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Erschienen in:

01.10.2011 | Original paper

The association between height and prostate cancer grade in the Early Stage Prostate Cancer Cohort Study

verfasst von: Wildon R. Farwell, Christopher Lourenco, Erika Holmberg, Robert B. Hall, Leonard D’Avolio, Elizabeth V. Lawler, J. Michael Gaziano

Erschienen in: Cancer Causes & Control | Ausgabe 10/2011

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Abstract

Objective

We examined the relationship between height and prostate cancer grade.

Methods

The Early Stage Prostate Cancer Cohort Study is an observational cohort of 1,037 men diagnosed with early-stage prostate cancer, T_0–3N_xM₀. High-grade prostate cancer was defined as a biopsy Gleason score ≥ 7 (4 + 3). Logistic regression models were created to calculate odds ratios (OR) and 95% confidence intervals (CI) for the cross-sectional relationship between height and prostate cancer grade in the overall cohort and subpopulations.

Results

We identified 939 participants with a biopsy Gleason score. High-grade prostate cancer was diagnosed in 138 participants. Overall, participants in the highest quartile of height were more than twice as likely to have a Gleason score ≥ 7 (4 + 3) than participants in the lowest quartile of height, OR 2.14 (95% CI 1.11, 4.14), after multivariate adjustment. Participants in the highest quartile of height were more likely to be diagnosed with high-grade prostate cancer than participants in the lowest quartile of height among participants who were black, OR 8.00 (95% CI 1.99, 32.18), and participants who had diabetes mellitus, OR 5.09 (95% CI 1.30, 19.98).

Conclusions

Height is associated with increased risk of high-grade prostate cancer overall and perhaps among certain subpopulations.

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Titel: The association between height and prostate cancer grade in the Early Stage Prostate Cancer Cohort Study
verfasst von: Wildon R. Farwell
Christopher Lourenco
Erika Holmberg
Robert B. Hall
Leonard D’Avolio
Elizabeth V. Lawler
J. Michael Gaziano
Publikationsdatum: 01.10.2011
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 10/2011
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-011-9820-x

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The association between height and prostate cancer grade in the Early Stage Prostate Cancer Cohort Study