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Inflammopharmacology

Erschienen in:

08.11.2020 | Review

The anti-inflammatory role of SSRI and SNRI in the treatment of depression: a review of human and rodent research studies

verfasst von: Vlad Dionisie, Gabriela Adriana Filip, Mihnea Costin Manea, Mirela Manea, Sorin Riga

Erschienen in: Inflammopharmacology | Ausgabe 1/2021

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Abstract

Rationale

Depression has the topmost prevalence of all psychiatric diseases. It is characterized by a high recurrence rate, disability, and numerous and mostly unclear pathogenic mechanisms. Besides the monoamine or the neurotrophic hypothesis of depression, the inflammatory mechanism has begun to be supported by more and more evidence. At the same time, the current knowledge about the standard treatment of choice, the selective serotonin reuptake inhibitors (SSRIs) and serotonin and noradrenaline reuptake inhibitors (SNRIs), is expanding rapidly, adding more features to the initial ones.

Objectives

This review summarizes the in vivo anti-inflammatory effects of SSRIs and SNRIs in the treatment of depression and outlines the particular mechanisms of these effects for each drug separately. In addition, we provide an overview of the inflammation-related theory of depression and the underlying mechanisms.

Results

SSRIs and SNRIs decrease the neuroinflammation through multiple mechanisms including the reduction of blood or tissue cytokines or regulating complex inflammatory pathways: nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), inflammasomes, Toll-like receptor 4 (TLR4), peroxisome proliferator-activated receptor gamma (PPARγ). Also, SSRIs and SNRIs show these effects in association with an antidepressant action.

Conclusions

SSRIs and SNRIs have an anti-neuroinflammatory role which might contribute the antidepressant effect.

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Titel: The anti-inflammatory role of SSRI and SNRI in the treatment of depression: a review of human and rodent research studies
verfasst von: Vlad Dionisie
Gabriela Adriana Filip
Mihnea Costin Manea
Mirela Manea
Sorin Riga
Publikationsdatum: 08.11.2020
Verlag: Springer International Publishing
Erschienen in: Inflammopharmacology / Ausgabe 1/2021
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI: https://doi.org/10.1007/s10787-020-00777-5

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The anti-inflammatory role of SSRI and SNRI in the treatment of depression: a review of human and rodent research studies

Abstract

Rationale

Objectives

Results

Conclusions

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Rationale

Objectives

Results

Conclusions

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