Background
Results
Overall miRNA expression in blood of lung cancer patients
Differential miRNA expression profiles in blood of patients with histological different lung cancer types
MiRNA | Adenocarcinoma vs squamous cell lung cancer | Adenocarcinoma vs SCLC | Squamous cell lung cancer vs SCLC | NSCLC vs SCLC |
---|---|---|---|---|
hsa-miR-296-5p |
0.009293704
|
0.002492158
| - | - |
hsa-miR-4286 |
-
| - | 0.042230044 | - |
hsa-miR-125b |
-
|
0.028149193
| - | - |
hsa-miR-222 |
-
| - | 0.04703922 | - |
hsa-miR-1202 |
0.007974179
| - | - | - |
hsa-miR-30c |
-
|
0.041578614
| - | - |
hsa-miR-30d |
0.023430857
| - | - | - |
hsa-miR-484 |
-
|
0.030142088
| - | - |
hsa-miR-191 |
0.037639111
| - | - | - |
hsa-miR-378* |
0.019775161
|
0.010497338
| - | - |
hsa-miR-494 |
0.019335653
| - | - | - |
hsa-miR-20a | 0.013479972 | - | - | - |
hsa-miR-93* |
0.047492422
|
-
| - | - |
hsa-miR-185 |
0.021057518
|
0.02356637
| - | - |
hsa-miR-93 | 0.025342321 | - | - | - |
hsa-miR-550a* |
0.031935527
|
0.021650736
| - | - |
hsa-miR-423-3p |
-
|
0.014698713
| - | - |
hsa-let-7c | - | 0.036109015 | - | 0.038753591 |
hsa-let-7f | 0.043924552 | - | - | - |
hsa-let-7 g | 0.015803657 | - | - | - |
hsa-miR-17 | 0.017017848 | - | - | - |
hsa-miR-16 | 0.04337876 | - | - | - |
hsa-miR-664 |
0.029957884
| - | - | - |
hsa-miR-26b | 0.044474487 | - | - | - |
hsa-miR-146a | - | 0.033986273 | - | - |
hsa-miR-107 | 0.031934222 | 0.023377571 | - | - |
MiRNA | Adenocarcinoma vs squamous cell lung cancer | Adenocarcinoma vs SCLC | Squamous cell lung cancer vs SCLC | NSCLC vs SCLC |
---|---|---|---|---|
hsa-miR-320b |
1.565908352
| - | 1.647174369 | - |
hsa-miR-320a |
1.682325336
| - | - | - |
hsa-miR-16-2* | - | 1.556819993 | 1.584825817 | 1.547144675 |
hsa-miR-425* | - |
1.558378991
| - | - |
hsa-miR-1825 | - |
1.601678188
| - | - |
hsa-miR-126 | 1.891966989 | - | - | - |
hsa-miR-19a | 1.649266976 | 2.162558226 | - | 1.578154988 |
hsa-miR-144* | 2.055635088 | - | - | - |
hsa-miR-1238 | - |
1.615812614
| - | - |
hsa-miR-1202 |
1.794851186
|
-
| - | - |
hsa-miR-33b* | - |
3.71072872
|
2.277178734
|
3.455716247
|
hsa-miR-3180-3p | - |
1.540492953
| - | - |
hsa-miR-21 | 1.576532119 | 1.517125311 | - | - |
hsa-miR-494 |
3.238384244
|
2.523949933
| - |
1.604162158
|
hsa-miR-125b | - |
1.893914674
| - | 1.576963025 |
hsa-miR-4286 | - | - |
1.606159073
| 1.505950661 |
hsa-miR-3651 |
1.507544659
| - | - | - |
hsa-miR-940 |
1.513643787
| - | - | - |
hsa-miR-20a |
1.807832821
| 1.644649446 | - | - |
hsa-miR-1228 |
1.613581053
| - | - | - |
hsa-miR-3162 |
1.560608345
| - | - | - |
hsa-miR-98 | 1.657974523 | - | - | - |
hsa-miR-96 | 1.65850084 | 1.519616853 | - | - |
hsa-miR-191* | - |
1.557935486
| - | - |
hsa-let-7b | - | - | 1.633347369 | - |
hsa-let-7a | 1.545768531 | - |
1.522487952
| - |
hsa-let-7 g |
1.580842517
| - | - | - |
hsa-miR-142-3p | 2.29109294 | 2.221864576 | - | 1.563956799 |
hsa-miR-197 | - |
1.506054329
| - | - |
hsa-miR-26b |
2.299936662
| - |
1.58391195
| - |
hsa-miR-146a | - |
1.681236456
| - | - |
hsa-miR-1281 | - |
1.501429345
| - | - |
hsa-miR-1280 |
1.601529185
| - | - | - |
Influence of metastases on the miRNA expression
Adenocarcinoma | Squamous cell lung carcinoma | SCLC | |
---|---|---|---|
accuracy, mean | 0.7526 | 0.5079 | 0.7526 |
specificity, mean | 0.8 | 0.4666 | 0.7792 |
sensitivity, mean | 0.7 | 0.545 | 0.7072 |
AUC, mean | 0.73 | 0.54 | 0.82 |
selected miRNAs | hsa-miR-361-5p hsa-miR-3651 hsa-miR-28-5p | hsa-miR-378* | hsa-miR-103 |
hsa-miR-423-3p | hsa-miR-328 | ||
hsa-miR-550a* | hsa-miR-15b | ||
hsa-miR-199a-5p |
Effect of cigarette smoke on the miRNA expression
Discussion
Conclusions
Materials and methods
Patients
Adenocarcinoma | Squamous cell lung cancer | SCLC | Χ2p-value | |
---|---|---|---|---|
number of samples | 20 | 20 | 20 | |
mean age, years (SD) | 63.5 (±10.15) | 65 (±8.12) | 63 (±10.15) | |
range | ||||
gender, n | 0.911 | |||
female | 5 | 5 | 4 | |
male | 15 | 15 | 16 | |
smoking, n | 0.0001989 | |||
never-smoker | 12 | 2 | 2 | |
current or former smoker | 8 | 18 | 18 | |
Staging, n | 0.02329 | |||
I-II | 7 | 2 | 1 | |
III-IV | 12 | 17 | 18 | |
unknown | 1 | 1 | 1 | |
metastases, n | 0.6095 | |||
M0 | 9 | 10 | 7 | |
M1a / M1b | 10 | 9 | 12 |