Ausgabe Sonderheft 1/2010
Breast Cancer Research 2010
Inhalt (68 Artikel)
Biomarkers for the diagnosis and prediction of therapeutic response in clinical breast cancer
J Bartlett
Male versus female breast cancer: a comparative study of 523 matched cases reveals differences behind similarity
V Speirs, G Ball
Upregulation of ADAM proteases and HER ligands through a feedback loop mediates acquired resistance to trastuzumab in HER2-amplified breast cancer
M Gijsen, P King, T Perera, P Parker, B Larijani, A Harris, A Kong
New regulators of the BRCA1 response to genotoxic stress
JR Morris, C Boutell, M Keppler, R Densham, D Weekes, A Alamshah, L Butler, Y Galanty, L Pangon, T Kiuchi, T Ng, E Solomon
DNA methylome of familial breast cancer identifies distinct profiles defined by mutation status
JM Flanagan, S Kugler, N Waddell, CN Johnstone, A Marsh, S Henderson, P Simpson, L da Silva, K Khanna, S Lakhani, C Boshoff, G Chenevix-Trench
Differentiation therapy: targeting breast cancer stem cells to reduce resistance to radiotherapy and chemotherapy
R Roy, PM Willan, R Clarke, G Farnie
Transforming growth factor-beta co-receptor endoglin suppresses breast cancer invasion and metastasis
LA Henry, DJ Johnson, S Lee, PR Quinlan, T Crook, AM Thompson, JS Reis-Filho, CM Isacke
Activin B functions downstream of BRCA1 in stem cell maintenance
MM Murray, N Buckley, DP Harkin
FOXM1 is a transcriptional target of ERα and has a critical role in breast cancer endocrine sensitivity and resistance
J Millour, EW Lam
A novel and selective PDK1 inhibitor reduces breast cancer cell invasion and tumour growth
C Raimondi, T Maffucci, BVL Potter, M Falasca
Regulation of mammary epithelial architecture by PTEN
JC Lim, L Davidson, NR Weerasinghe, G Zilidis, P Tibarewal, L Spinelli, NR Leslie
Genetic analysis of lobular carcinoma in situ and associated invasive lobular cancer
LR Yates, A Jones, H Patel, A Mackay, C Gillett, S Pinder, I Tomlinson, R Roylance, EJ Sawyer
Suppression of the NF-κB co-factor, Bcl3, delays the metastatic progression of breast cancer
AM Wakefield, RWE Clarkson
Identification of signalling pathways downstream of BRCA1 and p63
N Crawford, N Buckley, C Nic An tSaoir, D Tkocz, Z D'Costa, L Oram, P Mullan
D133P53, directly transactivated by p53, prevents p53-mediated apoptosis without inhibiting p53-mediated cell cycle arrest
M Aoubala, F Murray-Zmijewski, M Khoury, S Perrier, K Fernandes, AC Prats, D Lane, JC Bourdon
Loss of CSMD1 disrupts mammary epithelial morphogenesis
M Kamal, AM Shaaban, DL Holliday, C Toomes, V Speirs, SM Bell
Phosphoinositide 3-kinase class II beta is a novel target in breast cancer therapy
J Abbott, R Pineiro, MA Oliviero, R Lattanzio, M Piantelli, A Bilancio, T Maffucci, M Falasca
MicroRNA-92 targets the 3' untranslated region of ERβ1 mRNA and post-transcriptionally regulates its expression in breast cancer
HH Alnakhle, PA Burns, M Cummings, AM Hanby, TA Hughes, S Satheesha, AM Shaaban, L Smith, V Speirs
Regulation of the apoptotic genes in breast cancer cells by the transcription factor CTCF
CF Mendez-Catala, A Vostrov, E Pugacheva, Y Ito, F Docquier, I Chernukhin, D Farrar, G-X Kita, A Murrell, V Lobanankov, E Klenova
Fulvestrant-induced expression of erbB3 and erbB4 sensitizes ER-positive breast cancer cells to heregulins
IR Hutcheson, L Goddard, JMW Gee, D Barrow, RI Nicholson
Risks of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers
M Ahmed, F Lalloo, A Howell, DG Evans
ADAMTS15 metalloproteinase inhibits breast cancer cell migration
L Wagstaff, R Kelwick, J Decock, H Arnold, C Pennington, D Jaworski, D Edwards
Macrophage-mediated breast cancer cell chemotaxis: the role of sphingosine kinase-1 activation
J Nunes, L Sauer, J Turner, J Waxman, J Sturge, D Pshezhetskiy
PLU-1/Jarid1B contributes to estrogen-induced cell proliferation in the normal mammary gland and in breast cancer, and is required for embryonic survival
S Catchpole, B Spencer-Dene, D Hall, A Scibetta, J Burchell, J Taylor-Papadimitriou
C-terminal binding proteins play a critical nuclear function in the mitotic fidelity of breast cancer cells
CN Birts, JP Blaydes
Transcriptional regulation of cyclin-dependent kinase inhibitor 1A (P21) by the transcription factor AP-2γ
AG Scibetta, M Canosa, HC Hurst
Developmental protein HOXC11 cooperates with SRC-1 in breast cancer: an adaptive response to endocrine therapy
M McIlroy, D McCartan, S Early, S Pennington, P O'Gaora, A Hill, L Young
Insulin-like growth factor binding protein-2 alters the sensitivity of breast cancer cells to chemotherapy
EJ Foulstone, JM Holly, L Zeng, ZE Winters, CM Perks
Clinicopathologic and molecular predictors of axillary lymph node metastasis in early-stage breast cancer: a mathematical predictive model
MA Aleskandarany, AR Green, EA Rakha, SE Elsheikh, DG Powe, EC Paish, IO Ellis
Assessing the functional role of caspase-8 gene variants in breast cancer
SH Rigas, M Parry, MW Reed, N Camp, A Cox
Polymorphisms, endogenous hormone levels and familial breast cancer risk in premenopausal women
K Walker, O Fletcher, N Johnson, C Palles, E Folkerd, SG Hillier, S Moss, L Gibson, M Dowsett, J Peto, I dos santos Silva
A randomised controlled trial of the psychoneuroimmunological effects of reflexology in women with early-stage breast cancer
DM Sharp, MB Walker, A Chaturvedi, S Upadhyay, A Hamid, AA Walker, J Bateman, F Braid, K Ellwood, C Hebblewhite, T Hope, M Lines, LG Walker
An integrated informatics platform to facilitate transforming tissue into knowledge
PR Quinlan, A Ashfield, L Jordan, C Purdie, AM Thompson
Effect of intermittent versus continuous energy restriction on weight loss and breast cancer risk biomarkers
M Harvie, M Pegington, J Cuzick, J Frystyk, A Flyvbjerg, S Jebb, M Mattson, A Howell
Thioredoxin and related redox systems as targets in breast cancer
CM Woolston, L Zhang, H Evans, A Al-Attar, M Shehata, G Balls, SY Chan, SG Martin
Could side population cells be an indicator of progression to hormone nonresponsive breast cancer
KM Britton, IJ Harvey, K Stemke-Hale, TWJ Lennard, AP Meeson
A novel tumour-based test to identify breast cancer due to BRCA1 and BRCA2 mutations
Q An, L Jones, W Tapper, C Chelala, M Iravani, A MacKay, V Hammond, L Durcan, S Gerty, A Ferguson, J Strefford, S Peock, J Reis-Filho, D Easton, A Ashworth, D Eccles
Melanoma-associated antigen family protein-D4: clinical significance and functional relevance in breast cancer
S Germano, S Rani, S Kennedy, J Crown, M Clynes, L O'Driscoll
Identification of molecular subtypes within a formalin-fixed, paraffin-embedded breast cancer tumour cohort
JM Mulligan, F McDyer, S Deharo, V Farztdinov, I Halfpenny, T Delaney, F Couch, JE Quinn, P Harkin, R Kennedy
Evaluating gene expression in formalin-fixed, paraffin-embedded breast cancer tissues using DASL®
T Burr, R Dixon, A Green, I Ellis, C Murray
miR-433 overexpression attenuates the spindle assembly checkpoint response to paclitaxel
F Furlong, M Prencipe, A McGoldrick, P McGettigan, D Carney, E Doyle, E Kay, A McCann
Breast calcification: the 'Cinderella' breast element?
KD Rogers, R Baker, N Stone
Expression of migration stimulating factor in breast tissues and its clinical significance
AM Schor, S Perrier, AM Woolston, SJ Jones, IR Ellis, MR Islam, S Kazmi, C Purdie, AM Thompson, SL Schor
Lack of correlation between markers of breast cancer initiating cells
Y Liu, PJ Coates, R Nenutil, MVCL Appleyard, K Murray, AM Thompson
Mitochondrial translocator protein modulates metabolism and pharmacologically induced apoptosis in breast cancer cells
A Gastaldello, P Gami, H Callaghan, M Campanella
Identification of proteins and signalling pathways involved in neoadjuvant chemotherapy responsiveness of breast tumours using proteomics
CR Greenwood, LC Alldridge, S Chandra Sekharan, K Al-Janabi, P Sauven, S Souchelnytskyi
Reduced MCPH1 expression in breast cancer and response to chemotherapy
J Richardson, A Shaaban, M Kamal, I Ellis, V Speirs, A Green, SM Bell
Anti-HER2 imaging agents for breast cancer imaging
B Tolner, K Vigor, S Mather, M Robinson, G Adams, A Plueckthun, K Chester
Predicting interaction networks of breast cancer risk genes using multiple microarray data
K Yano
Microarray based expression profiling of BRCA1 mutated human tumours using a breast-specific platform to identify a profile of BRCA1 deficiency
E Lamers, FA McDyer, JM Mulligan, F Couch, KI Savage, NE O'Brien, PB Mullan, RD Kennedy, DP Harkin, JE Quinn
FKBPL: a novel prognostic and predictive biomarker?
HD McKeen, C Byrne, PV Jithesh, C Donley, A Yakkundi, L McCallum, HO McCarthy, DG Hirst, T Robson
Stick or switch? Audit of the use of switch therapy from tamoxifen to an aromatase inhibitor in breast cancer
S Weeraman, C Hunsley, M Wall, R Kirby
Topoisomerase 2 alpha as a predictor of response to anthracycline neoadjuvant chemotherapy in locally advanced breast cancer
M Shehata, A Al-Attar, J Reis-Filho, I Ellis, A Mukherjee, S Chan
CYP2D6 genotype affects outcome in postmenopausal breast cancer patients treated with tamoxifen monotherapy
AM Thompson, S Bray, AM Johnson, P Quinlan, DM Nikloff, DG Evans, R Clarke, HJ Lawrence, A Howell, A Latif, R Ferraldeschl, G Hillman, M Fontecha, WG Newman
Recruitment of insulin receptor substrate-1 by erbB3 impacts on IGF-IR signalling in oestrogen receptor-positive breast cancer cells
JM Knowlden, JMW Gee, D Barrow, JF Robertson, IO Ellis, RI Nicholson, IR Hutcheson
Targeting DNA replication before it starts: Cdc7 as a therapeutic target in p53 mutant Her2 and triple negative breast cancer
R Sainsbury, I Proctor, S Rodriguez, M Loddo, S Tudzarova, K Stoeber, G Williams
Genetic engineering of pharmacologically regulated T cells, specific for breast cancer target antigens
S Wilkie, S Burbridge, DM Davies, L Chiapero-Stanke, J Foster, SJ Mather, J Maher
Radiotherapy fraction size sensitivity is modulated by DNA repair systems
N Somaiah, J Yarnold, F Daley, A Pearson, K Rothkamm, T Helleday
Opticin: a potent anti-angiogenic/antiproliferative agent for breast cancer therapy
SF Sneddon, BA Telfer, KJ Williams, PN Bishop, IJ Stratford, RL Cowen
Completion of 5-year adjuvant endocrine therapy in the community
B Makubate, AM Thompson, JA Dewar, C McCowan
Psychosocial impact of breast cancer diagnosis and treatment in African, Caribbean and South Asian women
G Patel, D Harcourt, N Rumsey, H Naqvi
Intensity and features of acute postoperative pain after mastectomy and breast-conserving surgery
S Marfizo, AJ Thornton, NW Scott, AM Thompson, SD Hays, J Bruce
Breast cancer knowledge among women with learning disabilities and their experiences of breast mammography
LG Taggart, S McIlfatrick, MN Truesdale-Kennedy
A TRAIL-R1-specific ligand in combination with doxorubicin selectively targets primary breast tumour cells for apoptosis
D Twiddy, S Naik, R Mistry, J Edwards, RA Walker, GM Cohen, M MacFarlane
Modelling breast cancer in a three-dimensional heterotypic culture system
DL Holliday, S Maltby, MA Moss, AM Hanby, JL Jones, V Speirs