Erschienen in:
01.11.2008
T Regulatory Cells in Autoimmune Diabetes: Past Challenges, Future Prospects
verfasst von:
Jeffrey A. Bluestone, Qizhi Tang, Caitlin E. Sedwick
Erschienen in:
Journal of Clinical Immunology
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Ausgabe 6/2008
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Abstract
Introduction
Accumulating evidence suggests that defective regulation is an essential underlying cause of autoimmunity. The development of type 1 diabetes in the NOD mouse strain it is a complex process that depends on a fine balance between pathogenic and regulatory pathways.
Discussion
We have utilized a series of transgenic and knockout mice to determine the relative importance of regulatory T cells and negative regulatory receptors on the development and progression of type 1 diabetes.
Conclusion
This review will focus on the origins and function of Treg in peripheral self-tolerance. We will summarize the role of Treg in preventing autoimmune diseases, with a particular focus on Type 1 Diabetes (T1D), and discuss the prospects for Treg-based therapies for autoimmune diseases.