhui Zhang, Qi Wang, Rong Shen, Fei Xie, Weitao Zhang, Cheng Yang, Xiaofeng Gao, Yinghao Sun

Open Access Research

Gut microbiota accelerates cisplatin-induced acute liver injury associated with robust inflammation and oxidative stress in mice

Shenhai Gong, Yinglin Feng, Yunong Zeng, Huanrui Zhang, Meiping Pan, Fangjie He, Rong Wu, Jingrui Chen, Jiuling Lu, Siyou Zhang, Songhua Yuan, Xia Chen

Open Access Research

Eight-hour time-restricted feeding improves endocrine and metabolic profiles in women with anovulatory polycystic ovary syndrome

Chunzhu Li, Chuan Xing, Jiaqi Zhang, Han Zhao, Wenjing Shi, Bing He

Open Access COVID-19 Research

Dodging COVID-19 infection: low expression and localization of ACE2 and TMPRSS2 in multiple donor-derived lines of human umbilical cord-derived mesenchymal stem cells

Jonathan J. Hernandez, Doyle E. Beaty, Logan L. Fruhwirth, Ana P. Lopes Chaves, Neil H. Riordan

Open Access Research

Association between cigarette smoking and colorectal cancer sidedness: A multi-center big-data platform-based analysis

Lu-Ping Yang, Zi-Xian Wang, Rui Zhang, Na Zhou, A-Man Wang, Wei Liang, Zhi-Qiang Wang, Hui-Yan Luo, Feng Wang, Ji-Wei Liu, Fang Liu, Xiao-Chun Zhang, Yun-Peng Liu, Ying Jin

Open Access Research

Clinical pharmacogenomics in action: design, assessment and implementation of a novel pharmacogenetic panel supporting drug selection for diseases of the central nervous system (CNS)

E. Bothos, E. Ntoumou, K. Kelaidoni, D. Roukas, N. Drakoulis, M. Papasavva, F. A. Karakostis, P. Moulos, K. Karakostis

Open Access Research

Metabolic analysis of early nonalcoholic fatty liver disease in humans using liquid chromatography-mass spectrometry

Cheng Hu, Tao Wang, Xiaoyu Zhuang, Qiaoli Sun, Xiaochun Wang, Hui Lin, Mingli Feng, Jiaqi Zhang, Qin Cao, Yuanye Jiang

Open Access Protocol

Sulfur amino acid restriction, energy metabolism and obesity: a study protocol of an 8-week randomized controlled dietary intervention with whole foods and amino acid supplements

Emma Stolt, Thomas Olsen, Amany Elshorbagy, Viktor Kožich, Marleen van Greevenbroek, Bente Øvrebø, Magne Thoresen, Helga Refsum, Kjetil Retterstøl, Kathrine J. Vinknes

Open Access Research

Autism-associated synaptic vesicle transcripts are differentially expressed in maternal plasma exosomes of physiopathologic pregnancies

Yangwu Fang, Chan Wan, Youlu Wen, Ze Wu, Jing Pan, Mei Zhong, Nanbert Zhong

Open Access Review

Chemokines and their receptors: predictors of the therapeutic potential of mesenchymal stromal cells

Nerea Cuesta-Gomez, Gerard J. Graham, John D. M. Campbell

Open Access Research

Pirfenidone attenuates synovial fibrosis and postpones the progression of osteoarthritis by anti-fibrotic and anti-inflammatory properties in vivo and in vitro

Qilu Wei, Ning Kong, Xiaohui Liu, Run Tian, Ming Jiao, Yiyang Li, Huanshuai Guan, Kunzheng Wang, Pei Yang

Open Access Editorial

Translational metagenomics

Selvasankar Murugesan, Souhaila Al Khodor

Open Access Research

Hand grip strength and fatigability: correlation with clinical parameters and diagnostic suitability in ME/CFS

Bianka Jäkel, Claudia Kedor, Patricia Grabowski, Kirsten Wittke, Silvia Thiel, Nadja Scherbakov, Wolfram Doehner, Carmen Scheibenbogen, Helma Freitag

Open Access Letter to the Editor

Risk of detrimental recommendations for cancer pain management

Marco Maltoni, Romina Rossi

Open Access Research

Inhibition of DKC1 induces telomere-related senescence and apoptosis in lung adenocarcinoma

Guangyan Kan, Ziyang Wang, Chunjie Sheng, Chen Yao, Yizhi Mao, Shuai Chen

Open Access Research

Cigarette smoke-associated inflammation impairs bone remodeling through NFκB activation

Yi Lu, Yuanpu Peter Di, Ming Chang, Xin Huang, Qiuyan Chen, Ni Hong, Beth A. Kahkonen, Marissa E. Di, Chunyan Yu, Evan T. Keller, Jian Zhang

Open Access COVID-19 Review

MSC-derived exosomes carrying a cocktail of exogenous interfering RNAs an unprecedented therapy in era of COVID-19 outbreak

Monire Jamalkhah, Yasaman Asaadi, Mohammadreza Azangou-Khyavy, Javad Khanali, Masoud Soleimani, Jafar Kiani, Ehsan Arefian

Open Access Research

Combination of subtherapeutic anti-TNF dose with dasatinib restores clinical and molecular arthritogenic profiles better than standard anti-TNF treatment

Lydia Ntari, Christoforos Nikolaou, Ksanthi Kranidioti, Dimitra Papadopoulou, Eleni Christodoulou-Vafeiadou, Panagiotis Chouvardas, Florian Meier, Christina Geka, Maria C. Denis, Niki Karagianni, George Kollias

Open Access COVID-19 Research

Vitamin D status of Arab Gulf residents screened for SARS-CoV-2 and its association with COVID-19 infection: a multi-centre case–control study

Nasser M. Al-Daghri, Osama E. Amer, Naif H. Alotaibi, Dara A. Aldisi, Mushira A. Enani, Eman Sheshah, Naji J. Aljohani, Naemah Alshingetti, Suliman Y. Alomar, Hanan Alfawaz, Syed D. Hussain, Abdullah M. Alnaami, Shaun Sabico

Open Access Research

Automatic identification of myopic maculopathy related imaging features in optic disc region via machine learning methods

Yuchen Du, Qiuying Chen, Ying Fan, Jianfeng Zhu, Jiangnan He, Haidong Zou, Dazhen Sun, Bowen Xin, David Feng, Michael Fulham, Xiuying Wang, Lisheng Wang, Xun Xu

Open Access Retraction Note

Retraction Note to: Intra-articular injection in the knee of adipose derived stromal cells (stromal vascular fraction) and platelet rich plasma for osteoarthritis

Himanshu Bansal, Kristin Comella, Jerry Leon, Poonam Verma, Diwaker Agrawal, Prasad Koka, Thomas Ichim

Open Access Research

Targeting lactate dehydrogenase a improves radiotherapy efficacy in non-small cell lung cancer: from bedside to bench

Yang Yang, Yu Chong, Mengyuan Chen, Wumin Dai, Xia Zhou, Yongling Ji, Guoqin Qiu, Xianghui Du

Open Access Research

Phase angle and Mediterranean diet in patients with acne: Two easy tools for assessing the clinical severity of disease

Luigi Barrea, Marianna Donnarumma, Sara Cacciapuoti, Giovanna Muscogiuri, Ludovica De Gregorio, Chiara Blasio, Silvia Savastano, Annamaria Colao, Gabriella Fabbrocini

Open Access Research

Deregulation of IL-37 and its miRNAs modulators in sarcopenic patients after rehabilitation

Francesca La Rosa, Simone Agostini, Marina Saresella, Andrea Saul Costa, Federica Piancone, Rossella Miglioli, Fabio Trecate, Mario Clerici

Open Access Review

Is immunotherapy in the future of therapeutic management of sarcomas?

Ottavia Clemente, Alessandro Ottaiano, Giuseppe Di Lorenzo, Alessandra Bracigliano, Sabrina Lamia, Lucia Cannella, Antonio Pizzolorusso, Massimiliano Di Marzo, Mariachiara Santorsola, Annarosaria De Chiara, Flavio Fazioli, Salvatore Tafuto

Open Access Research

Identification of key methylation differentially expressed genes in posterior fossa ependymoma based on epigenomic and transcriptome analysis

Guanyi Wang, Yibin Jia, Yuqin Ye, Enming Kang, Huijun Chen, Jiayou Wang, Xiaosheng He

Open Access Research

The role of transcriptomic biomarkers of endometrial receptivity in personalized embryo transfer for patients with repeated implantation failure

Aihua He, Yangyun Zou, Cheng Wan, Jing Zhao, Qiong Zhang, Zhongyuan Yao, Fen Tian, Hong Wu, Xi Huang, Jing Fu, Chunxu Hu, Yue Sun, Lan Xiao, Tianli Yang, Zhaojuan Hou, Xin Dong, Sijia Lu, Yanping Li

Open Access Research

The gut microbiota is associated with the small intestinal paracellular permeability and the development of the immune system in healthy children during the first two years of life

Mariusz Kaczmarczyk, Ulrike Löber, Karolina Adamek, Dagmara Węgrzyn, Karolina Skonieczna-Żydecka, Damian Malinowski, Igor Łoniewski, Lajos Markó, Thomas Ulas, Sofia K. Forslund, Beata Łoniewska

Open Access Review

Transplantation of mesenchymal stem cells for spinal cord injury: a systematic review and network meta-analysis

Wei-can Chen, Wei-feng Liu, Yu-yan Bai, Ying-ying Zhou, Yan Zhang, Cong-mei Wang, Shu Lin, He-fan He

Open Access Methodology

Establishment and evaluation of a rat model of extracorporeal membrane oxygenation (ECMO) thrombosis using a 3D-printed mock-oxygenator

Nao Umei, Angela Lai, Jennifer Miller, Suji Shin, Kalliope Roberts, Saif AI Qatarneh, Shingo Ichiba, Atsuhiro Sakamoto, Keith E. Cook

Open Access Research

Impact of immediate cryopreservation on the establishment of patient derived xenografts from head and neck cancer patients

Lindsey Abel, Arda Durmaz, Rong Hu, Colin Longhurst, Andrew M. Baschnagel, Deric Wheeler, Jacob G. Scott, Randall J. Kimple

Open Access Research

Inhibition of CPT1a as a prognostic marker can synergistically enhance the antileukemic activity of ABT199

Shihui Mao, Qing Ling, Jiajia Pan, Fenglin Li, Shujuan Huang, Wenle Ye, Wenwen Wei, Xiangjie Lin, Yu Qian, Yungui Wang, Xin Huang, Jiansong Huang, Jinghan Wang, Jie Jin

Open Access Research

Expression and regulatory roles of lncRNAs in G-CIMP-low vs G-CIMP-high Glioma: an in-silico analysis

Indrani Datta, Houtan Noushmehr, Chaya Brodie, Laila M. Poisson

Open Access Research

Targeting the PI3K and MAPK pathways to improve response to HER2-targeted therapies in HER2-positive gastric cancer

M. Janusz Mezynski, Angela M. Farrelly, Mattia Cremona, Aoife Carr, Clare Morgan, Julie Workman, Paul Armstrong, Jennifer McAuley, Stephen Madden, Joanna Fay, Katherine M. Sheehan, Elaine W. Kay, Ciara Holohan, Yasir Elamin, Shereen Rafee, Patrick G. Morris, Oscar Breathnach, Liam Grogan, Bryan T. Hennessy, Sinead Toomey

Open Access Research

Reovirus enhances cytotoxicity of natural killer cells against colorectal cancer via TLR3 pathway

Shiqi Long, Yangzhuo Gu, Yuanyuan An, Xiaojin Lin, Xiaoqing Chen, Xianyao Wang, Chunxiang Liao, Weiwei Ouyang, Nianxue Wang, Zhixu He, Xing Zhao

Open Access Review

The roles and mechanisms of hypoxia in liver fibrosis

Jingyao Cai, Min Hu, Zhiyang Chen, Zeng Ling

Open Access Research

A combination of the percentages of IFN-γ+CD4+T cells and granzyme B+CD19+B cells is associated with acute hepatic rejection: a case control study

Ji-Qiao Zhu, Jing Wang, Xian-Liang Li, Wen-Li Xu, Shao-cheng Lv, Xin Zhao, Ren Lang, Qiang He

Open Access Research

Identifying the functions of two biomarkers in human oligodendrocyte progenitor cell development

Haipeng Zhou, Ying He, Zhaoyan Wang, Qian Wang, Caiyan Hu, Xiaohua Wang, Siliang Lu, Ke Li, Yinxiang Yang, Zuo Luan

Open Access Research

Genetic analysis using targeted next-generation sequencing of sporadic Chinese patients with idiopathic dilated cardiomyopathy

Mingmin Li, Shuang Xia, Lan Xu, Hong Tan, Junqing Yang, Zejia Wu, Xuyu He, Liwen Li

Open Access Research

Absence of the CXCR4 antagonist EPI-X4 from pharmaceutical human serum albumin preparations

Andrea Gilg, Mirja Harms, Lia-Raluca Olari, Ann-Kathrin Urbanowitz, Halvard Bonig, Jan Münch

Open Access Research

Optimizing the timing of diagnostic testing after positive findings in lung cancer screening: a proof of concept radiomics study

Zixing Wang, Ning Li, Fuling Zheng, Xin Sui, Wei Han, Fang Xue, Xiaoli Xu, Cuihong Yang, Yaoda Hu, Lei Wang, Wei Song, Jingmei Jiang

Open Access Research

Metformin ameliorates scleroderma via inhibiting Th17 cells and reducing mTOR-STAT3 signaling in skin fibroblasts

Jeonghyeon Moon, Seon-yeong Lee, Jeong Won Choi, A Ram Lee, Jin Hee Yoo, Su-Jin Moon, Sung-Hwan Park, Mi-La Cho

Open Access Research

Deconditioning does not explain orthostatic intolerance in ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome)

C. (Linda) M. C. van Campen, Peter C. Rowe, Frans C. Visser

Open Access Letter to the Editor

Seasonal rhythms of vasopressin release and aquaporin-2 excretion assure appropriate water conservation in humans

Nandu Goswami, Annarita Di Mise, Mariangela Centrone, Annamaria Russo, Marianna Ranieri, Johann Reichmuth, Bianca Brix, Natale Gaspare De Santo, Ferdinando Carlo Sasso, Grazia Tamma, Giovanna Valenti

Open Access Editorial

Emerging therapeutics

Gennaro Ciliberto

Open Access Correction

Correction to: Clinical feasibility of umbilical cord tissue-derived mesenchymal stem cells in the treatment of multiple sclerosis

Neil H. Riordan, Isabela Morales, Giselle Fernández, Nicole Allen, Neal E. Fearnot, Michael E. Leckrone, Dedra Jones Markovich, Darla Mansfield, Dorita Avila, Amit N. Patel, Santosh Kesari, Jorge Paz Rodriguez

Open Access COVID-19 Review

Therapeutic mechanisms of mesenchymal stem cells in acute respiratory distress syndrome reveal potentials for Covid-19 treatment

Wendi Wang, Wei Lei, Lina Jiang, Siqi Gao, Shijun Hu, Zi-Gang Zhao, Chun-Yu Niu, Zhen-Ao Zhao

Open Access Correction

Correction to: Total saponin from Anemone flaccida Fr. Schmidt abrogates osteoclast differentiation and bone resorption via the inhibition of RANKL-induced NF-κB, JNK and p38 MAPKs activation

Xiangying Kong, Wenbin Wu, Yue Yang, Hongye Wan, Xiaomin Li, Michun Zhong, Hongyan Zhao, Xiaohui Su, Shiwei Jia, Dahong Ju, Na Lin

Open Access Research

mTOR regulates GPVI-mediated platelet activation

Longsheng Wang, Gang Liu, Nannan Wu, Baiyun Dai, Shuang Han, Qiaoyun Liu, Fang Huang, Zhihua Chen, Weihong Xu, Dajing Xia, Cunji Gao

Open Access Review

Extracellular vesicle-derived miRNA as a novel regulatory system for bi-directional communication in gut-brain-microbiota axis

Liang Zhao, Yingze Ye, Lijuan Gu, Zhihong Jian, Creed M. Stary, Xiaoxing Xiong

Open Access Correction

Correction to: Automatic identification of myopic maculopathy related imaging features in optic disc region via machine learning methods

Yuchen Du, Qiuying Chen, Ying Fan, Jianfeng Zhu, Jiangnan He, Haidong Zou, Dazhen Sun, Bowen Xin, David Feng, Michael Fulham, Xiuying Wang, Lisheng Wang, Xun Xu

Open Access Research

Deconvolution of sarcoma methylomes reveals varying degrees of immune cell infiltrates with association to genomic aberrations

Malte Simon, Sadaf S. Mughal, Peter Horak, Sebastian Uhrig, Jonas Buchloh, Bogac Aybey, Albrecht Stenzinger, Hanno Glimm, Stefan Fröhling, Benedikt Brors, Charles D. Imbusch

Open Access Research

Identification of sensory and motor nerve fascicles by immunofluorescence staining after peripheral nerve injury

Xijie Zhou, Jian Du, Liming Qing, Thomas Mee, Xiang Xu, Zhuoran Wang, Cynthia Xu, Xiaofeng Jia

Open Access Correction

Correction to: Achyranthes bidentata extract exerts osteoprotective effects on steroid-induced osteonecrosis of the femoral head in rats by regulating RANKL/RANK/OPG signaling

Yini Jiang, Yanqiong Zhang, Weiheng Chen, Chunfang Liu, Xiaomin Li, Danni Sun, Zhenli Liu, Ying Xu, Xia Mao, Qiuyan Guo, Na Lin

Open Access Research

CCL21 activation of the MALAT1/SRSF1/mTOR axis underpins the development of gastric carcinoma

Qianmei Fu, Xiaohong Tan, Huaming Tang, Jijiang Liu

Open Access Research

PRICKLE1, a Wnt/PCP signaling component, is overexpressed and associated with inferior prognosis in acute myeloid leukemia

Duanfeng Jiang, Yanjuan He, Qiuyu Mo, Enyi Liu, Xin Li, Lihua Huang, Qin Zhang, Fangping Chen, Yan Li, Haigang Shao

Open Access Research

Gene alterations as predictors of radiation-induced toxicity in head and neck squamous cell carcinoma

Whitney Sumner, Xenia Ray, Leisa Sutton, Daniel Rebibo, Francesco Marincola, Parag Sanghvi, Vitali Moiseenko, Ida Deichaite

Open Access Research

Mir-139-5p inhibits glioma cell proliferation and progression by targeting GABRA1

Lei Wang, Yan Liu, Zhengtao Yu, Jianwu Gong, Zhiyong Deng, Nianjun Ren, Zhe Zhong, Hao Cai, Zhi Tang, Haofeng Cheng, Shuai Chen, Zhengwen He

Open Access Review

Mitochondrial transplantation therapy for ischemia reperfusion injury: a systematic review of animal and human studies

Kei Hayashida, Ryosuke Takegawa, Muhammad Shoaib, Tomoaki Aoki, Rishabh C. Choudhary, Cyrus E. Kuschner, Mitsuaki Nishikimi, Santiago J. Miyara, Daniel M. Rolston, Sara Guevara, Junhwan Kim, Koichiro Shinozaki, Ernesto P. Molmenti, Lance B. Becker

Open Access Research

The fecal microbiota of patients with pancreatic ductal adenocarcinoma and autoimmune pancreatitis characterized by metagenomic sequencing

Wenli Zhou, De Zhang, Zhengpeng Li, Huiqing Jiang, Jingnan Li, Rongrong Ren, Xuefeng Gao, Jianfeng Li, Xin Wang, Weifeng Wang, Yunsheng Yang

Open Access Research

eIF6 promotes the malignant progression of human hepatocellular carcinoma via the mTOR signaling pathway

Liping Sun, Shuguang Liu, Xiaopai Wang, Xuefeng Zheng, Ya Chen, Hong Shen

Open Access Research

Predicting phosphorylation sites using machine learning by integrating the sequence, structure, and functional information of proteins

Salma Jamal, Waseem Ali, Priya Nagpal, Abhinav Grover, Sonam Grover

Open Access Research

Pan-cancer characterization of metabolism-related biomarkers identifies potential therapeutic targets

Guoshu Bi, Yunyi Bian, Jiaqi Liang, Jiacheng Yin, Runmei Li, Mengnan Zhao, Yiwei Huang, Tao Lu, Cheng Zhan, Hong Fan, Qun Wang

Open Access Research

Cannabidiol has a unique effect on global brain activity: a pharmacological, functional MRI study in awake mice

Aymen H. Sadaka, Ana G. Ozuna, Richard J. Ortiz, Praveen Kulkarni, Clare T. Johnson, Heather B. Bradshaw, Bruce S. Cushing, Ai-Ling Li, Andrea G. Hohmann, Craig F. Ferris

Open Access Research

Effect of plasma vitamin C levels on Parkinson’s disease and age at onset: a Mendelian randomization study

Haijie Liu, Yan Zhang, Haihua Zhang, Longcai Wang, Tao Wang, Zhifa Han, Liyong Wu, Guiyou Liu

Open Access Research

Identification of immune subtypes of cervical squamous cell carcinoma predicting prognosis and immunotherapy responses

Yimin Li, Shun Lu, Shubin Wang, Xinhao Peng, Jinyi Lang

Open Access Research

miR-20a suppresses Treg differentiation by targeting Map3k9 in experimental autoimmune encephalomyelitis

Yishu Wang, Chong Xie, Yaying Song, Weiwei Xiang, Jing Peng, Lu Han, Jie Ding, Yangtai Guan

Open Access Research

MicroRNA-449a delays lung cancer development through inhibiting KDM3A/HIF-1α axis

Shan Hu, Peng Cao, Kangle Kong, Peng Han, Yu Deng, Fan Li, Bo Zhao

Open Access Research

The accumulation of exosome-associated microRNA-1246 and microRNA-150-3p in human red blood cell suspensions

Yujie Kong, Xue Tian, Rui He, Chenyue Li, Haixia Xu, Li Tian, Zhong Liu

Open Access Research

Identification of circRNA–miRNA–mRNA networks contributes to explore underlying pathogenesis and therapy strategy of gastric cancer

Zhijie Dong, Zhaoyu Liu, Min Liang, Jinhui Pan, Mingzhen Lin, Hai Lin, Yuanwei Luo, Xinke Zhou, Wenxia Yao

Open Access Research

Association of ADH1B polymorphism and alcohol consumption with increased risk of intracerebral hemorrhagic stroke

Chun-Hsiang Lin, Oswald Ndi Nfor, Chien-Chang Ho, Shu-Yi Hsu, Disline Manli Tantoh, Yi-Chia Liaw, Mochly-Rosen Daria, Che-Hong Chen, Yung-Po Liaw

Open Access Research

The landscape of gene co-expression modules correlating with prognostic genetic abnormalities in AML

Chao Guo, Ya-yue Gao, Qian-qian Ju, Chun-xia Zhang, Ming Gong, Zhen-ling Li

Open Access Research

Exosomal lncRNA UCA1 modulates cervical cancer stem cell self-renewal and differentiation through microRNA-122-5p/SOX2 axis

Zhihui Gao, Qianqing Wang, Mei Ji, Xiangcui Guo, Li Li, Xiaoke Su

Open Access Research

A large-scale investigation into the role of classical HLA loci in multiple types of severe infections, with a focus on overlaps with autoimmune and mental disorders

Ron Nudel, Rosa Lundbye Allesøe, Wesley K. Thompson, Thomas Werge, Simon Rasmussen, Michael E. Benros

Open Access Research

Targeting multiple genes containing long mononucleotide A-T repeats in lung cancer stem cells

Narumol Bhummaphan, Piyapat Pin-on, Preeyaporn Plaimee Phiboonchaiyanan, Jirattha Siriluksana, Chatchawit Aporntewan, Pithi Chanvorachote, Apiwat Mutirangura

Open Access Protocol

NIPU: a randomised, open-label, phase II study evaluating nivolumab and ipilimumab combined with UV1 vaccination as second line treatment in patients with malignant mesothelioma

Vilde Drageset Haakensen, Anna K. Nowak, Espen Basmo Ellingsen, Saima Jamil Farooqi, Maria Moksnes Bjaanæs, Henrik Horndalsveen, Tine Mcculloch, Oscar Grundberg, Susana M. Cedres, Åslaug Helland

Open Access Research

MAPK14 over-expression is a transcriptomic feature of polycythemia vera and correlates with adverse clinical outcomes

Chao Guo, Ya-yue Gao, Qian-qian Ju, Min Wang, Chun-xia Zhang, Ming Gong, Zhen-ling Li

Open Access COVID-19 Commentary

Exosomes contribution in COVID-19 patients’ treatment

Loubna Mazini, Luc Rochette, Gabriel Malka

Open Access Research

Comprehensive analysis of LncRNAs expression profiles in an in vitro model of steatosis treated with Exendin-4

Khaoula Errafii, Neyla S. Al-Akl, Olfa Khalifa, Abdelilah Arredouani

Open Access Research

Diffusion-weighted MRI for predicting pathologic response to neoadjuvant chemotherapy in breast cancer: evaluation with mono-, bi-, and stretched-exponential models

Shiteng Suo, Yan Yin, Xiaochuan Geng, Dandan Zhang, Jia Hua, Fang Cheng, Jie Chen, Zhiguo Zhuang, Mengqiu Cao, Jianrong Xu

Open Access Research

Interleukin-24 regulates mucosal remodeling in inflammatory bowel diseases

Anna Ónody, Apor Veres-Székely, Domonkos Pap, Réka Rokonay, Beáta Szebeni, Erna Sziksz, Franz Oswald, Gábor Veres, Áron Cseh, Attila J. Szabó, Ádám Vannay

Open Access Meeting report

Perspectives in immunotherapy: meeting report from the immunotherapy bridge (December 2nd–3rd, 2020, Italy)

Paolo A. Ascierto, Carlo Bifulco, Fortunato Ciardiello, Sandra Demaria, Leisha A. Emens, Robert Ferris, Silvia C. Formenti, Jerome Galon, Samir N. Khleif, Tomas Kirchhoff, Jennifer McQuade, Kunle Odunsi, Akash Patnaik, Chrystal M. Paulos, Janis M. Taube, John Timmerman, Bernard A. Fox, Patrick Hwu, Igor Puzanov

Open Access Letter to the Editor

Vitamin D association with coagulation factors in polycystic ovary syndrome is dependent upon body mass index

Abu Saleh Md Moin, Thozhukat Sathyapalan, Alexandra E. Butler, Stephen L. Atkin

Open Access COVID-19 Correction

Correction to: The urgency of utilizing COVID-19 biospecimens for research in the heart of the global pandemic

Iman Osman, Paolo Cotzia, Una Moran, Douglas Donnelly, Carolina Arguelles-Grande, Sandra Mendoza, Andre Moreira

Open Access Research

Oxidative stress response in regulatory and conventional T cells: a comparison between patients with chronic coronary syndrome and healthy subjects

Anna K. Lundberg, Rosanna W. S. Chung, Louise Zeijlon, Gustav Fernström, Lena Jonasson

Open Access COVID-19 Letter to the Editor

Health promoting behaviour of medical versus non-medical students during COVID-19 pandemic: results from the COLA cross-sectional study

Julius Steffen, Jenny Schlichtiger, Stefan Brunner, Bruno C. Huber

Open Access Correction

Correction to: HDACi mediate UNG2 depletion, dysregulated genomic uracil and altered expression of oncoproteins and tumor suppressors in B- and T-cell lines

Tobias S. Iveland, Lars Hagen, Animesh Sharma, Mirta M. L. Sousa, Antonio Sarno, Kristian Lied Wollen, Nina Beate Liabakk, Geir Slupphaug

Open Access Research

The effect of revascularization on recovery of mitochondrial respiration in peripheral artery disease: a case control study

Alexandra Gratl, Dominik Pesta, Leonhard Gruber, Fiona Speichinger, Ben Raude, Safwan Omran, Andreas Greiner, Jan Paul Frese

Open Access Review

Translational precision medicine: an industry perspective

Dominik Hartl, Valeria de Luca, Anna Kostikova, Jason Laramie, Scott Kennedy, Enrico Ferrero, Richard Siegel, Martin Fink, Sohail Ahmed, John Millholland, Alexander Schuhmacher, Markus Hinder, Luca Piali, Adrian Roth

Open Access COVID-19 Research

SARS-CoV-2 complete genome sequencing from the Italian Campania region using a highly automated next generation sequencing system

Anna Maria Rachiglio, Luca De Sabato, Cristin Roma, Michele Cennamo, Mariano Fiorenza, Daniela Terracciano, Raffaella Pasquale, Francesca Bergantino, Ernesta Cavalcanti, Gerardo Botti, Gabriele Vaccari, Giuseppe Portella, Nicola Normanno

Open Access Research

Collaborative relationships in translational medical research among Chinese clinicians: an internet-based cross-sectional survey

Meina Li, Bin Lian, Xiaoxiong Xu, Pan Zhao, Bihan Tang, Chaoqun Hu, Xiang Liu, Wenya Yu, Lulu Zhang

Open Access Letter to the Editor

The effect of a newly developed mini-light-emitting diode catheter for interstitial photodynamic therapy in pancreatic cancer xenografts

So-Young Kim, Eun A. Cho, Sang Mun Bae, Sang-Yeob Kim, Do Hyun Park

Open Access Research

Automated tumor proportion scoring for PD-L1 expression based on multistage ensemble strategy in non-small cell lung cancer

Boju Pan, Yuxin Kang, Yan Jin, Lin Yang, Yushuang Zheng, Lei Cui, Jian Sun, Jun Feng, Yuan Li, Lingchuan Guo, Zhiyong Liang

Open Access Research

Characterization of terminal-ileal and colonic Crohn’s disease in treatment-naïve paediatric patients based on transcriptomic profile using logistic regression

Ilkyu Park, Jaeeun Jung, Sugi Lee, Kunhyang Park, Jea-Woon Ryu, Mi-Young Son, Hyun-Soo Cho, Dae-Soo Kim

Open Access Review

Potential roles of N6-methyladenosine (m6A) in immune cells

Chang Liu, Zhe Yang, Rong Li, Yanju Wu, Ming Chi, Shuting Gao, Xun Sun, Xin Meng, Biao Wang

Open Access Letter to the Editor

Non-invasive monitoring of pH and oxygen using miniaturized electrochemical sensors

Mehrdad Farrokhi, Seyedeh Parisa Manavi, Fatemeh Taheri

Open Access Research

Increased risk of pulmonary and extrapulmonary tuberculosis infection in patients with polycystic kidney disease: a nationwide population-based study with propensity score-matching analysis

Ting-Fang Chiu, Tung-Min Yu, Chih-Wei Chiu, Brian K. Lee, Tsuo-Hung Lan, Chi-Yuan Li, Mei-Chen Lin, Chia-Hung Kao

Open Access Review

Cellular and molecular mediators of lymphangiogenesis in inflammatory bowel disease

Dickson Kofi Wiredu Ocansey, Bing Pei, Xinwei Xu, Lu Zhang, Chinasa Valerie Olovo, Fei Mao

Open Access Editorial

Immune radiobiology

Claire Vanpouille-Box

Open Access Research

Radiomic signature of the FOWARC trial predicts pathological response to neoadjuvant treatment in rectal cancer

Zhuokai Zhuang, Zongchao Liu, Juan Li, Xiaolin Wang, Peiyi Xie, Fei Xiong, Jiancong Hu, Xiaochun Meng, Meijin Huang, Yanhong Deng, Ping Lan, Huichuan Yu, Yanxin Luo

Open Access Review

Extrachromosomal circular DNA: a new potential role in cancer progression

Tianyi Wang, Haijian Zhang, Youlang Zhou, Jiahai Shi

Open Access Commentary

Childbearing vs. clinical trial participation: is it one or the other?

Sarah J. Hernandez, Lindsay A. Hohsfield

Open Access Research

Inhibition of c-Fos expression attenuates IgE-mediated mast cell activation and allergic inflammation by counteracting an inhibitory AP1/Egr1/IL-4 axis

Hui-Na Wang, Kunmei Ji, Li-Na Zhang, Chu-Chu Xie, Wei-Yong Li, Zhen-Fu Zhao, Jia-Jie Chen

Open Access Review

Manifestations of HbSE sickle cell disease: a systematic review

Ibrahim Khamees, Fateen Ata, Hassan Choudry, Ashraf T. Soliman, Vincenzo De Sanctis, Mohamed A. Yassin

Open Access Correction

Correction to: M2 macrophage-derived exosomal microRNAs inhibit cell migration and invasion in gliomas through PI3K/AKT/mTOR signaling pathway

Jie Yao, Zefen Wang, Yong Cheng, Chao Ma, Yahua Zhong, Yilei Xiao, Xu Gao, Zhiqiang Li

Open Access Methodology

Droplet digital PCR allows vector copy number assessment and monitoring of experimental CAR T cells in murine xenograft models or approved CD19 CAR T cell-treated patients

Rafik Haderbache, Walid Warda, Eric Hervouet, Mathieu Neto da Rocha, Rim Trad, Vincent Allain, Clementine Nicod, Catherine Thieblemeont, Nicolas Boissel, Pauline Varlet, Ibrahim Yakoub Agha, Lucie Bouquet, Melanie Guiot, Fabienne Venet, Pierre Sujobert, Xavier Roussel, Paul-Oliver Rouzaire, Denis Caillot, Olivier Casasnovas, Jean Christophe Bories, Emmanuel Bachy, Sophie Caillat-Zucman, Marina Deschamps, Christophe Ferrand

Open Access Correction

Correction to: Metformin ameliorates scleroderma via inhibiting Th17 cells and reducing mTOR-STAT3 signaling in skin fibroblasts

Jeonghyeon Moon, Seon-yeong Lee, Jeong Won Choi, A. Ram Lee, Jin Hee Yoo, Su-Jin Moon, Sung-Hwan Park, Mi-La Cho

Open Access Research

The landscape of biobanks in Poland—characteristics of Polish biobanking units at the beginning of BBMRI.pl organization

Anna Chróścicka, Angelika Paluch, Łukasz Kozera, Małgorzata Lewandowska-Szumieł

Open Access Research

The effect of acute intermittent hypoxia on postprandial triglyceride levels in humans: a randomized crossover trial

Renée Morin, Jean-François Mauger, Ruwan Amaratunga, Pascal Imbeault

Open Access Research

TPM, FPKM, or Normalized Counts? A Comparative Study of Quantification Measures for the Analysis of RNA-seq Data from the NCI Patient-Derived Models Repository

Yingdong Zhao, Ming-Chung Li, Mariam M. Konaté, Li Chen, Biswajit Das, Chris Karlovich, P. Mickey Williams, Yvonne A. Evrard, James H. Doroshow, Lisa M. McShane

Open Access Research

PD-1/PD-L1 checkpoint inhibitors during late stages of life: an ad-hoc analysis from a large multicenter cohort

Daniele Santini, Tea Zeppola, Marco Russano, Fabrizio Citarella, Cecilia Anesi, Sebastiano Buti, Marco Tucci, Alessandro Russo, Maria Chiara Sergi, Vincenzo Adamo, Luigia S. Stucci, Melissa Bersanelli, Giulia Mazzaschi, Francesco Spagnolo, Francesca Rastelli, Francesca Chiara Giorgi, Raffaele Giusti, Marco Filetti, Paolo Marchetti, Andrea Botticelli, Alain Gelibter, Marco Siringo, Marco Ferrari, Riccardo Marconcini, Maria Giuseppa Vitale, Linda Nicolardi, Rita Chiari, Michele Ghidini, Olga Nigro, Francesco Grossi, Michele De Tursi, Pietro Di Marino, Laura Pala, Paola Queirolo, Sergio Bracarda, Serena Macrini, Stefania Gori, Alessandro Inno, Federica Zoratto, Enrica T. Tanda, Domenico Mallardo, Maria Grazia Vitale, Thomas Talbot, Paolo A. Ascierto, David J. Pinato, Corrado Ficorella, Giampiero Porzio, Alessio Cortellini

Open Access SARS-CoV-2 Research

Exploratory analysis to identify the best antigen and the best immune biomarkers to study SARS-CoV-2 infection

Elisa Petruccioli, Saeid Najafi Fard, Assunta Navarra, Linda Petrone, Valentina Vanini, Gilda Cuzzi, Gina Gualano, Luca Pierelli, Antonio Bertoletti, Emanuele Nicastri, Fabrizio Palmieri, Giuseppe Ippolito, Delia Goletti

Open Access Research

Multi-omics analyses of human colorectal cancer revealed three mitochondrial genes potentially associated with poor outcomes of patients

Wei Zhang, Liewen Lin, Ligang Xia, Wanxia Cai, Weier Dai, Chang Zou, Lianghong Yin, Donge Tang, Yong Xu, Yong Dai

Open Access Research

Large-scale literature mining to assess the relation between anti-cancer drugs and cancer types

Chris Bauer, Ralf Herwig, Matthias Lienhard, Paul Prasse, Tobias Scheffer, Johannes Schuchhardt

Open Access Research

Long term prognostic implication of newly detected abnormal glucose tolerance among patients with stable cardiovascular disease: a population-based cohort study

Maryam Kabootari, Samaneh Asgari, Seyedeh Maryam Ghavam, Hengameh Abdi, Fereidoun Azizi, Farzad Hadaegh

Open Access Meeting report

Perspectives in Melanoma: meeting report from the Melanoma Bridge (December 3rd–5th, 2020, Italy)

Paolo A. Ascierto, Christian Blank, Reinhard Dummer, Marc S. Ernstoff, Soldano Ferrone, Bernard A. Fox, Thomas F. Gajewski, Claus Garbe, Patrick Hwu, Pawel Kalinski, Michelle Krogsgaard, Roger S. Lo, Jason J. Luke, Bart Neyns, Michael A. Postow, Sergio A. Quezada, Michele W. L. Teng, Giorgio Trinchieri, Alessandro Testori, Corrado Caracò, Iman Osman, Igor Puzanov, Magdalena Thurin

Open Access Research

Molecular subtype identification and prognosis stratification by a metabolism-related gene expression signature in colorectal cancer

Dagui Lin, Wenhua Fan, Rongxin Zhang, Enen Zhao, Pansong Li, Wenhao Zhou, Jianhong Peng, Liren Li

Open Access Research

SRPK1/AKT axis promotes oxaliplatin-induced anti-apoptosis via NF-κB activation in colon cancer

Jing-Qiang Huang, He-Feng Li, Jing Zhu, Jun-Wei Song, Xian-Bin Zhang, Peng Gong, Qiu-Yu Liu, Chun-Hui Zhou, Liang Wang, Li-Yun Gong

Open Access Research

Multi-institutional development and external validation of machine learning-based models to predict relapse risk of pancreatic ductal adenocarcinoma after radical resection

Xiawei Li, Litao Yang, Zheping Yuan, Jianyao Lou, Yiqun Fan, Aiguang Shi, Junjie Huang, Mingchen Zhao, Yulian Wu

Open Access Research

STAT3/HIF-1α signaling activation mediates peritoneal fibrosis induced by high glucose

Xiaoxiao Yang, Manchen Bao, Yi Fang, Xiaofang Yu, Jun Ji, Xiaoqiang Ding

Open Access Research

Association between serum advanced oxidation protein products and mortality risk in maintenance hemodialysis patients

Chun Zhou, Yuanyuan Zhang, Jianghua Chen, Changlin Mei, Fei Xiong, Wei Shi, Wei Zhou, Xusheng Liu, Shiren Sun, Jianwei Tian, Ziliang Ye, Qimeng Wu, Xianhui Qin, Jianping Jiang, Fan Fan Hou

Open Access Research

Nomogram for short-term outcome assessment in AChR subtype generalized myasthenia gravis

Rui Zhao, Ying Wang, Xiao Huan, Huahua Zhong, Zhirui Zhou, Jianying Xi, Yuwei Da, Lin Lei, Ting Chang, Zhe Ruan, Lijun Luo, Shengnan Li, Huan Yang, Yi Li, Sushan Luo, Chongbo Zhao

Open Access Research

Multi-trajectories of lipid indices with incident cardiovascular disease, heart failure, and all-cause mortality: 23 years follow-up of two US cohort studies

Fatemeh Koohi, Davood Khalili, Mohammad Ali Mansournia, Farzad Hadaegh, Hamid Soori

Open Access Research

ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA

Kristian Lied Wollen, Lars Hagen, Cathrine B. Vågbø, Renana Rabe, Tobias S. Iveland, Per Arne Aas, Animesh Sharma, Bjørnar Sporsheim, Hilde O. Erlandsen, Vuk Palibrk, Magnar Bjørås, Davi M. Fonseca, Nima Mosammaparast, Geir Slupphaug

Open Access Research

An easy-to-operate web-based calculator for predicting the progression of chronic kidney disease

Qian Xu, Yunyun Wang, Yiqun Fang, Shanshan Feng, Cuiyun Chen, Yanxia Jiang

Open Access Research

Combined IFN-γ and IL-2 release assay for detect active pulmonary tuberculosis: a prospective multicentre diagnostic study in China

Yaoju Tan, Yunhong Tan, Junlian Li, Pengnan Hu, Ping Guan, Haobin Kuang, Qide Liang, Yanyan Yu, Zhongnan Chen, Quan Wang, Zhenping Yang, DiLiNaZi AiKeReMu, Yu Pang, Jianxiong Liu

Open Access COVID-19 Research

HLA-dependent heterogeneity and macrophage immunoproteasome activation during lung COVID-19 disease

Christophe Desterke, Ali G. Turhan, Annelise Bennaceur-Griscelli, Frank Griscelli

Open Access Review

Heart failure with preserved ejection fraction based on aging and comorbidities

Ying Lin, Shihui Fu, Yao Yao, Yulong Li, Yali Zhao, Leiming Luo

Open Access Research

Chronic obstructive pulmonary disease does not impair responses to resistance training

Knut Sindre Mølmen, Daniel Hammarström, Gunnar Slettaløkken Falch, Morten Grundtvig, Lise Koll, Marita Hanestadhaugen, Yusuf Khan, Rafi Ahmad, Bente Malerbakken, Tore Jørgen Rødølen, Roger Lien, Bent R. Rønnestad, Truls Raastad, Stian Ellefsen

Open Access Research

CHN1 promotes epithelial–mesenchymal transition via the Akt/GSK-3β/Snail pathway in cervical carcinoma

Haoqi Zhao, Lan Wang, Shufang Wang, Xihua Chen, Min Liang, Xin Zhang, Jiedong Wang, Xiangbo Xu

Open Access Research

Dissecting immune cell stat regulation network reveals biomarkers to predict ICB therapy responders in melanoma

Jingwen Wang, Feng Li, Yanjun Xu, Xuan Zheng, Chunlong Zhang, Congxue Hu, Yingqi Xu, Wanqi Mi, Xia Li, Yunpeng Zhang

Open Access Review

GSTP1 as a novel target in radiation induced lung injury

Xiao Lei, Lehui Du, Wei Yu, Yao Wang, Na Ma, Baolin Qu

Open Access Research

MRI contributes to accurate and early diagnosis of non-radiographic HLA-B27 negative axial spondyloarthritis

Chun-Chi Lu, Guo-Shu Huang, Tony Szu-Hsien Lee, En Chao, Hsiang-Cheng Chen, Yong-Si Guo, Shi-Jye Chu, Feng-Cheng Liu, San-Yuan Kao, Tsung-Yun Hou, Chen-Hung Chen, Deh-Ming Chang, Sin-Yi Lyu

Open Access Research

WT1 and ACE mRNAs of blood extracellular vesicle as biomarkers of diabetic nephropathy

Ehsan Hashemi, Hojat Dehghanbanadaki, Alireza Abbasi Baharanchi, Katayoon Forouzanfar, Ardeshir Kakaei, Seyed Mohammad Mohammadi, Saba Zeidi, Farideh Razi

Open Access Research

The germline/somatic DNA damage repair gene mutations modulate the therapeutic response in Chinese patients with advanced pancreatic ductal adenocarcinoma

Lin Shui, Xiaofen Li, Yang Peng, Jiangfang Tian, Shuangshuang Li, Du He, Ang Li, Bole Tian, Mao Li, Heli Gao, Ning An, Cheng Yi, Dan Cao

Open Access Review

A paradigm shift in cell-free approach: the emerging role of MSCs-derived exosomes in regenerative medicine

Soudeh Moghadasi, Marischa Elveny, Heshu Sulaiman Rahman, Wanich Suksatan, Abduladheem Turki Jalil, Walid Kamal Abdelbasset, Alexei Valerievich Yumashev, Siavash Shariatzadeh, Roza Motavalli, Farahnaz Behzad, Faroogh Marofi, Ali Hassanzadeh, Yashwant Pathak, Mostafa Jarahian

Open Access Research

Weekly chemotherapy as first line treatment in frail head and neck cancer patients in the immunotherapy era

Andrea Botticelli, Giulia Pomati, Alessio Cirillo, Giulia Mammone, Fabio Ciurluini, Bruna Cerbelli, Paolo Sciattella, Massimo Ralli, Umberto Romeo, Francesca De Felice, Carlo Catalano, Francesco Vullo, Marco Della Monaca, Sasan Amirhassankhani, Silverio Tomao, Valentino Valentini, Marco De Vincentiis, Vincenzo Tombolini, Carlo Della Rocca, Antonella Polimeni, Cira di Gioia, Alessandro Corsi, Giulia D’Amati, Silvia Mezi, Paolo Marchetti

Open Access Research

Neural basis of implicit cognitive reappraisal in panic disorder: an event-related fMRI study

Hai-Yang Wang, Guo-Qing Xu, Ming-Fei Ni, Cui-Hong Zhang, Xue-Lin Li, Yi Chang, Xiao-Pei Sun, Bing-Wei Zhang

Open Access Research

tRNA derived fragment (tRF)-3009 participates in modulation of IFN-α-induced CD4+ T cell oxidative phosphorylation in lupus patients

Guannan Geng, Huijing Wang, Weiwei Xin, Zhe Liu, Jie Chen, Zhang Danting, Fei Han, Shuang Ye

Open Access Research

The effect of IL-2 stimulation and treatment of TRPM3 on channel co-localisation with PIP2 and NK cell function in myalgic encephalomyelitis/chronic fatigue syndrome patients

Natalie Eaton-Fitch, Hélène Cabanas, Stanley du Preez, Donald Staines, Sonya Marshall-Gradisnik

Open Access Research

Predictive models for chronic kidney disease after radical or partial nephrectomy in renal cell cancer using early postoperative serum creatinine levels

Dongwoo Chae, Na Young Kim, Ki Jun Kim, Kyemyung Park, Chaerim Oh, So Yeon Kim

Open Access Research

Molecular characteristics and clinical outcomes of complex ALK rearrangements identified by next-generation sequencing in non-small cell lung cancers

Peiyi Xia, Lan Zhang, Pan Li, Enjie Liu, Wencai Li, Jianying Zhang, Hui Li, Xiaoxing Su, Guozhong Jiang

Open Access Research

Trajectories of cardiovascular disease risk and their association with the incidence of cardiovascular events over 18 years of follow-up: The Tehran Lipid and Glucose study

Fatemeh Koohi, Nooshin Ahmadi, Farzad Hadaegh, Siavash Safiee, Fereidoun Azizi, Davood Khalili

Open Access Research

Model for in-vivo estimation of stiffness of tibiofemoral joint using MR imaging and FEM analysis

Sandeep Panwar Jogi, Rafeek Thaha, Sriram Rajan, Vidur Mahajan, Vasantha Kumar Venugopal, Anup Singh, Amit Mehndiratta

Open Access Research

Claudin-7 deficiency promotes stemness properties in colorectal cancer through Sox9-mediated Wnt/β-catenin signalling

Chang Xu, Yu-han Ding, Kun Wang, Mengdi Hao, Huimin Li, Lei Ding

Open Access Review

The role of exosomes in lung cancer metastasis and clinical applications: an updated review

Lei Yin, Xiaotian Liu, Xuejun Shao, Tao Feng, Jun Xu, Qi Wang, Shenghao Hua

Open Access Research

Characterization of genomic alterations in Chinese colorectal cancer patients with liver metastases

Hong-Wei Wang, Xiao-Luan Yan, Li-Jun Wang, Meng-Huan Zhang, Chun-He Yang, Wei-Liu, Ke-Min Jin, Quan Bao, Juan Li, Kun Wang, Bao-Cai Xing

Open Access Research

Hsa_circ_0000520 overexpression increases CDK2 expression via miR-1296 to facilitate cervical cancer cell proliferation

Qingling Zheng, Jin Zhang, Ting Zhang, Yanxiang Liu, Xiuluan Du, Xin Dai, Donghua Gu

Open Access Research

Sarcopenia associates with SNAP-25 SNPs and a miRNAs profile which is modulated by structured rehabilitation treatment

Simone Agostini, Roberta Mancuso, Andrea Saul Costa, Franca Rosa Guerini, Fabio Trecate, Rossella Miglioli, Elisabetta Menna, Beatrice Arosio, Mario Clerici

Open Access Research

N6-Methyladenosine RNA modification in cerebrospinal fluid as a novel potential diagnostic biomarker for progressive multiple sclerosis

Fei Ye, Tianzhu Wang, Xiaoxin Wu, Jie Liang, Jiaoxing Li, Wenli Sheng

Open Access Research

Constipation induced gut microbiota dysbiosis exacerbates experimental autoimmune encephalomyelitis in C57BL/6 mice

Xiuli Lin, Yingying Liu, Lili Ma, Xiaomeng Ma, Liping Shen, Xueying Ma, Zhaoyu Chen, Hao Chen, Donghong Li, Zhumin Su, Xiaohong Chen

Open Access Letter to the Editor

Analysis of microbial differences in amniotic fluid between advanced and normal age pregnant women

Ya Wang, Chunyu Luo, Yiwei Cheng, Li Li, Dong Liang, Ping Hu, Zhengfeng Xu

Open Access Research

An explainable supervised machine learning predictor of acute kidney injury after adult deceased donor liver transplantation

Yihan Zhang, Dong Yang, Zifeng Liu, Chaojin Chen, Mian Ge, Xiang Li, Tongsen Luo, Zhengdong Wu, Chenguang Shi, Bohan Wang, Xiaoshuai Huang, Xiaodong Zhang, Shaoli Zhou, Ziqing Hei

Open Access Research

Development and validation of a score to predict mortality in ICU patients with sepsis: a multicenter retrospective study

Jie Weng, Ruonan Hou, Xiaoming Zhou, Zhe Xu, Zhiliang Zhou, Peng Wang, Liang Wang, Chan Chen, Jinyu Wu, Zhiyi Wang

Open Access Research

Genetic alterations and functional networks of m6A RNA methylation regulators in pancreatic cancer based on data mining

Juan Zeng, Heying Zhang, Yonggang Tan, Zhe Wang, Yunwei Li, Xianghong Yang

Open Access Research

Chronotype: what role in the context of gastroenteropancreatic neuroendocrine tumors?

Luigi Barrea, Giovanna Muscogiuri, Gabriella Pugliese, Roberta Modica, Daniela Laudisio, Sara Aprano, Antongiulio Faggiano, Annamaria Colao, Silvia Savastano

Open Access Research

Cancer-associated fibroblast infiltration in gastric cancer: the discrepancy in subtypes pathways and immunosuppression

Xu Liu, Li Yao, Jingkun Qu, Lin Liu, Ning Lu, Jiansheng Wang, Jia Zhang

Open Access Research

Extracellular vesicle-derived AEBP1 mRNA as a novel candidate biomarker for diabetic kidney disease

Yiying Tao, Xing Wei, Yue Yue, Jiaxin Wang, Jianzhong Li, Lei Shen, Guoyuan Lu, Yang He, Shidi Zhao, Fan Zhao, Zhen Weng, Xiahong Shen, Ling Zhou

Open Access Review

Emerging trends and focus of human gastrointestinal microbiome research from 2010–2021: a visualized study

Xingzhu Yuan, Chengting Chang, Xinrong Chen, Ka Li

Open Access Research

Clinical outcome of renal cancer patients who early interrupted immunotherapy due to serious immune-related adverse events. Meet-Uro 13 trial on behalf of the MeetUro investigators

Marco Stellato, Giuseppe Procopio, Ugo De Giorgi, Marco Maruzzo, Davide Bimbatti, Alessia Mennitto, Andrea Sbrana, Giandomenico Roviello, Chiara Casadei, Pierangela Sepe, Sandro Pignata, Daniele Santini

Open Access Correction

Correction to: Characterization of terminal-ileal and colonic Crohn’s disease in treatment-naïve paediatric patients based on transcriptomic profile using logistic regression

Ilkyu Park, Jaeeun Jung, Sugi Lee, Kunhyang Park, Jea-Woon Ryu, Mi-Young Son, Hyun-Soo Cho, Dae-Soo Kim

Open Access Research

Immune and stromal scoring system associated with tumor microenvironment and prognosis: a gene-based multi-cancer analysis

Zihang Zeng, Jiali Li, Jianguo Zhang, Yangyi Li, Xingyu Liu, Jiarui Chen, Zhengrong Huang, Qiuji Wu, Yan Gong, Conghua Xie

Open Access Research

Identification of proteins associated with development of psoriatic arthritis in peripheral blood mononuclear cells: a quantitative iTRAQ-based proteomics study

Jie Zhu, Ling Han, Ruilai Liu, Zhenghua Zhang, Qiong Huang, Xu Fang, Ke Yang, Guiqin Huang, Zhizhong Zheng, Nikhil Yawalkar, Hui Deng, Kexiang Yan

Open Access Research

E3 ubiquitin ligase TRIM29 promotes pancreatic cancer growth and progression via stabilizing Yes-associated protein 1

Xueqiang Deng, Xiaowei Fu, Hong Teng, Lu Fang, Bo Liang, Rengui Zeng, Lian Chen, Yeqing Zou

Open Access Research

MYBL2-induced PITPNA-AS1 upregulates SIK2 to exert oncogenic function in triple-negative breast cancer through miR-520d-5p and DDX54

Bolong Liu, Pingbo Yao, Feng Xiao, Jianjin Guo, Lianghui Wu, Yong Yang

Open Access Research

DEAD-box helicase 27 enhances stem cell-like properties with poor prognosis in breast cancer

Shan Li, Jinfei Ma, Ang Zheng, Xinyue Song, Si Chen, Feng Jin

Open Access Research

BCL7A as a novel prognostic biomarker for glioma patients

Junhui Liu, Lun Gao, Baowei Ji, Rongxin Geng, Jing Chen, Xiang Tao, Qiang Cai, Zhibiao Chen

Open Access Research

Analysis of lncRNA-miRNA-mRNA expression pattern in heart tissue after total body radiation in a mouse model

Molykutty J. Aryankalayil, Shannon Martello, Michelle A. Bylicky, Sunita Chopra, Jared M. May, Aman Shankardass, Laurel MacMillan, Landy Sun, Jaleal Sanjak, Claire Vanpouille-Box, Iris Eke, C. Norman Coleman

Open Access Research

Fe3O4 magnetic nanoparticle-enhanced radiotherapy for lung adenocarcinoma via delivery of siBIRC5 and AS-ODN

Shuzhen Chen, Fushi Han, Dongdong Huang, Jinqian Meng, Jiapeng Chu, Meng Wang, Peijun Wang

Open Access Research

CYB561D2 up-regulation activates STAT3 to induce immunosuppression and aggression in gliomas

Bangbao Tao, Juanhong Shi, Shuai Shuai, Haiyan Zhou, Hongxia Zhang, Bin Li, Xiaoqiang Wang, Guohui Li, Hua He, Jun Zhong

Open Access Research

Bcl-2-associated transcription factor 1 Ser290 phosphorylation mediates DNA damage response and regulates radiosensitivity in gastric cancer

Jia Liu, Jingyi Li, Zhao Sun, Yangmiao Duan, Fengqin Wang, Guangwei Wei, Jing-Hua Yang

Open Access Research

Inhibition of microsomal prostaglandin E synthase-1 ameliorates acute lung injury in mice

Malarvizhi Gurusamy, Saeed Nasseri, Dileep Reddy Rampa, Huiying Feng, Dongwon Lee, Anton Pekcec, Henri Doods, Dongmei Wu

Open Access Research

ELK4 promotes the development of gastric cancer by inducing M2 polarization of macrophages through regulation of the KDM5A-PJA2-KSR1 axis

Lei Zheng, Hongmei Xu, Ya Di, Lanlan Chen, Jiao Liu, Liying Kang, Liming Gao

Open Access Research

Potential scalp stimulation targets for mental disorders: evidence from neuroimaging studies

Jin Cao, Thalia Celeste Chai-Zhang, Yiting Huang, Maya Nicole Eshel, Jian Kong

Open Access Research

Heparin-binding growth factor (HDGF) drives radioresistance in breast cancer by activating the STAT3 signaling pathway

Lingyun Qiu, Yan Ma, Xiaohua Chen, Liheng Zhou, Haibo Zhang, Guansheng Zhong, Lei Zhang, Jianming Tang

Open Access Correction

Correction to: The germline/somatic DNA damage repair gene mutations modulate the therapeutic response in Chinese patients with advanced pancreatic ductal adenocarcinoma

Lin Shui, Xiaofen Li, Yang Peng, Jiangfang Tian, Shuangshuang Li, Du He, Ang Li, Bole Tian, Mao Li, Heli Gao, Ning An, Cheng Yi, Dan Cao

Open Access Research

Multi-omics network characterization reveals novel microRNA biomarkers and mechanisms for diagnosis and subtyping of kidney transplant rejection

Yuxin Lin, Liangliang Wang, Wenqing Ge, Yu Hui, Zheng Zhou, Linkun Hu, Hao Pan, Yuhua Huang, Bairong Shen

Open Access Research

Tumor cell-imposed iron restriction drives immunosuppressive polarization of tumor-associated macrophages

Jia-Lei Sun, Ning-Ping Zhang, Ru-Chen Xu, Guang-Cong Zhang, Zhi-Yong Liu, Weinire Abuduwaili, Fu Wang, Xiang-Nan Yu, Xuan Shi, Guang-Qi Song, Hao Wu, Tao-Tao Liu, Xi-Zhong Shen, Bin Deng, Shu-Qiang Weng, Ling Dong, Ji-Min Zhu

Open Access Research

Deep learning-based predictive biomarker of pathological complete response to neoadjuvant chemotherapy from histological images in breast cancer

Fengling Li, Yongquan Yang, Yani Wei, Ping He, Jie Chen, Zhongxi Zheng, Hong Bu

Open Access Research

Metformin attenuates silica-induced pulmonary fibrosis via AMPK signaling

Demin Cheng, Qi Xu, Yue Wang, Guanru Li, Wenqing Sun, Dongyu Ma, Siyun Zhou, Yi Liu, Lei Han, Chunhui Ni

Open Access Research

Association of serum 25-OH-vitamin D level with FTO and IRX3 genes expression in obese and overweight boys with different FTO rs9930506 genotypes

Maryam Gholamalizadeh, Saeid Doaei, Zohreh Mokhtari, Vahideh Jalili, Fatemeh Bourbour, Saeed Omidi, Kamal Ebrahimi, Naser Kalantari, Sheyda Abdi, Ghasem Azizi Tabesh, Mohammad Naimi Joubani, Esmaeil Roohbakhsh, Seyed Alireza Mosavi Jarrahi

Open Access Research

Urinary metabolomic changes and microbiotic alterations in presenilin1/2 conditional double knockout mice

Jie Gao, Nian Zhou, Yongkang Wu, Mengna Lu, Qixue Wang, Chenyi Xia, Mingmei Zhou, Ying Xu

Open Access Research

Identification of tumor antigens and immune subtypes in lower grade gliomas for mRNA vaccine development

Liguo Ye, Long Wang, Ji’an Yang, Ping Hu, Chunyu Zhang, Shi’ao Tong, Zhennan Liu, Daofeng Tian

Open Access Research

Fibroblast growth factor 11 (FGF11) promotes non-small cell lung cancer (NSCLC) progression by regulating hypoxia signaling pathway

Xiaowei Wu, Minjie Li, Ying Li, Yu Deng, Shun Ke, Fan Li, Yujin Wang, Shuchang Zhou

Open Access Research

Different modulation effects of 1 Hz and 20 Hz transcutaneous auricular vagus nerve stimulation on the functional connectivity of the periaqueductal gray in patients with migraine

Jin Cao, Yue Zhang, Hui Li, Zhaoxian Yan, Xian Liu, Xiaoyan Hou, Weicui Chen, Sierra Hodges, Jian Kong, Bo Liu

Open Access Research

Urinary small extracellular vesicles derived CCL21 mRNA as biomarker linked with pathogenesis for diabetic nephropathy

Ye Feng, Xin Zhong, Hai-Feng Ni, Cui Wang, Tao-Tao Tang, Li-Ting Wang, Kai-Yun Song, Ri-Ning Tang, Hong Liu, Bi-Cheng Liu, Lin-Li Lv

Open Access Research

Lactobacillus paracasei R3 protects against dextran sulfate sodium (DSS)-induced colitis in mice via regulating Th17/Treg cell balance

Juan Huang, Ziyan Yang, Yanyun Li, Xingxing Chai, Yanfang Liang, Bihua Lin, Ziyu Ye, Shaobing Zhang, Zhengping Che, Hailiang Zhang, Xueying Zhang, Zhao Zhang, Tao Chen, Weiqing Yang, Jincheng Zeng

Open Access Methodology

Move to health-a holistic approach to the management of chronic low back pain: an intervention and implementation protocol developed for a pragmatic clinical trial

Daniel I. Rhon, Julie M. Fritz, Tina A. Greenlee, Katie E. Dry, Rachel J. Mayhew, Mary C. Laugesen, Edita Dragusin, Deydre S. Teyhen

Open Access Research

Age and gender differences in ACE2 and TMPRSS2 expressions in oral epithelial cells

Jinfeng Peng, Jiwei Sun, Jiajia Zhao, Xuliang Deng, Fengyuan Guo, Lili Chen

Open Access Research

Use of proteomics to identify mechanisms of hepatocellular carcinoma with the CYP2D6*10 polymorphism and identification of ANGPTL6 as a new diagnostic and prognostic biomarker

Guiming Hu, Fei Gao, Guanzhe Wang, Yan Fang, Yuanyuan Guo, Jun Zhou, Yuhan Gu, Cunzhen Zhang, Na Gao, Qiang Wen, Hailing Qiao

Open Access Research

Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus

Soumyalekshmi Nair, Dominic Guanzon, Nanthini Jayabalan, Andrew Lai, Katherin Scholz-Romero, Priyakshi Kalita de Croft, Valeska Ormazabal, Carlos Palma, Emilio Diaz, Elizabeth A. McCarthy, Alexis Shub, Jezid Miranda, Eduard Gratacós, Fátima Crispi, Gregory Duncombe, Martha Lappas, H. David McIntyre, Gregory Rice, Carlos Salomon

Open Access Research

Integrative analysis and experiments to explore angiogenesis regulators correlated with poor prognosis, immune infiltration and cancer progression in lung adenocarcinoma

Songhua Cai, Xiaotong Guo, Chujian Huang, Youjun Deng, Longde Du, Wenyi Liu, Chenglin Yang, Hongbo Zhao, Kai Ma, Lixu Wang, Jie He, Zhentao Yu

Open Access Research

Integrated analysis of competing endogenous RNA networks in peripheral blood mononuclear cells of systemic lupus erythematosus

Wencong Song, Jie Qiu, Lianghong Yin, Xiaoping Hong, Weier Dai, Donge Tang, Dongzhou Liu, Yong Dai

Open Access COVID-19 Research

What can the neurological manifestations of COVID-19 tell us: a meta-analysis

Yuanyuan He, Xiaojie Bai, Tiantian Zhu, Jialin Huang, Hong Zhang

Open Access Research

Expression profiles and functional prediction of long non-coding RNAs LINC01133, ZEB1-AS1 and ABHD11-AS1 in the luminal subtype of breast cancer

Sepideh Mehrpour Layeghi, Maedeh Arabpour, Abbas Shakoori, Mohammad Mehdi Naghizadeh, Yaser Mansoori, Javad Tavakkoly Bazzaz, Rezvan Esmaeili

Open Access Research

Convalescent plasma is of limited clinical benefit in critically ill patients with coronavirus disease-2019: a cohort study

Li Huang, Che Zhang, Xihui Zhou, Zhou Zhao, Weiping Wang, Weidong Leng, Xiao Su, Qizhou Lian

Open Access Research

Alterations of gut microbiota in gestational diabetes patients during the second trimester of pregnancy in the Shanghai Han population

Yao Su, Hong-Kun Wang, Xu-Pei Gan, Li Chen, Yan-Nan Cao, De-Cui Cheng, Dong-Yao Zhang, Wen-Yu Liu, Fei-Fei Li, Xian-Ming Xu

Open Access Research

SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis

Lei Feng, Kaikai Zhao, Liangchao Sun, Xiaoyang Yin, Junpeng Zhang, Conghe Liu, Baosheng Li

Open Access Research

Applying low coverage whole genome sequencing to detect malignant ovarian mass

Ming Chen, Pengqiang Zhong, Mengzhi Hong, Jinfeng Tan, Xuegao Yu, Hao Huang, Juan Ouyang, Xiaoping Lin, Peisong Chen

Open Access Research

Sex-specific plasma lipid profiles of ME/CFS patients and their association with pain, fatigue, and cognitive symptoms

Aurore Nkiliza, Megan Parks, Adam Cseresznye, Sarah Oberlin, James E. Evans, Teresa Darcey, Kristina Aenlle, Daniel Niedospial, Michael Mullan, Fiona Crawford, Nancy Klimas, Laila Abdullah

Open Access Research

Associations of immune cell homing gene signatures and infiltrates of lymphocyte subsets in human melanomas: discordance with CD163+ myeloid cell infiltrates

Minyoung Kwak, Gulsun Erdag, Katie M. Leick, Stefan Bekiranov, Victor H. Engelhard, Craig L. Slingluff

Open Access Research

Identification of prognostic values defined by copy number variation, mRNA and protein expression of LANCL2 and EGFR in glioblastoma patients

Hua-fu Zhao, Xiu-ming Zhou, Jing Wang, Fan-fan Chen, Chang-peng Wu, Peng-yu Diao, Lin-rong Cai, Lei Chen, Yan-wen Xu, Jing Liu, Zong-yang Li, Wen-lan Liu, Zhong-ping Chen, Guo-dong Huang, Wei-ping Li

Open Access Research

UBE2T promotes autophagy via the p53/AMPK/mTOR signaling pathway in lung adenocarcinoma

Jinhong Zhu, Haijiao Ao, Mingdong Liu, Kui Cao, Jianqun Ma

Open Access Research

TFH cells in systemic sclerosis

Pauline Beurier, Laure Ricard, Deborah Eshagh, Florent Malard, Lama Siblany, Olivier Fain, Mohamad Mohty, Béatrice Gaugler, Arsène Mekinian

Open Access COVID-19 Review

Role of rehabilitation amidst the COVID-19 pandemic: a review

Chaoran Yu, Ernest Johann Helwig

Open Access Research

Multi-parametric MRI phenotype with trustworthy machine learning for differentiating CNS demyelinating diseases

Jing Huang, Bowen Xin, Xiuying Wang, Zhigang Qi, Huiqing Dong, Kuncheng Li, Yun Zhou, Jie Lu

Open Access Research

Increased Tc17 cell levels and imbalance of naïve/effector immune response in Parkinson’s disease patients in a two-year follow-up: a case control study

Diana D. Álvarez-Luquín, Adrián Guevara-Salinas, Asiel Arce-Sillas, Raquel Espinosa-Cárdenas, Jaquelín Leyva-Hernández, Esteban U. Montes-Moratilla, Laura Adalid-Peralta

Open Access Research

Interferon regulatory factor family influences tumor immunity and prognosis of patients with colorectal cancer

Yan-Jie Chen, Shu-Neng Luo, Ling Dong, Tao-Tao Liu, Xi-Zhong Shen, Ning-Ping Zhang, Li Liang

Open Access Research

Evaluating predictive factors for toxicities experienced by head & neck cancer patients undergoing radiotherapy

Xenia Ray, Whitney Sumner, Leisa Sutton, Parag Sanghvi, Ida Deichaite, Vitali Moiseenko

Open Access Research

Single-cell analysis of a tumor-derived exosome signature correlates with prognosis and immunotherapy response

Jiani Wu, Dongqiang Zeng, Shimeng Zhi, Zilan Ye, Wenjun Qiu, Na Huang, Li Sun, Chunlin Wang, Zhenzhen Wu, Jianping Bin, Yulin Liao, Min Shi, Wangjun Liao

Open Access Research

Bufalin suppresses tumour microenvironment-mediated angiogenesis by inhibiting the STAT3 signalling pathway

Kai Fang, Yueping Zhan, Ruiqiu Zhu, Yuqian Wang, Chengqi Wu, Min Sun, Yanyan Qiu, Zeting Yuan, Xin Liang, Peihao Yin, Ke Xu

Open Access Research

Increased sensitivity to SMAC mimetic LCL161 identified by longitudinal ex vivo pharmacogenomics of recurrent, KRAS mutated rectal cancer liver metastases

Kushtrim Kryeziu, Seyed H. Moosavi, Christian H. Bergsland, Marianne G. Guren, Peter W. Eide, Max Z. Totland, Kristoffer Lassen, Andreas Abildgaard, Arild Nesbakken, Anita Sveen, Ragnhild A. Lothe

Open Access Research

microRNA-193-3p attenuates myocardial injury of mice with sepsis via STAT3/HMGB1 axis

Jianyuan Pan, Buse Alexan, Dorn Dennis, Chiristine Bettina, Laeuf Ilona Mariya Christoph, Yongqin Tang

Open Access Research

A direct negative feedback loop of miR-4721/FOXA1/Nanog promotes nasopharyngeal cell stem cell enrichment and metastasis

Mengyang Zhao, Zibo Tang, Yijun Wang, Jiaojiao Ding, Ying Guo, Tianhui Gao

Open Access Research

Platelet transcriptome profiles provide potential therapeutic targets for elderly acute myelocytic leukemia patients

Jizhang Bao, Xinhua Zhao, Jiahui Lu, Zhaoyang Hu, Minghui Hu, Xiaoxia Hu, Libing Wang, Qi Hu, Weiling Sun, Jie Wang, Hailin Chen, Hao Lu, Changgui Li, Jing Xu, Yongming Zhou, Wenwei Zhu

Open Access Research

Hsa_circ_0001361 facilitates the progress of lung adenocarcinoma cells via targeting miR-525-5p/VMA21 axis

Hong-Yu Shen, Liu-Xi Shi, Lin Wang, Le-Ping Fang, Wei Xu, Ju-Qing Xu, Bo-Qiang Fan, Wei-Fei Fan

Open Access Research

Monitoring the tissue perfusion during hemorrhagic shock and resuscitation: tissue-to-arterial carbon dioxide partial pressure gradient in a pig model

Yusuke Endo, Taku Hirokawa, Taku Miyasho, Ryosuke Takegawa, Koichiro Shinozaki, Daniel M. Rolston, Lance B. Becker, Kei Hayashida

Open Access Research

Comprehensive analysis of EMT-related genes and lncRNAs in the prognosis, immunity, and drug treatment of colorectal cancer

Yang Yang, Mingyang Feng, LiangLiang Bai, Weiting Liao, Kexun Zhou, Mengxi Zhang, Qiuji Wu, Feng Wen, Wanting Lei, Pengfei Zhang, Nan Zhang, Jiaxing Huang, Qiu Li

Open Access Research

IL-18 binding protein suppresses IL-17-induced osteoclastogenesis and rectifies type 17 helper T cell / regulatory T cell imbalance in rheumatoid arthritis

Hong Ki Min, Sehee Kim, Ji-Yeon Lee, Kyoung-Woon Kim, Sang-Heon Lee, Hae-Rim Kim

Open Access Research

Identification of circulating sphingosine kinase-related metabolites for prediction of type 2 diabetes

Qi Chen, Wei Wang, Ming-Feng Xia, You-li Lu, Hua Bian, Chen Yu, Xiao-Ying Li, Mathew A. Vadas, Xin Gao, Huan-Dong Lin, Pu Xia

Open Access Research

Longitudinal analysis of symptom-based clustering in patients with primary Sjogren’s syndrome: a prospective cohort study with a 5-year follow-up period

Jennifer Jooha Lee, Young Jae Park, Misun Park, Hyeon Woo Yim, Sung Hwan Park, Seung-Ki Kwok

Open Access Research

A new Mfn-2 related synthetic peptide promotes vascular smooth muscle cell apoptosis via regulating the mitochondrial apoptotic pathway by inhibiting Akt signaling

Xinxin Zhang, Xiangyu Xu, Li Lu, Xiaoning Wan, Yating Qin, Weibin Ruan, Chao Lv, Lin He, Xiaomei Guo

Open Access Research

CYT387, a potent IKBKE inhibitor, suppresses human glioblastoma progression by activating the Hippo pathway

Xin Wang, Jie Lu, Jing Li, Yang Liu, Gaochao Guo, Qiang Huang

Open Access Review

Vaso-occlusive crisis in sickle cell disease: a vicious cycle of secondary events

Tim Jang, Maria Poplawska, Emanuela Cimpeanu, George Mo, Dibyendu Dutta, Seah H. Lim

Open Access Research

Low CCL19 expression is associated with adverse clinical outcomes for follicular lymphoma patients treated with chemoimmunotherapy

Yu Zhou, Shasha Wang, Yunxia Tao, Haizhu Chen, Yan Qin, Xiaohui He, Shengyu Zhou, Peng Liu, Jianliang Yang, Sheng Yang, Lin Gui, Ning Lou, Zhishang Zhang, Jiarui Yao, Xiaohong Han, Yuankai Shi

Open Access Research

Long non-coding RNA NORAD promotes pancreatic cancer stem cell proliferation and self-renewal by blocking microRNA-202-5p-mediated ANP32E inhibition

Yu-Shui Ma, Xiao-Li Yang, Yu-Shan Liu, Hua Ding, Jian-Jun Wu, Yi Shi, Cheng-You Jia, Gai-Xia Lu, Dan-Dan Zhang, Hui-Min Wang, Pei-Yao Wang, Fei Yu, Zhong-Wei Lv, Gao-Ren Wang, Ji-Bin Liu, Da Fu

Open Access Research

FGFR2 alteration as a potential therapeutic target in poorly cohesive gastric carcinoma

Yue Wang, Tao Shi, Xuan Wang, Jinwei Hu, Lixia Yu, Qin Liu, Nandie Wu, Baorui Liu, Jia Wei

Open Access Correction

Correction to: Serum IFN-γ levels predict the therapeutic effect of mesenchymal stem cell transplantation in active rheumatoid arthritis

Yi Yang, Xiao He, Rongseng Zhao, Wei Guo, Ming Zhu, Wei Xing, Dongpo Jiang, Chongyang Liu, Xiang Xu

Open Access COVID-19 Research

Cytometric analysis of patients with COVID-19: what is changed in the second wave?

Giulia Scalia, Maddalena Raia, Monica Gelzo, Sara Cacciapuoti, Annunziata De Rosa, Biagio Pinchera, Riccardo Scotto, Agnese Giaccone, Mauro Mormile, Gabriella Fabbrocini, Ivan Gentile, Roberto Parrella, Giuseppe Castaldo

Open Access Research

Gene clusters based on OLIG2 and CD276 could distinguish molecular profiling in glioblastoma

Minjie Fu, Jinsen Zhang, Weifeng Li, Shan He, Jingwen Zhang, Daniel Tennant, Wei Hua, Ying Mao

Open Access Review

Role of galectin 3 binding protein in cancer progression: a potential novel therapeutic target

Emily Capone, Stefano Iacobelli, Gianluca Sala

Open Access Research

Feasibility and utility of MRI and dynamic 18F-FDG-PET in an orthotopic organoid-based patient-derived mouse model of endometrial cancer

Heidi Espedal, Hege F. Berg, Tina Fonnes, Kristine E. Fasmer, Camilla Krakstad, Ingfrid S. Haldorsen

Open Access Correction

Correction to: YM155 decreases radiation-induced invasion and reverses epithelial–mesenchymal transition by targeting STAT3 in glioblastoma

Xin Zhang, Xuehai Wang, Ran Xu, Jianxiong Ji, Yangyang Xu, Mingzhi Han, Yuzhen Wei, Bin Huang, Anjing Chen, Qing Zhang, Wenjie Li, Jian Wang, Xingang Li, Chen Qiu

Open Access Research

Nuclear HER3 expression improves the prognostic stratification of patients with HER1 positive advanced laryngeal squamous cell carcinoma

Giovanni Almadori, Antonella Coli, Eugenio De Corso, Dario Antonio Mele, Stefano Settimi, Giovanni Di Cintio, Francesca Brigato, Domenico Scannone, Thomas E. Carey, Gaetano Paludetti, Libero Lauriola, Franco Oreste Ranelletti

Open Access Review

Circadian rhythms affect bone reconstruction by regulating bone energy metabolism

Beibei Luo, Xin Zhou, Qingming Tang, Ying Yin, Guangxia Feng, Shue Li, Lili Chen

Open Access Research

Development of a two-circular RNA panel as potential prognostic biomarker for gastric cancer

Jing Liu, Xingwu Zhu, Meinan Yan, Hui Li

Open Access Research

Factors affecting improvement of neurologic status evaluated by Quantitative Myasthenia Gravis Score for patients with thymomatous myasthenia gravis after extended thymectomy

Zhu Haoshuai, Zou Jianyong, Yang Lei, Zeng Bo, Jiefei Xiao, Xin Zhang, Zhenguang Chen, Su Chunhua

Open Access Correction

Correction to: Delivery of oncolytic vaccinia virus by matched allogeneic stem cells overcomes critical innate and adaptive immune barriers

Dobrin D. Draganov, Antonio F. Santidrian, Ivelina Minev, Duong Nguyen, Mehmet Okyay Kilinc, Ivan Petrov, Anna Vyalkova, Elliot Lander, Mark Berman, Boris Minev, Aladar A. Szalay

Open Access Research

Niraparib exhibits a synergistic anti-tumor effect with PD-L1 blockade by inducing an immune response in ovarian cancer

Jinyu Meng, Jin Peng, Jie Feng, Jochen Maurer, Xiao Li, Yan Li, Shu Yao, Ran Chu, Xiyu Pan, Junting Li, Ting Zhang, Lu Liu, Qing Zhang, Zeng Yuan, Hualei Bu, Kun Song, Beihua Kong

Open Access Research

Chromosome aneuploidy analysis in embryos derived from in vivo and in vitro matured human oocytes

Jianhua Li, Jing Chen, Tiecheng Sun, Shuiwen Zhang, Tingting Jiao, Ri-Cheng Chian, Youzhu Li, Ye Xu

Open Access Research

CENPA promotes clear cell renal cell carcinoma progression and metastasis via Wnt/β-catenin signaling pathway

Qi Wang, Jiaju Xu, Zhiyong Xiong, Tianbo Xu, Jingchong Liu, Yuenan Liu, Jiaping Chen, Jian Shi, Yi Shou, Changjie Yue, Di Liu, Huageng Liang, Hongmei Yang, Xiong Yang, Xiaoping Zhang

Open Access Research

Integrative eQTL-weighted hierarchical Cox models for SNP-set based time-to-event association studies

Haojie Lu, Yongyue Wei, Zhou Jiang, Jinhui Zhang, Ting Wang, Shuiping Huang, Ping Zeng

Open Access Research

Regional brain tissue changes in patients with cystic fibrosis

Bhaswati Roy, Marlyn S. Woo, Susana Vacas, Patricia Eshaghian, Adupa P. Rao, Rajesh Kumar

Open Access Research

Inoculation of mother’s own milk could personalize pasteurized donor human milk used for feeding preterm infants

D. Mallardi, C. Tabasso, P. Piemontese, S. Morandi, T. Silvetti, F. Biscarini, P. Cremonesi, B. Castiglioni, V. Pica, M. Stuknyte, I. De Noni, O. Amato, N. Liotto, F. Mosca, P. Roggero

Open Access Letter to the Editor

XPO1-mutant NSCLC without STK11/KEAP1 mutations may predict better survival to immunotherapy

Xuanzong Li, Bing Zou, Shijiang Wang, Linlin Wang, Jinming Yu

Open Access Research

Microspheres present comparable efficacy and safety profiles compared with polyvinyl alcohol for bronchial artery embolization treatment in hemoptysis patients

Zhigang Fu, Xun Li, Fei Cai, Yinpeng Yuan, Xiaolin Zhang, Jingxia Qin, Yonghui Liang

Open Access Research

FAM83A promotes proliferation and metastasis via Wnt/β-catenin signaling in head neck squamous cell carcinoma

Huan Ji, Haiyang Song, Zeyu Wang, Pengfei Jiao, Jiani Xu, Xuan Li, Hongming Du, Heming Wu, Yi Zhong

Open Access Research

Long-term exposure to air pollution and the risk of developing sudden sensorineural hearing loss

Stella Chin-Shaw Tsai, Yi-Chao Hsu, Jung-Nien Lai, Ruey-Hwang Chou, Hueng-Chuen Fan, Frank Cheau-Feng Lin, Ruihong Zhang, Cheng-Li Lin, Kuang-Hsi Chang

Open Access Research

Downregulation of the FBXO43 gene inhibits tumor growth in human breast cancer by limiting its interaction with PCNA

Rulan Ma, Kun Zhu, Dawei Yuan, Meijun Gong, Yijun Li, Kang Li, Lei Meng

Open Access Letter to the Editor

Is human platelet lysate (hPL) the ideal candidate to substitute the foetal bovine serum for cell-therapy translational research?

M. Guiotto, M. O. Riehle, W. Raffoul, A. Hart, P. G. di Summa

Open Access Letter to the Editor

Angiopoietin-1: an early biomarker of diabetic nephropathy?

Alexandra E. Butler, Ahmed Al-Qaissi, Thozhukat Sathyapalan, Stephen L. Atkin

Open Access Research

Effect of the spatial–temporal specific theca cell Cyp17 overexpression on the reproductive phenotype of the novel TC17 mouse

Christian Secchi, Martina Belli, Tracy N. H. Harrison, Joseph Swift, CheMyong Ko, Antoni J. Duleba, Dwayne Stupack, R. Jeffrey Chang, Shunichi Shimasaki

Open Access Research

miR-3065-3p promotes stemness and metastasis by targeting CRLF1 in colorectal cancer

Yifan Li, Jing Xun, Botao Wang, Yuan Ma, Lanqiu Zhang, Lei Yang, Ruifang Gao, Jun Guan, Tianyu Liu, Hejun Gao, Ximo Wang, Qi Zhang

Open Access Research

Chronic itch induced by thalamic deep brain stimulation: a case for a central itch centre

Luciano Furlanetti, Harutomo Hasegawa, Natasha Hulse, Rachael Morris-Jones, Keyoumars Ashkan

Open Access Research

Clinical outcomes and safety of polymyxin B in the treatment of carbapenem-resistant Gram-negative bacterial infections: a real-world multicenter study

Xiaojuan Zhang, Shaoyan Qi, Xiaoguang Duan, Bing Han, Shuguang Zhang, Shaohua Liu, Haixu Wang, Haibo Zhang, Tongwen Sun

Open Access Research

MiR-144-3p inhibits gastric cancer progression and stemness via directly targeting GLI2 involved in hedgehog pathway

Yixun Lu, Benlong Zhang, Baohua Wang, Di Wu, Chuang Wang, Yunhe Gao, Wenquan Liang, Hongqing Xi, Xinxin Wang, Lin Chen

Open Access Research

Comprehensive analysis of oncogenic fusions in mismatch repair deficient colorectal carcinomas by sequential DNA and RNA next generation sequencing

Jing Wang, Ruiyu Li, Junjie Li, Yuting Yi, Xiaoding Liu, Jingci Chen, Hui Zhang, Junliang Lu, Cami Li, Huanwen Wu, Zhiyong Liang

Open Access Correction

Correction to: Pirfenidone attenuates synovial fibrosis and postpones the progression of osteoarthritis by anti-fibrotic and anti-inflammatory properties in vivo and in vitro

Qilu Wei, Ning Kong, Xiaohui Liu, Run Tian, Ming Jiao, Yiyang Li, Huanshuai Guan, Kunzheng Wang, Pei Yang

Open Access Correction

Correction to: Serum CCL20 combined with IL-17A as early diagnostic and prognostic biomarkers for human colorectal cancer

Dan Wang, Weitang Yuan, Yaping Wang, Qian Wu, Li Yang, Feng Li, Xinfeng Chen, Zhen Zhang, Weina Yu, Nomathamsanqa Resegofetse Maimela, Ling Cao, Dong Wang, Junxia Wang, Zhenqiang Sun, Jinbo Liu, Yi Zhang

Open Access Review

Immunobiology of cancer-associated fibroblasts in the context of radiotherapy

Turid Hellevik, Rodrigo Berzaghi, Kristin Lode, Ashraful Islam, Inigo Martinez-Zubiaurre

Open Access Review

DEL in China: the D antigen among serologic RhD-negative individuals

Qinan Yin, Willy Albert Flegel

Open Access Review

An update on extra-oral bitter taste receptors

Kamila Tuzim, Agnieszka Korolczuk

Open Access COVID-19 Correction

Correction to: Tocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective trial

Francesco Perrone, Maria Carmela Piccirillo, Paolo Antonio Ascierto, Carlo Salvarani, Roberto Parrella, Anna Maria Marata, Patrizia Popoli, Laurenzia Ferraris, Massimiliano M. Marrocco-Trischitta, Diego Ripamonti, Francesca Binda, Paolo Bonfanti, Nicola Squillace, Francesco Castelli, Maria Lorenza Muiesan, Miriam Lichtner, Carlo Calzetti, Nicola Duccio Salerno, Luigi Atripaldi, Marco Cascella, Massimo Costantini, Giovanni Dolci, Nicola Cosimo Facciolongo, Fiorentino Fraganza, Marco Massari, Vincenzo Montesarchio, Cristina Mussini, Emanuele Alberto Negri, Gerardo Botti, Claudia Cardone, Piera Gargiulo, Adriano Gravina, Clorinda Schettino, Laura Arenare, Paolo Chiodini, Ciro Gallo, Francesco Perrone, Maria Carmela Piccirillo, Clorinda Schettino, Adriano Gravina, Piera Gargiulo, Claudia Cardone, Laura Arenare, Paolo Antonio Ascierto, Maria Grazia Vitale, Claudia Trojaniello, Marco Palla, Attilio Antonio Montano Bianchi, Gerardo Botti, Gianfranco De Feo, Leonardo Miscio, Ciro Gallo, Paolo Chiodini, Laurenzia Ferraris, Massimiliano M. 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Combined cART including Tenofovir Disoproxil, Emtricitabine, and Dolutegravir has potent therapeutic effects in HIV-1 infected humanized mice

Matthew Weichseldorfer, Yvonne Affram, Alonso Heredia, Zahra Rikhtegaran-Tehrani, Mohammad M. Sajadi, Sumiko P. Williams, Yutaka Tagaya, Francesca Benedetti, Habib O. Ramadhani, Frank Denaro, Arshi Munawwar, Joseph Bryant, Davide Zella, Marvin Reitz, Fabio Romerio, Olga S. Latinovic

Open Access Research

Single-cell analysis revealed that IL4I1 promoted ovarian cancer progression

Hongyu Zhao, Yu Teng, Wende Hao, Jie Li, Zhefeng Li, Qi Chen, Chenghong Yin, Wentao Yue

Open Access Research

Circular RNA circ-ERBB2 promotes HER2-positive breast cancer progression and metastasis via sponging miR-136-5p and miR-198

Jin-xiu Zhong, Yun-yuan Kong, Rong-guang Luo, Guo-jin Xia, Wen-xing He, Xue-zhong Chen, Wei-wei Tan, Qing-jie Chen, Yu-yin Huang, Yan-xing Guan

Open Access Review

Advances in mesenchymal stem cell conditioned medium-mediated periodontal tissue regeneration

Hongbing Lin, Huishan Chen, Xuetao Zhao, Zhen Chen, Peipei Zhang, Yue Tian, Yawei Wang, Tong Ding, Lijing Wang, Yuqin Shen

Open Access Letter to the Editor

Enjoy your journey: the bergamot polyphenols from the tree to the cell metabolism

Salvatore Nesci, Ernesto Palma, Vincenzo Mollace, Giovanni Romeo, Francesca Oppedisano

Open Access Research

Mechanistically informed non-invasive peripheral nerve stimulation for peripheral neuropathic pain: a randomised double-blind sham-controlled trial

Selina Johnson, Anne Marshall, Dyfrig Hughes, Emily Holmes, Florian Henrich, Turo Nurmikko, Manohar Sharma, Bernhard Frank, Paul Bassett, Andrew Marshall, Walter Magerl, Andreas Goebel

Open Access Research

Contextual reprogramming of CAR-T cells for treatment of HER2+ cancers

Zhifen Yang, Lingyu Li, Ahu Turkoz, Pohan Chen, Rona Harari-Steinfeld, Maggie Bobbin, Ofir Stefanson, Hana Choi, Violena Pietrobon, Bennett Alphson, Angshumala Goswami, Vitaly Balan, Alper Kearney, Dharmesh Patel, Jin Yang, Damla Inel, Veena Vinod, Alessandra Cesano, Bing Wang, Kyung-Ho Roh, Lei S. Qi, Francesco M. Marincola

Open Access Protocol

Interleukin-1 blockade in cardiac sarcoidosis: study design of the multimodality assessment of granulomas in cardiac sarcoidosis: Anakinra Randomized Trial (MAGiC-ART)

Jordana Kron, Thomas Crawford, Virginia Mihalick, Frank Bogun, Jennifer H. Jordan, Todd Koelling, Huzaefah Syed, Aamer Syed, Thomas Iden, Kelly Polly, Emily Federmann, Kirsta Bray, Sangeeta Lathkar-Pradhan, Shilpa Jasti, Lynda Rosenfeld, David Birnie, Melissa Smallfield, Le Kang, Alpha Berry Fowler, Amy Ladd, Kenneth Ellenbogen, Benjamin Van Tassell, W. Gregory Hundley, Antonio Abbate

Open Access Research

mapMECFS: a portal to enhance data discovery across biological disciplines and collaborative sites

Ravi Mathur, Megan U. Carnes, Alexander Harding, Amy Moore, Ian Thomas, Alex Giarrocco, Michael Long, Marcia Underwood, Christopher Townsend, Roman Ruiz-Esparza, Quinn Barnette, Linda Morris Brown, Matthew Schu

Open Access Research

Hydrogen gas with extracorporeal cardiopulmonary resuscitation improves survival after prolonged cardiac arrest in rats

Tai Yin, Lance B. Becker, Rishabh C. Choudhary, Ryosuke Takegawa, Muhammad Shoaib, Koichiro Shinozaki, Yusuke Endo, Koichiro Homma, Daniel M. Rolston, Shuhei Eguchi, Tadashi Ariyoshi, Asami Matsumoto, Kentaro Oka, Motomichi Takahashi, Tomoaki Aoki, Santiago J. Miyara, Mitsuaki Nishikimi, Junichi Sasaki, Junhwan Kim, Ernesto P. Molmenti, Kei Hayashida

Open Access Research

Dexmedetomidine inhibits mitochondria damage and apoptosis of enteric glial cells in experimental intestinal ischemia/reperfusion injury via SIRT3-dependent PINK1/HDAC3/p53 pathway

Qin Zhang, Xiao-Ming Liu, Qian Hu, Zheng-Ren Liu, Zhi-Yi Liu, Huai-Gen Zhang, Yuan-Lu Huang, Qiu-Hong Chen, Wen-Xiang Wang, Xue-Kang Zhang

Open Access Research

Gene profiling of Toll-like receptor signalling pathways in neutrophils of patients with acute-on-chronic liver failure

Yi Zhang, Wei Wu, Yijie Wang, Lingjia Tong, Meng Hong, Qi Xia, Zhi Chen

Open Access Research

Identification of the regulatory role of lncRNA HCG18 in myasthenia gravis by integrated bioinformatics and experimental analyses

Shuang Li, Xu Wang, Tianfeng Wang, Huixue Zhang, Xiaoyu Lu, Li Liu, Lifang Li, Chunrui Bo, Xiaotong Kong, Si Xu, Shangwei Ning, Jianjian Wang, Lihua Wang

Open Access Research

Overexpression of E3 ubiquitin ligase Cbl attenuates endothelial dysfunction in diabetes mellitus by inhibiting the JAK2/STAT4 signaling and Runx3-mediated H3K4me3

Qingsong Jin, Liangyan Lin, Tiantian Zhao, Xiaoyan Yao, Yaqin Teng, Dongdong Zhang, Yongjun Jin, Meizi Yang

Open Access Research

Six splice site variations, three of them novel, in the ABO gene occurring in nine individuals with ABO subtypes

Xiaozhen Hong, Yanling Ying, Jingjing Zhang, Shu Chen, Xianguo Xu, Ji He, Faming Zhu

Open Access Research

The health risks of dysphagia for patients with head and neck cancer: a multicentre prospective observational study

Maria Giulia Cristofaro, Ida Barca, Francesco Ferragina, Daniela Novembre, Yvelise Ferro, Roberta Pujia, Tiziana Montalcini

Open Access COVID-19 Review

An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Klaus J. Wirth, Carmen Scheibenbogen, Friedemann Paul

Open Access Research

Ibrutinib protects T cells in patients with CLL from proliferation-induced senescence

Joanne E. Davis, Chia Sharpe, Kylie Mason, Constantine S. Tam, Rachel M. Koldej, David S. Ritchie

Open Access Research

High efficiency closed-system gene transfer using automated spinoculation

Victoria Ann Remley, Jianjian Jin, Sarmila Sarkar, Larry Moses, Michaela Prochazkova, Yihua Cai, Lipei Shao, Hui Liu, Tatyana Fuksenko, Ping Jin, David F. Stroncek, Steven L. Highfill

Open Access Research

MicroRNA 146a is associated with diabetic complications in type 1 diabetic patients from the EURODIAB PCS

Federica Barutta, Beatrice Corbetta, Stefania Bellini, Simonetta Guarrera, Giuseppe Matullo, Michela Scandella, Casper Schalkwijk, Coen D. Stehouwer, Nish Chaturvedi, Sabita S. Soedamah-Muthu, Marilena Durazzo, Gabriella Gruden

Open Access Correction

Correction to: Hsa_circ_0001361 facilitates the progress of lung adenocarcinoma cells via targeting miR-525-5p/VMA21 axis

Hong-Yu Shen, Liu-Xi Shi, Lin Wang, Le-Ping Fang, Wei Xu, Ju-Qing Xu, Bo-Qiang Fan, Wei-Fei Fan

Open Access Research

CD226 knockout alleviates high-fat diet induced obesity by suppressing proinflammatory macrophage phenotype

Jingchang Ma, Wei Hu, Dongliang Zhang, Jiangang Xie, Chujun Duan, Yitian Liu, Yuling Wang, Xuexue Xu, Kun Cheng, Boquan Jin, Yuan Zhang, Ran Zhuang

Open Access Correction

Correction to: An update on extra-oral bitter taste receptors

Kamila Tuzim, Agnieszka Korolczuk

Open Access Research

Barriers to translational research in Windsor Ontario: a survey of clinical care providers and health researchers

Justin B. Senecal, Karen Metcalfe, Kaila Wilson, Indryas Woldie, Lisa A. Porter

Open Access Research

The tumor immune microenvironment of primary and metastatic HER2− positive breast cancers utilizing gene expression and spatial proteomic profiling

Ilana Schlam, Sarah E. Church, Tyler D. Hether, Krysta Chaldekas, Briana M. Hudson, Andrew M. White, Emily Maisonet, Brent T. Harris, Sandra M. Swain

Open Access Research

A two-stage genome-wide association study of radiation-induced acute toxicity in head and neck cancer

Elnaz Naderi, Anne Petra Gerarda Crijns, Roel Johannes Henricus Marinus Steenbakkers, Johanna Geertruida Maria van den Hoek, Hendrika Marike Boezen, Behrooz Ziad Alizadeh, Johannes Albertus Langendijk

Open Access Research

CRISPR/Cas9-mediated TGFβRII disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells in vitro

Khadijeh Alishah, Matthias Birtel, Elham Masoumi, Leila Jafarzadeh, Hamid Reza Mirzaee, Jamshid Hadjati, Ralf-Holger Voss, Mustafa Diken, Sedighe Asad

Open Access Research

Effect of brain radiotherapy strategies on prognosis of patients with EGFR-mutant lung adenocarcinoma with brain metastasis

Guangchuan Deng, Yingyun Zhang, Jiaojiao Ke, Qi Wang, Hongyue Qin, Jianbin Li, Zhenxiang Li

Open Access Editorial

Translational signaling and systems biology

Marcello Maggiolini

Open Access Research

Alterations of thyroid microbiota across different thyroid microhabitats in patients with thyroid carcinoma

Daofeng Dai, Yan Yang, Yong Yang, Tianfeng Dang, Jiansheng Xiao, Weibin Wang, Lisong Teng, Juan Xu, Jing Ye, Hongqun Jiang

Open Access Research

Body mass index is not associated with survival outcomes and immune-related adverse events in patients with Hodgkin lymphoma treated with the immune checkpoint inhibitor nivolumab

Rosaria De Filippi, Fortunato Morabito, Armando Santoro, Giovanni Tripepi, Francesco D’Alò, Luigi Rigacci, Francesca Ricci, Emanuela Morelli, Pier Luigi Zinzani, Antonio Pinto

Open Access Research

Effect of fecal microbiota transplantation in patients with slow transit constipation and the relative mechanisms based on the protein digestion and absorption pathway

Lulu Xie, Chen Xu, Yadong Fan, Yuwei Li, Ying Wang, Xiaoyu Zhang, Shuang Yu, Jida Wang, Rundong Chai, Zeyu Zhao, Yutong Jin, Zhe Xu, Shuwu Zhao, Yuhong Bian

Open Access COVID-19 Research

Nonthyroidal illness syndrome (NTIS) in severe COVID-19 patients: role of T3 on the Na/K pump gene expression and on hydroelectrolytic equilibrium

Salvatore Sciacchitano, Carlo Capalbo, Christian Napoli, Andrea Negro, Luciano De Biase, Adriano Marcolongo, Paolo Anibaldi, Valentina Salvati, Lea Petrella, Luca Merlo, Daniela Alampi, Elisa Alessandri, Chiara Loffredo, Alessandra Ulivieri, Luca Lavra, Fiorenza Magi, Alessandra Morgante, Leila B. Salehi, Claudia De Vitis, Rita Mancini, Flaminia Coluzzi, Monica Rocco

Open Access Methodology

From biobank and data silos into a data commons: convergence to support translational medicine

Rebecca Asiimwe, Stephanie Lam, Samuel Leung, Shanzhao Wang, Rachel Wan, Anna Tinker, Jessica N. McAlpine, Michelle M. M. Woo, David G. Huntsman, Aline Talhouk

Open Access Research

The maintained attention assessment in patients affected by Myalgic encephalomyelitis/chronic fatigue syndrome: a reliable biomarker?

Iñigo Murga, Larraitz Aranburu, Pascual A. Gargiulo, Juan-Carlos Gómez-Esteban, José-Vicente Lafuente

Open Access Research

Expanding the phenotypic spectrum of mutations in LRP2: a novel candidate gene of non-syndromic familial comitant strabismus

Yue Wang, Xuejuan Chen, Tao Jiang, Yayun Gu, Xiaohan Zhang, Wenwen Yuan, Andi Zhao, Rui Li, Zijin Wang, Zhibin Hu, Hu Liu

Open Access Review

Virus infection induced pulmonary fibrosis

Wei Jie Huang, Xiao Xiao Tang

Open Access Research

Delineation of colorectal cancer ligand-receptor interactions and their roles in the tumor microenvironment and prognosis

Hexin Lin, Lu Xia, Jiabian Lian, Yinan Chen, Yiyi Zhang, Zhicheng Zhuang, HuaJun Cai, Jun You, Guoxian Guan

Open Access Research

Relations of physical signs to genotype, lipid and inflammatory markers, coronary stenosis or calcification, and outcomes in patients with heterozygous familial hypercholesterolemia

Ming-Ming Liu, Jia Peng, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Rui-Xia Xu, Qian Dong, Jian-Jun Li

Open Access Review

Optimization of metabolism to improve efficacy during CAR-T cell manufacturing

Meng Zhang, Xin Jin, Rui Sun, Xia Xiong, Jiaxi Wang, Danni Xie, MingFeng Zhao

Open Access Research

Serum metabolomic and lipidomic profiling identifies diagnostic biomarkers for seropositive and seronegative rheumatoid arthritis patients

Hemi Luan, Wanjian Gu, Hua Li, Zi Wang, Lu Lu, Mengying Ke, Jiawei Lu, Wenjun Chen, Zhangzhang Lan, Yanlin Xiao, Jinyue Xu, Yi Zhang, Zongwei Cai, Shijia Liu, Wenyong Zhang

Open Access COVID-19 Review

Multi-omics approach to COVID-19: a domain-based literature review

Chiara Montaldo, Francesco Messina, Isabella Abbate, Manuela Antonioli, Veronica Bordoni, Alessandra Aiello, Fabiola Ciccosanti, Francesca Colavita, Chiara Farroni, Saeid Najafi Fard, Emanuela Giombini, Delia Goletti, Giulia Matusali, Gabriella Rozera, Martina Rueca, Alessandra Sacchi, Mauro Piacentini, Chiara Agrati, Gian Maria Fimia, Maria Rosaria Capobianchi, Francesco Nicola Lauria, Giuseppe Ippolito

Open Access Research

Nationwide epidemiological characteristics of chronic fatigue syndrome in South Korea

Eun-Jin Lim, Jin-Seok Lee, Eun-Jung Lee, Seok-Ju Jeong, Ho-Young Park, Yo-Chan Ahn, Chang-Gue Son

Open Access Correction

Correction to: Effect of brain radiotherapy strategies on prognosis of patients with EGFR-mutant lung adenocarcinoma with brain metastasis

Guangchuan Deng, Yingyun Zhang, Jiaojiao Ke, Qi Wang, Hongyue Qin, Jianbin Li, Zhenxiang Li

Open Access Research

LINC00491 promotes cell growth and metastasis through miR-324-5p/ROCK1 in liver cancer

Wei Wang, Tao Yang, Dongsheng Li, Yinpeng Huang, Guang Bai, Qing Li

Open Access Commentary

Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis

José María Lamo-Espinosa, Felipe Prósper, Juan F. Blanco, Fermín Sánchez-Guijo, Mercedes Alberca, Verónica García, Margarita González-Vallinas, Javier García-Sancho

Open Access Research

Sex-related differences of early cardiac functional and proteomic alterations in a rat model of myocardial ischemia

Bálint András Barta, Mihály Ruppert, Klemens Erwin Fröhlich, Miguel Cosenza-Contreras, Attila Oláh, Alex Ali Sayour, Krisztián Kovács, Gellért Balázs Karvaly, Martin Biniossek, Béla Merkely, Oliver Schilling, Tamás Radovits

Open Access Research

TRIM38 triggers the ubiquitination and degradation of glucose transporter type 1 (GLUT1) to restrict tumor progression in bladder cancer

Xiaojing Wang, Hongchao He, Wenbin Rui, Ning Zhang, Yu Zhu, Xin Xie

Open Access Research

Identifying and characterizing lincRNA genomic clusters reveals its cooperative functions in human cancer

Hanxiao Zhou, Yue Gao, Xin Li, Shipeng Shang, Peng Wang, Hui Zhi, Shuang Guo, Dailin Sun, Hongjia Liu, Xia Li, Yunpeng Zhang, Shangwei Ning

Open Access Research

Colonization of fecal microbiota from patients with neonatal necrotizing enterocolitis exacerbates intestinal injury in germfree mice subjected to necrotizing enterocolitis-induction protocol via alterations in butyrate and regulatory T cells

Yu He, Weixia Du, Sa Xiao, Benhua Zeng, Xiang She, Dong Liu, Hua Du, Luquan Li, Fang Li, Qing Ai, Junli He, Chao Song, Hong Wei, Xiaodong Zhao, Jialin Yu

Open Access Research

Extracellular vesicles carrying miRNA-181b-5p affects the malignant progression of acute lymphoblastic leukemia

Wei Yan, Li Song, Huihan Wang, Wei Yang, Liang Hu, Ying Yang

Open Access Research

Cancer-associated fibroblasts promote oral squamous cell carcinoma progression through LOX-mediated matrix stiffness

Jia-Yi Zhang, Wei-Wen Zhu, Meng-Yao Wang, Run-Dong Zhai, Qiong Wang, Wei-Li Shen, Lai-Kui Liu

Open Access Review

NOX4: a potential therapeutic target for pancreatic cancer and its mechanism

Yawei Bi, Xiao Lei, Ningli Chai, Enqiang Linghu

Open Access Research

Global prevalence of myasthenia gravis and the effectiveness of common drugs in its treatment: a systematic review and meta-analysis

Nader Salari, Behnaz Fatahi, Yalda Bartina, Mohsen Kazeminia, Reza Fatahian, Payam Mohammadi, Shamarina Shohaimi, Masoud Mohammadi

Open Access Methodology

Development of an ultra-sensitive human IL-33 biomarker assay for age-related macular degeneration and asthma drug development

Elaine Mai, Joyce Chan, Levina Goon, Braeden K. Ego, Jack Bevers, Tiffany Wong, Manda Wong, Racquel Corpuz, Hongkang Xi, Jia Wu, Kellen Schneider, Dhaya Seshasayee, Michele Grimbaldeston, Gerald Nakamura, Vahan B. Indjeian, Menno van Lookeren Campagne, Kelly M. Loyet, Laetitia Comps-Agrar

Open Access Research

Influence of the trajectory of the urine output for 24 h on the occurrence of AKI in patients with sepsis in intensive care unit

Luming Zhang, Fengshuo Xu, Didi Han, Tao Huang, Shaojin Li, Haiyan Yin, Jun Lyu

Open Access Research

TRPC3, but not TRPC1, as a good therapeutic target for standalone or complementary treatment of DMD

Anna Creisméas, Claire Gazaille, Audrey Bourdon, Marc-Antoine Lallemand, Virginie François, Marine Allais, Mireille Ledevin, Thibaut Larcher, Gilles Toumaniantz, Aude Lafoux, Corinne Huchet, Ignacio Anegon, Oumeya Adjali, Caroline Le Guiner, Bodvaël Fraysse

Open Access Review

Bullous pemphigoid in diabetic patients treated by gliptins: the other side of the coin

Karim Chouchane, Giovanni Di Zenzo, Dario Pitocco, Laura Calabrese, Clara De Simone

Open Access Research

SIRT5 functions as a tumor suppressor in renal cell carcinoma by reversing the Warburg effect

Liu Yihan, Wang Xiaojing, Liu Ao, Zhang Chuanjie, Wang Haofei, Shen Yan, He Hongchao

Open Access Research

Identification and development of a novel 5-gene diagnostic model based on immune infiltration analysis of osteoarthritis

YaGuang Han, Jun Wu, ZhenYu Gong, YiQin Zhou, HaoBo Li, Bo Wang, QiRong Qian

Open Access Research

Establishment and validation of in-house cryopreserved CAR/TCR-T cell flow cytometry quality control

Yihua Cai, Michaela Prochazkova, Chunjie Jiang, Hannah W. Song, Jianjian Jin, Larry Moses, Nikolaos Gkitsas, Robert P. Somerville, Steven L. Highfill, Sandhya Panch, David F. Stroncek, Ping Jin

Open Access COVID-19 Research

Paradoxical sex-specific patterns of autoantibody response to SARS-CoV-2 infection

Yunxian Liu, Joseph E. Ebinger, Rowann Mostafa, Petra Budde, Jana Gajewski, Brian Walker, Sandy Joung, Min Wu, Manuel Bräutigam, Franziska Hesping, Elena Rupieper, Ann-Sophie Schubert, Hans-Dieter Zucht, Jonathan Braun, Gil Y. Melmed, Kimia Sobhani, Moshe Arditi, Jennifer E. Van Eyk, Susan Cheng, Justyna Fert-Bober

Open Access Research

Long-term memory T cells as preventive anticancer immunity elicited by TuA-derived heteroclitic peptides

Angela Mauriello, Beatrice Cavalluzzo, Carmen Manolio, Concetta Ragone, Antonio Luciano, Antonio Barbieri, Maria Lina Tornesello, Franco M. Buonaguro, Maria Tagliamonte, Luigi Buonaguro

Open Access Research

Analysis and validation of m6A regulatory network: a novel circBACH2/has-miR-944/HNRNPC axis in breast cancer progression

Wenchang Lv, Yufang Tan, Mingchen Xiong, Chongru Zhao, Yichen Wang, Min Wu, Yiping Wu, Qi Zhang

Open Access COVID-19 Research

Periodontal disease increases the host susceptibility to COVID-19 and its severity: a Mendelian randomization study

Yi Wang, Hui Deng, Yihuai Pan, Lijian Jin, Rongdang Hu, Yongyong Lu, Wenhai Deng, Weijian Sun, Chengshui Chen, Xian Shen, Xiu-Feng Huang

Open Access Research

Prognostic significance of natural killer cell-associated markers in gastric cancer: quantitative analysis using multiplex immunohistochemistry

Hee Young Na, Yujun Park, Soo Kyung Nam, Jiwon Koh, Yoonjin Kwak, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Kyu Sang Lee, Hye Seung Lee

Open Access Research

“Forever young at the table”: metabolic effects of eating speed in obesity

Luigi Barrea, Claudia Vetrani, Ludovica Verde, Bruno Napolitano, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri

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