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Targeted Oncology
Erschienen in: Targeted Oncology 1/2012

01.03.2012 | Review

Targeting regulatory T cells

verfasst von: Christine Ménétrier-Caux, Tyler Curiel, Julien Faget, Manuarii Manuel, Christophe Caux, Weiping Zou

Erschienen in: Targeted Oncology | Ausgabe 1/2012

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Abstract

Cancers express tumor-associated antigens that should elicit immune response to antagonize the tumor growth, but spontaneous immune rejection of established cancer is rare, suggesting an immunosuppressive environment hindering host antitumor immunity. Among the specific and active tumor-mediated mechanisms, CD4+CD25high T regulatory cells (Treg) are important mediators of active immune evasion in cancer. In this review, we will discuss Treg subpopulations and the mechanisms of their suppressive functions. Treg depletion improves endogenous antitumor immunity and the efficacy of active immunotherapy in animal models for cancer, suggesting that inhibiting Treg function could also improve the limited successes of human cancer immunotherapy. We will also discuss specific strategies for devising effective cancer immunotherapy targeting Treg.
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Metadaten
Titel
Targeting regulatory T cells
verfasst von
Christine Ménétrier-Caux
Tyler Curiel
Julien Faget
Manuarii Manuel
Christophe Caux
Weiping Zou
Publikationsdatum
01.03.2012
Verlag
Springer-Verlag
Erschienen in
Targeted Oncology / Ausgabe 1/2012
Print ISSN: 1776-2596
Elektronische ISSN: 1776-260X
DOI
https://doi.org/10.1007/s11523-012-0208-y

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