Skip to main content
Erschienen in: Clinical Orthopaedics and Related Research® 4/2014

01.04.2014 | Survey (Systematic Review)

Subungual Exostosis of the Toes: A Systematic Review

verfasst von: Mark P. DaCambra, MD, MSc, Sumit K. Gupta, MD, Fabio Ferri-de-Barros, MD, MSc

Erschienen in: Clinical Orthopaedics and Related Research® | Ausgabe 4/2014

Einloggen, um Zugang zu erhalten

Abstract

Background

Subungual exostosis is a relatively common benign bone tumor that occurs in the distal phalanges of the toes and can be a source of pain and nail deformity. There is controversy about the treatment of these lesions and there are few studies that have synthesized what is known and provided meaningful information on treatment.

Questions/purposes

We performed a systematic review to address the following questions: (1) What is the best surgical approach for excising these lesions? (2) What is the age range, sex distribution, and presenting symptoms of subungual exostoses and which toe is most frequently affected? (3) What complications arise from treatment?

Methods

Two authors independently searched multiple databases (Medline, 1950–May 2013; Cochrane EBM database, and EMBASE, 1980–May 2013 provided by OVID; ACP Journal Club, 2003–May 2013; CINAHL by EBSCO, 1937–May 2013; and PubMed by NLM, 1940–May 2013), and key words were chosen to achieve a broad search strategy. We included studies on the management of toe exostoses with > 10 cases and we excluded studies that reported on upper extremity exostoses or osteochondromas. Demographic and treatment data were collected from each article by two independent authors and collated. A total of 124 abstracts were screened, and 116 articles were reviewed in full, of which 13 met the inclusion criteria.

Results

Complete marginal excision through a fish mouth incision protecting the nail led to a recurrence rate of 4% and satisfactory clinical results, defined as no requirement for postoperative intervention and a satisfactory clinical appearance in 73%. Most studies provided incomplete descriptions of specific surgical techniques used. Fifty-five percent of the patients were younger than 18 years of age. A history of toe trauma before diagnosis was present in approximately 30% of the cases. Delayed diagnosis occurred in approximately 10% of the cases and onychodystrophy occurred in more than 10%.

Conclusions

There is weak evidence to guide management of subungual exostosis. Adequate wound management postexcision aiming to minimize disruption to the nail bed and matrix may prevent onychodystrophy, which is a common complication of treatment.
Literatur
1.
3.
Zurück zum Zitat Bervar M. [Subungual exostosis of the toe and its etiology] [in Serbian]. Vojnosanit Pregl. 1958;15:452–455.PubMed Bervar M. [Subungual exostosis of the toe and its etiology] [in Serbian]. Vojnosanit Pregl. 1958;15:452–455.PubMed
4.
Zurück zum Zitat Bostanci S, Ekmekçi P, Ekinci C, Akçaboy B, Gürgey E. Subungual osteochondroma: a case report. Dermatol Surg. 2001;27:591–593.PubMedCrossRef Bostanci S, Ekmekçi P, Ekinci C, Akçaboy B, Gürgey E. Subungual osteochondroma: a case report. Dermatol Surg. 2001;27:591–593.PubMedCrossRef
5.
6.
Zurück zum Zitat DaCambra MP, Gupta SK, Ferri-de-Barros F. A novel management strategy for subungual exostosis. BMJ Case Rep. 2013 Aug 30;2013. pii: bcr2013200396. doi: 10.1136/bcr-2013-200396. DaCambra MP, Gupta SK, Ferri-de-Barros F. A novel management strategy for subungual exostosis. BMJ Case Rep. 2013 Aug 30;2013. pii: bcr2013200396. doi: 10.​1136/​bcr-2013-200396.
7.
Zurück zum Zitat Dal Cin P, Pauwels P, Poldermans LJ, Sciot R, Van den Berghe H. Clonal chromosome abnormalities in a so-called Dupuytren’s subungual exostosis. Genes Chromosomes Cancer. 1999;24:162–164. Dal Cin P, Pauwels P, Poldermans LJ, Sciot R, Van den Berghe H. Clonal chromosome abnormalities in a so-called Dupuytren’s subungual exostosis. Genes Chromosomes Cancer. 1999;24:162–164.
8.
Zurück zum Zitat Davis D, Cohen P. Subungual exostosis: case report and review of the literature. Pediatr Dermatol. 1996;13:212–218.PubMedCrossRef Davis D, Cohen P. Subungual exostosis: case report and review of the literature. Pediatr Dermatol. 1996;13:212–218.PubMedCrossRef
9.
Zurück zum Zitat De Berker D, Langtry J. Treatment of subungual exostoses by elective day case surgery. Br J Dermatol. 1999;140:915–918.PubMedCrossRef De Berker D, Langtry J. Treatment of subungual exostoses by elective day case surgery. Br J Dermatol. 1999;140:915–918.PubMedCrossRef
10.
Zurück zum Zitat De Palma L, Gigante A, Specchia N. Subungual exostosis of the foot. Foot Ankle Int. 1996;17:758–63.CrossRef De Palma L, Gigante A, Specchia N. Subungual exostosis of the foot. Foot Ankle Int. 1996;17:758–63.CrossRef
11.
Zurück zum Zitat DiCenso A, Bayley L, Haynes RB. Accessing pre-appraised evidence: fine-tuning the 5S model into a 6S model. Evid Based Nurs. 2009;12:99–101.PubMedCrossRef DiCenso A, Bayley L, Haynes RB. Accessing pre-appraised evidence: fine-tuning the 5S model into a 6S model. Evid Based Nurs. 2009;12:99–101.PubMedCrossRef
13.
Zurück zum Zitat Fikry T, Dkhissi M, Harfaoui A, Adil A, Haddoun A, Zryouil B. Subungual exostosis: a retrospective study of 28 cases. Acta Orthop Belg. 1998;64:35–40.PubMed Fikry T, Dkhissi M, Harfaoui A, Adil A, Haddoun A, Zryouil B. Subungual exostosis: a retrospective study of 28 cases. Acta Orthop Belg. 1998;64:35–40.PubMed
14.
Zurück zum Zitat Grisafi PJ, Lombardi CM, Sciarrino AL, Rainer GF, Buffone WF. Three select subungual pathologies: subungual exostosis, subungual osteochondroma, and subungual hematoma. Clin Podiatr Med Surg. 1989;6:355–364.PubMed Grisafi PJ, Lombardi CM, Sciarrino AL, Rainer GF, Buffone WF. Three select subungual pathologies: subungual exostosis, subungual osteochondroma, and subungual hematoma. Clin Podiatr Med Surg. 1989;6:355–364.PubMed
15.
Zurück zum Zitat Guarneri C, Guarneri F, Risitano G, Lentini M, Vaccaro M. Solitary asymptomatic nodule of the great toe. Int J Dermatol. 2005;44:245–247.PubMedCrossRef Guarneri C, Guarneri F, Risitano G, Lentini M, Vaccaro M. Solitary asymptomatic nodule of the great toe. Int J Dermatol. 2005;44:245–247.PubMedCrossRef
16.
Zurück zum Zitat Ippolito E, Falez F, Tudisco C, Balus L, Fazio M, Morrone A. Subungual exostosis. Histological and clinical considerations on 30 cases. Ital J Orthop Traumatol. 1987;13:81–87.PubMed Ippolito E, Falez F, Tudisco C, Balus L, Fazio M, Morrone A. Subungual exostosis. Histological and clinical considerations on 30 cases. Ital J Orthop Traumatol. 1987;13:81–87.PubMed
17.
Zurück zum Zitat Kim S, Park K, Son S. Subungual osteochondroma presenting as verruca vulgaris in a 6-year-old boy. Pediatr Dermatol. 2007;24:584–585.PubMedCrossRef Kim S, Park K, Son S. Subungual osteochondroma presenting as verruca vulgaris in a 6-year-old boy. Pediatr Dermatol. 2007;24:584–585.PubMedCrossRef
18.
Zurück zum Zitat Landon GC, Johnson KA, Dahlin DC. Subungual exostoses. J Bone Joint Surg Am. 1979;61:256–259.PubMed Landon GC, Johnson KA, Dahlin DC. Subungual exostoses. J Bone Joint Surg Am. 1979;61:256–259.PubMed
19.
Zurück zum Zitat Lee SK, Jung MS, Lee YH, Gong HS, Kim JK, Baek GH. Two distinctive subungual pathologies: subungual exostosis and subungual osteochondroma. Foot Ankle Int. 2007;28:595–601.PubMedCrossRef Lee SK, Jung MS, Lee YH, Gong HS, Kim JK, Baek GH. Two distinctive subungual pathologies: subungual exostosis and subungual osteochondroma. Foot Ankle Int. 2007;28:595–601.PubMedCrossRef
20.
Zurück zum Zitat Letts M, Davidson D, Nizalik E. Subungual exostosis: diagnosis and treatment in children. J Trauma Acute Care Surg. 1998;44:346–349.CrossRef Letts M, Davidson D, Nizalik E. Subungual exostosis: diagnosis and treatment in children. J Trauma Acute Care Surg. 1998;44:346–349.CrossRef
21.
Zurück zum Zitat Li Y, Yue T, Han Y. Subungual exostosis. 1991;6:169–171. Li Y, Yue T, Han Y. Subungual exostosis. 1991;6:169–171.
22.
Zurück zum Zitat Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JPA, Clarke M, Devereaux PJ, Kleijnen J, Moher D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009;339:b2700–b2700.PubMedCentralPubMedCrossRef Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JPA, Clarke M, Devereaux PJ, Kleijnen J, Moher D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009;339:b2700–b2700.PubMedCentralPubMedCrossRef
23.
Zurück zum Zitat Lokiec F, Ezra E, Krasin E, Keret D, Wientroub S. A simple and efficient surgical technique for subungual exostosis. J Pediatr Orthop. 2001;21:76.PubMedCrossRef Lokiec F, Ezra E, Krasin E, Keret D, Wientroub S. A simple and efficient surgical technique for subungual exostosis. J Pediatr Orthop. 2001;21:76.PubMedCrossRef
24.
Zurück zum Zitat Mavrogenis A, Papagelopoulos P, Soucacos P. Skeletal osteochondromas revisited. Orthopedics. 2008;31:1018–1028.CrossRef Mavrogenis A, Papagelopoulos P, Soucacos P. Skeletal osteochondromas revisited. Orthopedics. 2008;31:1018–1028.CrossRef
25.
Zurück zum Zitat Mertens F, Möller E, Mandahl N, Picci P, Perez-Atayde AR, Samson I, Sciot R, Debiec-Rychter M. The t(X;6) in subungual exostosis results in transcriptional deregulation of the gene for insulin receptor substrate 4. Int J Cancer. 2011;128:487–491.PubMedCrossRef Mertens F, Möller E, Mandahl N, Picci P, Perez-Atayde AR, Samson I, Sciot R, Debiec-Rychter M. The t(X;6) in subungual exostosis results in transcriptional deregulation of the gene for insulin receptor substrate 4. Int J Cancer. 2011;128:487–491.PubMedCrossRef
26.
Zurück zum Zitat Miller-Breslow A, Dorfman H. Dupuytren’s (subungual) exostosis. Am J Surg Pathol. 1988;12:368.PubMedCrossRef Miller-Breslow A, Dorfman H. Dupuytren’s (subungual) exostosis. Am J Surg Pathol. 1988;12:368.PubMedCrossRef
27.
Zurück zum Zitat Multhopp-Stephens H, Walling A. Subungual (Dupuytren’s) exostosis. J Pediatr Orthop. 1995;15:582.PubMedCrossRef Multhopp-Stephens H, Walling A. Subungual (Dupuytren’s) exostosis. J Pediatr Orthop. 1995;15:582.PubMedCrossRef
28.
Zurück zum Zitat Murphey MD, Choi JJ, Kransdorf MJ, Flemming DJ, Gannon FH. Imaging of osteochondroma: variants and complications with radiologic-pathologic correlation. Radiographics. 2000;20:1407–1434.PubMedCrossRef Murphey MD, Choi JJ, Kransdorf MJ, Flemming DJ, Gannon FH. Imaging of osteochondroma: variants and complications with radiologic-pathologic correlation. Radiographics. 2000;20:1407–1434.PubMedCrossRef
29.
Zurück zum Zitat Oliveira AS, Picoto AS, Verde SF, Martins O. Subungual exostosis: treatment as an office procedure. J Dermatol Surg Oncol. 1980;6:555–558. Oliveira AS, Picoto AS, Verde SF, Martins O. Subungual exostosis: treatment as an office procedure. J Dermatol Surg Oncol. 1980;6:555–558.
30.
Zurück zum Zitat Ortega ORM, Sanchez HG. 23 observations of subungual exostosis. Med Cut ILA. 1988;16:11–14. Ortega ORM, Sanchez HG. 23 observations of subungual exostosis. Med Cut ILA. 1988;16:11–14.
31.
Zurück zum Zitat Smith LC, Funkhouser WK, Campion ER, Morrell DS. A firm nodule on the great toe of a 13-year-old boy. Pediatr Dermatol. 2009;26:747–748.PubMedCrossRef Smith LC, Funkhouser WK, Campion ER, Morrell DS. A firm nodule on the great toe of a 13-year-old boy. Pediatr Dermatol. 2009;26:747–748.PubMedCrossRef
32.
Zurück zum Zitat Stark JD, Adler NN, Robinson WH. Hereditary multiple exostoses. Radiology. 1952;59:212–215.PubMed Stark JD, Adler NN, Robinson WH. Hereditary multiple exostoses. Radiology. 1952;59:212–215.PubMed
33.
Zurück zum Zitat Storlazzi C, Wozniak A, Panagopoulos I, Sciot R, Mandahl N, Mertens F, Debiec-Rychter M. Rearrangement of the COL12A1 and COL4A5 genes in subungual exostosis: molecular cytogenetic delineation of the tumor-specific translocationt (X; 6)(q13-14; q22). Int J Cancer. 2006;118:1972–1976.PubMedCrossRef Storlazzi C, Wozniak A, Panagopoulos I, Sciot R, Mandahl N, Mertens F, Debiec-Rychter M. Rearrangement of the COL12A1 and COL4A5 genes in subungual exostosis: molecular cytogenetic delineation of the tumor-specific translocationt (X; 6)(q13-14; q22). Int J Cancer. 2006;118:1972–1976.PubMedCrossRef
35.
Zurück zum Zitat Toyoda M, Morohashi M. An ultrastructural study of subungual exostosis, with specila reference to intranuclear inclusions. Medical Electron Microscopy. 1998;31:142–146.CrossRef Toyoda M, Morohashi M. An ultrastructural study of subungual exostosis, with specila reference to intranuclear inclusions. Medical Electron Microscopy. 1998;31:142–146.CrossRef
36.
Zurück zum Zitat Tuzuner T, Kavak A, Ustundag N, Parlak A. A painful subungual nodule: subungual exostosis. Acta Orthop Traumatol Turc. 2004;38:71.PubMed Tuzuner T, Kavak A, Ustundag N, Parlak A. A painful subungual nodule: subungual exostosis. Acta Orthop Traumatol Turc. 2004;38:71.PubMed
37.
Zurück zum Zitat Valinsky MS, Hettinger DF, Gennet PM. Subungual exostosis removal utilizing a minimal incision technique. Curr Podiatr Med. 1991;40:10–15. Valinsky MS, Hettinger DF, Gennet PM. Subungual exostosis removal utilizing a minimal incision technique. Curr Podiatr Med. 1991;40:10–15.
38.
39.
Zurück zum Zitat Wright JG, Kocher MS, Sanders JO. Evidence-based pediatric orthopaedics: an introduction, Part I. J Pediatr Orthop. 2012;32:S83–S90.PubMedCrossRef Wright JG, Kocher MS, Sanders JO. Evidence-based pediatric orthopaedics: an introduction, Part I. J Pediatr Orthop. 2012;32:S83–S90.PubMedCrossRef
40.
Zurück zum Zitat Wright JG, Swiontkowski MF, Heckman JD. Introducing levels of evidence to the journal. J Bone Joint Surg Am. 2003;85:1–3.PubMedCrossRef Wright JG, Swiontkowski MF, Heckman JD. Introducing levels of evidence to the journal. J Bone Joint Surg Am. 2003;85:1–3.PubMedCrossRef
41.
Zurück zum Zitat Zambrano E, Nosé V, Perez-Atayde A, Gebhardt M, Hresko MT, Kleinman P, Richkind KE, Kozakewich HP. Distinct chromosomal rearrangements in subungual (Dupuytren) exostosis and bizarre parosteal osteochondromatous proliferation (Nora lesion). Am J Surg Pathol. 2004;28:1033.PubMedCrossRef Zambrano E, Nosé V, Perez-Atayde A, Gebhardt M, Hresko MT, Kleinman P, Richkind KE, Kozakewich HP. Distinct chromosomal rearrangements in subungual (Dupuytren) exostosis and bizarre parosteal osteochondromatous proliferation (Nora lesion). Am J Surg Pathol. 2004;28:1033.PubMedCrossRef
Metadaten
Titel
Subungual Exostosis of the Toes: A Systematic Review
verfasst von
Mark P. DaCambra, MD, MSc
Sumit K. Gupta, MD
Fabio Ferri-de-Barros, MD, MSc
Publikationsdatum
01.04.2014
Verlag
Springer US
Erschienen in
Clinical Orthopaedics and Related Research® / Ausgabe 4/2014
Print ISSN: 0009-921X
Elektronische ISSN: 1528-1132
DOI
https://doi.org/10.1007/s11999-013-3345-4

Weitere Artikel der Ausgabe 4/2014

Clinical Orthopaedics and Related Research® 4/2014 Zur Ausgabe

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Proximale Humerusfraktur: Auch 100-Jährige operieren?

01.05.2024 DCK 2024 Kongressbericht

Mit dem demographischen Wandel versorgt auch die Chirurgie immer mehr betagte Menschen. Von Entwicklungen wie Fast-Track können auch ältere Menschen profitieren und bei proximaler Humerusfraktur können selbst manche 100-Jährige noch sicher operiert werden.

Sind Frauen die fähigeren Ärzte?

30.04.2024 Gendermedizin Nachrichten

Patienten, die von Ärztinnen behandelt werden, dürfen offenbar auf bessere Therapieergebnisse hoffen als Patienten von Ärzten. Besonders gilt das offenbar für weibliche Kranke, wie eine Studie zeigt.

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Arthroskopie kann Knieprothese nicht hinauszögern

25.04.2024 Gonarthrose Nachrichten

Ein arthroskopischer Eingriff bei Kniearthrose macht im Hinblick darauf, ob und wann ein Gelenkersatz fällig wird, offenbar keinen Unterschied.

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.