Erschienen in:
01.10.2011 | Materno-fetal Medicine
The association between inherited thrombophilias and pregnancy-related hypertension recurrence
verfasst von:
Inanc Mendilcioglu, Turker Bilgen, Yunus Arikan, Ibrahim Keser, Mehmet Simsek, Aysen Timuragaoglu
Erschienen in:
Archives of Gynecology and Obstetrics
|
Ausgabe 4/2011
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Abstract
Purpose
The aim of this study was to determine the association between inherited thrombophilias and pregnancy-related hypertension recurrence.
Methods
In this case–control study, blood samples were obtained from patients who had at least two pregnancies complicated with pregnancy-related hypertension (n = 41) and healthy, normotensive pregnancies delivered without any complication (n = 38). Following the DNA extraction, samples were tested for factor V Leiden, prothrombin G20210A and homozygous methylene tetrahydrofolate reductase (MTHFR) C677T mutations using reverse hybridization method.
Results
Common inherited thrombophilias were present in 26.8% of women with recurrent pregnancy-related hypertension group and 23.7% of control subjects (odds ratio 1.1; 95% confidence interval, 0.6–1.9). No significant difference was observed between two groups in terms of factor V Leiden, prothrombin G20210A and MTHFR C677T mutations.
Conclusion
Our data suggest that factor V Leiden, prothrombin G20210A and MTHFR C677T mutations are not associated with pregnancy-related hypertension recurrence.