nach oben

Forensic Science, Medicine and Pathology

Erschienen in:

27.07.2016 | Case Report

Sudden unexpected death from an undiagnosed histiocytic sarcoma in an adolescent female

verfasst von: H. R. Haynes, Z. Melegh, S. Vanjani, M. Cieka, S. Beavers, N. Rooney, B. Purdue

Erschienen in: Forensic Science, Medicine and Pathology | Ausgabe 4/2016

Einloggen, um Zugang zu erhalten

Abstract

A previously well 15-year-old female who was awaiting medical investigations for a proptosed right eye collapsed and died suddenly while walking. Postmortem examination revealed diffuse distortion and infiltration of multiple organs by a suspected neoplastic process. Histology confirmed the invasion of multiple organs by atypical cells and myocardial infiltration was the likely cause of death. An extensive panel of immunohistochemistry established the diagnosis of a histiocytic sarcoma. Sudden unexpected death due to a clinically undiagnosed neoplasia in childhood and adolescence is uncommon. This is the first report of a histiocytic sarcoma causing sudden unexpected death and highlights the importance of considering undiagnosed hematological malignancies when examining a case of sudden death at postmortem.

Gilbert-Barness E, Debich-Spicer D. Handbook of paediatric autopsy pathology. New York City: Humana Press; 2005.CrossRef

Gatter K, Delsol G, Warnke R, Pezzella F. Diagnosis of lymphoproliferative diseases. 2nd ed. Hoboken: Wiley-Blackwell; 2012.

Marafioti T, Paterson JC, Ballabio E, et al. Novel markers of normal and neoplastic human plasmacytoid dendritic cells. Blood. 2008;111:3778–92.CrossRefPubMed

Dierksen J, Buja LM, Chen L. Clinicopathologic findings of hematological malignancy: a retrospective autopsy study. Ann Clin Lab Sci. 2015;45:565–73.PubMed

Gowda RM, Khan IA. Clinical perspectives of primary cardiac lymphoma. Angiology. 2003;54:599–604.CrossRefPubMed

Somers GR, Smith CR, Perrin DG, et al. Sudden unexpected death in infancy and childhood due to undiagnosed neoplasia: an autopsy study. Am J Forensic Med Pathol. 2006;27:64–9.CrossRefPubMed

Dearth JC, Fountain KS, Smithson WA, et al. Extreme leukemic leukocytosis (blast crisis) in childhood. Mayo Clin Proc. 1978;53:207–11.PubMed

Bray RJ, Fernandes FJ. Mediastinal tumour causing airway obstruction in anaesthetised children. Anaesthesia. 1982;37:571–5.CrossRefPubMed

Levin H, Bursztein S, Heifetz M. Cardiac arrest in a child with an anterior mediastinal mass. Anesth Analg. 1985;64:1129–30.CrossRefPubMed

10.

Hon K-E, Leung A, Chik K-W, et al. Critical airway obstruction, superior vena cava syndrome, and spontaneous cardiac arrest in a child with acute leukemia. Pediatr Emerg Care. 2005;21:844–6.CrossRefPubMed

11.

Whybourne A, Zillman MA, Miliauskas J, et al. Sudden and unexpected infant death due to occult lymphoblastic leukaemia. J Clin Forensic Med. 2001;8:160–2.CrossRefPubMed

12.

Maleszewski J, Lu J, Fox-Talbot K, et al. Robust immunohistochemical staining of several classes of proteins in tissues subjected to autolysis. J Histochem Cytochem. 2007;55:597–606.CrossRefPubMed

13.

Warnke R, Weiss L, Chan J, Cleary M, Dorfman R. Tumours of the lymph nodes and spleen. Washington, DC: Armed Forces Institute of Pathology; 1995.

14.

Ralfkiaer E, Delsol G, O’Connor NT, et al. Malignant lymphomas of true histiocytic origin. A clinical, histological, immunophenotypic and genotypic study. J Pathol. 1990;160:9–17.CrossRefPubMed

15.

Franchino C, Reich C, Distenfeld A, et al. A clinicopathologically distinctive primary splenic histiocytic neoplasm. Demonstration of its histiocyte derivation by immunophenotypic and molecular genetic analysis. Am J Surg Pathol. 1988;12:398–404.CrossRefPubMed

16.

Kobayashi S, Kimura F, Hama Y, et al. Histiocytic sarcoma of the spleen: case report of asymptomatic onset of thrombocytopenia and complex imaging features. Int J Hematol. 2008;87:83–7.CrossRefPubMed

17.

Sun W, Nordberg ML, Fowler MR. Histiocytic sarcoma involving the central nervous system: clinical, immunohistochemical, and molecular genetic studies of a case with review of the literature. Am J Surg Pathol. 2003;27:258–65.CrossRefPubMed

18.

Zhang X, Kryston JJ, Michalak WA, et al. Histiocytic sarcoma in the small intestine: a case report with flow cytometry study and review of the literature. Pathol Res Pract. 2008;204:763–70.CrossRefPubMed

19.

Akishima Y, Akasaka Y, Yih-Chang G, et al. Histiocytic sarcoma with fatal duodenal ulcers. Pathol Res Pract. 2004;200:473–8.CrossRefPubMed

20.

Wilson MS, Weiss LM, Gatter KC, et al. Malignant histiocytosis. A reassessment of cases previously reported in 1975 based on paraffin section immunophenotyping studies. Cancer. 1990;66:530–6.CrossRefPubMed

Titel: Sudden unexpected death from an undiagnosed histiocytic sarcoma in an adolescent female
verfasst von: H. R. Haynes
Z. Melegh
S. Vanjani
M. Cieka
S. Beavers
N. Rooney
B. Purdue
Publikationsdatum: 27.07.2016
Verlag: Springer US
Erschienen in: Forensic Science, Medicine and Pathology / Ausgabe 4/2016
Print ISSN: 1547-769X
Elektronische ISSN: 1556-2891
DOI: https://doi.org/10.1007/s12024-016-9800-2

Springer Medizin

Sudden unexpected death from an undiagnosed histiocytic sarcoma in an adolescent female

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2016

The forensic implications of predatory publishing

Splenic rupture and mediastinal mass associated with rare TdT-negative T-LBL/T-ALL lead to sudden death of a juvenile

Customary law, traditional punishment, and death in the Anangu Pitjantjatjara Yankunytjatjara (APY) lands of Central Australia

Green pus in the subdural space and within the ventricles: an uncommon finding but a straightforward macroscopic diagnosis

The use of nails as an alternative matrix for the long-term detection of previous drug intake: validation of sensitive UHPLC-MS/MS methods for the quantification of 76 substances and comparison of analytical results for drugs in nail and hair samples

Fluid content in the pleural cavity protects internal structures against heat

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie