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International Urogynecology Journal

Erschienen in:

01.03.2013 | Original Article

The familiality of pelvic organ prolapse in the Utah Population Database

verfasst von: Peggy A. Norton, Kristina Allen-Brady, Lisa A. Cannon-Albright

Erschienen in: International Urogynecology Journal | Ausgabe 3/2013

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Abstract

Introduction and hypothesis

Pelvic organ prolapse (POP) in women is a common condition whose etiology is poorly understood. There is increasing evidence that POP is heritable. The aim of our study was to define and evaluate familial clustering of POP.

Methods

Using a population-based Utah genealogy linked to more than a decade of hospital data, we calculated relative risks (RR) of POP in female relatives of women with POP using age- and birth year-specific rates of POP. We compared the average pairwise relatedness of all POP cases to the population using a measure of genetic distance.

Results

We identified 1,292 women with diagnostic and procedure codes for POP. The RR of POP was significantly elevated in first- and third-degree female relatives (RR 4.15, p < 0.001; RR 1.24, p = 0.05). The average pairwise relatedness for all individuals with POP was significantly higher than expected (p < 0.001).

Conclusions

These results strongly support a significant heritable contribution to POP.

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Titel: The familiality of pelvic organ prolapse in the Utah Population Database
verfasst von: Peggy A. Norton
Kristina Allen-Brady
Lisa A. Cannon-Albright
Publikationsdatum: 01.03.2013
Verlag: Springer-Verlag
Erschienen in: International Urogynecology Journal / Ausgabe 3/2013
Print ISSN: 0937-3462
Elektronische ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-012-1866-0

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Springer Medizin

The familiality of pelvic organ prolapse in the Utah Population Database

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

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Springer Medizin

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

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