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Journal of Bone and Mineral Metabolism

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24.11.2022 | Original Article

The effect of ferritin levels on distal femoral cartilage thickness in patients with beta thalassaemia major

verfasst von: Alper Uysal, Gönül Oktay, Cihan Ural, Nimet Bilge Kalkan

Erschienen in: Journal of Bone and Mineral Metabolism | Ausgabe 1/2023

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Abstract

Introduction

To the best of our knowledge, the present study is the first in the literature to assess distal femoral cartilage thickness and its relationship with ferritin levels in adult patients with beta thalassaemia major (BTM).

Materials and methods

45 patients with BTM and 45 healthy controls were included in the study. Ferritin and haemoglobin levels of the patient and healthy groups were determined by blood analysis and distal femoral cartilage thicknesses were measured via ultrasound. Then, the patient group was divided into subgroups according to whether their ferritin levels were below or above 2500 µg/L. They were then compared among themselves and with the healthy control group using the available data.

Results

Distal femoral cartilage thickness values were statistically significantly lower in the BTM group compared to the healthy control group (p values < 0.001). Patients with a ferritin level below 2500 µg/L had statistically significantly higher right and left average distal femoral cartilage thickness values than the patients with a ferritin level above 2500 µg/L (p = 0.029 and p = 0.019, respectively). The right and left average distal femoral cartilage thickness values of the patient subgroup with low ferritin levels were statistically similar to the control group (p = 0.146 and p = 0.164, respectively).

Conclusion

Our study showed that thalassaemia patients are more likely to develop osteoarthritis (OA) than the normal population and possible OA development can be prevented by keeping the ferritin levels of these patients in the optimum range.

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Titel: The effect of ferritin levels on distal femoral cartilage thickness in patients with beta thalassaemia major
verfasst von: Alper Uysal
Gönül Oktay
Cihan Ural
Nimet Bilge Kalkan
Publikationsdatum: 24.11.2022
Verlag: Springer Nature Singapore
Erschienen in: Journal of Bone and Mineral Metabolism / Ausgabe 1/2023
Print ISSN: 0914-8779
Elektronische ISSN: 1435-5604
DOI: https://doi.org/10.1007/s00774-022-01384-w

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The effect of ferritin levels on distal femoral cartilage thickness in patients with beta thalassaemia major

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Materials and methods

Results

Conclusion

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