nach oben

European Journal of Applied Physiology

Erschienen in:

01.02.2009 | Original Article

The effect of 60-h sleep deprivation on cardiovascular regulation and body temperature

verfasst von: Jani Vaara, Heikki Kyröläinen, Mikko Koivu, Mikko Tulppo, Taija Finni

Erschienen in: European Journal of Applied Physiology | Ausgabe 3/2009

Einloggen, um Zugang zu erhalten

Abstract

This study examined cardiovascular regulation and body temperature (BT) during 60 h of sleep deprivation in 20 young healthy cadets. Heart rate variability was measured during an active orthostatic test (AOT). Measurements were performed each day in the morning and evening after 2, 14, 26, 38, 50 and 60 h of sleep deprivation. In AOT, in the sitting and standing positions, heart rate decreased (P < 0.001), while high frequency and low frequency power increased (P < 0.05–0.001) during sleep deprivation. Body temperature also decreased (P < 0.001), but no changes were detected in blood pressure. In conclusion, the accumulation of 60 h of sleep loss resulted in increased vagal outflow, as evidenced by decreased heart rate. In addition, BT decreased during sleep deprivation. Thus, sleep deprivation causes alterations in autonomic regulation of the heart, and in thermoregulation.

Ax A, Luby ED (1961) Autonomic responses to sleep deprivation. Arch Gen Psychiatry 4:55–59PubMed

Ballard RD, Tan WC, Kelly PL, Pak J, Pandey R, Martin RJ (1990) Effect of sleep and sleep deprivation on ventilatory response to bronchoconstriction. J Appl Physiol 69:490–497PubMed

Bond V, Balkissoon B, Franks BD, Brwnlow R, Caprarola M, Bartley D, Banks M (1986) Effects of sleep deprivation on performance during submaximal and maximal exercise. J Sports Med Phys Fitness 26:169–174PubMed

Chen HI (1991) Effects of 30-h sleep loss on cardiorespiratory functions at rest and in exercise. Med Sci Sports Exerc 23:193–198PubMed

Burgess HJ, Trinder J, Kim Y, Luke D (1997) Sleep and circadian influences on cardiac autonomic nervous system activity. Am J Physiol 273:1761–1768

Dimitrov S, Lange T, Tieken S, Fehm HL, Born J (2004) Sleep associated regulation of T helper 1/T helper 2 cytokine balance in humans. Brain Behav Immun 18:341–348PubMedCrossRef

Eckberg DL (2003) The human respiratory gate. J Physiol 15:339–352

Folkard S, Monk TH, Lobban MC (1979) Towards a predictive test of adjustment to shift work. Ergonomics 22:79–91PubMedCrossRef

Gonzalez-Ortiz M, Martinez-Abundis E, Balcazar-Munoz BR, Pascoe-Gonzalez S (2000) Effect of sleep deprivation on insulin sensitivity and cortisol concentration in healthy subjects. Diabetes Nutr Metab 13:80–83PubMed

Harrison Y, Horne JA, Rothwell (2000) A prefrontal neuropsychological effects of sleep deprivation in young adults—a model for healthy aging? Sleep 15(23):1067–1073

Holmes AL, Burgess HJ, Dawson D (2002) Effects of sleep pressure on endogenous cardiac autonomic activity and body temperature. J Appl Physiol 92:2578–2584PubMed

Horne JA (1983) Human sleep and tissue restitution: some qualifications and doubts. Clin Sci 65:569–577PubMed

Horne JA (1993) Human sleep, sleep loss and behaviour implications for the prefrontal cortex and psychiatric disorder. Br J Psychiatry 162:413–419PubMedCrossRef

Horne JA, Pettitt AN (1985) High incentive effects on vigilance performance during 72 hours of total sleep deprivation. Acta Psychol 58:123–139CrossRef

Irwin M (2002) Effects of sleep and sleep loss on immunity and cytokines. Brain Behav Immun 16:503–512PubMedCrossRef

Jurca R, Church TS, Morss GM, Jordan AN, Earnest CP (2004) Eight weeks of moderate-intensity exercise training increases heart rate variability in sedentary postmenopausal women. Am Heart J 147:21CrossRef

Kandel ER, Schwartz JH, Jessell TM (2000) Principles of neural science international ed, 4th edn. McGraw-Hill, New York

Kato M, Phillips BG, Sigurdsson G, Narkiewicz K, Pesek CA, Somers VK (2000) Effects of sleep deprivation on neural circulatory control. Hypertension 35:1173–1175PubMed

Knutson KL, Spiegel K, Penev P, Van Cauter E (2007) The metabolic consequences of sleep deprivation. Sleep Med Rev 11:163–178PubMedCrossRef

Kolka MA, Martin BJ, Elizondo RS (1984) Exercise in a cold environment after sleep deprivation. Eur J Appl Physiol Occup Physiol 53:282–285PubMedCrossRef

Lubin A, Hord DJ, Tracy ML, Johnson LC (1976) Effects of exercise, bed rest and napping on performance decrement during 40 hours. Psychophysiology 13:334–339PubMedCrossRef

Lusardi P, Zoppi A, Preti P, Pesce RM, Piazza E, Fogari R (1999) Effects of insufficient sleep on blood pressure in hypertensive patients: a 24-h study. Am J Hypertens 12:63–68PubMedCrossRef

Meier-Ewert HK, Ridker PM, Rifai N, Regan MM, Price NJ, Dinges DF, Mullington JM (2004) Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J Am Coll Cardiol 43:678–683PubMedCrossRef

Narkiewicz K, van de Borne PJ, Hausberg M, Cooley RL, Winniford MD, Davison DE, Somers VK (1998) Cigarette smoking increases sympathetic outflow in humans. Circulation 98:528–534PubMed

Neilly JB, Kribbs NB, Maislin G, Pack AI (1992) Effects of selective sleep deprivation on ventilation during recovery sleep in normal humans. J Appl Physiol 72:100–109PubMed

Ogawa Y, Kanbayashi T, Saito Y, Takahashi Y, Kitajima T, Takahashi K, Hishikawa Y, Shimizu T (2003) Total sleep deprivation elevates blood pressure through arterial baroreflex resetting: a study with microneurographic technique. Sleep 15:986–989

Pilcher JJ, Huffcutt AI (1996) Effects of sleep deprivation on performance: a meta-analysis. Sleep 19:318–326PubMed

Shamsuzzaman AS, Caples SM, Somers VK (2003) Sleep deprivation and circulatory control. Sleep 15:934–936

Shearer WT, Reuben JM, Mullington JM, Price NJ, Lee BN, Smith EO, Szuba MP, Van Dongen HP, Dinges DF (2001) Soluble TNF-alpha receptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight. J. Allergy Clin Immunol 107:165–170PubMedCrossRef

Spengler CM, Shea SA (2000) Sleep deprivation per se does not decrease the hypercapnic ventilatory response in humans. Am J Respir Crit Care Med 161:1124–1128PubMed

Spiegel K, Leproult R, Van Cauter E (1999) Impact of sleep debt on metabolic and endocrine function. Lancet 23:1435–1439CrossRef

Thomas M, Sing H, Belenky G (2000) Neuronal basis of alertness and cognitive performance impairments during sleepiness. Effects of 24 h of sleep deprivation on waking human regional brain activity. J Sleep Res 9:335–352PubMedCrossRef

Van Cauter E, Blackman JD, Roland D, Spire JP, Refetoff S, Polonsky KS (1991) Modulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep. J Clin Invest 88:934–942PubMedCrossRef

Van Cauter E, Holmback U, Knutson K, Leproult R, Miller A, Nedeltcheva A, Pannain S, Penev P, Tasali E, Spiegel K (2007) Impact of sleep and sleep loss on neuroendocrine and metabolic function. Horm Res 67(1):2–9PubMedCrossRef

Vanhelder T, Randomski MW (1989) Sleep deprivation and the effect on exercise performance. Sports Med 7:235–247PubMedCrossRef

Vgontzas AN, Papanicolaou DA, Bixler EO, Lotsikas A, Zachman K, Kales A, Prolo P, Wong M-L, Licinio J, Gold PW, Hermida RC, Mastorakos G, Chrousos GP (1999) Circadian interleukin-6 secretion and quantity and depth of sleep. J Clin Endocrinol Metab 84:2603–2607PubMedCrossRef

White DP, Douglas NJ, Pickett CK, Zwillich CW, Weil JV (1983) Sleep deprivation and the control of ventilation. Am Rev Respir 128:984–986

Wu JC, Gillin JC, Buchsbaum MS, Hershey T, Hazlett E, Sicotte N, Bunney WE Jr (1991) The effect of sleep deprivation on cerebral glucose metabolic rate in normal humans assessed with positron emission tomography. Sleep 14:155–162PubMed

Zhong X, Hilton HJ, Gates GJ, Jelic S, Stern Y, Bartels MN, Demeersman RE, Basner RC (2005) Increased sympathetic and decreased parasympathetic cardiovascular modulation in normal humans with acute sleep deprivation. J Appl Physiol 98:2024–2032PubMedCrossRef

Titel: The effect of 60-h sleep deprivation on cardiovascular regulation and body temperature
verfasst von: Jani Vaara
Heikki Kyröläinen
Mikko Koivu
Mikko Tulppo
Taija Finni
Publikationsdatum: 01.02.2009
Verlag: Springer-Verlag
Erschienen in: European Journal of Applied Physiology / Ausgabe 3/2009
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-008-0921-5

Neu im Fachgebiet Arbeitsmedizin

Elterliches Belastungserleben, Unaufmerksamkeits‑/Hyperaktivitätssymptome und elternberichtete ADHS bei Kindern und Jugendlichen: Ergebnisse aus der KiGGS-Studie

Open Access ADHS Leitthema

Die Aufmerksamkeitsdefizit‑/Hyperaktivitätsstörung (ADHS) ist eine der häufigsten psychischen Störungen im Kindes- und Jugendalter [ 1 ]. In Deutschland beträgt die Prävalenz einer elternberichteten ADHS-Diagnose bei Kindern und Jugendlichen 4,4 % …

Substanzkonsum und Nutzung von sozialen Medien, Computerspielen und Glücksspielen unter Auszubildenden an beruflichen Schulen

Open Access Leitthema

Die Begrenzung von Schäden durch Substanzkonsum und andere abhängige Verhaltensweisen von Jugendlichen und jungen Erwachsenen ist ein wichtiges Anliegen der öffentlichen Gesundheit. Der Übergang von der Adoleszenz zum jungen Erwachsenenalter ist …

Berufsbelastung und Stressbewältigung von weiblichen und männlichen Auszubildenden

Leitthema

In der Öffentlichkeit wird die berufliche Ausbildung oftmals unter ökonomischen Gesichtspunkten diskutiert: Mit den geburtenstarken Jahrgängen gehen erfahrene Fachkräfte in Rente und von nachfolgenden Generationen rücken zu wenige Arbeitskräfte …

Rauschtrinken in der frühen Adoleszenz

COVID-19 Leitthema

Alkohol ist in Deutschland die mit Abstand am häufigsten konsumierte psychoaktive Substanz. Mehr als 2 Drittel aller Erwachsenen im Alter von 18 bis 64 Jahren (70,5 %) hat 2021 in den letzten 30 Tagen Alkohol konsumiert [ 1 ]. Von diesen …

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2009

Cardiac response to exercise in young, normal weight and overweight men and women

Modulation of heart rate variability by estrogen in young women undergoing induction of ovulation

The effects of acute whole body vibration as a recovery modality following high-intensity interval training in well-trained, middle-aged runners

Exercise affects platelet-promoted tumor cell adhesion and invasion to endothelium

Helmet-based physiological signal monitoring system

The effect of angiotensin-converting enzyme genotype on acute mountain sickness and summit success in trekkers attempting the summit of Mt. Kilimanjaro (5,895 m)

Neu im Fachgebiet Arbeitsmedizin

Elterliches Belastungserleben, Unaufmerksamkeits‑/Hyperaktivitätssymptome und elternberichtete ADHS bei Kindern und Jugendlichen: Ergebnisse aus der KiGGS-Studie

Substanzkonsum und Nutzung von sozialen Medien, Computerspielen und Glücksspielen unter Auszubildenden an beruflichen Schulen

Berufsbelastung und Stressbewältigung von weiblichen und männlichen Auszubildenden

Rauschtrinken in der frühen Adoleszenz