nach oben

Erschienen in:

28.04.2018 | Health Economics (N Khera, Section Editor)

The Effect of Psychosocial Interventions on Outcomes for Caregivers of Hematopoietic Cell Transplant Patients

verfasst von: Lauren R. Bangerter, Joan M. Griffin, Shelby Langer, Bashar Hasan, Wonsun (Sunny) Kim, M. Hassan Murad, Nandita Khera

Erschienen in: Current Hematologic Malignancy Reports | Ausgabe 3/2018

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

Hematopoietic cell transplant (HCT) patients are required to have a caregiver present for up to 100 days post-transplant. Caregivers provide essential support during HCT but experience immense stress and burden. Increasing research has developed interventions for HCT caregivers. This review systematically evaluates psychosocial interventions for caregivers of HCT patients.

Recent Findings

The search yielded 12 studies (7 efficacy and 5 feasibility studies) enrolling 931 caregivers. Interventions were feasible and acceptable as evidenced by high rates of completion (70–100%) with attrition due to patient morbidity or mortality. Feasibility was augmented by flexible delivery (in-person, teleconference, smartphones, or Web-based platforms). Acceptability was demonstrated by objective measures of satisfaction. Effectiveness was found for fatigue and mental health service use, but not for burden, sleep-quality, and inconsistently for caregiver depression, anxiety, coping, and quality of life.

Summary

Psychosocial interventions are feasible, acceptable, and show mixed effects on HCT caregiver outcomes.

Nur mit Berechtigung zugänglich

Majhail NS, Tao L, Bredeson C, Davies S, Dehn J, Gajewski JL, et al. Prevalence of hematopoietic cell transplant survivors in the United States. Biol Blood Marrow Transplant. 2013;19(10):1498–501.CrossRefPubMedPubMedCentral

Foster LW, McLellan L, Rybicki L, Dabney J, Copelan E, Bolwell B. Validating the positive impact of in-hospital lay care-partner support on patient survival in allogeneic BMT: a prospective study. Bone Marrow Transplant. 2013;48(5):671–7.CrossRefPubMed

Foster LW, McLellan LJ, Rybicki LA, Sassano DA, Hsu A, Bolwell BJ. Survival of patients who have undergone allogeneic bone marrow transplantation: the relative importance of in-hospital lay care-partner support. J Psychosoc Oncol. 2005;22(2):1–20.CrossRef

Cooke L, Grant M, Eldredge DH, Maziarz RT, Nail LM. Informal caregiving in hematopoietic blood and marrow transplant patients. Eur J Oncol Nurs. 2011;15(5):500–7.CrossRefPubMedPubMedCentral

Siston AK, List MA, Daugherty CK, Banik DM, Menke C, Cornetta K, et al. Psychosocial adjustment of patients and caregivers prior to allogeneic bone marrow transplantation. Bone Marrow Transplant. 2001;27(11):1181–8.CrossRefPubMed

Von Ah D, Spath M, Nielsen A, Fife B. The Caregiver’s role across the bone marrow transplantation trajectory. Cancer Nurs. 2016;39(1):E12–9.

Eldredge DH, Nail LM, Maziarz RT, Hansen LK, Ewing D, Archbold PG. Explaining family caregiver role strain following autologous blood and marrow transplantation. J Psychosoc Oncol. 2006;24(3):53–74.CrossRefPubMed

Bishop MM, Beaumont JL, Hahn EA, Cella D, Andrykowski MA, Brady MJ, et al. Late effects of cancer and hematopoietic stem-cell transplantation on spouses or partners compared with survivors and survivor-matched controls. J Clin Oncol. 2007;25(11):1403–11.CrossRefPubMed

Langer S, Abrams J, Syrjala K. Caregiver and patient marital satisfaction and affect following hematopoietic stem cell transplantation: a prospective, longitudinal investigation. Psychooncology. 2003;12(3):239–53.CrossRefPubMed

10.

Gemmill R, Cooke L, Williams AC, Grant M. Informal caregivers of hematopoietic cell transplant patients: a review and recommendations for interventions and research. Cancer Nurs. 2011;34(6):E13–21.CrossRefPubMedPubMedCentral

11.

Lazarus RSL, Folkman S. Stress appraisal, and coping. Springer: Publishing Company; 1984. 466 p.

12.

Bowen DJ, Kreuter M, Spring B, Cofta-Woerpel L, Linnan L, Weiner D, et al. How we design feasibility studies. Am J Prev Med. 2009;36(5):452–7.CrossRefPubMedPubMedCentral

13.

Higgins J, Green S. Cochrane Handbook for Systematic Reviews of Interventions [Internet]. [cited 2018 Feb 20]. Available from: http://handbook-5-1.cochrane.org/.

14.

Miake-Lye IM, Hempel S, Shanman R, Shekelle PG. What is an evidence map? A systematic review of published evidence maps and their definitions, methods, and products. Syst Rev [Internet]. 2016 Dec [cited 2018 Feb 13];5(1). Available from: http://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-016-0204-x.

15.

Higgins JPT, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011;343(oct18 2):d5928.CrossRefPubMedPubMedCentral

16.

Wells G, Shea B, O’Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses [Internet]. [cited 2018 Feb 20]. Available from: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.

17.

Pensak NA, Joshi T, Simoneau T, Kilbourn K, Carr A, Kutner J, et al. Development of a Web-based intervention for addressing distress in caregivers of patients receiving stem cell transplants: formative evaluation with qualitative interviews and focus groups. JMIR Res Protoc. 2017;6(6):e120.CrossRefPubMedPubMedCentral

18.

• Simoneau TL, Kilbourn K, Spradley J, Laudenslager ML. An evidence-based stress management intervention for allogeneic hematopoietic stem cell transplant caregivers: development, feasibility and acceptability. Support Care Cancer. 2017;10:1–9. Provides important explanaiton of feasibility study.

19.

Heermann JA, Eilers JG, Carney PA. Use of modified OSCEs to verify technical skill performance and competency of lay caregivers. J Cancer Educ. 2001;16(2):93–8.PubMed

20.

Metoyer LJ. Education of hematopoietic stem cell transplant caregivers in preparation for their role. J Adv Pract Oncol. 2013;4(6):432–7.PubMedPubMedCentral

21.

Bevans M, Castro K, Prince P, Shelburne N, Prachenko O, Loscalzo M, et al. An individualized dyadic problem-solving education intervention for patients and family caregivers during allogeneic hematopoietic stem cell transplantation: a feasibility study. Cancer Nurs. 2010;33(2):E24–32.CrossRefPubMedPubMedCentral

22.

Bevans M, Wehrlen L, Castro K, Prince P, Shelburne N, Soeken K, et al. A problem-solving education intervention in caregivers and patients during allogeneic hematopoietic stem cell transplantation. J Health Psychol. 2014;19(5):602–17.CrossRefPubMed

23.

El-Jawahri A, LeBlanc T, VanDusen H, Traeger L, Greer JA, Pirl WF, et al. Effect of inpatient palliative care on quality of life 2 weeks after hematopoietic stem cell transplantation: a randomized clinical trial. JAMA. 2016;316(20):2094–103.CrossRefPubMedPubMedCentral

24.

Fife BL, Von Ah DM, Spath ML, Weaver MT, Yang Z, Stump T, et al. Preliminary efficacy of a brief family intervention to prevent declining quality of life secondary to parental bone marrow transplantation. Bone Marrow Transplant. 2017;52(2):285–91.CrossRefPubMed

25.

Laudenslager ML, Simoneau TL, Kilbourn K, Natvig C, Philips S, Spradley J, et al. A randomized control trial of a psychosocial intervention for caregivers of allogeneic hematopoietic stem cell transplant patients: effects on distress. Bone Marrow Transplant. 2015;50(8):1110–8.CrossRefPubMedPubMedCentral

26.

Laudenslager ML, Simoneau TL, Philips S, Benitez P, Natvig C, Cole S. A randomized controlled pilot study of inflammatory gene expression in response to a stress management intervention for stem cell transplant caregivers. J Behav Med. 2016;39(2):346–54.CrossRefPubMed

27.

Ouseph R, Croy C, Natvig C, Simoneau T, Laudenslager ML. Decreased mental health care utilization following a psychosocial intervention in caregivers of hematopoietic stem cell transplant patients. Ment Illn [Internet]. 2014 Mar 25 [cited 2017 May 24];6(1). Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253397/.

28.

Rexilius SJ, Mundt C, Erickson Megel M, Agrawal S. Therapeutic effects of massage therapy and handling touch on caregivers of patients undergoing autologous hematopoietic stem cell transplant. Oncol Nurs Forum. 2002;29(3):E35–44.CrossRefPubMed

29.

Henig I, Zuckerman T. Hematopoietic stem cell transplantation—50 years of evolution and future perspectives. Rambam Maimonides Med J [Internet]. 2014 Oct 29 [cited 2018 Feb 20];5(4). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222417/.

30.

Kim Y, Carver CS, Spiegel D, Mitchell H-R, Cannady RS. Role of family caregivers’ self-perceived preparedness for the death of the cancer patient in long-term adjustment to bereavement. Psychooncology. 2017;26(4):484–92.CrossRefPubMed

31.

Kent EE, Rowland JH, Northouse L, Litzelman K, Chou W-YS, Shelburne N, et al. Caring for caregivers and patients: research and clinical priorities for informal cancer caregiving. Cancer. 2016;122(13):1987–95.CrossRefPubMedPubMedCentral

32.

Burns LJ, Abbetti B, Arnold SD, Bender J, Doughtie S, El-Jawahiri A, et al. Engaging patients in setting a patient-centered outcomes research agenda in hematopoietic cell transplantation. Biol Blood Marrow Transplant [Internet]. 2018 Feb 2 [cited 2018 Mar 1];0(0). Available from: http://www.bbmt.org/article/S1083-8791(18)30046-6/fulltext.

33.

• Langer S, Lehane C, Yi J. Patient and caregiver adjustment to hematopoietic stem cell transplantation: a systematic review of dyad-based studies. Curr Hematol Malig Rep. 2017. Provides a systematic review of dyad-based studies.

Titel: The Effect of Psychosocial Interventions on Outcomes for Caregivers of Hematopoietic Cell Transplant Patients
verfasst von: Lauren R. Bangerter
Joan M. Griffin
Shelby Langer
Bashar Hasan
Wonsun (Sunny) Kim
M. Hassan Murad
Nandita Khera
Publikationsdatum: 28.04.2018
Verlag: Springer US
Erschienen in: Current Hematologic Malignancy Reports / Ausgabe 3/2018
Print ISSN: 1558-8211
Elektronische ISSN: 1558-822X
DOI: https://doi.org/10.1007/s11899-018-0445-y

Springer Medizin

The Effect of Psychosocial Interventions on Outcomes for Caregivers of Hematopoietic Cell Transplant Patients