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Journal of Clinical Immunology

Erschienen in:

01.09.2008

The Dynamics of Articular Leukocyte Trafficking and the Immune Response to Self Heat-Shock Protein 65 Influence Arthritis Susceptibility

verfasst von: Md. Y. Mia, Eugene Y. Kim, Shailesh R. Satpute, Kamal D. Moudgil

Erschienen in: Journal of Clinical Immunology | Ausgabe 5/2008

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Abstract

Introduction

Adjuvant arthritis (AA) shares several features with human rheumatoid arthritis, and it can be induced in the Lewis (LEW) rat but not the Wistar Kyoto (WKY) rat (both RT.1^l) by immunization with heat-killed Mycobacterium tuberculosis (Mtb). We set out to unravel the mechanisms underlying the differential susceptibility to AA of these MHC-compatible rat strains.

Materials and Methods

We compared the levels of T-cell proliferative and cytokine response to the immunoregulatory self (rat) hsp65 (Rhsp65) after an arthritogenic (Mtb) challenge and the kinetics of migration of adoptively transferred, ¹¹¹Indium-labeled, Mtb-primed leukocytes into the hind paw joints of recipient rats.

Results and Discussion

The WKY rats raised a significantly higher level of T-cell proliferative response coupled with a temporally opposite cytokine profile against the disease-regulating Rhsp65 compared to that of LEW rats. Moreover, the arthritogenic leukocytes accumulated into the joints of WKY rats at significantly lower numbers than that in LEW rats.

Conclusions

These results offer novel insights into the immune events influencing the pathogenesis of autoimmune arthritis.

Shoenfeld Y, Gilburd B, Abu-Shakra M, Amital H, Barzilai O, Berkun Y, et al. The mosaic of autoimmunity: genetic factors involved in autoimmune diseases–2008. Isr Med Assoc J 2008;10:3–7.PubMed

Kuchroo VK, Anderson AC, Waldner H, Munder M, Bettelli E, Nicholson LB. T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire. Annu Rev Immunol 2002;20:101–23.PubMedCrossRef

Sun B, Rizzo LV, Sun SH, Chan CC, Wiggert B, Wilder RL, et al. Genetic susceptibility to experimental autoimmune uveitis involves more than a predisposition to generate a T helper-1-like or a T helper-2-like response. J Immunol 1997;159:1004–11.PubMed

McIndoe RA, Bohlman B, Chi E, Schuster E, Lindhardt M, Hood L. Localization of non-Mhc collagen-induced arthritis susceptibility loci in DBA/1j mice. Proc Natl Acad Sci U S A 1999;96:2210–4.PubMedCrossRef

Moudgil KD, Chang TT, Eradat H, Chen AM, Gupta RS, Brahn E, et al. Diversification of T cell responses to carboxy-terminal determinants within the 65-kD heat-shock protein is involved in regulation of autoimmune arthritis. J Exp Med 1997;185:1307–16.PubMedCrossRef

Pearson C. Development of arthritis, periarthritis and periostitis in rats given adjuvants. Proc Soc Exp Biol (NY) 1956;91:95–101.

van Eden W, Thole JE, van der Zee R, Noordzij A, van Embden JD, Hensen EJ, et al. Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis. Nature 1988;331:171–3.PubMedCrossRef

Ulmansky R, Cohen CJ, Szafer F, Moallem E, Fridlender ZG, Kashi Y, et al. Resistance to adjuvant arthritis is due to protective antibodies against heat shock protein surface epitopes and the induction of IL-10 secretion. J Immunol 2002;168:6463–9.PubMed

Cohen IR. Autoimmunity to chaperonins in the pathogenesis of arthritis and diabetes. Annu Rev Immunol 1991;9:567–89.PubMedCrossRef

10.

Holoshitz J, Klajman A, Drucker I, Lapidot Z, Yaretzky A, Frenkel A, et al. T lymphocytes of rheumatoid arthritis patients show augmented reactivity to a fraction of mycobacteria cross-reactive with cartilage. Lancet 1986;2:305–9.PubMedCrossRef

11.

Gaston JS, Life PF, Bailey LC, Bacon PA. In vitro responses to a 65-kilodalton mycobacterial protein by synovial T cells from inflammatory arthritis patients. J Immunol 1989;143:2494–500.PubMed

12.

Quayle AJ, Wilson KB, Li SG, Kjeldsen-Kragh J, Oftung F, Shinnick T, et al. Peptide recognition, T cell receptor usage and HLA restriction elements of human heat-shock protein (hsp) 60 and mycobacterial 65-kDa hsp-reactive T cell clones from rheumatoid synovial fluid. Eur J Immunol 1992;22:1315–22.PubMedCrossRef

13.

Durai M, Gupta RS, Moudgil KD. The T cells specific for the carboxyl-terminal determinants of self (rat) heat-shock protein 65 escape tolerance induction and are involved in regulation of autoimmune arthritis. J Immunol 2004;172:2795–802.PubMed

14.

Quintana FJ, Carmi P, Mor F, Cohen IR. Inhibition of adjuvant arthritis by a DNA vaccine encoding human heat shock protein 60. J Immunol 2002;169:3422–8.PubMed

15.

Kim HR, Kim EY, Cerny J, Moudgil KD. Antibody responses to mycobacterial and self heat shock protein 65 in autoimmune arthritis: epitope specificity and implication in pathogenesis. J Immunol 2006;177:6634–41.PubMed

16.

Kim EY, Chi HH, Bouziane M, Gaur A, Moudgil KD. Regulation of autoimmune arthritis by the pro-inflammatory cytokine interferon-gamma. Clin Immunol 2008;127:98–106.PubMedCrossRef

17.

Durai M, Kim HR, Moudgil KD. The regulatory C-terminal determinants within mycobacterial heat shock protein 65 are cryptic and cross-reactive with the dominant self homologs: implications for the pathogenesis of autoimmune arthritis. J Immunol 2004;173:181–8.PubMed

18.

Issekutz T, Chin W, Hay JB. Measurement of lymphocyte traffic with indium-111. Clin Exp Immunol 1980;39:215–21.PubMed

19.

Stevens DB, Gold DP, Sercarz EE, Moudgil KD. The Wistar Kyoto (RT1(l)) rat is resistant to myelin basic protein-induced experimental autoimmune encephalomyelitis: comparison with the susceptible Lewis (RT1(l)) strain with regard to the MBP-directed CD4+ T cell repertoire and its regulation. J Neuroimmunol 2002;126:25–36.PubMedCrossRef

20.

Miyata M, Sato H, Sato H, Sato Y, Kodama E, Kasukawa R. Significance of endogenous heat shock protein in adjuvant arthritis. J Rheumatol 1999;26:2210–4.PubMed

21.

Hershko AY, Ulmansky R, Moallem E, Naparstek Y. Susceptibility and resistance to experimental adjuvant arthritis. Front Biosci 2004;9:3268–75.PubMedCrossRef

22.

Miletic T, Kovacevic-Jovanovic V, Stanojevic S, Vujic V, Kosec D, Mitic K, et al. Strain differences and the role for HSP47 and HSP70 in adjuvant arthritis in rats. Scand J Immunol 2006;64:623–32.PubMedCrossRef

23.

Pardon MC, Gould GG, Garcia A, Phillips L, Cook MC, Miller SA, et al. Stress reactivity of the brain noradrenergic system in three rat strains differing in their neuroendocrine and behavioral responses to stress: implications for susceptibility to stress-related neuropsychiatric disorders. Neuroscience 2002;115:229–42.PubMedCrossRef

24.

Stohr T, Szuran T, Welzl H, Pliska V, Feldon J, Pryce CR. Lewis/Fischer rat strain differences in endocrine and behavioural responses to environmental challenge. Pharmacol Biochem Behav 2000;67:809–19.PubMedCrossRef

25.

Tonelli L, Webster JI, Rapp KL, Sternberg E. Neuroendocrine responses regulating susceptibility and resistance to autoimmune/inflammatory disease in inbred rat strains. Immunol Rev 2001;184:203–11.PubMedCrossRef

26.

Joe B, Cannon GW, Griffiths MM, Dobbins DE, Gulko PS, Wilder RL, et al. Evaluation of quantitative trait loci regulating severity of mycobacterial adjuvant-induced arthritis in monocongenic and polycongenic rats: identification of a new regulatory locus on rat chromosome 10 and evidence of overlap with rheumatoid arthritis susceptibility loci. Arthritis Rheum 2002;46:1075–85.PubMedCrossRef

27.

Kawahito Y, Cannon GW, Gulko PS, Remmers EF, Longman RE, Reese VR, et al. Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases. J Immunol 1998;161:4411–9.PubMed

28.

de Graeff-Meeder ER, van Eden W, Rijkers GT, Prakken BJ, Kuis W, Voorhorst-Ogink MM, et al. Juvenile chronic arthritis: T cell reactivity to human HSP60 in patients with a favorable course of arthritis. J Clin Invest 1995;95:934–40.PubMedCrossRef

29.

Prakken AB, van Eden W, Rijkers GT, Kuis W, Toebes EA, de Graeff-Meeder ER, et al. Autoreactivity to human heat-shock protein 60 predicts disease remission in oligoarticular juvenile rheumatoid arthritis. Arthritis Rheum 1996;39:1826–32.PubMedCrossRef

30.

de Kleer IM, Kamphuis SM, Rijkers GT, Scholtens L, Gordon G, De Jager W, et al. The spontaneous remission of juvenile idiopathic arthritis is characterized by CD30+ T cells directed to human heat-shock protein 60 capable of producing the regulatory cytokine interleukin-10. Arthritis Rheum 2003;48:2001–10.PubMedCrossRef

31.

Caldas C, Spadafora-Ferreira M, Fonseca JA, Luna E, Iwai LK, Kalil J, et al. T-cell response to self HSP60 peptides in renal transplant recipients: a regulatory role. Transplant Proc 2004;36:833–5.PubMedCrossRef

32.

Guedez YB, Whittington KB, Clayton JL, Joosten LA, van de Loo FA, van den Berg WB, et al. Genetic ablation of interferon-gamma up-regulates interleukin-1beta expression and enables the elicitation of collagen-induced arthritis in a nonsusceptible mouse strain. Arthritis Rheum 2001;44:2413–24.PubMedCrossRef

33.

Chu CQ, Swart D, Alcorn D, Tocker J, Elkon KB. Interferon-gamma regulates susceptibility to collagen-induced arthritis through suppression of interleukin-17. Arthritis Rheum 2007;56:1145–51.PubMedCrossRef

34.

Zheng CL, Hossain MA, Kukita A, Ohki K, Satoh T, Kohashi O. Complete Freund’s adjuvant suppresses the development and progression of pristane-induced arthritis in rats. Clin Immunol 2002;103:204–9.PubMedCrossRef

35.

Zheng CL, Ohki K, Hossain A, Kukita A, Satoh T, Kohashi O. Complete Freund’s adjuvant promotes the increases of IFN-gamma and nitric oxide in suppressing chronic arthritis induced by pristane. Inflammation 2003;27:247–55.PubMedCrossRef

36.

Nakajima H, Takamori H, Hiyama Y, Tsukada W. The effect of treatment with recombinant gamma-interferon on adjuvant-induced arthritis in rats. Agents Actions 1991;34:63–5.PubMedCrossRef

37.

Wiesenberg I, Van der Meide PH, Schellekens H, Alkan S. Suppression and augmentation of rat adjuvant arthritis with monoclonal anti-interferon-gamma antibody. Clin Exp Immunol 1989;78:245–9.PubMed

38.

Afanasyeva M, Wang Y, Kaya Z, Stafford EA, Dohmen KM, Sadighi Akha AA, et al. Interleukin-12 receptor/STAT4 signaling is required for the development of autoimmune myocarditis in mice by an interferon-gamma-independent pathway. Circulation 2001;104:3145–51.PubMedCrossRef

39.

Steinman L. A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage. Nat Med 2007;13:139–45.PubMedCrossRef

40.

Tarrant TK, Silver PB, Wahlsten JL, Rizzo LV, Chan CC, Wiggert B, et al. Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis. J Exp Med 1999;189:219–30.PubMedCrossRef

41.

Willenborg DO, Fordham SA, Staykova MA, Ramshaw IA, Cowden WB. IFN-gamma is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue: a possible role for nitric oxide. J Immunol 1999;163:5278–86.PubMed

42.

La Cava A, Van Kaer L, Fu Dong S. CD4+CD25+ Tregs and NKT cells: regulators regulating regulators. Trends Immunol 2006;27:322–7.PubMedCrossRef

43.

Zanin-Zhorov A, Cahalon L, Tal G, Margalit R, Lider O, Cohen IR. Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signaling. J Clin Invest 2006;116:2022–32.PubMedCrossRef

44.

DeJoy SQ, Ferguson-Chanowitz K, Oronsky AL, Zabriskie JB, Kerwar SS. Studies on the homing of Mycobacterium-sensitized T lymphocytes to the synovium during passive adjuvant arthritis. Cell Immunol 1990;130:195–203.PubMedCrossRef

45.

Spargo LD, Hawkes JS, Cleland LG, Mayrhofer G. Recruitment of lymphoblasts derived from peripheral and intestinal lymph to synovium and other tissues in normal rats and rats with adjuvant arthritis. J Immunol 1996;157:5198–207.PubMed

46.

Cleland LG, Wing SJ, Spargo LD, Mayrhofer G. Temporal changes in the distribution of thoracic duct lymphoblasts to synovium and other tissues of rats with adjuvant-induced arthritis. Immunol Cell Biol 2002;80:148–55.PubMedCrossRef

47.

Bush KA, Walker JS, Lee CS, Kirkham BW. Cytokine expression and synovial pathology in the initiation and spontaneous resolution phases of adjuvant arthritis: interleukin-17 expression is upregulated in early disease. Clin Exp Immunol 2001;123:487–95.PubMedCrossRef

48.

Van de Langerijt AG, Volsen SG, Hicks CA, Craig PJ, Billingham ME, Van den Berg WB. Cell migration studies in the adoptive transfer of adjuvant arthritis in the Lewis rat. Immunology 1994;81:414–9.PubMed

49.

Issekutz AC, Mu JY, Liu G, Melrose J, Berg EL. E-selectin, but not P-selectin, is required for development of adjuvant-induced arthritis in the rat. Arthritis Rheum 2001;44:1428–37.PubMedCrossRef

50.

Issekutz AC, Nakazato S, Issekutz TB. Differential roles of VLA-4(CD49d/CD29) and LFA-1(CD11a/CD18) integrins and E- and P-selectin during developing and established active or adoptively transferred adjuvant arthritis in the rat. Immunol Cell Biol 2003;81:397–408.PubMedCrossRef

51.

Haas CS, Martinez RJ, Attia N, Haines GK 3rd, Campbell PL, Koch AE. Chemokine receptor expression in rat adjuvant-induced arthritis. Arthritis Rheum 2005;52:3718–30.PubMedCrossRef

52.

Shahrara S, Proudfoot AE, Woods JM, Ruth JH, Amin MA, Park CC, et al. Amelioration of rat adjuvant-induced arthritis by Met-RANTES. Arthritis Rheum 2005;52:1907–19.PubMedCrossRef

Titel: The Dynamics of Articular Leukocyte Trafficking and the Immune Response to Self Heat-Shock Protein 65 Influence Arthritis Susceptibility
verfasst von: Md. Y. Mia
Eugene Y. Kim
Shailesh R. Satpute
Kamal D. Moudgil
Publikationsdatum: 01.09.2008
Verlag: Springer US
Erschienen in: Journal of Clinical Immunology / Ausgabe 5/2008
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-008-9205-4

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Abstract

Introduction

Materials and Methods

Results and Discussion

Conclusions

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