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Clinical Reviews in Allergy & Immunology

Erschienen in:

17.09.2022

The Genetics of Eczema Herpeticum

verfasst von: Elisabeth Hodara, Peck Y. Ong

Erschienen in: Clinical Reviews in Allergy & Immunology | Ausgabe 3/2022

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Abstract

Eczema herpeticum (EH) is a viral skin infection caused by herpes simplex virus (HSV) superimposed on eczematous skin lesions in atopic dermatitis (AD). Though the pathogenesis of EH has yet to be fully elucidated, the fact that EH is relatively rare despite a majority of adults showing serologic evidence of HSV exposure points to a genetic component predisposing to the disease. A number of genetic variants have been isolated in EH which may help distinguish a subgroup of patients susceptible to developing the condition. These unique genetic characteristics include deficiencies in skin barrier function and hydration, as well as at the level of the immune system. In this review, we summarize the genetic findings associated with EH identified to date. Isolating genetic markers in EH will be instrumental in stratifying patients at risk for EH and will have significant implications in the development and tailoring of targeted therapies.

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Titel: The Genetics of Eczema Herpeticum
verfasst von: Elisabeth Hodara
Peck Y. Ong
Publikationsdatum: 17.09.2022
Verlag: Springer US
Erschienen in: Clinical Reviews in Allergy & Immunology / Ausgabe 3/2022
Print ISSN: 1080-0549
Elektronische ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-022-08953-x

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The Genetics of Eczema Herpeticum

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