Erschienen in:
01.05.2010 | Poster presentation
Suppression of the NF-κB co-factor, Bcl3, delays the metastatic progression of breast cancer
verfasst von:
AM Wakefield, RWE Clarkson
Erschienen in:
Breast Cancer Research
|
Sonderheft 1/2010
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Excerpt
A large proportion of breast cancers overexpress the HER receptors, HER1 or HER2. Generally these patients have a poor prognosis, exhibit resistance to first-line anti-cancer drugs, and frequently develop metastatic disease - the most common cause of patient death. NF-κB transcription factors lie downstream of HER1/2 signalling pathways and are aberrantly activated in the majority of these breast tumours. …