Skip to main content
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology 10/2018

11.07.2018 | Cornea

The efficacy of fascial granuloma excision with conjunctival autografting after pterygium surgery

verfasst von: Hui-Ya Fan, Zi-Lin Chen

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 10/2018

Einloggen, um Zugang zu erhalten

Abstract

Background and objective

Pterygium has a high recurrence rate after simple excision, and fascial granuloma is one of the common complications of pterygium excision. This study aimed to investigate the treatment for the fascial granuloma.

Methods

In this study, the 36 eyes of 36 cases with fascial granuloma after pterygium excision were collected and divided into two groups to receive granuloma excision and conjunctival autografting or simple granuloma excision. The patients in the treatment group containing 20 cases received granuloma excision and conjunctival autografting, while the patients in the control group containing 16 cases received simple granuloma excision.

Results

The pathology examination results showed that all the removed granulomas were inflammatory granulation tissues that without bacterial infection. After 12 months’ follow-up, there was no recurrence of fascia granuloma and pterygium in the treatment group, in which the cure rate was up to 100%. In the control group, 6 cases experienced a recurrence of the granuloma fascia 2~3 weeks after operation; after further granuloma excision and conjunctival autografting, pterygium recurred in 8 cases.

Conclusion

The fascial granuloma excision with conjunctival autografting is effective and safe in treating fascial granuloma after pterygium surgery, which contributes to reducing the recurrence of pterygium.
Literatur
1.
Zurück zum Zitat Tano T, Ono K, Hiratsuka Y et al (2013) Prevalence of pterygium in a population in Northern Japan: the locomotive syndrome and health outcome in Aizu Cohort Study. Acta Ophthalmol 91:232–236CrossRef Tano T, Ono K, Hiratsuka Y et al (2013) Prevalence of pterygium in a population in Northern Japan: the locomotive syndrome and health outcome in Aizu Cohort Study. Acta Ophthalmol 91:232–236CrossRef
2.
Zurück zum Zitat Desmouliere A, Redard M, Darby I et al (1995) Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar. Am J Pathol 146:56–66PubMedPubMedCentral Desmouliere A, Redard M, Darby I et al (1995) Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar. Am J Pathol 146:56–66PubMedPubMedCentral
3.
Zurück zum Zitat Sibbald RG, Williamson D, Orsted HL et al (2000) Preparing the wound bed—debridement, bacterial balance and moisture balance. Ostomy Wound Manage 46:14–22 24–18, 30–15; quiz 36–17PubMed Sibbald RG, Williamson D, Orsted HL et al (2000) Preparing the wound bed—debridement, bacterial balance and moisture balance. Ostomy Wound Manage 46:14–22 24–18, 30–15; quiz 36–17PubMed
5.
7.
Zurück zum Zitat Martins TGDS, Costa ALFDA, Alves MR et al (2016) Mitomycin C in pterygium treatment. International Journal of Ophthalmology 9:465PubMedPubMedCentral Martins TGDS, Costa ALFDA, Alves MR et al (2016) Mitomycin C in pterygium treatment. International Journal of Ophthalmology 9:465PubMedPubMedCentral
8.
Zurück zum Zitat Prabhasawat P, Barton K, Burkett G et al (1997) Comparison of conjunctival autografts, amniotic membrane grafts, and primary closure for pterygium excision. Ophthalmology 104:974CrossRefPubMed Prabhasawat P, Barton K, Burkett G et al (1997) Comparison of conjunctival autografts, amniotic membrane grafts, and primary closure for pterygium excision. Ophthalmology 104:974CrossRefPubMed
9.
Zurück zum Zitat Zhang L, Wang CC (2014) Inflammatory response of macrophages in infection. Hepatobiliary Pancreat Dis Int 13:138–152CrossRefPubMed Zhang L, Wang CC (2014) Inflammatory response of macrophages in infection. Hepatobiliary Pancreat Dis Int 13:138–152CrossRefPubMed
10.
Zurück zum Zitat Yun-Shain L, Annette W, David W et al (2012) Wound healing in development. Birth Defects Res C Embryo Today 96:213–222CrossRef Yun-Shain L, Annette W, David W et al (2012) Wound healing in development. Birth Defects Res C Embryo Today 96:213–222CrossRef
11.
Zurück zum Zitat Nigwekar SP, Chaudhari SV, Gupte CP et al (2014) Pyogenic granuloma: post operative complication of pterygium surgery. International Journal of Medical Research & Health Sciences 3:759CrossRef Nigwekar SP, Chaudhari SV, Gupte CP et al (2014) Pyogenic granuloma: post operative complication of pterygium surgery. International Journal of Medical Research & Health Sciences 3:759CrossRef
12.
Zurück zum Zitat Ozsutcu M, Ayintap E, Akkan JC et al (2014) Repeated bevacizumab injections versus mitomycin C in rotational conjunctival flap for prevention of pterygium recurrence. Indian J Ophthalmol 62:407–411CrossRefPubMedPubMedCentral Ozsutcu M, Ayintap E, Akkan JC et al (2014) Repeated bevacizumab injections versus mitomycin C in rotational conjunctival flap for prevention of pterygium recurrence. Indian J Ophthalmol 62:407–411CrossRefPubMedPubMedCentral
13.
Zurück zum Zitat Li J, Zhou DH, Lu LN (2011) Clinical observations of conjunctival autografting combined with mitomycin C in treatment of pterygium. Journal of Shanghai Jiaotong University 31:1102–1104 Li J, Zhou DH, Lu LN (2011) Clinical observations of conjunctival autografting combined with mitomycin C in treatment of pterygium. Journal of Shanghai Jiaotong University 31:1102–1104
14.
Zurück zum Zitat Prabhasawat P, Tesavibul N, Leelapatranura K et al (2006) Efficacy of subconjunctival 5-fluorouracil and triamcinolone injection in impending recurrent pterygium. Ophthalmology 113:1102–1109CrossRefPubMed Prabhasawat P, Tesavibul N, Leelapatranura K et al (2006) Efficacy of subconjunctival 5-fluorouracil and triamcinolone injection in impending recurrent pterygium. Ophthalmology 113:1102–1109CrossRefPubMed
15.
Zurück zum Zitat Kasetsuwan N, Reinprayoon U, Satitpitakul V (2015) Prevention of recurrent pterygium with topical bevacizumab 0.05% eye drops: a randomized controlled trial. Clin Ther 37:2347–2351CrossRefPubMed Kasetsuwan N, Reinprayoon U, Satitpitakul V (2015) Prevention of recurrent pterygium with topical bevacizumab 0.05% eye drops: a randomized controlled trial. Clin Ther 37:2347–2351CrossRefPubMed
16.
Zurück zum Zitat Dong MC, Kim KH, Choi HJ et al (2012) A comparative study of the effect of fibrin glue versus sutures on clinical outcome in patients undergoing pterygium excision and conjunctival autografts. Korean Journal of Ophthalmology Kjo 26:407–413CrossRef Dong MC, Kim KH, Choi HJ et al (2012) A comparative study of the effect of fibrin glue versus sutures on clinical outcome in patients undergoing pterygium excision and conjunctival autografts. Korean Journal of Ophthalmology Kjo 26:407–413CrossRef
17.
Zurück zum Zitat Detorakis ET, Zaravinos A, Spandidos DA (2010) Growth factor expression in ophthalmic pterygia and normal conjunctiva. Int J Mol Med 25:513–516CrossRefPubMed Detorakis ET, Zaravinos A, Spandidos DA (2010) Growth factor expression in ophthalmic pterygia and normal conjunctiva. Int J Mol Med 25:513–516CrossRefPubMed
18.
Zurück zum Zitat Kuo CH, Miyazaki D, Yakura K et al (2010) Role of periostin and interleukin-4 in recurrence of pterygia. Invest Ophthalmol Vis Sci 51:139–143CrossRefPubMed Kuo CH, Miyazaki D, Yakura K et al (2010) Role of periostin and interleukin-4 in recurrence of pterygia. Invest Ophthalmol Vis Sci 51:139–143CrossRefPubMed
19.
Zurück zum Zitat Talghini S, Shenasi A (2013) Concomitant examination of inflammation and angiogenesis in the pathogenesis of primary moderate pterygium in a well-designed case-control study. Pakistan Journal of Biological Sciences Pjbs 16:1046–1050CrossRefPubMed Talghini S, Shenasi A (2013) Concomitant examination of inflammation and angiogenesis in the pathogenesis of primary moderate pterygium in a well-designed case-control study. Pakistan Journal of Biological Sciences Pjbs 16:1046–1050CrossRefPubMed
Metadaten
Titel
The efficacy of fascial granuloma excision with conjunctival autografting after pterygium surgery
verfasst von
Hui-Ya Fan
Zi-Lin Chen
Publikationsdatum
11.07.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 10/2018
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-018-4054-1

Weitere Artikel der Ausgabe 10/2018

Graefe's Archive for Clinical and Experimental Ophthalmology 10/2018 Zur Ausgabe

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Die Verwendung von Ophthalmika in der Schwangerschaft und Stillzeit stellt immer eine Off-label-Anwendung dar. Ein Einsatz von Arzneimitteln muss daher besonders sorgfältig auf sein Risiko-Nutzen-Verhältnis bewertet werden. In der vorliegenden …

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Vitrektomie Originalie

Die endogene Endophthalmitis ist eine hämatogen fortgeleitete, bakterielle oder fungale Infektion, die über choroidale oder retinale Gefäße in den Augapfel eingeschwemmt wird [ 1 – 3 ]. Von dort infiltrieren die Keime in die Netzhaut, den …

Bakterielle endogene Endophthalmitis

Vitrektomie Leitthema

Eine endogene Endophthalmitis stellt einen ophthalmologischen Notfall dar, der umgehender Diagnostik und Therapie bedarf. Es sollte mit geeigneten Methoden, wie beispielsweise dem Freiburger Endophthalmitis-Set, ein Keimnachweis erfolgen. Bei der …

So erreichen Sie eine bestmögliche Wundheilung der Kornea

Die bestmögliche Wundheilung der Kornea, insbesondere ohne die Ausbildung von lichtstreuenden Narben, ist oberstes Gebot, um einer dauerhaften Schädigung der Hornhaut frühzeitig entgegenzuwirken und die Funktion des Auges zu erhalten.   

Update Augenheilkunde

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.