Background
Review
Key features of cerebral malaria
Neurological deficits in survivors of cerebral malaria
The result of imaging studies
In vivo studies of angiopathy in cerebral malaria
Retinal changes on fundoscopy and fundus fluorescein angiography
Changes of vascular tone
Changes of blood flow on cerebral Doppler studies
The role of nitric oxide in cerebral malaria
The role of haemolysis in cerebral malaria
The role of endothelins
Post-mortem examination of patients who died of cerebral malaria
Retinal histopathology
Treatment of cerebral malaria
Nitric oxide donors
Discussion
The evidence for vasospasm in cerebral malaria
Clinical features |
Seizures, headaches, persistent neurological deficits, including aphasia, hemiplegia, hemianopia, or cortical blindness |
Radiological features |
MRI findings of sub-arachnoid and intracerebral haemorrhages, cerebral infarction, and reversible brain oedema, hyperintensities on T2 imaging involving the cortex and sub-cortical and deep white matter |
Doppler ultrasonographic findings |
Maximum mean flow velocities in the middle cerebral arteries might be normal during the first few days after onset of symptoms |