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European Radiology
Erschienen in: European Radiology 5/2021

30.10.2020 | Musculoskeletal

Texture analysis using T1-weighted images for muscles in Charcot-Marie-Tooth disease patients and volunteers

verfasst von: Ji Hyun Lee, Young Cheol Yoon, Hyun Su Kim, Jae-Hun Kim, Byung-Ok Choi

Erschienen in: European Radiology | Ausgabe 5/2021

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Abstract

Objectives

To explore whether texture features using T1-weighted images correlate with fat fraction, and whether they differ between Charcot-Marie-Tooth (CMT) disease patients and volunteers.

Methods

The institutional review board approved this retrospective study, and the requirement for informed consent was waived; data of eighteen CMT patients and eighteen healthy volunteers from a previous study was used. Texture features of the muscles including mean, standard deviation (SD), skewness, kurtosis, and entropy of the signal intensity were derived from T1-weighted images. Spearman’s correlation analysis was used to assess the relationship between texture features and fat fraction measured by 3D multiple gradient echo Dixon-based sequence. Mann-Whitney U test was used to compare the texture features between CMT patients and volunteers. Intraobserver and interobserver agreements for the texture features were assessed using the intraclass correlation coefficient.

Results

The SD (ρ = 0.256, p < 0.001) and entropy (ρ = 0.263, p < 0.001) were significantly and positively correlated with fat fraction; skewness (ρ = − 0.110, p = 0.027) and kurtosis (ρ = − 0.149, p = 0.003) were significantly and inversely correlated with fat fraction. The CMT patients showed a significantly higher SD (63.45 vs. 49.26; p < 0.001), skewness (1.06 vs. 0.56; p < 0.001), kurtosis (4.00 vs. 1.81; p < 0.001), and entropy (3.20 vs. 3.02; p < 0.001) than did the volunteers. Intraobserver and interobserver agreements were almost perfect for mean, SD, and entropy.

Conclusions

Texture features using T1-weighted images correlated with fat fraction and differed between CMT patients and volunteers.

Key Points

• Standard deviation and entropy of muscles derived from T1-weighted images were significantly and positively correlated with the muscle fat fraction.
• Mean, standard deviation, and entropy were considered highly reliable in muscle analyses.
• Texture features may have the potential to diagnose early stage of intramuscular fatty infiltration.
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Metadaten
Titel
Texture analysis using T1-weighted images for muscles in Charcot-Marie-Tooth disease patients and volunteers
verfasst von
Ji Hyun Lee
Young Cheol Yoon
Hyun Su Kim
Jae-Hun Kim
Byung-Ok Choi
Publikationsdatum
30.10.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 5/2021
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-020-07435-y

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