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Clinical and Experimental Nephrology
Erschienen in: Clinical and Experimental Nephrology 3/2017

23.06.2016 | Original article

The Fukuoka Kidney disease Registry (FKR) Study: design and methods

verfasst von: Shigeru Tanaka, Toshiharu Ninomiya, Kiichiro Fujisaki, Hisako Yoshida, Masaharu Nagata, Kosuke Masutani, Masanori Tokumoto, Koji Mitsuiki, Hideki Hirakata, Satoru Fujimi, Yutaka Kiyohara, Takanari Kitazono, Kazuhiko Tsuruya, Fukuoka Kidney disease Registry (FKR) Study Collaboration Group

Erschienen in: Clinical and Experimental Nephrology | Ausgabe 3/2017

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Abstract

Background

Chronic kidney disease (CKD) is an established independent risk factor for progression to end-stage renal disease (ESRD) and incidence of cardiovascular disease (CVD). The onset and progression of CKD are associated with both genetic predisposition and various lifestyle-related factors, but little is known about the influence of genetic-environmental interactions on the incidence of ESRD or CVD in patients with CKD.

Methods

The Fukuoka Kidney disease Registry (FKR) Study is designed as one of the largest prospective, multicenter, observational cohort studies in non-dialysis dependent CKD patients. The FKR Study aims to enroll approximately 5000 individuals at multiple clinical centers and follow them for up to at least 5 years. At baseline, subjects enrolled in the FKR Study will fill out extensive lifestyle-related questionnaires. Further, their health status and treatments will be monitored annually through a research network of nephrology centers. Blood and urine samples, including DNA/RNA, will be collected at the time of enrolment and every 5-years follow-up.

Conclusions

The FKR Study will provide many insights into the onset and progression of CKD, which will suggest hypothesis-driven interventional clinical trials aimed at reducing the burden of CKD. The features of the FKR Study may also facilitate innovative research to identify and validate novel risk factors, including genetic susceptibility and biomarkers, using biomaterials by high-throughput omics technologies.
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Metadaten
Titel
The Fukuoka Kidney disease Registry (FKR) Study: design and methods
verfasst von
Shigeru Tanaka
Toshiharu Ninomiya
Kiichiro Fujisaki
Hisako Yoshida
Masaharu Nagata
Kosuke Masutani
Masanori Tokumoto
Koji Mitsuiki
Hideki Hirakata
Satoru Fujimi
Yutaka Kiyohara
Takanari Kitazono
Kazuhiko Tsuruya
Fukuoka Kidney disease Registry (FKR) Study Collaboration Group
Publikationsdatum
23.06.2016
Verlag
Springer Japan
Erschienen in
Clinical and Experimental Nephrology / Ausgabe 3/2017
Print ISSN: 1342-1751
Elektronische ISSN: 1437-7799
DOI
https://doi.org/10.1007/s10157-016-1294-4

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