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Archives of Gynecology and Obstetrics

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01.04.2009 | Case Report

Term delivery following successful treatment of choriocarcinoma with brain metastases, a case report and review of literature

verfasst von: Nadereh Behtash, Fariba Behnamfar, Bahareh Hamedi, Fatemeh Ramezanzadeh

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 4/2009

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Abstract

Background

Cerebral metastases from choriocarcinoma are a poor prognostic indicator of outcome in both the World Health Organization and FIGO classification systems. Although gestational trophoblastic neoplasia has become the most curable of gynecological malignancies, failure rate among “high-risk” patients is still high despite of the use of aggressive multidrug regimens.

Case

A 27-year-old woman (G₄P₂Ab₁) presented with hemiplegia due to brain metastases of choriocarcinoma 1 year after spontaneous abortion. She underwent craniotomy and was treated with nine courses of multiple agent etoposide, methotrexate, actinomycin- etoposide, and cisplatinum (EMA-EP) regimen combined with whole brain irradiation. She delivered a term healthy child 2 years after termination of treatment.

Conclusion

Multiagent EMA-EP chemotherapy and whole brain irradiation with craniotomy in selected patients preserves fertility and may improve a patient overall prognosis.

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Titel: Term delivery following successful treatment of choriocarcinoma with brain metastases, a case report and review of literature
verfasst von: Nadereh Behtash
Fariba Behnamfar
Bahareh Hamedi
Fatemeh Ramezanzadeh
Publikationsdatum: 01.04.2009
Verlag: Springer-Verlag
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 4/2009
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-008-0753-x

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