Skip to main content

Supportive Care in Cancer

Ausgabe 1/2023

Inhalt (98 Artikel)

Open Access Research

Fatigue trajectories during pediatric ALL therapy are associated with fatigue after treatment: a national longitudinal cohort study

Elin Irestorm, Lindsay M. H. Steur, Gertjan J. L. Kaspers, Natasha K. A. Van Eijkelenburg, Inge M. Van der Sluis, Natasja Dors, Cor Van den Bos, Wim J. E. Tissing, Martha A. Grootenhuis, Raphaele R. L. Van Litsenburg

Research

The least costly pharmacy for cancer supportive care medications over time: the logistic toxicity of playing catch up

Andrew Etteldorf, Ramy Sedhom, Shannon M. Rotolo, Rachel I. Vogel, Christopher M. Booth, Anne H. Blaes, Beth A. Virnig, Stacie B. Dusetzina, Arjun Gupta

Research

Analysis of preoperative sleep quality and related influencing factors in cancer patients

Zihan Wang, Wenwen Du, Shenhui Jin, Yurun Zhu, Chonglei Quan, Xi Zhang, Yuping Feng, Yunchang Mo, Junlu Wang

Research

Health-related quality of life is associated with fecal microbial composition in breast cancer survivors

Kristen S. Smith, Abby Tissier, Jennifer R. Bail, Josh R. Novak, Casey D. Morrow, Wendy Demark-Wahnefried, Andrew D. Frugé

Review

Dressing to prevent surgical site infection in adult patients with cancer: a systematic review with meta-analysis

Thais Almeida Dias, Daiane Rubinato Fernandes, Bruna Nogueira dos Santos, Paula Elaine Diniz dos Reis, Amanda Salles Margatho, Renata Cristina de Campos Pereira Silveira

Open Access Research

PENS approach for breaking bad news in the oncology outpatient setting: a real-world report

Sharada Mailankody, Prathika Sherigar, Ananth Pai, Ramnath Shenoy, Karthik Udupa, Shirley Lewis, Seema R. Rao

Open Access Research

Refocusing cancer supportive care: a framework for integrated cancer care

Meinir Krishnasamy, Amelia Hyatt, Holly Chung, Karla Gough, Margaret Fitch

Research

Adapting to the burdens of care: a telehealth program for cancer survivors with ostomies

Matthew C. Rock, Zuleyha Cidav, Virginia Sun, Elizabeth Ercolano, Mark C. Hornbrook, Christopher S. Wendel, Julia Mo, Harrison Fellheimer, Ruth McCorkle, Michael Holcomb, Marcia Grant, Ronald S. Weinstein, Robert S. Krouse

Research

Comorbidities and perceived health status in persons with history of cancer in the USA

Mavis Obeng-Kusi, Janette L. Vardy, Melanie L. Bell, Briana M. Choi, David R. Axon

Research

From evidence to practice: early integration of palliative care in a comprehensive cancer center

Shamsah Lakhani, David A. Scalzitti, Laura Padrone, Diana Martins-Welch

Review

Risk factors of unilateral breast cancer-related lymphedema: an updated systematic review and meta-analysis of 84 cohort studies

Aomei Shen, Qian Lu, Xin Fu, Xiaoxia Wei, Liyuan Zhang, Jingru Bian, Wanmin Qiang, Dong Pang

Research

Relationship between physical activity and bone mineral density loss after gastrectomy in gastric cancer patients

Yuto Sakurai, Michitaka Honda, Hidetaka Kawamura, Hiroshi Kobayashi, Satoshi Toshiyama, Ryuya Yamamoto, Eiichi Nakao, Cong Yue, Minoru Takano, Keishi Hayao, Shinichi Konno

Open Access Research

Effects of esters’ cetylated fatty acids taping for chronic neck pain with mobility deficit in patients with breast cancer

Rosanna Izzo, Mariasole Rossato, Germano Tarantino, Nicola Mascolo, Mauro Puleio

Research

Barriers and facilitators to early-stage lung cancer care in the USA: a qualitative study

Joshua Herb, Hannah Friedman, Sachita Shrestha, Erin E. Kent, Karyn Stitzenberg, Benjamin Haithcock, Gita N. Mody

Research

Effects of selfcare and selected factors on the quality of life in women with breast cancer-related lymphedema

Cansu Hazal Yanardağ, Gülsüm Nihal Çürük, Özgül Karayurt

Review

Experiences of bowel symptoms in patients with rectal cancer after sphincter-preserving surgery: a qualitative meta-synthesis

Cong Li, Haiyan Tang, Yue Zhang, Qiuwen Zhang, Wantong Yang, Hongxia Yu, Dong Pang

Original Article

Opioid withdrawal symptoms after neurolytic splanchnic nerve block in cancer patients

Ryota Yanaizumi, Yusuke Nagamine, Shinsuke Harada, Tomoko Kuramochi, Shuhei Ota, Takahisa Goto

Open Access Research

Partnership, sexuality, and fertility-related communication: findings from a register-based study among long-term hematological cancer survivors

Britta Lohmann, Katharina Kuba, Heide Götze, Anja Mehnert-Theuerkauf, Svenja Heyne, Peter Esser

Research

Pain, cancer-related distress, and physical and functional well-being among men with advanced prostate cancer

Emily A. Walsh, Patricia B. Pedreira, Patricia I. Moreno, Paula J. Popok, Rina S. Fox, Betina Yanez, Michael H. Antoni, Frank J. Penedo

Research

A randomized, double-blinded feasibility trial of educational materials for hiccups in chemotherapy-treated patients with cancer

Christopher J. Ehret, Jennifer Le-Rademacher, Michael H. Storandt, Nichole Martin, Arush Rajotia, Aminah Jatoi

Research

Risk factors for worse anxiety trajectories among patients undergoing cancer chemotherapy

Johanna A. Suskin, Steven Paul, Ashley R. Stuckey, Yvette P. Conley, Christine Miaskowski, Laura B. Dunn

Research

Therapeutic yoga reduces pro-tumorigenic cytokines in cancer survivors

Darpan I. Patel, G. J. Almeida, N. T. Darby, M. C. Serra, T. Calderon, A. Lapetoda, B. Gutierrez, A. G. Ramirez, D. C. Hughes

Research

Time course and predictors of persistent cancer-related fatigue in long-term breast cancer survivors: a prospective observational study

Francisco Álvarez-Salvago, José Daniel Jiménez-García, Antonio Martínez-Amat, Fidel Hita-Contreras, Agustín Aibar-Almazán

Research

Healthcare professionals’ perspectives on the unmet needs of cancer patients and family caregivers: global psycho-oncology investigation

Ashley Wei-Ting Wang, Youngmee Kim, Amanda Ting, Wendy Wing Tak Lam, Sylvie D. Lambert

Open Access Research

How do patients interpret and respond to a single-item global indicator of cancer treatment tolerability?

John Devin Peipert, Sara Shaunfield, Karen Kaiser, Patricia I. Moreno, Rina S. Fox, Sheetal Kircher, Nisha Mohindra, Edward Ip, Fengmin Zhao, Lynne Wagner, David Cella

Research

Impact of adjuvant trastuzumab treatment on fatigue, emotional status and quality of personal and work life of patients with localised breast cancer: results of the ‘HER-ception’ study

Gwenn Le Gall, Sabine Noal, Natacha Heutte, Bénédicte Clarisse, Alexandra Leconte, François Cherifi, Corinne Delcambre, Florence Joly, Bénédicte Clin

Review

Multinational Association of Supportive Care in Cancer (MASCC) expert opinion/consensus guidance on the use of cannabinoids for gastrointestinal symptoms in patients with cancer

Bryony Alderman, David Hui, Sandip Mukhopadhyay, Carole Bouleuc, Amy A. Case, Koji Amano, Gregory B. Crawford, Giulia de Feo, Andrea Sbrana, Kimberson Tanco, Josephine To, Jessica Garsed, Mellar Davis

Research

Dietary supplement use and recommendations for discontinuation in an integrative oncology clinic

Stacy D. D’Andre, Brent A. Bauer, Margaret B. Hofmann, Jenna L. Burckhard, Heather N. Montane, Charles L. Loprinzi

Original Article

Safety of direct oral anticoagulants in patients with advanced solid tumors receiving anti-VEGF agents: a retrospective study

Alice Boileve, Laurence Albiges, Michel Ducreux, Eric Baudin, Alexandra Leary, Benjamin Besse, Julien Hadoux, David Malka, André Rieutord, Florian Scotté, Amandine Maulard, Olivier Mir

Open Access Original Article

Fascia training in patients undergoing allogeneic hematopoietic cell transplantation—a pilot study

Sandra Weigmann-Faßbender, Hanna Ulbricht, Marianne de Schultz, Christine Pawandenat, Desiree Kunadt, Michaela Wolff, Nadine Giesemann, Katja Prate, Johannes Schetelig, Martin Bornhäuser, Friedrich Stölzel, Nadja Knauthe, Friederike Stölzel

Original Article

Serum metabolomics reveals the effects of accompanying treatment on fatigue in patients with multiple myeloma

Hui-tao Zhang, Hao Xiong, Hong-wen Xiao, Zhi-hong Zhang, Chun-lan Huang, Mei-zhou Huang

Review

Systematic review of aquatic therapeutic exercise efficacy in breast cancer survivors

Elena Muñoz-Gómez, Anna Arnal-Gómez, Alba López Cascón, Gemma V. Espí-López

Research

Essential elements of optimal dietary and exercise referral practices for cancer survivors: expert consensus for medical and nursing health professionals

Ria Joseph, Nicolas H. Hart, Natalie Bradford, Matthew P. Wallen, Chad Y. Han, Elizabeth P. Pinkham, Brigid Hanley, Gemma Lock, David Wyld, Laurelie Wishart, Bogda Koczwara, Alexandre Chan, Oluwaseyifunmi Andi Agbejule, Megan Crichton, Laisa Teleni, Justin J. Holland, Kelli Edmiston, Leonie Naumann, Teresa Brown, Raymond J. Chan

Research

Dyadic coping in young and middle-aged women with gynecological cancer: a latent class analysis

Meimei Shang, Tingting Cai, Yingtao Meng, Qian Wang, Yongchun Cui, Fang Zhang

Open Access Research

Social Support, social ties, and cognitive function of women with breast cancer: findings from the Women’s Health Initiative (WHI) Life and Longevity After Cancer (LILAC) Study

Yesol Yang, Eric M. McLaughlin, Michelle J. Naughton, Maryam B. Lustberg, Timiya S. Nolan, Candyce H. Kroenke, Julie C. Weitlauf, Nazmus Saquib, Aladdin H. Shadyab, Shawna Follis, Kathy Pan, Electra D. Paskett

Open Access Research

The effects of myofascial induction therapy in survivors of head and neck cancer: a randomized, controlled clinical trial

Lucía Ortiz-Comino, Lydia Martín-Martín, Noelia Galiano-Castillo, Eduardo Castro-Martín, Miguel Ángel Fernández-Gualda, Mario Lozano-Lozano, Carolina Fernández-Lao

Research

Hypnosis and relaxation interventions for chronic pain management in cancer survivors: a randomized controlled trial

Linda H. Eaton, Min Kyeong Jang, Mark P. Jensen, Kenneth C. Pike, Margaret M. Heitkemper, Ardith Z. Doorenbos

Research

Sexual dysfunction among gynecologic cancer survivors in a population-based cohort study

Chun-Pin Chang, Christina M. Wilson, Kerry Rowe, John Snyder, Mark Dodson, Vikrant Deshmukh, Michael Newman, Alison Fraser, Ken Smith, Ankita Date, Joseph B. Stanford, David Gaffney, Kathi Mooney, Mia Hashibe

Research

Evaluating laser photobiomodulation for chemotherapy-induced peripheral neuropathy: a randomised phase II trial

Christina Teng, Sam Egger, Prunella L. Blinman, Janette L. Vardy

Research

Moderators of physical activity and quality of life response to a physical activity intervention for breast cancer survivors

Erica Schleicher, Edward McAuley, Kerry S. Courneya, Phillip Anton, Diane K. Ehlers, Siobhan M. Phillips, Robert A. Oster, Dorothy Pekmezi, Laura Q. Rogers

Research

Recommendations for a Patient Concerns Inventory specific to patients with head and neck cancer receiving palliative treatment

Cecilie Holländer-Mieritz, Anne Marie Juhl Elsborg, Claus Andrup Kristensen, Simon N. Rogers, Helle Pappot, Karin Piil

Review

Correlates of stigma for patients with breast cancer: a systematic review and meta-analysis

Wen-zhen Tang, Azlina Yusuf, Kui Jia, Yulita Hanum P. Iskandar, Ernest Mangantig, Xin-shao Mo, Tian-fu Wei, Shi-li Cheng

Review

Effects of prehabilitation on postoperative outcomes in frail cancer patients undergoing elective surgery: a systematic review and meta-analysis

Yinning Guo, Lingyu Ding, Xueyi Miao, Xiaoman Jiang, Ting Xu, Xinyi Xu, Shuqin Zhu, Qin Xu, Jieman Hu

Correspondence

Heart rate variability as an indicator of the beneficial effects of Qigong and mindfulness training on the mind–body well-being of cancer survivors

Yi-Hua Lee, Yuan-Ping Chang, Jih-Teng Lee, De-Chih Lee, Eng-Yen Huang, Lee-Jang Tsai Lai

Open Access Research

Zopiclone versus placebo for short-term treatment of insomnia in patients with advanced cancer—a double-blind, randomized placebo-controlled clinical multicenter phase IV trial

Gunnhild Jakobsen, Karin Sjue, Ørnulf Paulsen, Stein Kaasa, Marianne Jensen Hjermstad, Pål Klepstad

Research

Financial hardship in breast cancer survivors: a prospective analysis of change in financial concerns over time

Michael H. Storandt, Urshila Durani, Daniela Stan, Nicole Larson, Charles Loprinzi, Fergus Couch, Janet E. Olson, Nandita Khera, Kathryn J. Ruddy

Original Article

Inorganic nitrate supplementation may improve diastolic function and the O2 cost of exercise in cancer survivors: a pilot study

Vanessa-Rose G. Turpin, Garrett M. Lovoy, Shannon K. Parr, Stephen T. Hammond, Hunter K. Post, Jacob T. Caldwell, Heather R. Banister, Britton C. Scheuermann, Trenton D. Colburn, Carl J. Ade

Review Article

What are the outcomes of hospice care for cancer patients? A systematic review

Simin Sharafi, Atefeh Ziaee, Hanie Dahmardeh

Original Article

Exploring the relationship between DNA methylation age measures and psychoneurological symptoms in women with early-stage breast cancer

Gee Su Yang, Kai Yang, Michael T. Weaver, Debra Lynch Kelly, Susan G. Dorsey, Colleen K. Jackson-Cook, Debra E. Lyon

Research

Influence of social and behavioral determinants on health-related quality of life among cancer survivors in the USA

Natasha Renee Burse, Xingran Weng, Li Wang, Yendelela L. Cuffee, Susan Veldheer

Research

Implementing a web-based system of screening for symptoms and needs using patient-reported outcomes in people with cancer

Bogda Koczwara, Reegan Knowles, Lisa Beatty, Heather L. Shepherd, Joanne M. Shaw, Haryana M. Dhillon, Jonathan Karnon, Shahid Ullah, Phyllis Butow

Comment

The growth and evolution of the MASCC-ISOO Annual Conference from 2014 to 2019

Julia Lou, Victoria Rico, Liying Zhang, Carlo De Angelis, Edward Chow, Fiona Lim

Research

Effectiveness of healthy lifestyle–based interventions in lung cancer survivors: a systematic review and meta-analysis

Alejandro Heredia-Ciuró, Javier Martín-Núñez, José Antonio López-López, Laura López-López, María Granados-Santiago, Andrés Calvache-Mateo, Marie Carmen Valenza

Research

Development and validation of an online dynamic nomogram system for predicting cancer cachexia among inpatients: a real-world cohort study in China

Zhenyu Huo, Feifei Chong, Liangyu Yin, Na Li, Mengyuan Zhang, Jing Guo, Xin Lin, Yang Fan, Ling Zhang, Hongmei Zhang, Muli Shi, Xiumei He, Zongliang Lu, Jie Liu, Wei Li, Hanping Shi, Hongxia Xu

Correction

Correction to: Identification of socially vulnerable cancer patients — development of a register‑based index (rSVI)

Jens-Jakob Kjer Møller, Karen la Cour, Marc Sampedro Pilegaard, Sören Möller, Lene Jarlbaek

Open Access Review

Systematic review of caregiver burden, unmet needs and quality-of-life among informal caregivers of patients with pancreatic cancer

Eric Chong, Lisa Crowe, Keno Mentor, Sanjay Pandanaboyana, Linda Sharp

Research

Diet quality indices and changes in cognition during chemotherapy

Sylvia L. Crowder, Taylor L. Welniak, Aasha I. Hoogland, Brent J. Small, Yvelise Rodriguez, Kristen M. Carpenter, Stacy M. Fischer, Daneng Li, Anita Y. Kinney, Daniel Rotroff, Arshiya Mariam, Naomi Brownstein, Richard R. Reich, Tim Hembree, Mary C. Playdon, Anna E. Arthur, Christian AMaino Vieytes, Zonggui Li, Martine Extermann, Richard Kim, Donna L. Berry, Heather S. L. Jim

Research

Exploring cancer care needs for Latinx adults: a qualitative evaluation

Gladys M. Rodriguez, Maria Leach, Jennifer Osorio, Gerardo Villicana, Zachary Koontz, Emily H. Wood, Ysabel Duron, Dale O’Brien, Lisa G. Rosas, Manali I. Patel

Open Access Research

Communication with patients with limited prognosis—an integrative mixed-methods evaluation study

Anja Siegle, Laura Unsöld, Nicole Deis, Katja Krug, Jasmin Bossert, Johannes Krisam, Corinna Jung, Jana Jünger, Michel Wensing, Michael Thomas, Matthias Villalobos

COVID-19 Research

Differences in urban and suburban/rural settings regarding care provision and barriers of cancer care for older adults during COVID-19

Janell L. Pisegna, Karlynn BrintzenhofeSzoc, Armin Shahrokni, Beverly Canin, Elana Plotkin, Leigh M. Boehmer, Leana Chien, Mariuxi Viteri Malone, Amy R. MacKenzie, Jessica L. Krok-Schoen

Open Access Research

“Like one part of a puzzle” — individualized aromatherapy for women with gynecological cancers in aftercare: results from a qualitative-focused mixed-methods study

Judith Czakert, Wiebke Stritter, Sarah B. Blakeslee, Jacek P. Grabowski, Jalid Sehouli, Georg Seifert

Open Access Research

What do bereaved relatives of cancer patients dying in hospital want to tell us? Analysis of free-text comments from the International Care of the Dying Evaluation (i-CODE) survey: a mixed methods approach

Christina Gerlach, Miriam Baus, Emilio Gianicolo, Oliver Bayer, Dagny Faksvåg Haugen, Martin Weber, Catriona R. Mayland, Katrin Sigurdardottir, Marit Irene Tuen Hansen, Karl Ove Hufthammer, Wojciech Leppert, Katarzyna Wolszczak, Eduardo Garcia Yanneo, Vilma Tripodoro, Gabriel Goldraij, Christina Gerlach, Lair Zambon, Juliana Nalin Passarini, Ivete Bredda Saad, John Ellershaw, Grace Ting

Research

Impact of early palliative care on additional line of chemotherapy in metastatic breast cancer patients: results from the randomized study OSS

Gisèle Chvetzoff, Carole Bouleuc, Audrey Lardy-Cléaud, Pierre Saltel, Véronique Dieras, Magali Morelle, Jean-Paul Guastalla, Olivier Tredan, Paul Rebattu, Simona Pop, Isabelle Ray-Coquard, Jean-Yves Pierga, Laurent Mignot, Valérie Laurence, Valérie Bourne-Branchu, David Pérol, Thomas Bachelot

Research

A silence full of words: sociocultural beliefs behind the sexual health of Iranian women undergoing breast cancer treatment, a qualitative study

Sanaz Zangeneh, Mitra Savabi-Esfahani, Fariba Taleghani, Mohammad Reza Sharbafchi, Mehrdad Salehi

Review

Pain prevalence and characteristics in survivors of solid cancers: a systematic review and meta-analysis

Vincent Haenen, Margaux Evenepoel, Tom De Baerdemaecker, Mira Meeus, Nele Devoogdt, Bart Morlion, Lore Dams, Sophie Van Dijck, Elien Van der Gucht, Tessa De Vrieze, Thijs Vande Vyvere, An De Groef

Correspondence

A systematic review of m-health apps on managing side effects of breast cancer treatment

Ausanee Wanchai, Elizabeth A. Anderson, Jane M. Armer

Research

“More than conquerors”: a qualitative analysis of war metaphors for patients with cancer

Monica H. Bodd, Nikki C. Daniels, Hermioni L. Amonoo, Tyler Tate, Kris W. Herring, Thomas W. LeBlanc

Review

Factors influencing adherence to healthy eating behaviors among adult colorectal cancer survivors: a systematic mixed method review

Jialu Chen, Luyao Jia, Yan Li, Yu Shi, Xueqi Dong, Jiannan Yao, Mingyue Zhu, Xiuying Zhang, Hua Yuan

Research

Availability and affordability of anticancer medicines in Iran based on WHO/HAI standard survey methods

Mehdi Varmaghani, Sepideh Elyasi, Mohammad M. Mojahedian, Vahid Ghavami, Behnam Borhani, Javad Javan-Noughabi, Shirin Sarafraz

Research

Conversion ratios for opioid switching: a pragmatic study

Sebastiano Mercadante, Claudio Adile, Patrizia Ferrera, Yasmine Grassi, Alessio Lo Cascio, Alessandra Casuccio

Original Article

Antiviral therapy use and related outcomes in patients with cancer and viral infections: results from SWOG S1204

Jessica P. Hwang, Kathryn B. Arnold, Joseph M. Unger, Rashmi Chugh, Monica A. Tincopa, Rohit Loomba, Dawn Hershman, Scott D. Ramsey

Review

Exploration of shared decision making in oncology within the United States: a scoping review

Rachel Bennett, Pamela B. DeGuzman, Virginia LeBaron, Daniel Wilson, Randy A. Jones

Research

Perspectives of caregivers of older adults with acute myeloid leukemia during initial hypomethylating agents and venetoclax chemotherapy

Kelly R. Tan, Ya-Ning Chan, Katie Iadonisi, Elissa Poor, Stephanie Betancur, Ahrang Jung, Kathryn Sagester, Susan Coppola, Mackenzi Pergolotti, Erin E. Kent, Todd Schwartz, Daniel Richardson, Ashley Leak Bryant

Original Article

“I was never one of those people who just jumped right in for me”: patient perspectives on self-advocacy training for women with advanced cancer

Teresa Hagan Thomas, Patty Jo Murray, Margaret Rosenzweig, Sarah Taylor, Adam Brufsky, Catherine Bender, Mikayla Larkin, Yael Schenker

Research

Baseline gut microbiota composition is associated with oral mucositis and tumour recurrence in patients with head and neck cancer: a pilot study

Ghanyah Al-Qadami, Joanne Bowen, Ysabella Van Sebille, Kate Secombe, Mohsen Dorraki, Johan Verjans, Hannah Wardill, Hien Le

Alphablocker schützt vor Miktionsproblemen nach der Biopsie

16.05.2024 alpha-1-Rezeptorantagonisten Nachrichten

Nach einer Prostatabiopsie treten häufig Probleme beim Wasserlassen auf. Ob sich das durch den periinterventionellen Einsatz von Alphablockern verhindern lässt, haben australische Mediziner im Zuge einer Metaanalyse untersucht.

Antikörper-Wirkstoff-Konjugat hält solide Tumoren in Schach

16.05.2024 Zielgerichtete Therapie Nachrichten

Trastuzumab deruxtecan scheint auch jenseits von Lungenkrebs gut gegen solide Tumoren mit HER2-Mutationen zu wirken. Dafür sprechen die Daten einer offenen Pan-Tumor-Studie.

Mammakarzinom: Senken Statine das krebsbedingte Sterberisiko?

15.05.2024 Mammakarzinom Nachrichten

Frauen mit lokalem oder metastasiertem Brustkrebs, die Statine einnehmen, haben eine niedrigere krebsspezifische Mortalität als Patientinnen, die dies nicht tun, legen neue Daten aus den USA nahe.

Labor, CT-Anthropometrie zeigen Risiko für Pankreaskrebs

13.05.2024 Pankreaskarzinom Nachrichten

Gerade bei aggressiven Malignomen wie dem duktalen Adenokarzinom des Pankreas könnte Früherkennung die Therapiechancen verbessern. Noch jedoch klafft hier eine Lücke. Ein Studienteam hat einen Weg gesucht, sie zu schließen.

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.