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BioDrugs

Erschienen in:

01.12.2010 | Review Article

Systemic and Mucosal Delivery of Drugs within Polymeric Microparticles Produced by Spray Drying

verfasst von: Kristen Bowey, Dr Ronald J. Neufeld

Erschienen in: BioDrugs | Ausgabe 6/2010

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Abstract

Encapsulation of therapeutic and diagnostic materials into polymeric particles is a means to protect and control or target the release of active substances such as drugs, vaccines, and genetic material. In terms of mucosal delivery, polymeric encapsulation can be used to promote absorption of the active substance, while particles can improve the half-life of drugs administered systemically. Spray drying is an attractive technology used to produce such microparticles, because it combines both the encapsulation and drying steps in a rapid, single-step operation. Even so, spray drying is not classically associated with processes used for drug and therapeutic material encapsulation, since elevated temperatures could potentially denature the active substance. However, a comprehensive review of the literature revealed a number of studies demonstrating that spray drying can be used to produce microparticulate formulations with labile therapeutics. Polymers commonly employed include synthetics such as methacrylic copolymers and polyesters, and natural materials including chitosan and alginate. Drugs and active substances are diverse and included antibiotics, anti-inflammatory agents, and chemotherapeutics. Regarding the delivery of spray-dried particles, the pulmonary, oral, colonic, and nasal mucosal routes are often investigated because they offer a convenient means of administration, which promotes physician and patient compliance. In addition, spray drying has been widely used to produce polymeric microparticles for systemic delivery in order to control the delivery of drugs, vaccines, or genetic material that may exhibit poor pharmacokinetic profiles or pose toxicity concerns. This review presents a brief introduction to the technology of spray drying and outlines the delivery routes and the applications of spray-dried polymeric microparticles.

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Titel: Systemic and Mucosal Delivery of Drugs within Polymeric Microparticles Produced by Spray Drying
verfasst von: Kristen Bowey
Dr Ronald J. Neufeld
Publikationsdatum: 01.12.2010
Verlag: Springer International Publishing
Erschienen in: BioDrugs / Ausgabe 6/2010
Print ISSN: 1173-8804
Elektronische ISSN: 1179-190X
DOI: https://doi.org/10.2165/11539070-000000000-00000

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Systemic and Mucosal Delivery of Drugs within Polymeric Microparticles Produced by Spray Drying

Abstract

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

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