Introduction
Methods
Literature search
Inclusion and exclusion criteria
Data extraction
Statistical methods
Results
Study characteristics
First author | Year | Country | Ethnicity | Study type | Genotype method | Sample size | P
HWE
| |
---|---|---|---|---|---|---|---|---|
Case | Control | |||||||
Sanyal et al. | 2004 | Sweden | Caucasian | PB | PCR-RFLP | 309 | 246 | 0.294 |
Sak et al. | 2005 | England | Caucasian | HB | TaqMan | 532 | 561 | 0.191 |
Garcia-Closas et al. | 2006 | Spain | Caucasian | HB | TaqMan | 1137 | 1138 | 0.470 |
Wu et al. | 2006 | USA | Caucasian | HB | TaqMan | 606 | 596 | 0.744 |
Zhu et al. | 2007 | USA | Caucasian | HB | Taqman | 550 | 554 | 0.668 |
Fontana et al. | 2008 | French | Caucasian | HB | TaqMan | 51 | 45 | 0.456 |
de Verdier et al. | 2010 | Sweden | Caucasian | PB | PCR-RFLP | 305 | 328 | 0.147 |
Gangwar et al. | 2010 | India | Asian | HB | PCR-RFLP | 208 | 245 | 0.054 |
Rouissi et al.1 | 2011 | Tunisia | African | HB | PCR-RFLP | 193 | 193 | 0.537 |
Rouissi et al.2 | 2011 | Tunisia | African | HB | PCR-RFLP | 125 | 125 | 0.449 |
Mittal et al. | 2012 | India | Asian | PB | PCR-RFLP | 212 | 250 | 0.073 |
Liu et al. | 2012 | China | Asian | HB | PCR-RFLP | 600 | 609 | 0.824 |
Meta-analysis results
Variables | No. of studies | OR (95% CI) | Ph | P | OR (95% CI) | Ph | P | OR (95% CI) | Ph | P |
---|---|---|---|---|---|---|---|---|---|---|
Gln/Gln vs Lys/Lys | Gln/Gln vs Gln/Lys | Gln/Lys vs Lys/Lys | ||||||||
Total | 9 | 1.352 (1.088 1.681) | 0.000 |
0.00
| 1.354 (1.085 1.688) | 0.001 |
0.007
| 1.017 (0.932 1.109) | 0.592 | 0.712 |
Ethnicity
| ||||||||||
Caucasian | 3 | 1.240 (0.927 1.658) | 0.002 | 0.148 | 1.184 (0.913 1.536) | 0.006 | 0.203 | 1.041 (0.938 1.155) | 0.278 | 0.448 |
African | 3 | 1.758 (1.097 2.819) | 0.373 |
0.019
| 1.800 (0.969 3.342) | 0.196 | 0.063 | 0.955 (0.680 1.341) | 0.575 | 0.791 |
Asian | 2 | 1.476 (1.110 1.962) | 0.554 |
0.007
| 1.586 (1.105 2.276) | 0.256 |
0.012
| 0.962 (0.802 1.154) | 0.655 | 0.677 |
Source of controls
| ||||||||||
HB | 5 | 1.225 (0.967 1.551) | 0.009 | 0.093 | 1.233 (0.969 1.570) | 0.88 | 0.088 | 1.017 (0.924 1.120) | 0.382 | 0.728 |
PB | 3 | 1.854 (1.338 2.569) | 0.958 |
0.000
| 1.806 (1.310 2.491) | 0.896 |
0.000
| 1.013 (0.823 1.247) | 0.678 | 0.900 |
Variables
|
No. of studies
|
OR (95% CI)
|
Ph
|
P
|
OR (95% CI)
|
Ph
|
P
|
OR (95% CI)
|
Ph
|
P
|
Lys/Lys vs Gln/Gln + Gln/Lys (dominant model)
|
Gln/Gln vs Gln/Lys + Lys/Lys (recessive model)
|
Gln allele vs Lys allele
| ||||||||
Total | 9 | 0.945 (0.867 1.029) | 0.397 | 0.194 | 1.362 (1.099 1.688) | 0.18 | 0.18 | 1.109 (1.013 1.214) | 0.019 |
0.024
|
Ethnicity
| ||||||||||
Caucasian | 3 | 0.940 (0.814 1.085) | 0.086 | 0.397 | 1.219 (0.934 1.591) | 0.002 | 0.145 | 1.097 (0.960 1.254) | 0.003 | 0.175 |
African | 3 | 0.890 (0.649 1.220) | 0.948 | 0.468 | 1.781 (1.057 3.002) | 0.241 |
0.030
| 1.258 (1.001 1.579) | 0.546 | 0.049 |
Asian | 2 | 0.954 (0.803 1.133) | 0.846 | 0.590 | 1.489 (1.130 1.962) | 0.357 |
0.005
| 1.123 (0.989 1.275) | 0.996 | 0.073 |
Source of controls
| ||||||||||
HB | 5 | 0.962 (0.865 1.070) | 0.264 | 0.480 | 1.239 (0.982 1.563) | 0.003 | 0.071 | 1.078 (0.971 1.197) | 0.021 | 0.160 |
PB | 3 | 0.874 (0.718 1.065) | 0.655 | 0.183 | 1.824 (1.343 2.477) | 0.956 |
0.000
| 1.233 (1.067 1.423) | 0.749 |
0CPA004
|