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Archives of Gynecology and Obstetrics

Erschienen in:

01.10.2011 | Gynecologic Oncology

Successful treatment of a very rare case: locally treated cervical rhabdomyosarcoma

verfasst von: Erbil Karaman, Ozgur Akbayir, Yasemin Kocatürk, Sema Cekic, Filiz Balci Filiz, Ahmet Gulkilik

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 4/2011

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Abstract

Aim

To study the local treatment of uterine cervical rhabdomyosarcoma in which fertility-sparing surgery is done.

Methods

We report an embryonal rhabdomyosarcoma of the uterine cervix which presented as a cervical polyp in a 22-year-old nulliparous woman.

Results

The tumor was composed of rhabdomyoblasts of varying differentiation dispersed within a loose, myxoid stroma, and formed a distinct cambium layer beneath the epithelium. The patient was successfully treated with fertility-sparing surgery and adjuvant chemotherapy.

Conclusion

The treatment modality should be done according to the patients individually. Treatment has recently inclined toward conservative therapy. Patients with favorable prognostic factors such as localized disease, single polyp and embryonal histologic subtype and without deep invasion can be treated with minimal invasive surgery.

Young JL, Miller RW (1975) Incidence of malignant tumors in US children. J Pediat 86:254–258PubMedCrossRef

Maurer HM (1981) The Intergroup Rhabdomyosarcoma Study: update, Nov. 1978. Natl Cancer Inst Monogr 56:61–68PubMed

Bell J, Averette H, Davis J, Toledano S (1986) Genital rhabdomyosarcoma. Current management and review of the literature. Obstet Gynecol Surv 41:257–263PubMedCrossRef

Porzio G, Toro G, Paris I, Ricevuto E, Ficorella C, Marchetti P (2000) Cervical sarcoma botryoides treated with conservative surgery and adjuvant chemotherapy: a case report. Eur J Gynaecol Oncol 21(5):499–500PubMed

Fletcher CD, Unni KK, Mertens F (eds) (2002) World Health Organization classification of tumors. IARC Press, Lyon, pp 146–149

Perrone T, Carson LF, Dehner LP (1990) Rhabdomyosarcoma with heterologous cartilage of the uterine cervix: a clinicopathologic and immunohistochemical study of an aggressive neoplasm in a young female. Med Pediatr Oncol 18(1):72–76PubMedCrossRef

Daya DA, Scully RE (1988) Sarcoma botryoides of the uterine cervix in young women: a clinicopathological study of 13 cases. Gynecol Oncol 29(3):290–304PubMedCrossRef

Bernal KL, Fahmy L, Remmenga S, Bridge J, Baker J (2004) Embryonal rhabdomyosarcoma (sarcoma botryoides) of the cervix presenting as a cervical polyp treated with fertility-sparing surgery and adjuvant chemotherapy. Gynecol Oncol 95(1):243–246PubMedCrossRef

Semczuk A, Baranowski W, Berbe TH, Marzec B, Skomra D, Miturski R (1999) Analysis of p53 and K-ras genes and their proteins in a sarcoma botryoides of the uterine cervix. Eur J Gynaecol Oncol 20(4):311–314PubMed

10.

Plazzo JP, Gibas Z, Dunton CJ, Talerman A (1993) Cytogenetic study of botryoid rhabdomyosarcoma of the uterine cervix. Virchows Arch A Pathol Anat Histopathol 422(1):87–91CrossRef

11.

Stankovic ZB, Djuricic S, Stankovic DS, Zdravkovic S, Gazikalovic S, Sedlecki K (2007) Minimal invasive treatment of cervical rhabdomyosarcoma in an adolescent girl. J BUON 12(1):121–123PubMed

12.

Lin J, Lam SK, Cheung TH (1995) Sarcoma botryoides of the cervix treated with limited surgery and chemotherapy to preserve fertility. Gynecol Oncol 58(2):270–273PubMedCrossRef

13.

Zeisler H, Mayerhofer K, Joura EA, Bancher-Todesca D, Kainz C, Breitenecker G et al (1998) Embryonal rhabdomyosarcoma of the uterine cervix: case report and review of the literature. Gynecol Oncol 69(1):78–83PubMedCrossRef

14.

Vlahos NP, Matthews R, Veridiano NP (1999) Cervical sarcoma botryoides. A case report. J Reprod Med 44(3):306–308PubMed

15.

Crist WM, Anderson JR, Meza JL et al (2001) Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic disease. J Clin Oncol 19:3091–3102PubMed

16.

Raney RB, Gehan EA, Hays DM, Tefft M, Newton W, Maurer HM (1990) Primary chemotherapy with or without radiation and/or surgery for children with localized sarcoma of the bladder, prostate, vagina, uterus and cervix: comparison of results in Intergroup Rhabdomyosarcoma Studies 1 and 11. Cancer 66:2072–2081PubMedCrossRef

Titel: Successful treatment of a very rare case: locally treated cervical rhabdomyosarcoma
verfasst von: Erbil Karaman
Ozgur Akbayir
Yasemin Kocatürk
Sema Cekic
Filiz Balci Filiz
Ahmet Gulkilik
Publikationsdatum: 01.10.2011
Verlag: Springer-Verlag
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 4/2011
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-011-1974-y

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Successful treatment of a very rare case: locally treated cervical rhabdomyosarcoma

Abstract