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Seminars in Immunopathology

Erschienen in:

01.12.2008 | Review

Strategies for reconstituting and boosting T cell-based immunity following haematopoietic stem cell transplantation: pre-clinical and clinical approaches

verfasst von: Ann P. Chidgey, Natalie Seach, Jarrod Dudakov, Maree V. Hammett, Richard L. Boyd

Erschienen in: Seminars in Immunopathology | Ausgabe 4/2008

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Abstract

Poor immune recovery is characteristic of bone marrow transplantation and leads to high levels of morbidity and mortality. The primary underlying cause is a compromised thymic function, resulting from age-induced atrophy and further compounded by the damaging effects of cytoablative conditioning regimes on thymic epithelial cells (TEC). Several strategies have been proposed to enhance T cell reconstitution. Some, such as the use of single biological agents, are currently being tested in clinical trials. However, a more rational approach to immune restoration will be to leverage the evolving repertoire of new technologies. Specifically, the combined targeting of TEC, thymocytes and peripheral T cells, together with the bone marrow niches, promises a more strategic clinical therapeutic platform.

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Titel: Strategies for reconstituting and boosting T cell-based immunity following haematopoietic stem cell transplantation: pre-clinical and clinical approaches
verfasst von: Ann P. Chidgey
Natalie Seach
Jarrod Dudakov
Maree V. Hammett
Richard L. Boyd
Publikationsdatum: 01.12.2008
Verlag: Springer-Verlag
Erschienen in: Seminars in Immunopathology / Ausgabe 4/2008
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-008-0140-5

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