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Current Nutrition Reports

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12.09.2021 | Gastroenterology, Critical Care, and Lifestyle Medicine (SA McClave and M Eisa, Section Editors)

“The Gluten-Free Diet and Its Relationship with Metabolic Syndrome: Dietary Friend or Foe?”

verfasst von: Vishal Dhruva, Christy Lawson, Caitlin Green, Carolyn Newberry

Erschienen in: Current Nutrition Reports | Ausgabe 4/2021

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Abstract

Purpose of Review

Celiac disease (CD) is a prevalent digestive illness as well as a budding area of research in the field of gastroenterology. While investigations are underway to find new and improved pharmacological therapies for CD, the gluten-free diet (GFD) remains the only option to effectively manage the condition.

Recent Findings

While the GFD is recommended for patients diagnosed with CD and other gluten-related conditions, studies show the number of individuals on the GFD surpasses the projected number of patients with these medical indications (1). The implications of widespread adoption of this dietary approach are still being determined, with many patients believing this diet will improve overall health and cardiovascular risk.

Summary

This review analyzes the relationship between a GFD and metabolic syndrome in both non-celiac and celiac patients, concluding that although the diet may slightly improve overall cardiac risk factors, weight, and/or insulin resistance, its use in the absence of a gluten-related disorder is controversial.

Ana Real, Isabel Comino, Laura de Lorenzo et al. Molecular and immunological characterization of gluten proteins isolated from oat cultivars that differ in toxicity for celiac disease. PLoS One. 2012;7(12):e48365. Available from: https://www.ncbi.nlm.nih.gov/pubmed/23284616.

Stamnaes J|, L.M. Celiac disease: autoimmunity in response to food antigen. Semin Immunol. 2015;27(5):343–52. Available from: https://www.clinicalkey.es/playcontent/1-s2.0-S104453231500072X.

Sapone A, Bai JC, Ciacci C, et al. Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC medicine. 2012;10(1):13. https://search.datacite.org/works/https://doi.org/10.1186/1741-7015-10-13.

De Re V, Magris R, Cannizzaro R. New insights into the pathogenesis of celiac disease. Front Med (Lausanne). 2017;31(4):137. https://doi.org/10.3389/fmed.2017.00137.PMID:28913337;PMCID:PMC5583152.CrossRef

Patel N, Samant H. Wheat Allergy. [Updated 2020 Oct 15]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK536992/.

Dr. Schär Institute. Pathology of NCGS. https://www.drschaer.com/us/institute/a/pathogenesis-ncgs.

Davis W. Wheat belly: lose the wheat, lose the weight, and find your path back to health. Emmaus, Penn.: Rodale 2011.

Perlmutter D, Loberg K. Grain brain: the surprising truth about wheat, carbs, and sugar—your brain’s silent killers. Little: Brown, and Co.; 2013.

Reilly NR, MD. The gluten-free diet: Recognizing fact, fiction, and fad. J Pediatr. 2016;175:206–210. https://www-clinicalkey-es.proxy.libraries.rutgers.edu/playcontent/1-s2.0-S0022347616300622. https://doi.org/10.1016/j.jpeds.2016.04.014.

10.

Staudacher HM, Gibson PR. How healthy is a gluten-free diet? Br J Nutr. 2015;114(10):1539–41. https://doi.org/10.1017/S000711451500330X.CrossRefPubMed

11.

Flores Quan CV, Redecillas Ferreiro SE, Segarra Cantón O. Gluten-free diet: always as easy, useful, and healthy as people think?. J Child Sci. 2018;8(1):e75–e81. http://dx.doi.org.proxy.libraries.rutgers.edu/. https://doi.org/10.1055/s-0038-1669381.

12.

Diez-Sampedro A, Olenick M, Maltseva T, Flowers M. A gluten-free diet, not an appropriate choice without a medical diagnosis. J nutr metab. 2019;2019:2438934–5. https://dx-doi-org.proxy.libraries.rutgers.edu/https://doi.org/10.1155/2019/2438934.

13.

Welstead L. The gluten-free diet in the 3rd millennium: rules, risks and opportunities. Diseases. 2015;3(3):136–149. Published 2015 Jul 13. https://doi.org/10.3390/diseases3030136.

14.

Blackett J, Shamsunder M, Reilly N, Green P, Lebwohl B. Characteristics and comorbidities of inpatients without celiac disease on a gluten-free diet. European J Gastroenterol Hepatol. 2018;30(4):477–483. https://www-ncbi-nlm-nih-gov.proxy.libraries.rutgers.edu/pubmed/29315154. https://doi.org/10.1097/MEG.0000000000001071.

15.

Niland B, Cash BD. Health benefits and adverse effects of a gluten-free diet in non-celiac disease patients. Gastroenterol Hepatol. 2018;14(2):82–91. https://www-ncbi-nlm-nih-gov.proxy.libraries.rutgers.edu/pubmed/29606920. 2015;47(12):2563–2570. https://doi.org/10.1249/MSS.0000000000000699.

16.

Kmietowicz Z. Gluten-free diet is not recommended for people without celiac disease. BMJ. 2017;357:j2135. http://dx.doi.org.proxy.libraries.rutgers.edu/10.1136/bmj.j2135. https://doi.org/10.1136/bmj.j2135.

17.

Itzlinger A, Branchi F, Elli L, Schumann M. Gluten-Free diet in celiac disease-forever and for all?. Nutrients. 2018;10(11):1796. Published 2018 Nov 18. https://doi.org/10.3390/nu10111796.

18.

Levran N, Wilschanski M, Livovsky J, et al. Obesogenic habits among children and their families in response to initiation of gluten-free diet. Eur J Pediatr. 2018;177(6):859–866. https://www-ncbi-nlm-nih-gov.proxy.libraries.rutgers.edu/pubmed/29594339. https://doi.org/10.1007/s00431-018-3128-8.

19.

Więch P, Chmiel Z, Bazaliński D, et al. The relationship between body composition and a gluten free diet in children with celiac disease. Nutrients. 2018;10(11):1817. https://www-ncbi-nlm-nih-gov.proxy.libraries.rutgers.edu/pubmed/30469383. https://doi.org/10.3390/nu10111817.

20.

Sansotta N, Guandalini S, Romano S, et al. The gluten free diet’s impact on growth in children with celiac disease in two different countries. Nutrients. 2020;12(6):1547. Published 2020 May 26. https://doi.org/10.3390/nu12061547.

21.

Barone M, Della Valle N, Rosania R, et al. A comparison of the nutritional status between adult celiac patients on a long-term, strictly gluten-free diet and healthy subjects. Eur J Clin Nutr. 2016;70(1):23–7. https://doi.org/10.1038/ejcn.2015.114.CrossRefPubMed

22.

Perrin L, Allès B, Buscail C, et al. Gluten-free diet in French adults without coeliac disease: Sociodemographic characteristics, motives and dietary profile. British j nutr. 2019;122(2):231–239. https://www-ncbi-nlm-nih-gov.proxy.libraries.rutgers.edu/pubmed/31232248. https://doi.org/10.1017/S0007114519001053.

23.

Kim H, Demyen M, Mathew J, Kothari N, Feurdean M, Ahlawat S. Obesity, metabolic syndrome, and cardiovascular risk in gluten-free followers without celiac disease in the United States: results from the National Health and Nutrition Examination Survey 2009–2014. Dig Dis Sci. 2017;62(9):2440–2448. https://www-ncbi-nlm-nih-gov.proxy.libraries.rutgers.edu/pubmed/28451915. https://doi.org/10.1007/s10620-017-4583-1.

24.

Emilsson L, Semrad C. Obesity, metabolic syndrome, and cardiac risk factors: going gluten-free, for better or worse? Dig Dis Sci. 2017;62(9):2215–6. https://www-ncbi-nlm-nih-gov.proxy.libraries.rutgers.edu/pubmed/28639127. https://doi.org/10.1007/s10620-017-4649-0.

25.

Williams KV, Cristaldi CL, Miller RG, et al. Celiac autoimmunity is associated with lower blood pressure and renal risk in type 1 diabetes. J Clin Endocrinol Metab. 2018;103(10):3828–36. https://doi.org/10.1210/jc.2018-00908.CrossRefPubMedPubMedCentral

26.

Hill MF BB. Hyperlipidemia. StatPearls [Internet]. https://www-ncbi-nlm-nih-gov.proxy.libraries.rutgers.edu/books/NBK559182/#_NBK559182_pubdet.

27.

American College of Cardiology. 2014. Celiac Disease Linked to Increased Risk of Coronary Artery Disease - American College of Cardiology. [online] Available at: <https://www.acc.org/about-acc/press-releases/2014/03/29/08/40/gajulapalli-celiac-disease> [Accessed 12 June 2021].

28.

Iqbal AM JS. Essential hypertension. In: StatPearls [Internet]. 2020;Treasure Island (FL): StatPearls Publishing. https://www-ncbi-nlm-nih-gov.proxy.libraries.rutgers.edu/books/NBK539859/.

29.

Tavakkoli A, Lewis SK, Tennyson CA, Lebwohl B, Green PH. Characteristics of patients who avoid wheat and/or gluten in the absence of celiac disease. Dig Dis Sci. 2014;59(6):1255–61. https://doi.org/10.1007/s10620-013-2981-6.CrossRefPubMed

30.

Forchielli ML, Fernicola P, Diani L, et al. Gluten-free diet and lipid profile in children with celiac disease: comparison with general population standards. J Pediatr Gastroenterol Nutr. 2015.

31.

Brar P, Kwon GY, Holleran S, et al. Change in lipid profile in celiac disease: beneficial effect of gluten-free diet. Am J Med. 2006;119(9):786-790S0002-9343(06)00032-5[pii].

32.

Aguilar EC, Navia-Pelaez JM, Fernandes-Braga W, et al. Gluten exacerbates atherosclerotic plaque formation in ApoE–/– mice with diet-induced obesity. Nutr (Burbank, Los Angeles County, Calif.). 2020;75–76:110658. http://dx.doi.org.proxy.libraries.rutgers.edu/. https://doi.org/10.1016/j.nut.2019.110658.

33.

Kharroubi AT, Darwish HM. Diabetes mellitus: the epidemic of the century. World J Diabetes. 2015;6(6):850–67. https://doi.org/10.4239/wjd.v6.i6.850.CrossRefPubMedPubMedCentral

34.

Kahaly GJ, Frommer L, Schuppan D. Celiac disease and glandular autoimmunity. Nutrients. 2018;10(7):814. Published 2018 Jun 25. https://doi.org/10.3390/nu10070814.

35.

Kylökäs A, Kaukinen K, Huhtala H, Collin P, Mäki M, Kurppa K. Type 1 and type 2 diabetes in celiac disease: prevalence and effect on clinical and histological presentation. BMC Gastroenterol. 2016;16(1):76. Published 2016 Jul 25. https://doi.org/10.1186/s12876-016-0488-2

36.

Kizilgul M, Ozcelik O, Beysel S, et al. Screening for celiac disease in poorly controlled type 2 diabetes mellitus: worth it or not?. BMC Endocr Disord. 2017;17(1):62. Published 2017 Oct 6. https://doi.org/10.1186/s12902-017-0212-4.

37.

Tiberti C, Montuori M, Trovato CM, et al. Gluten-free diet impact on dynamics of pancreatic islet-specific autoimmunity detected at celiac disease diagnosis. Pediatr Diabetes. 2020;n/a. https://doi-org.proxy.libraries.rutgers.edu/. https://doi.org/10.1111/pedi.13054.

38.

Neuman V, Pruhova S, Kulich M, et al. Gluten‐free diet in children with recent‐onset type 1 diabetes: a 12‐month intervention trial. Diabetes Obes Metab. 2020;22(5):866–872. https://onlinelibrary-wiley-com.proxy.libraries.rutgers.edu/doi/abs/. https://doi.org/10.1111/dom.13974.

39.

Pham-Short A, Donaghue KC, Ambler G, Garnett S, Craig ME. Quality of life in type 1 diabetes and celiac disease: role of the gluten-free diet. J Pediatr. 2016;179:131-138.e1S0022-3476(16)30888-5[pii].

40.

De Melo EN, Deda L, Har R, et al. The urinary inflammatory profile in gluten free diet—adherent adolescents with type 1 diabetes and celiac disease. Journal of Diabetes and Its Complications. 2015;30(2):295–299. https://www-clinicalkey-es.proxy.libraries.rutgers.edu/playcontent/1-s2.0-S1056872715004584. https://doi.org/10.1016/j.jdiacomp.2015.11.020.

41.

Salardi S, Maltoni G, Zucchini S, et al. Celiac disease negatively influences lipid profiles in young children with type 1 diabetes: effect of the gluten-free diet. Diabetes Care. 2016;39(8):e119. http://care.diabetesjournals.org.proxy.libraries.rutgers.edu/content/39/8/e119.abstract. https://doi.org/10.2337/dc16-0717.

42.

Patoulias DI, Keryttopoulos P. Does a gluten-free diet determine the efficacy of sotagliflozin in patients with concomitant type 1 diabetes mellitus and celiac disease? Przegląd gastroenterologiczny. 2018;13(3):249–250. https://www-ncbi-nlm-nih-gov.proxy.libraries.rutgers.edu/pubmed/30302172. https://doi.org/10.5114/pg.2018.78291.

43.

Haupt-Jorgensen M, Holm LJ, Josefsen K, Buschard K. Possible prevention of diabetes with a gluten-free diet. Nutrients. 2018;10(11):1746. https://www-ncbi-nlm-nih-gov.proxy.libraries.rutgers.edu/pubmed/30428550. https://doi.org/10.3390/nu10111746.

44.

Antvorskov JC, Josefsen K, Haupt-Jorgensen M, Fundova P, Funda DP, Buschard K. Gluten-free diet only during pregnancy efficiently prevents diabetes in NOD mouse offspring. Journal of diabetes research. 2016;2016:3047574–7. https://dx-doi-org.proxy.libraries.rutgers.edu/. https://doi.org/10.1155/2016/3047574.

45.

Haupt-Jorgensen M, Buschard K, Hansen AK, Josefsen K, Antvorskov JC. Gluten-free diet increases beta-cell volume and improves glucose tolerance in an animal model of type 2 diabetes. Diabetes Metab Res Rev. 2016;32(7):675–684. https://doi-org.proxy.libraries.rutgers.edu/. https://doi.org/10.1002/dmrr.2802.

46.

Svensson J, Sildorf S, Pipper C, et al. Potential beneficial effects of a gluten-free diet in newly diagnosed children with type 1 diabetes: a pilot study. SpringerPlus. 2016;5(1):1–8. https://www-ncbi-nlm-nih-gov.proxy.libraries.rutgers.edu/pubmed/27398272. https://doi.org/10.1186/s40064-016-2641-3.

47.

Zong G, Lebwohl B, Hu FB, et al. Gluten intake and risk of type 2 diabetes in three large prospective cohort studies of US men and women. Diabetologia. 2018;61(10):2164–73. https://doi.org/10.1007/s00125-018-4697-9.CrossRefPubMedPubMedCentral

48.

Smith BW, Adams LA. Non-alcoholic fatty liver disease. Crit Rev Clin Lab Sci. 2011;48(3):97–113. https://doi.org/10.3109/10408363.2011.596521.CrossRefPubMed

49.

Tovoli F, Negrini G, Farì R, et al. Increased risk of nonalcoholic fatty liver disease in patients with coeliac disease on a gluten-free diet: beyond traditional metabolic factors. Aliment Pharmacol Ther. 2018;48(5):538–546. https://doi-org.proxy.libraries.rutgers.edu/. https://doi.org/10.1111/apt.14910.

50.

O’Neill S, O'Driscoll L. Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies. Obesity reviews. 2015;16(1):1–12. https://search.datacite.org/works/. https://doi.org/10.1111/obr.12229.

51.

Takamiya T, Zaky WR, Edmundowics D, et al. World health organization-defined metabolic syndrome is a better predictor of coronary calcium than the adult treatment panel III criteria in american men aged 40–49 years. Diabetes Care. 2004;27(12):2977. http://care.diabetesjournals.org/content/27/12/2977.abstract. https://doi.org/10.2337/diacare.27.12.2977.

52.

Mazloomzadeh S, Karami Zarandi F, Shoghli A, Dinmohammadi H. Metabolic syndrome, its components and mortality: a population-based study. Med J Islamic Rep Iran. 2019;33:11. https://pubmed.ncbi.nlm.nih.gov/31086790https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504944/. https://doi.org/10.34171/mjiri.33.11.

53.

Tortora R, Capone P, De Stefano G, et al. metabolic syndrome in patients with coeliac disease on a gluten-free diet. Aliment Pharmacol Ther. 2015;41(4):352–359. https://doi-org.proxy.libraries.rutgers.edu/. https://doi.org/10.1111/apt.13062.

54.

Chiarioni G, De Marchi S, Prior M, Arosio E. Letter: metabolic syndrome in patients with coeliac disease on a gluten-free diet. Aliment Pharmacol Ther. 2015;41(8):795–796. https://doi-org.proxy.libraries.rutgers.edu/. https://doi.org/10.1111/apt.13125.

55.

Ehteshami M, Shakerhosseini R, Sedaghat F, Hedayati M, Eini-Zinab H, Hekmatdoost A. The effect of gluten free diet on components of metabolic syndrome: a randomized clinical trial. Asian Pacific journal of cancer prevention : APJCP. 2018;19(10):2979–2984. https://www-ncbi-nlm-nih-gov.proxy.libraries.rutgers.edu/pubmed/30362336. https://doi.org/10.22034/APJCP.2018.19.10.2979.

56.

Raehsler SL, Choung RS, Marietta EV, Murray JA. Accumulation of heavy metals in people on a gluten-free diet. Clin Gastroenterol Hepatol. 2017;16(2):244–251. https://www-clinicalkey-es.proxy.libraries.rutgers.edu/playcontent/1-s2.0-S1542356517301866. https://doi.org/10.1016/j.cgh.2017.01.034.

Titel: “The Gluten-Free Diet and Its Relationship with Metabolic Syndrome: Dietary Friend or Foe?”
verfasst von: Vishal Dhruva
Christy Lawson
Caitlin Green
Carolyn Newberry
Publikationsdatum: 12.09.2021
Verlag: Springer US
Erschienen in: Current Nutrition Reports / Ausgabe 4/2021
Elektronische ISSN: 2161-3311
DOI: https://doi.org/10.1007/s13668-021-00371-3

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Abstract

Purpose of Review

Recent Findings

Summary

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