Skip to main content
main-content

15.12.2017 | review | Ausgabe 5/2019

Spektrum der Augenheilkunde 5/2019

Systemic side effects after intravitreal administration of antivascular endothelial growth factors for neovascular age-related macular degeneration

A systematic review

Zeitschrift:
Spektrum der Augenheilkunde > Ausgabe 5/2019
Autoren:
Alina Popa-Cherecheanu, Raluca Iancu, Danut Vasile, Ruxandra Pirvulescu, Aida Geamanu, Cristina Coman, George Iancu

Summary

Background

Age-related macular degeneration is a chronic and progressive disease of the retina that occurs with increasing frequency with age, representing the leading cause of irreversible blindness in patients over 50 years of age. The loss of visual perception occurs due to neovascular proliferation. Antivascular endothelial growth factors revolutionized the treatment of exudative age-related macular degeneration.

Materials and methods

Our aim was to assess the systemic safety of intravitreal administration of ranibizumab, bevacizumab, or aflibercept in patients with neovascular age-related macular degeneration. The study was conducted and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) checklist. The primary outcomes included: all-cause death and all serious systemic adverse events. We calculated the incidence of systemic adverse events, relative risk of the outcomes, and 95% confidence intervals.

Results

This review included representative outcome data on 12,292 participants from 24 trials, which included both men and women aged 50 years or older with neovascular age-related macular degeneration. In bevacizumab-treated patients, the most frequent systemic adverse event in our analysis was nonocular hemorrhage. In ranibizumab-treated patients, systemic adverse events were not dose-dependent. The number of systemic adverse events was similar in patients treated with ranibizumab (4.73%) or with aflibercept (4.76%).

Conclusion

This meta-analysis did not find any statistically significant difference regarding the occurrence of death or other serious systemic adverse events such as treatment-emergent hypertension, myocardial infarction, stroke, or nonocular hemorrhage after intravitreal use of antivascular endothelial growth factors.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 5/2019

Spektrum der Augenheilkunde 5/2019 Zur Ausgabe

Neu im Fachgebiet Augenheilkunde

22.10.2019 | Erkrankungen der Lider | CME | Ausgabe 11/2019

Floppy-Eyelid-Syndrom

Ein häufig unterdiagnostiziertes Krankheitsbild mit interdisziplinärer Bedeutung

24.09.2019 | Der Ophthalmologe | CME | Ausgabe 10/2019

Konjunktivale Malignome

18.09.2019 | Leitthema | Ausgabe 10/2019

Toxizität von schweren Flüssigkeiten