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European Spine Journal
Erschienen in: European Spine Journal 5/2013

01.05.2013 | Review Article

The challenge and advancement of annulus fibrosus tissue engineering

verfasst von: Li Jin, Adam L. Shimmer, Xudong Li

Erschienen in: European Spine Journal | Ausgabe 5/2013

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Abstract

Background

Intervertebral disc degeneration, a main cause of back pain, is an endemic problem and a big economic burden for the health care system. Current treatments are symptom relieving but do not address underlying problems—biological and structural deterioration of the disc. Tissue engineering is an emerging approach for the treatment of intervertebral disc degeneration since it restores the functionality of native tissues. Although numerous studies have focused on the nucleus pulposus tissue engineering and achieved successes in laboratory settings, disc tissue engineering without annulus fibrosus for the end stage of disc degeneration is deemed to fail. The purpose of this article is to review the advancement of annulus fibrosus tissue engineering.

Material and Methods

Relevant articles regarding annulus fibrosus tissue engineering were identified in PubMed and Medline databases.

Results

The ideal strategy for disc regeneration is to restore the function and integrity of the disc by using biomaterials, native matrices, growth factors, and cells that producing matrices. In the past decades there are tremendous advancement in annulus fibrosus tissue engineering including cell biology, biomaterials, and whole disc replacement. The recent promising results on whole disc tissue engineering—a composite of annulus fibrosus and nucleus pulposus—make the tissue engineering approach more appealing.

Conclusion

Despite the promising results in disc tissue engineering, there is still much work to be done regarding the clinical application.
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Metadaten
Titel
The challenge and advancement of annulus fibrosus tissue engineering
verfasst von
Li Jin
Adam L. Shimmer
Xudong Li
Publikationsdatum
01.05.2013
Verlag
Springer-Verlag
Erschienen in
European Spine Journal / Ausgabe 5/2013
Print ISSN: 0940-6719
Elektronische ISSN: 1432-0932
DOI
https://doi.org/10.1007/s00586-013-2663-2

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Answer to the Letter to the Editor of T.A. Mattei concerning “Far lateral approaches (XLIF) in adult scoliosis” by P. Berjano and C. Lamartina (Eur Spine J. 2012 Jul 27. [Epub ahead of print])

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Announcements for issue 5, 2013

Author's Reply

Answer to the letter to the editor of Hilla Sarig Bahat entitled “Do these large numbers contrast multiple smaller-number prior studies?”

Original Article

What are the associative factors of adjacent segment degeneration after anterior cervical spine surgery? Comparative study between anterior cervical fusion and arthroplasty with 5-year follow-up MRI and CT

Original Article

Long-term health care utilisation and costs after spinal fusion in elderly patients

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
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Update Orthopädie und Unfallchirurgie

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