nach oben

Diabetologia

Erschienen in:

01.01.2015 | Commentary

The dark side of islet vasculature

verfasst von: Peter In’t Veld, Eckhard Lammert

Erschienen in: Diabetologia | Ausgabe 1/2015

Einloggen, um Zugang zu erhalten

Excerpt

Pancreatic islets are highly vascularised and contain about five times more capillaries than exocrine pancreatic tissue [1, 2]. In addition, the islets receive 5–15% of the entire pancreatic blood supply, even though they represent only 1–2% of the pancreatic mass [3]. Moreover, as determined by beta cell- or pancreas-specific deletion of vascular endothelial growth factor-A (VEGF-A), the islet microvasculature is required for normal insulin release and physiological blood glucose levels [4, 5], indicating that a dense islet vasculature is needed for proper islet function. In addition, VEGF-A is necessary for proper islet revascularisation following islet transplantation [5, 6]. …

Bonner-Weir S, Orci L (1982) New perspectives on the microvasculature of the islets of Langerhans in the rat. Diabetes 31:883–889PubMedCrossRef

Konstantinova I, Lammert E (2004) Microvascular development: learning from pancreatic islets. BioEssays 26:1069–1075PubMedCrossRef

Ballian N, Brunicardi FC (2007) Islet vasculature as a regulator of endocrine pancreas function. World J Surg 31:705–714PubMedCrossRef

Lammert E, Gu G, McLaughlin M et al (2003) Role of VEGF-A in vascularization of pancreatic islets. Curr Biol 13:1070–1074PubMedCrossRef

Brissova M, Shostak A, Shiota M et al (2006) Pancreatic islet production of vascular endothelial growth factor-A is essential for islet vascularization, revascularization, and function. Diabetes 55:2974–2985PubMedCrossRef

Lai Y, Schneider D, Kidszun A et al (2005) Vascular endothelial growth factor increases functional beta-cell mass by improvement of angiogenesis of isolated human and murine pancreatic islets. Transplantation 79:1530–1536PubMedCrossRef

Olsson R, Carlsson PO (2011) A low-oxygenated subpopulation of pancreatic islets constitutes a functional reserve of endocrine cells. Diabetes 60:2068–2075PubMedCentralPubMedCrossRef

Lau J, Svensson J, Grapensparr L, Johansson A, Carlsson PO (2012) Superior beta cell proliferation, function and gene expression in a subpopulation of rat islets identified by high blood perfusion. Diabetologia 55:1390–1399PubMedCrossRef

Henriksnäs J, Lau J, Zang G, Berggren PO, Köhler M, Carlsson PO (2012) Markedly decreased blood perfusion of pancreatic islets transplanted into the liver. Diabetes 61:665–673PubMedCentralPubMedCrossRef

10.

Schuit F, de Vos A, Farfari S (1997) Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells. J Biol Chem 272:18572–18579PubMedCrossRef

11.

Nikolova G, Jabs N, Konstantinova I et al (2006) The vascular basement membrane: a niche for insulin gene expression and beta cell function. Dev Cell 10:397–405PubMedCrossRef

12.

Johansson M, Mattsson G, Andersson A, Jansson L, Carlsson PO (2006) Islet endothelial cells and pancreatic beta-cell proliferation: studies in vitro and during pregnancy in adult rats. Endocrinology 147:2315–2324PubMedCrossRef

13.

Ullsten S, Lau J, Carlsson P-O (2014) Vascular heterogeneity between native rat pancreatic islets is responsible for differences in survival and revascularisation post transplantation. Diabetologia. doi:10.1007/s00125-014-3385-7 PubMed

14.

Atkinson MA, Bluestone JA, Eisenbarth GS et al (2011) How does type 1 diabetes develop? The notion of homicide or beta-cell suicide revisited. Diabetes 60:1370–1379PubMedCentralPubMedCrossRef

15.

Kang S, Park HS, Jo A et al (2012) Endothelial progenitor cell cotransplantation enhances islet engraftment by rapid revascularization. Diabetes 61:866–876PubMedCentralPubMedCrossRef

16.

Shimoda M, Chen S, Noguchi H, Matsumoto S, Grayburn PA (2010) In vivo non-viral gene delivery of human vascular endothelial growth factor improves revascularization and restoration of euglycaemia after human islet transplantation into mouse liver. Diabetologia 53:1669–1679PubMedCentralPubMedCrossRef

17.

Brissova M, Fowler MJ, Nicholson WE et al (2005) Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy. J Histochem Cytochem 53:1087–1097PubMedCrossRef

18.

Carbrera O, Berman DM, Kenyon NS, Ricordi C, Berggren PO, Caicedo A (2006) The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc Natl Acad Sci 103:2334–2339CrossRef

19.

Nyman LR, Wells KS, Head WS et al (2008) Real-time, multidimensional in vivo imaging used to investigate blood flow in mouse pancreatic islets. J Clin Invest 118:3790–3797PubMedCentralPubMedCrossRef

20.

In’t Veld P (2011) Insulitis in human type 1 diabetes: the quest for an elusive lesion. Islets 3:131–138PubMedCentralPubMedCrossRef

21.

Westermark P, Wilander E (1978) The influence of amyloid deposits on the islet volume in maturity onset diabetes mellitus. Diabetologia 15:417–421PubMedCrossRef

22.

Keymeulen B, Gillard P, Mathieu C et al (2006) Correlation between beta cell mass and glycemic control in type 1 diabetic recipients of islet graft. Proc Natl Acad Sci U S A 103:17444–17449PubMedCentralPubMedCrossRef

Titel: The dark side of islet vasculature
verfasst von: Peter In’t Veld
Eckhard Lammert
Publikationsdatum: 01.01.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Diabetologia / Ausgabe 1/2015
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-014-3418-2

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

The dark side of islet vasculature

Excerpt

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

15% bedauern gewählte Blasenkrebs-Therapie

Costims – das nächste heiße Ding in der Krebstherapie?

Update Innere Medizin

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Excerpt

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2015

Deletion of the gene encoding G0/G1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice

SLC30A8 mutations in type 2 diabetes

Enhanced fatty acid uptake in visceral adipose tissue is not reversed by weight loss in obese individuals with the metabolic syndrome

Enterovirus infection is associated with an increased risk of childhood type 1 diabetes in Taiwan: a nationwide population-based cohort study

Retraction Note: Abstracts of the 47th Annual Meeting of the EASD, Lisbon 2011. ‘Reduced syntaxin-5 in skeletal muscle of patients with type 2 diabetes is linked to increased diacylglycerol, activation of PKCtheta and impaired insulin signalling’

Metabolic response to 36 hours of fasting in young men born small vs appropriate for gestational age

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

15% bedauern gewählte Blasenkrebs-Therapie

Costims – das nächste heiße Ding in der Krebstherapie?

Update Innere Medizin