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Journal of Clinical Immunology

Erschienen in:

01.11.2008

Molecular Mechanisms of Regulatory T Cell Development

verfasst von: Talal Chatila

Erschienen in: Journal of Clinical Immunology | Ausgabe 6/2008

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Abstract

Background

CD4⁺CD25⁺ natural regulatory T (nT_R) lymphocytes represent a distinct thymus-derived T cell lineage that serves to establish immunological tolerance in the periphery. The discovery of Foxp3 as a transcription factor essential to the differentiation of CD4⁺CD25⁺ T_R cells enabled detailed studies into the molecular mechanisms of T_R cell development, peripheral homeostasis, and effector functions.

Discussion

Comparative analysis of Foxp3⁺ nT_R cells and nT_R cell precursors expressing a functionally inactive Foxp3 mutant protein indicated that while Foxp3 is not essential for nT_R cell development in the thymus, it is critical to the peripheral homeostasis and suppressor functions of nT_R cells. A second subset of Foxp3⁺ regulatory T cells can be induced de novo from conventional CD4⁺ Foxp3⁻ T cells both in vitro, upon antigenic stimulation in the presence of transforming growth factor β and interleukin-2, and in vivo. Like nT_R cells, the induced regulatory T (iT_R) cells are also dependent on Foxp3 expression for their suppressor function. It is likely that nT_R and iT_R cells serve nonredundant functions in the maintenance of immunological tolerance.

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Titel: Molecular Mechanisms of Regulatory T Cell Development
verfasst von: Talal Chatila
Publikationsdatum: 01.11.2008
Verlag: Springer US
Erschienen in: Journal of Clinical Immunology / Ausgabe 6/2008
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-008-9241-0

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