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Erschienen in: Clinical and Experimental Nephrology 10/2019

27.06.2019 | Original article

The association between cardiac valvular calcification and fetuin-A levels in kidney transplant recipients

verfasst von: Nizameddin Koca, Alparslan Ersoy, Barış Şensoy, Emine Kırhan, Sümeyye Güllülü, Canan Ersoy, Melahat Dirican, Emre Sarandöl

Erschienen in: Clinical and Experimental Nephrology | Ausgabe 10/2019

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Abstract

Objectives

Low fetuin-A levels in hemodialysis patients can be associated with development of vascular and valvular calcifications. The mechanisms underlying vascular and valvular calcifications are multifactorial. There are a few studies showing the relationship between low fetuin-A levels and valvular calcification after kidney transplantation. We aimed to evaluate the association between serum fetuin-A levels and valvular calcification in kidney transplant recipients.

Methods

The cardiac valvular calcification was assessed by echocardiography in 56 recipients. Patients were divided into two groups as those with (n = 11) and without (n = 45) aortic and/or mitral valve calcification. The extent of valvular calcification was visually assessed according to the standard visual score method: moderately (multiple larger spots) and heavily calcified (extensive thickening and calcification) of all cusps. Serum fetuin-A levels were measured.

Results

The demographic features of both groups were comparable. There was no significant difference between regular physical exercise (63.6% vs. 55.6%), obesity (18.2% vs. 17.8%), abdominal obesity (54.5% vs. 46.7%), smoking (0% vs. 13.3%), hypertension (63.6% vs. 68.9%), left ventricular hypertrophy (45.5% vs. 33.3%) and diabetes mellitus (9.1% vs. 20%) ratios in groups with or without valvular calcification, respectively (p > 0.05). Fetuin-A levels of both groups did not differ. Fetuin-A levels positively correlated with serum creatinine (r 0.326, p = 0.014), and negatively correlated with estimated glomerular filtration rate (r − 0.297, p = 0.026).

Conclusions

We could not find a relationship between serum fetuin-A levels and valvular calcification in kidney recipients. In this population, further studies are needed to assess the role of serum fetuin-A in valvular calcification.
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Metadaten
Titel
The association between cardiac valvular calcification and fetuin-A levels in kidney transplant recipients
verfasst von
Nizameddin Koca
Alparslan Ersoy
Barış Şensoy
Emine Kırhan
Sümeyye Güllülü
Canan Ersoy
Melahat Dirican
Emre Sarandöl
Publikationsdatum
27.06.2019
Verlag
Springer Singapore
Erschienen in
Clinical and Experimental Nephrology / Ausgabe 10/2019
Print ISSN: 1342-1751
Elektronische ISSN: 1437-7799
DOI
https://doi.org/10.1007/s10157-019-01761-2

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