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01.02.2011

Substance P Enhances Th17 Phenotype in Individuals with Generalized Anxiety Disorder: an Event Resistant to Glucocorticoid Inhibition

verfasst von: Priscila O. Barros, Thais B. Ferreira, Morgana M. M. Vieira, Carla Renata M. Almeida, Carlos Fernando Araújo-Lima, Renato G. Silva-Filho, Joana Hygino, Regis M. Andrade, Arnaldo F. Andrade, Cleonice A. Bento

Erschienen in: Journal of Clinical Immunology | Ausgabe 1/2011

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Abstract

Our objective was to evaluate the effect of stress-related dose of substance P (SP) on the in vitro proliferation and cytokine production in polyclonally activated T cells from healthy individuals or individuals with generalized anxiety disorder (GAD). Our results demonstrated that cell cultures from GAD group proliferated less following T cell activation, as compared with control group. The addition of SP enhanced, while the glucocorticoid (GC) reduced, the proliferative response in activated cell cultures from healthy but not from GAD individuals. The cytokine profile in GAD individuals revealed Th1 and Th2 deficiencies were associated with dominate Th17 phenotype which was enhanced by SP. Differently from control, the production of Th17 cytokines in GAD individuals was not affected by GC. In conclusion, our results show that complex T cell functional dysregulation in GAD individuals is significantly amplified by SP. These immune abnormalities can have impact in increasing the susceptibility to infectious diseases and inflammatory/autoimmune disorders in anxious individuals.

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Titel: Substance P Enhances Th17 Phenotype in Individuals with Generalized Anxiety Disorder: an Event Resistant to Glucocorticoid Inhibition
verfasst von: Priscila O. Barros
Thais B. Ferreira
Morgana M. M. Vieira
Carla Renata M. Almeida
Carlos Fernando Araújo-Lima
Renato G. Silva-Filho
Joana Hygino
Regis M. Andrade
Arnaldo F. Andrade
Cleonice A. Bento
Publikationsdatum: 01.02.2011
Verlag: Springer US
Erschienen in: Journal of Clinical Immunology / Ausgabe 1/2011
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-010-9466-6

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