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Intensive Care Medicine

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20.06.2016 | Editorial

Statins do not prevent cardiac surgery-associated AKI: is ubiquinone the missing link?

verfasst von: Miet Schetz, Heleen Oudemans-Van Straaten

Erschienen in: Intensive Care Medicine | Ausgabe 9/2016

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Excerpt

Statins have become one of the most commonly prescribed drugs worldwide in the prevention of cardiovascular disease. Most benefits are secondary to inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA reductase) which lowers low-density lipoprotein cholesterol levels. However, statins also have cholesterol-independent, pleiotropic effects that occur within hours of initiation and include improved endothelial function, anti-apoptotic, anti-inflammatiory, antioxidant, antithrombotic, and immunomodulatory effects [1]. …

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Titel: Statins do not prevent cardiac surgery-associated AKI: is ubiquinone the missing link?
verfasst von: Miet Schetz
Heleen Oudemans-Van Straaten
Publikationsdatum: 20.06.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Intensive Care Medicine / Ausgabe 9/2016
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-016-4424-2

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